-
1
-
-
0015228022
-
Mammalian methylenetetrahydrofolate reductase: Partial purification, properties, and inhibition by S-adenosylmethionine
-
Kutzbach C, Stokstad EL (1971) Mammalian methylenetetrahydrofolate reductase: partial purification, properties, and inhibition by S-adenosylmethionine. Biochim Biophys Acta 250:459-477
-
(1971)
Biochim Biophys Acta
, vol.250
, pp. 459-477
-
-
Kutzbach, C.1
Stokstad, E.L.2
-
2
-
-
0032771346
-
Homocysteine metabolism
-
Selhub J (1999) Homocysteine metabolism. Annu Rev Nutr 19:217-246
-
(1999)
Annu Rev Nutr
, vol.19
, pp. 217-246
-
-
Selhub, J.1
-
3
-
-
0032573077
-
A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells
-
Bagley PJ, Selhub J (1998) A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells. Proc Natl Acad Sci USA 95:13217-13220
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 13217-13220
-
-
Bagley, P.J.1
Selhub, J.2
-
4
-
-
0033808685
-
Folic acid: Nutritional biochemistry, molecular biology, and role in disease processes
-
Lucock M (2000) Folic acid: nutritional biochemistry, molecular biology, and role in disease processes. Mol Genet Metab 71:121-138
-
(2000)
Mol Genet Metab
, vol.71
, pp. 121-138
-
-
Lucock, M.1
-
5
-
-
0002528229
-
Regulation of homocysteine metabolism
-
Carmel R, Jacobsen DW eds, Cambridge University Press, Cambridge, United Kingdom, pp
-
Finkelstein JD (2001) Regulation of homocysteine metabolism. In: Carmel R, Jacobsen DW (eds) Homocysteine in health and disease. Cambridge University Press, Cambridge, United Kingdom, pp 92-99
-
(2001)
Homocysteine in health and disease
, pp. 92-99
-
-
Finkelstein, J.D.1
-
7
-
-
0029049553
-
-
Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GHJ, den Heijer M, Kluijtmans LAJ, van den Heuvel LP, et al (1995) A candidate genetic risk factor for vascular disease: a common mutation at the methylenetetrahydrofolate reductase. Nat Genet 10:111-113
-
Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GHJ, den Heijer M, Kluijtmans LAJ, van den Heuvel LP, et al (1995) A candidate genetic risk factor for vascular disease: a common mutation at the methylenetetrahydrofolate reductase. Nat Genet 10:111-113
-
-
-
-
8
-
-
0023696435
-
Intermediate homocysteinemia: A thermolabile variant of methylenetetrahydrofolate reductase
-
Kang SS, Zhou J, Wong PW, Kowalisyn J, Strokosch G (1988) Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase. Am J Hum Genet 43: 414-421
-
(1988)
Am J Hum Genet
, vol.43
, pp. 414-421
-
-
Kang, S.S.1
Zhou, J.2
Wong, P.W.3
Kowalisyn, J.4
Strokosch, G.5
-
9
-
-
85176674435
-
-
Kluijtmans LA, van den Heuvel LP, Boers GH, Frosst P, Stevens EM, van Oost BA, den Heijer M, Trijbels FJ, Rozen R, Blom HJ (1996) Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease. Am J Hum Genet 58:35-41
-
Kluijtmans LA, van den Heuvel LP, Boers GH, Frosst P, Stevens EM, van Oost BA, den Heijer M, Trijbels FJ, Rozen R, Blom HJ (1996) Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease. Am J Hum Genet 58:35-41
-
-
-
-
10
-
-
0037163849
-
MTHFR 677C→T polymorphism and risk of coronary heart disease - a meta-analysis
-
