Monitoring of vitamin B-12 nutritional status in the United States by using plasma methylmalonic acid and serum vitamin B-12

American Journal of Clinical Nutrition

Volumn 94, Issue 2, 2011, Pages 552-561

  Bailey, Regan L ^a   Carmel, Ralph ^b,c   Green, Ralph ^d   Pfeiffer, Christine M ^e   Cogswell, Mary E ^f   Osterloh, John D ^e   Sempos, Christopher T ^a   Yetley, Elizabeth A ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NEW YORK METHODIST HOSPITAL   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e NATIONAL CENTER FOR ENVIRONMENTAL HEALTH   (United States)

^f NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYANOCOBALAMIN; METHYLMALONIC ACID;

ADULT; ARTICLE; CHEMICAL ANALYSIS; CYANOCOBALAMIN DEFICIENCY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLISM; NUTRITIONAL STATUS; OUTCOME ASSESSMENT; PREVALENCE; UNITED STATES; VITAMIN BLOOD LEVEL;

ADULT; BIOLOGICAL MARKERS; COGNITION DISORDERS; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; MALE; METHYLMALONIC ACID; MIDDLE AGED; NUTRITIONAL STATUS; UNITED STATES; VITAMIN B 12;

EID: 79960865571     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.111.015222     Document Type: Article

References (46)

