Apolipoprotein E deficiency promotes increased oxidative stress and compensatory increases in antioxidants in brain tissue

Free Radical Biology and Medicine

Volumn 33, Issue 8, 2002, Pages 1115-1120

  Shea, Thomas B ^a   Rogers, Eugene ^a   Ashline, David ^a   Ortiz, Daniela ^a   Sheu, Min Shyan ^b  

^a UNIVERSITY OF MASSACHUSETTS LOWELL   (United States)

^b AST Products Inc   (United States)

Author keywords

Antioxidants; ApoE; Folate deprivation; Free radicals; Glutathione; Oxidative damage

Indexed keywords

ANTIOXIDANT; APOLIPOPROTEIN E; FOLIC ACID; GLUTATHIONE; IRON;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CONTROLLED STUDY; DIET; GENETIC PREDISPOSITION; HYPERLIPOPROTEINEMIA TYPE 3; MOUSE; NONHUMAN; NUTRITIONAL DEFICIENCY; OXIDATIVE STRESS; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; ANIMALS; ANTIOXIDANTS; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; BRAIN; DISEASE MODELS, ANIMAL; FOLIC ACID DEFICIENCY; GLUTATHIONE; HUMANS; IRON; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; OXIDATIVE STRESS; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

MUS MUSCULUS;

EID: 0037108213     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(02)01001-8     Document Type: Article

References (65)