Klerk M, Verhoef P, Clarke R, Blom HJ, Kok FJ, Schouten EG (2002) MTHFR 677C→T polymorphism and risk of coronary heart disease - a meta-analysis. JAMA 288:2023-2031
-
(2002)
JAMA
, vol.288
, pp. 2023-2031
-
-
Klerk, M.1
Verhoef, P.2
Clarke, R.3
Blom, H.J.4
Kok, F.J.5
Schouten, E.G.6
-
11
-
-
0028844492
-
-
van der Put NM, Steegers-Theunissen RP, Frosst P, Trijbels FJ, Eskes TK, van den Heuvel LP, Mariman EC, den Heyer M, Rozen R, Blom HJ (1995) Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida. Lancet 346:1070-1071
-
van der Put NM, Steegers-Theunissen RP, Frosst P, Trijbels FJ, Eskes TK, van den Heuvel LP, Mariman EC, den Heyer M, Rozen R, Blom HJ (1995) Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida. Lancet 346:1070-1071
-
-
-
-
12
-
-
0033365197
-
The "thermolabile" variant of methylenetetrahydrofolate reductase and neural tube defects: An evaluation of genetic risk and the relative importance of the genotypes of the embryo and the mother
-
Shields DC, Kirke PN, Mills JL, Ramsbottom D, Molloy AM, Burke H, Weir DG, Scott JM, Whitehead AS (1999) The "thermolabile" variant of methylenetetrahydrofolate reductase and neural tube defects: an evaluation of genetic risk and the relative importance of the genotypes of the embryo and the mother. Am J Hum Genet 64:1045-1055
-
(1999)
Am J Hum Genet
, vol.64
, pp. 1045-1055
-
-
Shields, D.C.1
Kirke, P.N.2
Mills, J.L.3
Ramsbottom, D.4
Molloy, A.M.5
Burke, H.6
Weir, D.G.7
Scott, J.M.8
Whitehead, A.S.9
-
13
-
-
0030615085
-
Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer
-
Ma J, Stampfer MJ, Giovannucci E, Artigas C, Hunter DJ, Fuchs C, Willett WC, Selhub J, Hennekens CH, Rozen R (1997) Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Res 57:1098-1102
-
(1997)
Cancer Res
, vol.57
, pp. 1098-1102
-
-
Ma, J.1
Stampfer, M.J.2
Giovannucci, E.3
Artigas, C.4
Hunter, D.J.5
Fuchs, C.6
Willett, W.C.7
Selhub, J.8
Hennekens, C.H.9
Rozen, R.10
-
14
-
-
11144236628
-
Colorectal cancer and the methylenetetrahydrofolate reductase 677C→T and methionine synthase 2756A→G polymorphisms: A study of 2,168 case-control pairs from the JANUS cohort
-
Ulvik A, Vollset SE, Hansen S, Gislefoss R, Jellum E, Ueland PM (2004) Colorectal cancer and the methylenetetrahydrofolate reductase 677C→T and methionine synthase 2756A→G polymorphisms: a study of 2,168 case-control pairs from the JANUS cohort. Cancer Epidemiol Biomarkers Prev 13:2175-2180
-
(2004)
Cancer Epidemiol Biomarkers Prev
, vol.13
, pp. 2175-2180
-
-
Ulvik, A.1
Vollset, S.E.2
Hansen, S.3
Gislefoss, R.4
Jellum, E.5
Ueland, P.M.6
-
15
-
-
27144526086
-
Genetic polymorphisms of methylenetetrahydrofolate reductase and colorectal cancer and adenoma
-
Kono S, Chen K (2005) Genetic polymorphisms of methylenetetrahydrofolate reductase and colorectal cancer and adenoma. Cancer Sci 96:535-542
-
(2005)
Cancer Sci
, vol.96
, pp. 535-542
-
-
Kono, S.1
Chen, K.2
-
16
-
-
0002051637
-
Polymorphisms of folate and cobalamin metabolism
-
Carmel R, Jacobsen DW eds, Cambridge University Press, Cambridge, United Kingdom, pp
-
