High levels of homocysteine results in cerebral amyloid angiopathy in mice

Journal of Alzheimer's Disease

Volumn 43, Issue 1, 2014, Pages 29-35

  Li, Jian Guo ^a   Praticò, Domenico ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; amyloid ; homocysteine; transgenic mouse model

Indexed keywords

AMYLOID BETA PROTEIN; HOMOCYSTEINE;

ALZHEIMER DISEASE; ANIMAL; ANIMAL FOOD; BRAIN; CEREBRAL AMYLOID ANGIOPATHY; COMPLICATION; DIET; DISEASE MODEL; FEMALE; HYPERHOMOCYSTEINEMIA; MALE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; RANDOMIZATION; TRANSGENIC MOUSE; VASCULARIZATION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMAL FEED; ANIMALS; BRAIN; CEREBRAL AMYLOID ANGIOPATHY; DIET; DISEASE MODELS, ANIMAL; FEMALE; HOMOCYSTEINE; HYPERHOMOCYSTEINEMIA; MALE; MICE, TRANSGENIC; RANDOM ALLOCATION;

EID: 84908662112     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-141101     Document Type: Article

References (30)

1. Gandy S (2012) Lifelong management of amyloid beta metabolism to prevent Alzheimers disease. N Engl J Med 367, 864-866.
2. Ellis RJ, Olichney JM, Thal LJ, Mirra SS, Morris JC, Beekly D, Heyman A (1996) Cerebral amyloid angiopathy in the brains of patients with Alzheimers disease: The CERAD experience, Part XV. Neurology 46, 1592-1596.
3. Revesz T, Ghiso J, Lashley T, Plant G, Rostagno A, Frangione B, Holton JL (2003) Cerebral amyloid angiopathies: A pathologic, biochemical, and genetic view. J Neuropathol Exp Neurol 62, 885-898.
4. Weller RO, Preston SD, Subsh M, Carare RO (2009) Cerebral amyloid angiopathy in the aetiology and immunotherapy of Alzheimers disease. Alzheimers Res Ther 1, 6.
5. Zhang-Numes SX, Maat-SChieman ML, van Duinen SG, Roos RA, Frosch MP, Greenberg SM (2006) The cerebral beta-amyloid angiopathies: Hereditary and sporadic. Brain Pathol 16, 30-39.
6. Morris MS (2003) Homocysteine and Alzheimers disease. Lancet Neurol 2, 425-428.
7. Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, DAgostino RB, Wilson PW, Wolf PA (2002) Plasma homocysteine as a risk factor for dementia and Alzheimers disease. N Engl J Med 346, 476-483.
8. Selhub J (1999) Homocysteine metabolism. Ann Rev Nutr 19, 217-246.
9. Zhuo JM, Portugal GS, Kruger WD, Wang H, Gould TJ, Pratico D (2010) Diet-induced hyperhomocysteinemia increases amyloid-beta formation and deposition in a mouse model of Alzheimers disease. Curr Alzheimer Res 7, 140-149.
10. Pacheco-Quinto J, Rodrihguez de Turco EB, DeRosa S, Howard A, Crzi-Sanchez F, Sambamurti K, Refolo L, Petanceska S, Pappolla MA (2006) Hyperhomocysteinemic Alzheimers mouse model of amyloidosis shows increased brain amyloid beta peptide levels. Neurobiol Dis 22, 651-656.
11. Zhuo JM, Wang H, Pratico D (2011) Is hyperhomocysteinemia an Alzheimers disease (AD) risk factor, and AD marker or neither? Trends Pharmacol Sci 32, 562-571.
12. Li J-G, Chu J, Barrero C, Merali S, Pratico D (2014) Homocysteine exacerbates Aβ, tau pathology and cognitive deficit in a mouse model of Alzheimers with plaques and tangles. Ann Neurol 75, 851-863.
13. Hawkes CA, Shaw JE, Brown M, Sampson AP, McLaurin J, Carare RO (2014) MK886 reduces cerebral amyloid angiopathy severity in TgCRND8 mice. Neurodegener Dis 13, 17-23.