1. Growdon J. Incorporating biomarkers into clinical drug trials in Alzheimer's disease. J. Alzheim. Dis. 3:2001;287-292.
2. Ramassamy C., Averill D., Beffert L., Throux L., Lussier-Cacan S., Cohn J.S., Christen Y., Schoofs J., Davignon J. Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer's disease is related to the apolipoprotein E genotype. Free Radic. Biol. Med. 27:1999;544-553.
3. Masliah E., Mallory M., Ge N., Alford M., Veinbergs I., Roses A.D. Neurodegeneration in the central nervous system of apoE-deficient mice. Exp. Neurol. 136:1995;107-122.
4. Hayek T., Oiknine J., Brook J.G., Aviram M. Increased plasma and lipoprotein lipid peroxidation in apo E-deficient mice. Biochem. Biophys. Res. Commun. 201:1994;1567-1574.
5. Ignatius M.J., Gebicke-Haeter P.J., Skene J.H.P., Schilling J.W., Weisgraber K.H., Mahley R., Shooter E.M. Expression of apolipoprotein E during nerve degeneration and regeneration. Proc. Natl. Acad. Sci. USA. 83:1986;1125-1129.
6. Pitas R.E., Boyles J.K., Lee S.H., Foss D., Mahley R.W. Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins. Biochim. Biophys. Acta. 917:1987;148-161.
7. Poirier J., Hess M., May P.C., Finch C.E. Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning. Brain Res. Mol. Brain Res. 11:1991;97-106.
8. Snipes, G. J.; McGuire, C. B.; Norden, J. J.; Freman, J. A. Nerve injury stimulates the secretion of apolipoprotein E by nonneuronal cells. Proc. Natl. Acad. Sci. USA 83:1130-1134.
9. Huang G.S., Yang S.M., Hong M.Y., Yang P.C., Liu Y.C. Differential gene expression of livers from ApoE-deficient mice. Life Sci. 68:2000;19-28.
10. Bayes B., Pastor M.C., Bonal J., Junca J., Romero R. Homocysteine and lipid peroxidation in hemodialysis role of folinic acid and vitamin E . Nephrol. Dial. Transplant. 16:2001;2172-2175.
11. Huang R.F., Hsu Y.C., Lin H.L., Yang F. Folate depletion and elevated plasma homocysteine promote oxidative stress in rat livers. J. Nutr. 131:2001;33-88.
12. Kruman I.I., Culmsee C., Chan S., Kruman Y., Guo Z., Penix L., Mattson M.P. Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. J. Neurosci. 20:2000;6920-6926.
13. Whittaker P., Wamer W.G., Chanderbhan R.F., Dunkel V.C. Effects of α-tocopherol and β-carotene on hepatic lipid peroxidation and blood lipids in rats with dietary iron overload. Nutr. Cancer. 25:1996;119-128.
14. Piedrahita J.A., Zhang S.H., Hagamen J.R., Olver P.M., Maida N. Genetics of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. Proc. Natl. Acad. Sci. USA. 89:1992;4471-4475.
15. Ibrahim W., Lee U.-S., Yeh C.-C., Szabo J., Bruckner G., Chow C.K. Oxidative stress and antioxidant status in mouse liver effects of dietary lipid, vitamin E, and iron . J. Nutr. 127:1997;1401-1406.
16. Shea, T. B.; Rogers, E. Folate quenches oxidative damage in brains of apolipoprotein E-deficient mice: augmentation by vitamin E. Mol. Brain Res. In press.
17. Shea T.B., Ekinci F.J., Ortiz D., Linsley M.-D., Wilson T.O., Nicolosi R.J. Efficacy of vitamin E, phosphatidyl choline, and pyruvate on buffering neuronal degeneration and oxidative stress in cultured cortical neurons and in central nervous tissue of apolipoprotein E-deficient mice. Free Radic. Biol. Med. 33:2002;276-282.
18. Pratico D., Rokach J., Tangirala R.K. Brains of aged apolipoprotein E-deficient mice have increased levels of F2-isoprostanes, in vivo markers of lipid peroxidation. J. Neurochem. 73:1999;736-741.
19. Araki A., Sako Y. Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection. J. Chromatogr. 422:1987;43-52.
20. Lovell M.A., Ehmann W.D., Butler S.M., Markesbery W.R. Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease. Neurology. 45:1995;1594-1601.
21. Miyata M., Smith J.D. Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and β-amyloid peptides. Nature Gen. 14:1996;55-61.
22. Okatani Y., Wakatsuki A., Reiter R.J., Miyahara Y. Melatonin reduces oxidative damage of neural lipids and proteins in senescence-accelerated mouse. Neurobiol. Aging. 23:2002;639-644.
23. Miller N.J., Rice-Evans C., Davies M.J., Gopinathan V., Milner A. A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates. Clin. Sci. 84:1993;407-412.