Rozen R (2001) Polymorphisms of folate and cobalamin metabolism. In: Carmel R, Jacobsen DW (eds) Homocysteine in health and disease. Cambridge University Press, Cambridge, United Kingdom, pp 259-269
-
(2001)
Homocysteine in health and disease
, pp. 259-269
-
-
Rozen, R.1
-
17
-
-
85030524354
-
Genetic and environmental influences on plasma homocysteine: Results from a Danish twin study
-
in press
-
Bathum L, Pedersen I, Christiansen L, Konieczna A, Sørensen TlA, Kyvik KO. Genetic and environmental influences on plasma homocysteine: results from a Danish twin study. Clin Chem (in press)
-
Clin Chem
-
-
Bathum, L.1
Pedersen, I.2
Christiansen, L.3
Konieczna, A.4
Sørensen, T.A.5
Kyvik, K.O.6
-
18
-
-
1842370239
-
Plasma homocysteine levels and mortality in patients with coronary artery disease
-
Nygård O, Nordrehaug JE, Refsum H, Ueland PM, Farstad M, Vollset SE (1997) Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med 337: 230-236
-
(1997)
N Engl J Med
, vol.337
, pp. 230-236
-
-
Nygård, O.1
Nordrehaug, J.E.2
Refsum, H.3
Ueland, P.M.4
Farstad, M.5
Vollset, S.E.6
-
19
-
-
0036229212
-
Homocysteine, B vitamin status, and cognitive function in the elderly
-
Duthie SJ, Whalley LJ, Collins AR, Leaper S, Berger K, Deary IJ (2002) Homocysteine, B vitamin status, and cognitive function in the elderly. Am J Clin Nutr 75:908-913
-
(2002)
Am J Clin Nutr
, vol.75
, pp. 908-913
-
-
Duthie, S.J.1
Whalley, L.J.2
Collins, A.R.3
Leaper, S.4
Berger, K.5
Deary, I.J.6
-
20
-
-
2342464257
-
Homocysteine as a predictive factor for hip fracture in older persons
-
McLean RR, Jacques PF, Selhub J, Tucker KL, Samelson EJ, Broe KE, Hannan MT, Cupples LA, Kiel DP (2004) Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med 350:2042-2049
-
(2004)
N Engl J Med
, vol.350
, pp. 2042-2049
-
-
McLean, R.R.1
Jacques, P.F.2
Selhub, J.3
Tucker, K.L.4
Samelson, E.J.5
Broe, K.E.6
Hannan, M.T.7
Cupples, L.A.8
Kiel, D.P.9
-
21
-
-
28044433175
-
Increased osteoclast activity in the presence of increased homocysteine concentrations
-
Herrmann M, Widmann T, Colaianni G, Colucci S, Zallone A, Herrmann W (2005) Increased osteoclast activity in the presence of increased homocysteine concentrations. Clin Chem 51:2348-2353
-
(2005)
Clin Chem
, vol.51
, pp. 2348-2353
-
-
Herrmann, M.1
Widmann, T.2
Colaianni, G.3
Colucci, S.4
Zallone, A.5
Herrmann, W.6
-
22
-
-
0035107609
-
Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model
-
Hofmann MA, Lalla E, Lu Y, Gleason MR, Wolf BM, Tanji N, Ferran LJ Jr, Kohl B, Rao V, Kisiel W, et al (2001) Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model. J Clin Invest 107:675-683
-
(2001)
J Clin Invest
, vol.107
, pp. 675-683
-
-
Hofmann, M.A.1
Lalla, E.2
Lu, Y.3
Gleason, M.R.4
Wolf, B.M.5
Tanji, N.6
Ferran Jr, L.J.7
Kohl, B.8
Rao, V.9
Kisiel, W.10
-
23
-
-
0037164375
-
Homocysteine and cardiovascular disease: Evidence on causality from a meta-analysis
-
Wald DS, Law M, Morris JK (2002) Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ 325:1202-1208
-
(2002)
BMJ
, vol.325
, pp. 1202-1208
-
-
Wald, D.S.1
Law, M.2
Morris, J.K.3
-
24
-
-
3142680190
-