14. Sudduth TL, Powell DK, Smith CD, Greenstein A, Wilcock DM (2013) Induction of hyperhomocysteinemia models vascular dementia by induction of cerebral microhemorrhages and neuroinflammation. J Cereb Blood Flow Metab 33, 708-715.
15. Yamada M, Naiki H (2012) Cerebral amyloid angiopathy. Prog Mol Biol Transl Sci 107, 41-78.
16. Carare RO, Bernardes-Silva M, Newman TA, Page AM, Nicoll JA, Perry VH,Weller RO (2008) Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: Significance for cerebral amyloid angiopathy and neuroimmunology. Neuropathol Appl Neurobiol 34, 131-144.
17. Hawkes CA, McLaurin J (2009) Selective targeting of perivascular macrophages for clearance of β-amyloid in cerebral amyloid angiopathy. Proc Natl Acad Sci U S A 106, 1261-1266.
18. Wisnieski T, Lalowski M, Golabek A, Vogel T, Frangione B (1995) Is Alzheimers disease an apolipoprotein E amyloidosis? Lancet 345, 956-958.
19. Mahley RW (1988) Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology. Science 240, 622-630.
20. Pitas RE, Boyles JK, Lee SH, Foss D, Mahley RW (1987) Astrocytes synthesize apolipoproteinEand metabolize apolipoprotein E-containing lipoproteins. Biochim Biophys Acta 917, 148-161.
21. Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS, Roses AD (1993) Apolipoprotein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimers disease. Proc Natl Acad Sci U S A 90, 1977-1981.
22. MunsonGW, Roher AE, Kuo Ym, Gilligan SM, Reardon CA, Getz GS, LaDu MJ (2000) SDS-stable complex formation between native apolipoprotein E3 and beta-amyloid peptides. Biochemistry 39, 16119-16124.
23. Naslund J, Thyberg J, Tjernberg LO, Wernstedt C (1995) Characterization of stable complexes involving apolipoprotein E and the amyloid beta peptide in Alzheimers disease brain. Neuron 15, 219-228.
24. Shibata M, Yamada S, Kumar SR, Calero M, Banding J, Frangione B, Holtzman DM, Miller CA, Strckland DK, Ghiso J, Zlokovic BV (2000) Clearance of Alzheimers amyloid-ss (1- 40) peptide from brain by LDL-receptor-related-protein-1 at the blood-brain-barrier. J Clin Invest 106, 1489-1499.
25. JiY, Permanne B, SigurdssonEM,HoltzmanDM,Wisniewski T (2001) Amyloid beta 40/42 clearance across the blood brain barrier following intra-ventricular injections in wild type, apoE knockout and human apoE3 or E4 expressing transgenic mice. J Alzheimers Dis 3, 23-30.
26. Deane R, Wu Z, Sagare A, Davis J, Du Yan S, Hamm K, Xu P, Parisi M, LaRue B, Hu HW, mSpijkers P, Guo H, Song X, Lenting Pj, Van Nostrand WE, Zlokovic BV (2004) LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron 43, 333-344.
27. Kanekiyo T, Liu CC, Shinohara M, Li J, Bu G (2012) LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimers amyloid be. J Neurosci 32, 16458-16465.
28. Kanekiyo T, Cirrito J, Liu CC, Shinohara M, Li J, Schuler DR, Shinohara M, Hlotzman D, Bu G (2013) Neuronal clearance of amyloid beta by endocytic receptor LRP1. J Neurosci 33, 19276-19283.
29. Gurol ME, Dierksen G, Betensky R, Gidicsin C, Halpin A, Becker A, Carmasin J, Ayres A, Schwab K, Viswanathan A, Salat D, Rosand J, Johnson KA, Greenberg SM (2012) Predicting sites of new hemorrhage with amyloid imaging in cerebral amyloid angiopathy. Neurology 79, 320-326.
30. Baumbach GL, Sigmund CD, Bottiglieri T, Lentz SR (2002) Structure of cerebral arterioles in cystathionine bet-sinthasedeficient mice. Circ Res 15, 931-937.