24. Ramassamy C., Krzywkowski P., Averill D., Lussier-Cacan S., Throux L., Christen Y., Davignon J., Poirier J. Impact of apolipoprotein E deficiency on oxidative insults and antioxidant levels in the brain. Mol. Brain Res. 86:2002;76-83.
25. Mosharov E., Cranford M.R., Banerjee R. The quantitatively important relationship between homocysteine metabolism and glutathione synthesis by the trans-sulfuration pathway and its regulation by redox changes. Biochemistry. 39:2000;13005-13011.
26. Pocernich C.B., Cardin A.L., Racine C.L., Lauderback C.M., Butterfield D.A. Glutathione elevation and its protective role in acrolein-induced protein in synaptosomal membranes relevance to brain lipid peroxidation in neurodegenerative disease . Neurochem. Int. 39:2001;141-149.
27. Barkats M., Millecamps S., Abrioux P., Geoffroy M.C., Mallet J. Overexpression of glutathione peroxidase increases the resistance of neuronal cells to Abeta-mediated neurotoxicity. J. Neurochem. 75:2000;1438-1446.
28. Lievre V., Becuwe P., Bianchi A., Bossenmeyer-Pourie C., Koziel V., Franck P., Nicolas M.B., Dauca M., Vert P., Daval J.L. Intracellular generation of free radicals and modifications of detoxifying enzymes in cultured neurons from the developing rat forebrain in response to transient hypoxia. Neuroscience. 105:2001;287-297.
29. Allen R.H., Stabler S.P., Lindenbaum J. Relevance of vitamins, homocysteine, and other metabolites in neuropsychiatric disorders. Eur. J. Pediatr. 157:(Suppl. 2):1998;S122-S126.
30. Clarke R., Smith A.D., Jobst K.A., Refsum H., Sutton L., Ueland P.M. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch. Neurol. 55:1998;1449-1455.
31. Ebly E.M., Schaefer J.P., Campbell N.R., Hogan D.B. Folate status, vascular disease, and cognition in elderly Canadians. Age Aging. 27:1998;485-491.
32. Renvall M.J., Spindler A.A., Ramsdell J.W., Paskvan M. Nutritional status of free-living Alzheimer's patients. Am. J. Med. Sci. 298:1989;20-27.
33. Hassing L., Wahlin A., Winblad B., Backman L. Further evidence on the effects of vitamin B12 and folate levels on episodic memory functioning a population-based study of healthy very old adults . Biol. Psych. 45:1999;1472-1480.
34. Wang H.-X., Wahlin A., Basun H., Fastom J., Winblad B., Fratiglioni L. Vitamin B12 and folate in relation to the development of Alzheimer's disease. Neurology. 56:2001;1188-1194.
35. Snowdon D.A., Tully C.L., Smith C.D., Riley D., Markesbery W. Serum folate and the severity of atrophy of the neocortex in Alzheimer disease findings from the nun study . Am. J. Clin. Nutr. 71:2000;993-998.
36. Serot J.M., Christman D., Dubost T., Bene M.C., Faure G.C. CSF-folate levels are decreased in late-onset AD patients. J. Neural Trans. 108:2001;93-99.
37. Gray G.E. Nutrition and dementia. J. Am. Diet Assn. 89:1989;1795-1802.
38. Fiskerstrand T., Ueland P.M., Refsum H. Folate depletion induced by methotrexate affects methionine synthase activity and its susceptibility to inactivation by nitrous oxide. J. Pharmacol. Exp. Ther. 282:1997;1305-1311.
39. Ho P.I., Collins S.C., Dhitavat S., Ortiz D., Ashline D., Rogers E., Shea T.B. Homocysteine potentiates β-amyloid neurotoxicity role of oxidative stress . J. Neurochem. 78:(2):2001;249-253.
40. White A.R., Huang X., Jobling M.F., Barrow C.H., Beyreuther K., Masters C.L., Bush A.I., Cappai R. Homocysteine potentiates copper- and amyloid β peptide-mediated toxicity in primary cultures possible risk factors in the Alzheimer's-type neurodegenerative pathways . J. Neurochem. 76:2001;1509-1520.
41. Upchurch G.R., Welch G.N., Fabian A.J., Freedman J.E., Johnson J.L., Keaney J.F., Loscalzo J. Homocysteine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase. J. Biol. Chem. 272:1997;17012-17017.
42. Henning S.M., Swendseid M.E., Ivandic B.T., Liao F. Vitamins C, E, and A and heme oxygenase in rats fed methyl/folate-deficient diets. Free Radic. Biol. Med. 23:1997;936-942.
43. Duan W., Ladenheim B., Cutler R.G., Kruman I.I., Cadet J.L., Mattson M.P. Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease. J. Neurochem. 80:2002;101-110.