Homocysteine and cardiovascular disease: Biological mechanisms, observational epidemiology, and the need for randomized trials
-
Splaver A, Lamas GA, Hennekens CH (2004) Homocysteine and cardiovascular disease: biological mechanisms, observational epidemiology, and the need for randomized trials. Amer Heart J 148:34-40
-
(2004)
Amer Heart J
, vol.148
, pp. 34-40
-
-
Splaver, A.1
Lamas, G.A.2
Hennekens, C.H.3
-
25
-
-
33645796222
-
Homocysteine lowering and cardiovascular events after acute myocardial infarction
-
Bønaa KH, Njølstad I, Ueland PM, Schirmer H, Tverdal A, Steigen T, Wang H, Nordrehaug JE, Arnesen E, Rasmussen K (2006) Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Engl J Med 354:1578-1588
-
(2006)
N Engl J Med
, vol.354
, pp. 1578-1588
-
-
Bønaa, K.H.1
Njølstad, I.2
Ueland, P.M.3
Schirmer, H.4
Tverdal, A.5
Steigen, T.6
Wang, H.7
Nordrehaug, J.E.8
Arnesen, E.9
Rasmussen, K.10
-
26
-
-
0036116394
-
NORCCAP (Norwegian Colorectal Cancer Prevention): A randomised trial to assess the safety and efficacy of carbon dioxide versus air insufflation in colonoscopy
-
Bretthauer M, Thiis-Evensen E, Huppertz-Hauss G, Gisselsson L, Grotmol T, Skovlund E, Hoff G (2002) NORCCAP (Norwegian Colorectal Cancer Prevention): a randomised trial to assess the safety and efficacy of carbon dioxide versus air insufflation in colonoscopy. Gut 50:604-607
-
(2002)
Gut
, vol.50
, pp. 604-607
-
-
Bretthauer, M.1
Thiis-Evensen, E.2
Huppertz-Hauss, G.3
Gisselsson, L.4
Grotmol, T.5
Skovlund, E.6
Hoff, G.7
-
27
-
-
34247588291
-
-
serum
-
Windelberg A, Årseth O, Kvalheim G, Ueland PM (2005) Automated assay for the determination of methylmalonic acid, total homocysteine, and related amino acids in human serum
-
(2005)
Automated assay for the determination of methylmalonic acid, total homocysteine, and related amino acids in human
-
-
Windelberg, A.1
Årseth, O.2
Kvalheim, G.3
Ueland, P.M.4
-
28
-
-
27444444053
-
-
or plasma by means of methylchloroformate derivatization and gas chromatography-mass spectrometry. Clin Chem 51: 2103-2109
-
or plasma by means of methylchloroformate derivatization and gas chromatography-mass spectrometry. Clin Chem 51: 2103-2109
-
-
-
-
29
-
-
23444447854
-
Multianalyte quantification of vitamin B6 and B2 species in the nanomolar range in human plasma by liquid chromatography-tandem mass spectrometry
-
Midttun Ø, Hustad S, Solheim E, Schneede J, Ueland PM (2005) Multianalyte quantification of vitamin B6 and B2 species in the nanomolar range in human plasma by liquid chromatography-tandem mass spectrometry. Clin Chem 51: 1206-1216
-
(2005)
Clin Chem
, vol.51
, pp. 1206-1216
-
-
Midttun, O.1
Hustad, S.2
Solheim, E.3
Schneede, J.4
Ueland, P.M.5
-
30
-
-
0030744634
-
Microbiological assay for serum, plasma, and red cell folate using cryopreserved, microtiter plate method
-
Molloy AM, Scott JM (1997) Microbiological assay for serum, plasma, and red cell folate using cryopreserved, microtiter plate method. Methods Enzymol 281:43-53
-
(1997)
Methods Enzymol
, vol.281
, pp. 43-53
-
-
Molloy, A.M.1
Scott, J.M.2
-
31
-
-
0025860071
-
Microbiological assay for vitamin B12 performed in 96-well microtitre plates
