Is MTHFR polymorphism a risk factor for Alzheimer's disease like apoe?

Arquivos de Neuro-Psiquiatria

Volumn 63, Issue 1, 2005, Pages 1-6

  Lisboa Fernandez, Liana ^a,b   Machado Scheibe, Rosane ^a  

^a PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b NONE   (Brazil)

Author keywords

Alzheimer's disease; Apolipoprotein E; Methylenetetrahydrofolate reductase; PCR RFLP; Risk factors

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); APOLIPOPROTEIN E; APOLIPOPROTEIN E2; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4;

ACADEMIC ACHIEVEMENT; ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; ATHEROSCLEROSIS; CASE CONTROL STUDY; CHI SQUARE TEST; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; FAMILY HISTORY; FEMALE; FISHER EXACT TEST; GENE AMPLIFICATION; GENE MUTATION; GENETIC POLYMORPHISM; GENOTYPE; HEART ATRIUM FIBRILLATION; HORMONE SUBSTITUTION; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; MALE; MANTEL HAENSZEL TEST; NEUROIMAGING; NEUROPSYCHOLOGICAL TEST; POLYACRYLAMIDE GEL ELECTROPHORESIS; RISK FACTOR; SMOKING;

EID: 17444402415     PISSN: 0004282X     EISSN: None     Source Type: Journal    
DOI: 10.1590/s0004-282x2005000100001     Document Type: Article

References (37)