1. Lindenbaum J, Rosenberg IH, Wilson PW, Stabler SP, Allen RH. Prevalence of cobalamin deficiency in the Framingham elderly population. Am J Clin Nutr 1994;60:2-11.
2. Pennypacker LC, Allen RH, Kelly JP, et al. High prevalence of cobalamin deficiency in elderly outpatients. J Am Geriatr Soc 1992;40:1197-204.
3. Yetley EA, Pfeiffer CP, Phinney KW, et al. Biomarkers of vitamin B-12 status in NHANES: a roundtable summary. Am J Clin Nutr (Epub ahead of print 25 May 2011).
4. Green R, Miller JW. Vitamin B12 deficiency is the dominant nutritional cause of hyperhomocysteinemia in a folic acid-fortified population. Clin Chem Lab Med 2005;43:1048-51. (Pubitemid 41581959)
5. Carmel R. Biomarkers of cobalamin (vitamin B-12) status in the epidemiologic setting: a critical overview of context, applications, and performance characteristics of cobalamin, methylmalonic acid, and holotranscobalamin II. Am J Clin Nutr (Epub ahead of print 25 May 2011).
6. Carmel R, Sarrai M. Diagnosis and management of clinical and subclinical cobalamin deficiency: advances and controversies. Curr Hematol Rep 2006;5:23-33.
7. Carmel R, Green R, Rosenblatt DS, Watkins D. Update on cobalamin, folate, and homocysteine. Hematology Am Soc Hematol Educ Program 2003;62-81.
8. Response rates & CPS population totals, National Health and Nutrition Examination Survey. National Center for Health Statistics. Available from: http://www.cdc.gov/nchs/nhanes/response-rates-cps.htm (cited March 2011).
9. Vogiatzoglou A, Oulhaj A, Smith AD, et al. Determinants of plasma methylmalonic acid in a large population: implications for assessment of vitamin B12 status. Clin Chem 2009;55:2198-206.
10. Bailey RL, Dodd KW, Gahche JJ, et al. Total folate and folic acid intake from foods and dietary supplements in the United States: 2003-2006. Am J Clin Nutr 2010;91:231-7.
11. 12, pantothenic acid, biotin, and choline. Washington, DC: National Academy Press, 1998.
12. Wechsler D. Wechsler Adult Intelligence Scale-III. San Antonio, TX: Harcourt Brace and Company, 1997.
13. National Center for Health Statistics. National Health and Nutrition Examination Survey. Household Interview Questionnaire. 2004. Available from: http://www.cdc.gov/nchs/nhanes/nhanes-questionnaires.htm (cited March 2011).
14. Morris MS, Jacques PF, Rosenberg IH, Selhub J. Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors. Am J Clin Nutr 2010;91:1733-44.
15. National Center for Health Statistics. Datasets and related documentation. Available from: http://www.cdc.gov/nchs/nhanes/nhanes- questionnaires.htm (cited 19 March 2011).
16. Pfeiffer CM, Osterloh JD, Kennedy-Stephenson J, et al. Trends in circulating concentrations of total homocysteine among US adolescents and adults: findings from the 1991-1994 and 1999-2004 National Health and Nutrition Examination Surveys. Clin Chem 2008;54:801-13. (Pubitemid 351671605)
17. Selvin E, Manzi J, Stevens LA, et al. Calibration of serum creatinine in the National Health and Nutrition Examination Surveys (NHANES) 1988-1994, 1999-2004. Am J Kidney Dis 2007;50:918-26. (Pubitemid 350122815)
18. National Center for Health Statistics. National Health and Nutrition Examination Survey. Laboratory methods, 1999-2000. Available from: http://www.cdc.gov/nchs/nhanes/lab99-00.htm (cited 19 March 2011).
19. National Center for Health Statistics. National Health and Nutrition Examination Survey. Laboratory methods, 2001-2002. Available from: http://www.cdc.gov/nchs/nhanes/nhanes2001-2002/lab01-02.htm (cited 19 March 2011).
20. National Center for Health Statistics. National Health and Nutrition Examination Survey. Laboratory methods, 2003-2004. Available from: http://www.cdc.gov/nchs/nhanes/nhanes2003-2004/lab03-04.htm (cited 19 March 2011).
21. Selhub J, Morris MS, Jacques PF. In vitamin B12 deficiency, higher serum folate is associated with increased total homocysteine and methylmalonic acid concentrations. Proc Natl Acad Sci USA 2007; 104:19995-20000.
22. Morris MS, Jacques PF, Rosenberg IH, Selhub J. Elevated serum methylmalonic acid concentrations are common among elderly Americans. J Nutr 2002;132:2799-803. (Pubitemid 35013273)
23. Pfeiffer CM, Caudill SP, Gunter EW, Osterloh J, Sampson EJ. Biochemical indicators of B vitamin status in the US population after folic acid fortification: results from the National Health and Nutrition Examination Survey 1999-2000. Am J Clin Nutr 2005;82:442-50.
24. Vanderjagt DJ, Ujah IA, Patel A, et al. Subclinical vitamin B12 deficiency in pregnant women attending an antenatal clinic in Nigeria. J Obstet Gynaecol 2009;29:288-95.
25. Wahlin A, Hill RD, Winblad B, Backman L. Effects of serum vitamin B12 and folate status on episodic memory performance in very old age: a population-based study. Psychol Aging 1996;11:487-96. (Pubitemid 26355251)
26. Clarke R, Grimley Evans J, Schneede J, et al. Vitamin B12 and folate deficiency in later life. Age Ageing 2004;33:34-41. (Pubitemid 38111446)
27. Hvas AM, Nexo E. Holotranscobalamin as a predictor of vitamin B12 status. Clin Chem Lab Med 2003;41:1489-92. (Pubitemid 37493565)
28. Johnson MA, Hausman DB, Davey A, Poon LW, Allen RH, Stabler SP. Vitamin B12 deficiency in African American and white octogenarians and centenarians in Georgia. J Nutr Health Aging 2010; 14:339-45.
29. Robertson J, Iemolo F, Stabler SP, Allen RH, Spence JD. Vitamin B12, homocysteine and carotid plaque in the era of folic acid fortification of enriched cereal grain products. CMAJ 2005;172:1569-73. (Pubitemid 40839528)
30. Stabler SP. Screening the older population for cobalamin (vitamin B12) deficiency. J Am Geriatr Soc 1995;43:1290-7.
31. Savage DG, Lindenbaum J, Stabler SP, Allen RH. Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies. Am J Med 1994;96: 239-46. (Pubitemid 24099223)
32. Allen RH, Stabler SP, Savage DG, Lindenbaum J. Diagnosis of cobalamin deficiency I: usefulness of serum methylmalonic acid and total homocysteine concentrations. Am J Hematol 1990;34:90-8. (Pubitemid 20180100)
33. Lindenbaum J, Savage DG, Stabler SP, Allen RH. Diagnosis of cobalamin deficiency: II. Relative sensitivities of serum cobalamin, methylmalonic acid, and total homocysteine concentrations. Am J Hematol 1990;34:99-107. (Pubitemid 20180101)
34. Stabler SP, Allen RH, Savage DG, Lindenbaum J. Clinical spectrum and diagnosis of cobalamin deficiency. Blood 1990;76:871-81. (Pubitemid 20295496)
35. Subar AF, Block G. Use of vitamin and mineral supplements: demographics and amounts of nutrients consumed. The 1987 Health Interview Survey. Am J Epidemiol 1990;132:1091-101.
36. Rajan S, Wallace JI, Beresford SA, Brodkin KI, Allen RA, Stabler SP. Screening for cobalamin deficiency in geriatric outpatients: prevalence and influence of synthetic cobalamin intake. JAm Geriatr Soc 2002;50:624-30. (Pubitemid 34298749)
37. Stabler SP, Allen RH, Fried LP, et al. Racial differences in prevalence of cobalamin and folate deficiencies in disabled elderly women. Am J Clin Nutr 1999;70:911-9. (Pubitemid 29512919)
38. Kuzminski AM, Del Giacco EJ, Allen RH, Stabler SP, Lindenbaum J. Effective treatment of cobalamin deficiency with oral cobalamin. Blood 1998;92:1191-8. (Pubitemid 28369032)
39. Park S, Johnson MA, Shea-Miller K, De Chicchis AR, Allen RH, Stabler SP. Age-related hearing loss, methylmalonic acid, and vitamin B12 status in older adults. J Nutr Elder 2006;25:105-20. (Pubitemid 47434394)
40. Morris MS, Jacques PF, Rosenberg IH, Selhub J. Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. Am J Clin Nutr 2007;85:193-200. (Pubitemid 46067634)
41. Selhub J, Morris MS, Jacques PF, Rosenberg IH. Folate-vitamin B-12 interaction in relation to cognitive impairment, anemia, and biochemical indicators of vitamin B-12 deficiency. Am J Clin Nutr 2009;89:702S-6S.
42. Carmel R. Prevalence of undiagnosed pernicious anemia in the elderly. Arch Intern Med 1996;156:1097-100. (Pubitemid 26158066)
43. Hazra A, Kraft P, Selhub J, et al. Common variants of FUT2 are associated with plasma vitamin B12 levels. Nat Genet 2008;40:1160-2.
44. Carmel R, Green R, Jacobsen DW, Rasmussen K, Florea M, Azen C. Serum cobalamin, homocysteine, and methylmalonic acid concentrations in a multiethnic elderly population: ethnic and sex differences in cobalamin and metabolite abnormalities. Am J Clin Nutr 1999;70:904-10. (Pubitemid 29512918)
45. Hvas AM, Juul S, Gerdes LU, Nexo E. The marker of cobalamin deficiency, plasma methylmalonic acid, correlates to plasma creatinine. J Intern Med 2000;247:507-12. (Pubitemid 30253171)
46. Vesper HW, Thienpont LM. Traceability in laboratory medicine. Clin Chem 2009;55:1067-75.