A polymorphism of the methionine synthase gene: Association with plasma folate, vitamin B12, homocyst(e)ine, and colorectal cancer risk

Cancer Epidemiology Biomarkers and Prevention

Volumn 8, Issue 9, 1999, Pages 825-829

  Ma, Jing ^a,e   Stampfer, Meir J ^a,b   Christensen, Benedicte ^c   Giovannucci, Edward ^a,b   Hunter, David J ^a,b   Chen, Jia ^a   Willett, Walter C ^a,b   Selhub, Jacob ^d   Hennekens, Charles H ^a,b,f   Gravel, Roy ^c   Rozen, Rima ^c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c MONTREAL CHILDREN S HOSPITAL   (Canada)

^d TUFTS UNIVERSITY   (United States)

^e CHANNING LABORATORY   (United States)

^f NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTINE; METHIONINE SYNTHASE;

ADULT; AGED; ALCOHOL CONSUMPTION; ARTICLE; CANCER RISK; CLINICAL TRIAL; COLORECTAL CANCER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FOLLOW UP; GENE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK;

5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE S-METHYLTRANSFERASE; ADULT; AGED; AGED, 80 AND OVER; ALCOHOL DRINKING; CANADA; CASE-CONTROL STUDIES; COLORECTAL NEOPLASMS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FOLIC ACID; GENOTYPE; HOMOCYSTEINE; HUMANS; MALE; MIDDLE AGED; ODDS RATIO; POLYMORPHISM, GENETIC; QUESTIONNAIRES; RISK FACTORS; UNITED STATES; VITAMIN B 12;