-
Kelleher BP, Broin SD (1991) Microbiological assay for vitamin B12 performed in 96-well microtitre plates. J Clin Pathol 44:592-595
-
(1991)
J Clin Pathol
, vol.44
, pp. 592-595
-
-
Kelleher, B.P.1
Broin, S.D.2
-
32
-
-
0034771723
-
Single nucleotide polymorphism (SNP) genotyping in unprocessed whole blood and serum by real-time PCR: Application to SNPs affecting homocysteine and folate metabolism
-
Ulvik A, Ueland PM (2001) Single nucleotide polymorphism (SNP) genotyping in unprocessed whole blood and serum by real-time PCR: application to SNPs affecting homocysteine and folate metabolism. Clin Chem 47:2050-2053
-
(2001)
Clin Chem
, vol.47
, pp. 2050-2053
-
-
Ulvik, A.1
Ueland, P.M.2
-
33
-
-
0027382008
-
Vitamin status and intake as primary determinants of homocysteinemia in an elderly population
-
Selhub J, Jacques PF, Wilson PW, Rush D, Rosenberg IH (1993) Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA 270:2693-2698
-
(1993)
JAMA
, vol.270
, pp. 2693-2698
-
-
Selhub, J.1
Jacques, P.F.2
Wilson, P.W.3
Rush, D.4
Rosenberg, I.H.5
-
34
-
-
0037420190
-
Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancer
-
Zhang SM, Willett WC, Selhub J, Hunter DJ, Giovannucci EL, Holmes MD, Colditz GA, Hankinson SE (2003) Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancer. J Natl Cancer Inst 95:373-380
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 373-380
-
-
Zhang, S.M.1
Willett, W.C.2
Selhub, J.3
Hunter, D.J.4
Giovannucci, E.L.5
Holmes, M.D.6
Colditz, G.A.7
Hankinson, S.E.8
-
35
-
-
0037322022
-
Mendelian randomization': Can genetic epidemiology contribute to understanding environmental determinants of disease?
-
Smith GD, Ebrahim S (2003) 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol 32:1-22
-
(2003)
Int J Epidemiol
, vol.32
, pp. 1-22
-
-
Smith, G.D.1
Ebrahim, S.2
-
36
-
-
5144232463
-
Phenotypic expression of the methylenetetrahydrofolate reductase 677C→T polymorphism and flavin cofactor availability in thyroid dysfunction
-
Hustad S, Nedrebø BG, Ueland PM, Schneede J, Vollset SE, Ulvik A, Lien EA (2004) Phenotypic expression of the methylenetetrahydrofolate reductase 677C→T polymorphism and flavin cofactor availability in thyroid dysfunction. Am J Clin Nutr 80:1050-1057
-
(2004)
Am J Clin Nutr
, vol.80
, pp. 1050-1057
-
-
Hustad, S.1
Nedrebø, B.G.2
Ueland, P.M.3
Schneede, J.4
Vollset, S.E.5
Ulvik, A.6
Lien, E.A.7
-
37
-
-
0035116307
-
Lifestyle effects on homocysteine and an alcohol paradox
-
Halsted CH (2001) Lifestyle effects on homocysteine and an alcohol paradox. Am J Clin Nutr 73:501-502
-
(2001)
Am J Clin Nutr
, vol.73
, pp. 501-502
-
-
Halsted, C.H.1
-
38
-
-
0035313224
-
Biological and clinical implications of the MTHFR C677T polymorphism
-
Ueland PM, Hustad S, Schneede J, Refsum H, Vollset SE (2001) Biological and clinical implications of the MTHFR C677T polymorphism. Trends Pharmacol Sci 22:195-201
-
(2001)
Trends Pharmacol Sci
, vol.22
, pp. 195-201
-
-
Ueland, P.M.1
Hustad, S.2
Schneede, J.3
Refsum, H.4
Vollset, S.E.5
-
39
-
-
0033869703
-