44. Kruman I.I., Kumaravel T.S., Lohani A., Pedersen W.A., Cutler R.G., Kruman Y., Haughey N., Lee J., Evans M., Mattson M.P. Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease. J. Neurosci. 22:2002;1752-1762.
45. Miller J.W. Homocysteine, Alzheimer's disease, and cognitive function. Nutrition. 16:2000;675-677.
46. Lomnitski L., Chapman S., Hochman A., Kohen R., Shohami E., Chen Y., Trembvler V., Michaelson D.W. Antioxidant mechanisms in apolipoprotein E-deficient mice prior to and following closed head injury. Biochim. Biophys. Acta. 1453:1999;359-368.
47. Reich E.E., Montine K.S., Gross M.D., Roberts L.J. II, Swift L.L., Morrow J.D., Montine T.J. Interactions between apolipoprotein E gene and dietary α-tocopherol influence cerebral oxidative damage in aged mice. J. Neurosci. 21:2001;5993-5999.
48. Veinbergs I., Mallory M., Sagara Y., Masliah E. Vitamin E supplementation prevents spatial learning deficits and dendritic alterations in aged apolipoprotein E-deficient mice. Eur J. Neurosci. 12:2000;4541-4546.
49. Mattson M.P., Tomaselli K.J., Rydel R.E. Calcium-destabilizing and neurodegenerative effects of aggregated β amyloid peptide are attenuated by basic FGF. Brain Res. 621:1993;35-49.
50. Bogdanovic N., Zilmer M., Zilmer K., Rehema A., Karelson E. The swedish app670/671 Alzheimer's disease mutation the first evidence for strikingly increased oxidative injury in the temporal inferior cortex . Dement. Geriatr. Cogn. Disord. 12:(6):2001;364-370.
51. Kontush A. Amyloid β an antioxidant that becomes a pro-oxidant and critically contributes to Alzheimer's disease . Free Radic. Biol. Med. 31:(9):2001;1120-1131.
52. Subramaniam R., Koppal T., Green M., Yatin S., Jordan B., Drake J., Butterfield D.A. The free radical antioxidant vitamin E protects cortical synaptosomal membranes from amyloid β-peptide (25-35) toxicity but not from hydroxynonenol toxicity relevance to the free radical hypothesis of Alzheimer's disease . Neurochem. Res. 23:1998;1403-1410.
53. Karelson E., Bogdanovic N., Garlind A., Winblad B., Zilmer K., Kullisaar T., Vihalemm T., Kairane C., Zilmer M. The cerebrocortical areas in normal brain aging and in Alzheimer's disease noticeable differences in the lipid peroxidation level and in antioxidant defense . Neurochem. Res. 26:(4):2001;353-361.
54. Mattson M.P. Cellular actions of β-amyloid precursor protein and its soluble and fibrillogenic derivatives. Physiol Rev. 77:1997;1081-1132.
55. Davey G.P., Peuchen S., Clark J.B. Energy thresholds in brain mitochondria. Potential involvement in neurodegeneration. J. Biol. Chem. 273:1998;12753-12757.
56. Kourie J.I. Mechanisms of amyloid β protein-induced modification in ion transport systems implications for neurodegenerative diseases . Cell Mol. Neurobiol. 21:2001;173-213.
57. Munch G., Schinzel R., Loske C., Wong A., Durany N., Li J.J., Vlassara H., Smith M.A., Perry G., Riederer P. Alzheimer's disease synergistic effects of glucose deficit, oxidative stress, and advanced glycation endproducts . J. Neural Trans. 105:1998;439-461.
58. Pereira C., Santos M.S., Oliveira C. Involvement of oxidative stress on the impairment of energy metabolism induced by Abeta peptides on PC12 cells protection by antioxidants . Neurobiol. Dis. 6:1999;209-219.
59. Smith-Swintosky V.L., Mattson M.P. Glutamate, β-amyloid precursor proteins, and calcium-mediated neurofibrillary degeneration. J. Neural Trans. 44:(Suppl.):1994;29-45.
60. Grant W.B. Dietary links to Alzheimer's disease 1999 update . J. Alzheim. Dis. 1:1999;197-201.
61. McDowell I. Alzheimer's disease insights from epidemiology . Aging. 13:2000;143-162.
62. Newman P.E. Could diet be used to reduce the risk of Alzheimer's disease? Med. Hypoth. 50:1998;335-337.
63. Shea, T. B.; Lyons-Wieler, J.; Rogers, E. Homocysteine, folate deprivation, and Alzheimer's disease. J. Alzheim. Dis. In press.
64. Smith M.A., Petot G.J., Perry G. Diet and oxidative stress a novel synthesis of epidemiological data on Alzheimer's disease . J. Alzheim. Dis. 1:1999;203-206.
65. Smith M.A., Perry G. Free radical damage, iron, and Alzheimer's disease. J. Neurol. Sci. 134:(Suppl.):1995;92-94.