Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease

PLoS ONE

Volumn 5, Issue 9, 2010, Pages 1-8

  Astarita, Giuseppe ^a,b   Jung, Kwang Mook ^a   Berchtold, Nicole C ^a   Nguyen, Vinh Q ^c   Gillen, Daniel L ^c   Head, Elizabeth ^d   Cotman, Carl W ^a   Piomelli, Daniele ^a,e,f  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c Ringgold Standard Institution Informatics   (United States)

^d UNIVERSITY OF KENTUCKY   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DOCOSAHEXAENOIC ACID; DOCOSAPENTAENOIC ACID; FATTY ACID; ICOSAPENTAENOIC ACID; LINOLEIC ACID; LIVER ENZYME; PHOSPHATIDYLETHANOLAMINE; PHYTANIC ACID; PRISTANIC ACID; TETRAHEXAENOIC ACID; UNCLASSIFIED DRUG;

AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN REGION; CATALYSIS; CEREBELLUM; COGNITIVE DEFECT; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; FATTY ACID ANALYSIS; FATTY ACID SYNTHESIS; FEMALE; GLOBAL DETERIORATION SCALE; HUMAN; HUMAN TISSUE; LIPID BRAIN LEVEL; LIPID LIVER LEVEL; LIVER FUNCTION; LIVER METABOLISM; MALE; MINI MENTAL STATE EXAMINATION; NEUROPROTECTION; PROTEIN FUNCTION; PSYCHOLOGICAL RATING SCALE; SYNAPTOGENESIS; TEMPORAL CORTEX; TISSUE DISTRIBUTION; BRAIN; CASE CONTROL STUDY; COGNITION; LIVER; METABOLISM; NEUROPSYCHOLOGICAL TEST; PSYCHOLOGICAL ASPECT; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BRAIN; CASE-CONTROL STUDIES; COGNITION; DOCOSAHEXAENOIC ACIDS; FEMALE; HUMANS; LIVER; MALE; NEUROPSYCHOLOGICAL TESTS;

EID: 77958518079     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0012538     Document Type: Article

References (43)