Riboflavin as a determinant of plasma total homocysteine: Effect modification by the methylenetetrahydrofolate reductase C677T polymorphism
-
Hustad S, Ueland PM, Vollset SE, Zhang Y, Bjørke-Monsen AL, Schneede J (2000) Riboflavin as a determinant of plasma total homocysteine: effect modification by the methylenetetrahydrofolate reductase C677T polymorphism. Clin Chem 46:1065-1071
-
(2000)
Clin Chem
, vol.46
, pp. 1065-1071
-
-
Hustad, S.1
Ueland, P.M.2
Vollset, S.E.3
Zhang, Y.4
Bjørke-Monsen, A.L.5
Schneede, J.6
-
40
-
-
0035116352
-
Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort
-
Jacques PF, Bostom AG, Wilson PW, Rich S, Rosenberg IH, Selhub J (2001) Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort. Am J Clin Nutr 73:613-621
-
(2001)
Am J Clin Nutr
, vol.73
, pp. 613-621
-
-
Jacques, P.F.1
Bostom, A.G.2
Wilson, P.W.3
Rich, S.4
Rosenberg, I.H.5
Selhub, J.6
-
41
-
-
0030027668
-
Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations
-
Jacques PF, Bostom AG, Williams RR, Ellison RC, Eckfeldt JH, Rosenberg IH, Selhub J, Rozen R (1996) Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 93:7-9
-
(1996)
Circulation
, vol.93
, pp. 7-9
-
-
Jacques, P.F.1
Bostom, A.G.2
Williams, R.R.3
Ellison, R.C.4
Eckfeldt, J.H.5
Rosenberg, I.H.6
Selhub, J.7
Rozen, R.8
-
42
-
-
0030922255
-
Vitamin intake: A possible determinant of plasma homocysteine among middle-aged adults
-
Shimakawa T, Nieto FJ, Malinow MR, Chambless LE, Schreiner PJ, Szklo M (1997) Vitamin intake: a possible determinant of plasma homocysteine among middle-aged adults. Ann Epidemiol 7:285-293
-
(1997)
Ann Epidemiol
, vol.7
, pp. 285-293
-
-
Shimakawa, T.1
Nieto, F.J.2
Malinow, M.R.3
Chambless, L.E.4
Schreiner, P.J.5
Szklo, M.6
-
43
-
-
0024378545
-
Two interconnected B vitamins: Riboflavin and pyridoxine
-
McCormick DB (1989) Two interconnected B vitamins: riboflavin and pyridoxine. Physiol Rev 69:1170-1198
-
(1989)
Physiol Rev
, vol.69
, pp. 1170-1198
-
-
McCormick, D.B.1
-
44
-
-
0344603864
-
Molecular cloning, expression and physical mapping of the human methionine synthase reductase gene
-
Leclerc D, Odièvre MH, Wu Q, Wilson A, Huizenga JJ, Rozen R, Scherer SW, Gravel RA (1999) Molecular cloning, expression and physical mapping of the human methionine synthase reductase gene. Gene 240:75-88
-
(1999)
Gene
, vol.240
, pp. 75-88
-
-
Leclerc, D.1
Odièvre, M.H.2
Wu, Q.3
Wilson, A.4
Huizenga, J.J.5
Rozen, R.6
Scherer, S.W.7
Gravel, R.A.8
-
45
-
-
0032895522
-
The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia
-
Guenther BD, Sheppard CA, Tran P, Rozen R, Matthews RG, Ludwig ML (1999) The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia. Nature Struct Biol 6:359-365
-
(1999)
Nature Struct Biol
, vol.6
, pp. 359-365
-
-
Guenther, B.D.1
Sheppard, C.A.2
Tran, P.3
Rozen, R.4
Matthews, R.G.5
Ludwig, M.L.6
-
46
-
-
0035909980
-
Effects of common polymorphisms on the properties of recombinant human methylenetetrahydrofolate reductase
-
Yamada K, Chen ZT, Rozen R, Matthews RG (2001) Effects of common polymorphisms on the properties of recombinant human methylenetetrahydrofolate reductase. Proc Nat Acad Sci USA 98:14853-14858
-
(2001)