EID: 0032878590     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Banerjee, R. V., and Matthews, R. G. Cobalamin-dependent methionine synthase. FASEB J., 4: 1450-1459, 1990.
2. Fearon, E. R., and Vogelstein, B. A genetic model for colorectal tumorigenesis. Cell, 61: 759-767, 1990.
3. Greenblatt, M. S., Bennett, W. P., Hollstein, M., and Harris, C. C. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res., 54: 4855-4878, 1994.
4. Issa, J-P., Ottaviano, Y. L., Celano, P., Hamilton, S. R., Davidson, N. E., and Baylin, S. B. Methylation of the oestrogen receptor CpG island links aging and neoplasia in human colon. Nat. Genet., 7: 536-540, 1994.
5. Watkins, D., and Rosenblatt, D. S. Functional methionine synthase deficiency (cb1E and cb1G): clinical and biochemical heterogeneity. Am. J. Med. Genet., 34: 427-434, 1989.
6. Fowler, B., Whitehouse, C., Wenzel, F., and Wraith, J. E. Methionine and serine formation in control and mutant cultured fibroblasts: evidence for methyl trapping and characterization of remethylation defects. Pediatr. Res., 41: 145-151, 1997.
7. Blount, B. C., and Ames, B. N. DNA damage in folate deficiency. Baillieres Clin. Haematol., 8: 461-478, 1995.
8. Vogelstein, B., Fearon, E. R., Kern, S. E., Hamilton, S. R., Preisinger, A. C., Nakamura, Y., and White, R. Allelotype of colorectal carcinomas. Science (Washington DC), 244: 207-211, 1989.
9. Talley, N. J., Chute, C. G., Larson, D. E., Epstein, R., Lydick, E. G., and Melton, L. J. Risk for colorectal adenocarcinoma in pernicious anemia: a population-based cohort study. Ann. Intern. Med., 111: 738-742, 1989.
10. Hsing, A. W., Hansson, L. E., McLaughlin, J. K., Myren, O., Blot, W. J., Ekbom, A., and Fraumeni, J. F., Jr. Pernicious anemia and subsequent cancer. A population-based cohort study. Cancer (Phila.), 71: 745-750, 1993.
11. Leclerc, D., Campeau, E., Goyette, P., Adjalla, C. E., Christensen, B., Ross, M., Eydoux, P., Rosenblatt, D. S., Rozen, R., and Gravel, R. A. Human methionine synthase: cDNA cloning and identification of mutations in patients of the cb1G complementation group of folate/cobalamin disorders. Hum. Mol. Genet., 5: 1967-1974, 1996.
12. Chen, J., Giovannucci, E., Kelsey, K., Rimm, E. B., Stampfer, M. J., Colditz, G. A., Spiegelman, D., Willett, W. C., and Hunter, D. J. A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer. Cancer Res., 56: 4862-4864, 1996.
13. Ma, J., Stampfer, M., Giovannucci, E., Artigas, C., Hunter, D., Fuchs, C., Willett, W., Selhub, J., Hennekens, C., Rozen, R. Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Rev., 57: 1098-1102, 1997.
14. Tucker, K. L., Mahnken, B., Wilson, P. W. F., Jacques, P., and Selhub, J. Folic acid fortification of the food supply: potential benefits and risks for the elderly population. J. Am. Med. Assoc., 276: 1879-1885, 1996.
15. Mehta, C., and Patel, N. LogXact Users Manual. Cambridge, MA: Cytel Software Corporation, 1993.
16. SAS Institute. I. SAS/STATR User's Guide Version 6. Cary, NC: SAS Institute Inc., 1989.
17. van der Put, N. M. J., van der Molen, E. F., Kluijtmans, L. A. J., Heil, S. G., Trijbels, J. M. F., Eskes, T. K. A. B., Van Oppenraajj-Emmerzaal, D., Banerjee, R., and Blom, H. J. Sequence analysis of the coding region of human methionine synthase relevance to hyperhomocysteinaemia in neural-tube defects and vascular disease. QJM, 90: 511-517, 1997.
18. Ma, J., Stampfer, M. J., Hennekens, C. H., Frosst, P., Selhub, J., Horsford, J., Malinow, M. R., Willett, W. C., and Rozen, R. Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in U. S. physicians. Circulation, 94: 2410-2416, 1996.
19. Luschinsky Drennan, C., Huang, S., Drummond, J. T., Matthews, R. G., and Ludwig, M. L. How a protein binds B12: a 30 A X-ray structure of B12-binding domains of methionine synthase. Science (Washington DC), 266: 1669-1674, 1994.
20. Green, R., and Jacobsen, D. W. Clinical implications of hyperhomocysteinemia. New York: Marcel Dekker, Inc., 1992.
21. Finkelstein, J. D., Martin, J. J., Harris, B. J., Kyle, and W. E. Regulation of hepatic betaine-homocysteine methyltransferase by dietary betaine. J. Nutr., 113: 519-521, 1983.
22. Finkelstein, J. D., Martin, J. J., Harris, B. J., and Kyle, W. E. Regulation of the betaine content of rat liver. Arch. Biochem. Biophys., 218: 169-173, 1982.
23. Finkelstein, J. D., Harris, B. J., Martin, J. J., and Kyle, W. E. Regulation of hepatic betaine-homocysteine methyltransferase by dietary methionine. Biochem. Biophys. Res. Commun., 108: 344-348, 1982.
24. Lumb, M., Sharrer, N., Deacon, R., Jennings, P., Purkiss, P., Perry, J., and Chanarin, I. Effects of nitrous oxide-induced inactivation of cobalamin on methionine and S-adenosylmethionine metabolism in the rat. Biochim. Biophys. Acta. 756: 354-359, 1983.
25. Barak, A. J., Beckenhauer, H. C., Tuma, D. J., and Dunahue, T. M. J. Adaptive increase in betaine: homocysteine methyltransferase activity maintains hepatic S-adenosylmethionine levels in ethanol-treated rats. IRCS (Int. Res. Commun. Syst.) Med Sci, 12: 866-877, 1984.
26. Laird, P., Jackson-Grusby, L., Fazeli, A., Dickinson, S., Jung, W., Li, E., Weinberg, R., and Jaenisch, R. Suppression of intestinal neoplasia by DNA hypomethylation. Cell, 81: 197-205, 1995.
27. Bender, C. M., Pao, M. M., and Jones, P. A. Inhibition of DNA methylation by 5-aza-2′-deoxycytidine suppresses the growth of human tumor cell lines. Cancer Res., 58: 95-101, 1998.
28. Crossman, M. R., Finkelstein, J. D., Kyle, W. E., and Morris, H. P. The enzymology of methionine metabolism in rat hepatomas. Cancer Res., 34: 794-800, 1974.
29. Grzelakowska-Sztabert, B., Chnurzynska, M. M. W., and Sikora, E. Age-and tumor-related changes in methionine biosynthesis in mice. Cancer Lett., 32: 207-217, 1986.
30. Hoffman, R. M. Altered methionine metabolism. DNA methylation and oncogene expression in carcinogenesis. Biochim. Biophys. Acta, 738: 49-87, 1984.
31. Stern, P. H., and Hoffman, R. M. Elevated overall rates of transmethylation in cell lines from diverse human tumors. In Vitro (Rockville), 20:663-670, 1984.
32. Breillout, F., Antoine, E., and Poupon, M. F. Methionine dependency of malignant tumors: a possible approach for therapy. J. Natl. Cancer Inst., 82: 1628-1632, 1990.
33. Chen, J., Giovannucci, E., Hankinson, S. E., Willett, W. C., Spiegelman, D., Kelsey, K. T., and Hunter, D. J. A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphism and risk of coloreetal adenoma. Carcinogenesis (Lond.), 19: 2129-2132, 1998.