1. Cummings JL (2004) Alzheimer's disease. N Engl J Med 351: 56-67.
2. Prince M, Jackson J. (2009) World Alzheimer Report. London. http://www.alz. co.uk/research/worldreport/. Accessed August 09, 2010.
3. LaFerla FM, Green KN, Oddo S (2007) Intracellular amyloid-beta in Alzheimer's disease. Nat Rev Neurosci 8: 499-509.
4. Crawford MA, Bazinet RP, Sinclair AJ (2009) Fat intake and CNS functioning: ageing and disease. Ann Nutr Metab 55: 202-228.
5. Marszalek JR, Lodish HF (2005) Docosahexaenoic acid, fatty acid-interacting proteins, and neuronal function: breastmilk and fish are good for you. Annu Rev Cell Dev Biol 21: 633-657.
6. Lukiw WJ, Cui JG, Marcheselli VL, Bodker M, Botkjaer A, et al. (2005) A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease. J Clin Invest 115: 2774-2783.
7. Bazan NG (2006) Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors. Trends Neurosci 29: 263-271.
8. Mukherjee PK, Marcheselli VL, Serhan CN, Bazan NG (2004) Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. Proc Natl Acad Sci USA 101: 8491-8496.
9. Scott B, Bazan N (1989) Membrane docosahexaenoate is supplied to the developing brain and retina by the liver. Proc Natl Acad Sci U S A 86: 2903-2907.
10. Burdge G, Calder P (2005) Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults. Reproduction, Nutrition, Development 45: 581-597.
11. Rapoport S, Rao J, Igarashi M (2007) Brain metabolism of nutritionally essential polyunsaturated fatty acids depends on both the diet and the liver. Prostaglandins Leukot Essent Fatty Acids 77: 251-261.
12. Cordain L, Eaton SB, Sebastian A, Mann N, Lindeberg S, et al. (2005) Origins and evolution of the Western diet: health implications for the 21st century. Am J Clin Nutr 81: 341-354.
13. Rapoport SI, Igarashi M (2009) Can the rat liver maintain normal brain DHA metabolism in the absence of dietary DHA? Prostaglandins Leukot Essent Fatty Acids 81: 119-123.
14. Rapoport SI, Igarashi M, Gao F (2010) Quantitative contributions of diet and liver synthesis to docosahexaenoic acid homeostasis. Prostaglandins Leukot Essent Fatty Acids 82: 273-276.
15. Voss A, Reinhart M, Sankarappa S, Sprecher H (1991) The metabolism of 7,10,13,16,19-docosapentaenoic acid to 4,7,10,13,16,19-docosahexaenoic acid in rat liver is independent of a 4-desaturase. J Biol Chem 266: 19995-20000.
16. Sprecher H, Luthria DL, Mohammed BS, Baykousheva SP (1995) Reevaluation of the pathways for the biosynthesis of polyunsaturated fatty acids. J Lipid Res 36: 2471-2477.
17. Moore SA, Hurt E, Yoder E, Sprecher H, Spector AA (1995) Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid. J Lipid Res 36: 2433-2443.
18. Su HM, Moser AB, Moser HW, Watkins PA (2001) Peroxisomal straight-chain Acyl-CoA oxidase and D-bifunctional protein are essential for the retroconversion step in docosahexaenoic acid synthesis. J Biol Chem 276: 38115-38120.
19. Innis SM (2008) Dietary omega 3 fatty acids and the developing brain. Brain Res 1237: 35-43.
20. Calon F, Lim GP, Yang F, Morihara T, Teter B, et al. (2004) Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model. Neuron 43: 633-645.
21. Lim GP, Calon F, Morihara T, Yang F, Teter B, et al. (2005) A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. J Neurosci 25: 3032-3040.
22. Green KN, Martinez-Coria H, Khashwji H, Hall EB, Yurko-Mauro KA, et al. (2007) Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels. J Neurosci 27: 4385-4395.
23. Lukiw W, Bazan N (2008) Docosahexaenoic acid and the aging brain. J Nutr 138: 2510-2514.
24. Brooksbank BW, Martinez M (1989) Lipid abnormalities in the brain in adult Down's syndrome and Alzheimer's disease. Mol Chem Neuropathol 11: 157-185.
25. Soderberg M, Edlund C, Kristensson K, Dallner G (1991) Fatty acid composition of brain phospholipids in aging and in Alzheimer's disease. Lipids 26: 421-425.
26. Guan Z, Wang Y, Cairns NJ, Lantos PL, Dallner G, et al. (1999) Decrease and structural modifications of phosphatidylethanolamine plasmalogen in the brain with Alzheimer disease. J Neuropathol Exp Neurol 58: 740-747.
27. Skinner ER, Watt C, Besson JA, Best PV (1993) Differences in the fatty acid composition of the grey and white matter of different regions of the brains of patients with Alzheimer's disease and control subjects. Brain 116: 717-725.
28. Corrigan FM, Horrobin DF, Skinner ER, Besson JA, Cooper MB (1998) Abnormal content of n-6 and n-3 long-chain unsaturated fatty acids in the phosphoglycerides and cholesterol esters of parahippocampal cortex from Alzheimer's disease patients and its relationship to acetyl CoA content. Int J Biochem Cell Biol 30: 197-207.
29. Prasad MR, Lovell MA, Yatin M, Dhillon H, Markesbery WR (1998) Regional membrane phospholipid alterations in Alzheimer's disease. Neurochem Res 23: 81-88.
30. Fraser T, Tayler H, Love S (2009) Fatty Acid Composition of Frontal, Temporal and Parietal Neocortex in the Normal Human Brain and in Alzheimer's Disease. Neurochem Res 35: 503-513.
31. Cunnane SC, Plourde M, Pifferi F, Begin M, Feart C, et al. (2009) Fish, Docosahexaenoic Acid and Alzheimer's Disease. Prog Lipid Res 48: 239-256.
32. Han X, Holtzman DM, McKeel DW, Jr. (2001) Plasmalogen deficiency in early Alzheimer's disease subjects and in animal models: molecular characterization using electrospray ionization mass spectrometry. J Neurochem 77: 1168-1180.
33. Jiang LL, Kurosawa T, Sato M, Suzuki Y, Hashimoto T (1997) Physiological role of D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydroge-nase bifunctional protein. J Biochem 121: 506-513.
34. Martinez M (1992) Abnormal profiles of polyunsaturated fatty acids in the brain, liver, kidney and retina of patients with peroxisomal disorders. Brain Res 583: 171-182.
35. Martinez M (1990) Severe deficiency of docosahexaenoic acid in peroxisomal disorders: a defect of delta 4 desaturation? Neurology 40: 1292-1298.
36. Youssef J, Badr M (1999) Biology of senescent liver peroxisomes: role in hepatocellular aging and disease. Environ Health Perspect 107: 791-797.
37. Haining JL, Legan JS (1973) Catalase turnover in rat liver and kidney as a function of age. Exp Gerontol 8: 85-91.
38. Goodenowe DB, Cook LL, Liu J, Lu Y, Jayasinghe DA, et al. (2007) Peripheral ethanolamine plasmalogen deficiency: a logical causative factor in Alzheimer's disease and dementia. J Lipid Res 48: 2485-2498.
39. Yilmaz Y, Ozdogan O (2009) Liver disease as a risk factor for cognitive decline and dementia: an under-recognized issue. Hepatology 49: 698.
40. Bazan N (1990) Supply of n3 polyunsaturated fatty acids and their significance in the central nervous system. In: Wurtman R, Wurtman J, eds. Nutrition and the Brain. New York: Raven Press Ltd. pp 1-24.
41. Bazan NG, Scott BL, Reddy TS, Pelias MZ (1986) Decreased content of docosahexaenoate and arachidonate in plasma phospholipids in Usher's syndrome. Biochem Biophys Res Commun 141: 600-604.
42. Liang K, Zeger S (1986) Longitudinal data analysis using generalized linear models. Biometrika 73: 13-22.
43. White H (1980) A heteroskedasticity-consistent covariance matrix estimator and a direct test for heteroskedasticity. Econometrica 48: 817-838.