Proc Nat Acad Sci USA
, vol.98
, pp. 14853-14858
-
-
Yamada, K.1
Chen, Z.T.2
Rozen, R.3
Matthews, R.G.4
-
47
-
-
0036199911
-
High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K(m)): Relevance to genetic disease and polymorphisms
-
Ames BN, Elson-Schwab I, Silver EA (2002) High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K(m)): relevance to genetic disease and polymorphisms. Am J Clin Nutr 75:616-658
-
(2002)
Am J Clin Nutr
, vol.75
, pp. 616-658
-
-
Ames, B.N.1
Elson-Schwab, I.2
Silver, E.A.3
-
48
-
-
0034168107
-
The role of vitamin B-12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene - a case-control study of patients with early-onset thrombotic events
-
D'Angelo A, Coppola A, Madonna P, Fermo I, Pagano A, Mazzola G, Galli L, Cerbone AM (2000) The role of vitamin B-12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene - a case-control study of patients with early-onset thrombotic events. Thromb Haemost 83:563-570
-
(2000)
Thromb Haemost
, vol.83
, pp. 563-570
-
-
D'Angelo, A.1
Coppola, A.2
Madonna, P.3
Fermo, I.4
Pagano, A.5
Mazzola, G.6
Galli, L.7
Cerbone, A.M.8
-
49
-
-
4344715540
-
Folate and homocysteine interrelationships including genetics of the relevant enzymes
-
Molloy AM (2004) Folate and homocysteine interrelationships including genetics of the relevant enzymes. Curr Opin Lipidol 15:49-57
-
(2004)
Curr Opin Lipidol
, vol.15
, pp. 49-57
-
-
Molloy, A.M.1
-
50
-
-
0344514862
-
Cobalamin status and its biochemical markers methylmalonic acid and homocysteine in different age groups from 4 days to 19 years
-
Monsen ALB, Refsum H, Markestad T, Ueland PM (2003) Cobalamin status and its biochemical markers methylmalonic acid and homocysteine in different age groups from 4 days to 19 years. Clin Chem 49:2067-2075
-
(2003)
Clin Chem
, vol.49
, pp. 2067-2075
-
-
Monsen, A.L.B.1
Refsum, H.2
Markestad, T.3
Ueland, P.M.4
-
51
-
-
33644863502
-
-
McNulty H, Dowey LRC, Strain JJ, Dunne A, Ward M, Molloy AM, McAnena LB, Hughes JP, Hannon-Fletcher M, Scott JM (2006) Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C→T polymorphism. Circulation 113:74-80
-
McNulty H, Dowey LRC, Strain JJ, Dunne A, Ward M, Molloy AM, McAnena LB, Hughes JP, Hannon-Fletcher M, Scott JM (2006) Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C→T polymorphism. Circulation 113:74-80
-
-
-
-
52
-
-
0026533906
-
The pathogenesis of homocysteinemia: Interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine
-
Selhub J, Miller JW (1992) The pathogenesis of homocysteinemia: interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine. Am J Clin Nutr 55:131-138
-
(1992)
Am J Clin Nutr
, vol.55
, pp. 131-138
-
-
Selhub, J.1
Miller, J.W.2
-
53
-
-
0035076561
-
-
McKinley MC, McNulty H, McPartlin J, Strain JJ, Pentieva K, Ward M, Weir DG, Scott JM (2001) Low-dose vitamin B-6 effectively lowers fasting plasma homocysteine in healthy elderly persons who are folate and riboflavin replete. Am J Clin Nutr 73:759-764
-
McKinley MC, McNulty H, McPartlin J, Strain JJ, Pentieva K, Ward M, Weir DG, Scott JM (2001) Low-dose vitamin B-6 effectively lowers fasting plasma homocysteine in healthy elderly persons who are folate and riboflavin replete. Am J Clin Nutr 73:759-764