1. Prince DL, Sisodia SS, Borchett DR. Alzheimer disease: when or why? Nature Genetics 1998;19:314-316.
2. Goate A, Chartier-Harlin MC, Mullan M, et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 1991;349:704-706.
3. Sherrington R, Froelich S, Sorbi S, et al. Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant. Hum Molec Genet 1996;5:985-988.
4. Levy-Lahad E, Wijsman EM, Memens E, et al. A familial Alzheimer's disease locus on chromosome 1. Science 1995;269:970-973.
5. Tanzi RE, Bertram L. New frontiers in Alzheimer's disease genitics. Neuron 2001;32:181-184.
6. Strittmatter W, Saunders AM, Schmechel D, et al. Apolipoprotein E: high-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci USA 1993; 90:1977-1981.
7. Mayeux R, Stern Y, Ottman R, et al. The apolipoprotein E4 allele in patients with Alzheimer's disease. Ann Neurol 1993;34:752-754.
8. Saunders AM, Strittmatter WJ, Schmechel D, et al. Association of apolipoprotein E allele E4 with late-onset familial and sporadic Alzheimer's disease. Neurology 1993;43:1467-1472.
9. Regland B, Blennow K, Germgard T, et al. The role of polymorphic genes apolipoprotein E and methylenotetrahidrofolate reductase in the development of dementia of Alzheimer type. Dement Geriatr Cogn Disord 1999;10:245-251
10. Farrer LA, Cupples LA, Haines JL, et al. Effects of age, sex, end ethnicity on the association between apolipoprotein E genotype and Alzheimer disease: a meta-analysis. JAMA 1997;278:1349-1356.
11. Blacker D, Haines JL, Rods L, et al. ApoE4 and age at onset of Alzheimer's disease: the NIMH genetics iniciative. Neurology 1997;48:139-147.
12. Lendon CL, Ashall F, Goate AM. Exploring the etiology of Alzheimer disease using molecular genetics. JAMA 1997;277:825-831.
13. Tol J, Roks G, Slooter AJC, et al. Genetic and environmental factors in Alzheimer's disease. Rev Neurol (Paris) 1999;155:(Suppl4):S10-S16.
14. Blacker D, Tanzi RE. The genetics of Alzheimer disease: current status and future prospects. Arch Neurol 1998;55:294-296.
15. Selhub J, Bagley LC, Miller J, et al. B vitamins, homocysteine, and neurocognitive function in the elderly. Am J Clin Nutr 2000;71(Suppl):S614-S620.
16. Snowdon DA, Tully CL, Smith CD, et al. Serum folate and the severity of atrophy of the neocortex in Alzheimer disease: findings from the Nun Study. Am J Clin Nutr 2000;71:993-998.
17. Miller JW. Homocystein, Alzheimer's disease, and cognitive function. Nutricion 2000;16:675-677.
18. Nourhashemi F, Gillette-Guyonnet S, Andrieu S, et al. Alzheimer disease: protective factors. Am J Clin Nutr 2000;71(Suppl):S643-S649.
19. Clarke R, Smith AD, Jobst KA, et al. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998;55:1449-1455.
20. Nishiyama M, Kato Y, Hashimoto M, et al. Apolipoprotein E, methylenetetrahydrofolate reductase (MTHFR) mutation and the risk of senile dementia- an epidemiological study using the polymerase chain reaction (PCR) method. Epidemiology 2000;10:163-172.
21. Mc Khann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Service Task force on Alzheimer's Disease. Neurology 1984;34:939-944.
22. Cummings JI, Benson DF. Dementia of the Alzheimer type: an inventory of diagnostic clinical features. JAGS 1986;34:12-19.
23. Wenham PR, Price WH, Blundell G. Apolipoprotein E genotyping by one-stage PCR. Lancet 1991;337:1158-1159.
24. Simopoulus AP. Genetic variations and nutrition. Nutrition Reviews 1999;57:S10-S19.
25. Andrade FM, Larrandaburu M, Callegari-Jacques SM, et al. Association of apolipoprotein E polymorphism with plasma lipids and Alzheimer's disease in a Southern Brazilian population. Braz J Med Biol Res. 2000;33:529-537.
26. Schwanke CHA, Cruz IBM, Leal NF, et al. Analysis of association between apolipoprotein E polymorphism and cardiovascular risk factors in na elderly population with longevity. Arq Bras Cardiol 2002,78:571-579.
27. Almeida OP, Shimokomaki CM. Apolipoprotein E4 and Alzheimer's disease in São Paulo-Brazil. Arq Neuropsiquiatr 1997;55:1-7.
28. Molero AE, Pino-Ramirez G, Maestre GE. Modulation by age and gender of risk for Alzheimer's disease and vascular dementia associated with the apolipoprotein E-E4 allele in Latin Americans: findings from Maracaibo Aging Study. Neurosci Letters 2001;307:5-8.
29. Myers AM, Goate AM. The genetics of late-onset Alzheimer's disease. Curr Opin Neurol 2001;14:433-440.
30. Selkoe DJ. Alzheimer's disease: genes, proteins and therapy. Phisiol Rev 2001;81:741-766
31. Lippa CF, Smith TW, Saunders AM, et al. Apolipoprotein E epsilon 2 and Alzheimer's disease: genotype influences pathologic phenotype. Neurology 1997;48:515-519.
32. Bradford-Hill A. The environment and disease: association or Causation? J R Soc Med 1965;58:295-300.
33. Postiglione A, Milan G, Ruoceo A, et al. Plasma folate, vitamine B12, and total homocystein and homozygosity for the C677T mutation of the 5,10methylene tetrahydrofolate reductase gene in patients with Alzheimer's dementia: a case-control study. Gerontology 2001;47:324-329.
34. Brunelli T, Bagnoli S, Giusti B, et al. The C677T methylenetetrahydrofolate reductase mutation is not associated with Alzheimer's disease. Neurosci Letters 2001;315:103-105.
35. Prince JA, Feuk L, Sawyer SL, et al. Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease. Eur J Hum Genet 2001 Jun;9:437-444.
36. Seripa D, Forno GD, Matera MG et al. Methylenetetrahydrofolate reductase and angiotensin converting enzyme gene polymorphisms in two genetically and diagnostically distinct cohort of Alzheimer patients. Neurobiol Aging, 2003;24:933-939.
37. Religa D, Styczynska M, Peplonska, B et al. Homocysteine, apolipoproteine E and methylenetetrahydrofolate reductase in Alzheimer1s disease and mild cognitive impairment. Dement Geriatr Cogn Disord, 2003:16:64-70.