-
-
-
-
54
-
-
0030035427
-
The effect of a subnormal vitamin B-6 status on homocysteine metabolism
-
Ubbink JB, van der Merwe A, Delport R, Allen RH, Stabler SP, Riezler R, Vermaak WJ (1996) The effect of a subnormal vitamin B-6 status on homocysteine metabolism. J Clin Invest 98:177-184
-
(1996)
J Clin Invest
, vol.98
, pp. 177-184
-
-
Ubbink, J.B.1
van der Merwe, A.2
Delport, R.3
Allen, R.H.4
Stabler, S.P.5
Riezler, R.6
Vermaak, W.J.7
-
55
-
-
0029995348
-
Vitamins as homocysteine-lowering agents
-
Brattström L (1996) Vitamins as homocysteine-lowering agents. J Nutr 126:1276S-1280S
-
(1996)
J Nutr
, vol.126
-
-
Brattström, L.1
-
56
-
-
0029974036
-
Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (≥40 μmol/liter) - the Hordaland homocysteine study
-
Guttormsen AB, Ueland PM, Nesthus I, Nygard O, Schneede J, Vollset SE, Refsum H (1996) Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (≥40 μmol/liter) - the Hordaland homocysteine study. J Clin Invest 98:2174-2183
-
(1996)
J Clin Invest
, vol.98
, pp. 2174-2183
-
-
Guttormsen, A.B.1
Ueland, P.M.2
Nesthus, I.3
Nygard, O.4
Schneede, J.5
Vollset, S.E.6
Refsum, H.7
-
57
-
-
0037568152
-
Cobalamin deficiency
-
Carmel R, Jacobsen DW eds, Cambridge University Press, Cambridge, United Kingdom, pp
-
Carmel R (2001) Cobalamin deficiency. In: Carmel R, Jacobsen DW (eds) Homocysteine in health and disease. Cambridge University Press, Cambridge, United Kingdom, pp 289-305
-
(2001)
Homocysteine in health and disease
, pp. 289-305
-
-
Carmel, R.1
-
58
-
-
33645753544
-
Homocysteine lowering with folic acid and B vitamins in vascular disease
-
Lonn E, Yusuf S, Arnold MJ, Sheridan P, Pogue J, Micks M, McQueen MJ, Probstfield J, Fodor G, Held C, et al (2006) Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med 354:1567-1577
-
(2006)
N Engl J Med
, vol.354
, pp. 1567-1577
-
-
Lonn, E.1
Yusuf, S.2
Arnold, M.J.3
Sheridan, P.4
Pogue, J.5
Micks, M.6
McQueen, M.J.7
Probstfield, J.8
Fodor, G.9
Held, C.10
-
59
-
-
22244492982
-
Essential nutrients: Food or supplements? Where should the emphasis be?
-
Lichtenstein AH, Russell RM (2005) Essential nutrients: food or supplements? Where should the emphasis be? JAMA 294: 351-358
-
(2005)
JAMA
, vol.294
, pp. 351-358
-
-
Lichtenstein, A.H.1
Russell, R.M.2
-
60
-
-
0032146855
-
A common mutation in the methylenetetrahydrofolate reductase gene and risk of coronary heart disease: Results among U.S. men
-
Verhoef P, Rimm EB, Hunter DJ, Chen J, Willett WC, Kelsey K, Stampfer MJ (1998) A common mutation in the methylenetetrahydrofolate reductase gene and risk of coronary heart disease: results among U.S. men. J Am Coll Cardiol 32: 353-359
-
(1998)
J Am Coll Cardiol
, vol.32
, pp. 353-359
-
-
Verhoef, P.1
Rimm, E.B.2
Hunter, D.J.3
Chen, J.4
Willett, W.C.5
Kelsey, K.6
Stampfer, M.J.7
-
61
-
-
0036147706
-
The history and future of food fortification in the United States: A public health perspective
-
Backstrand JR (2002) The history and future of food fortification in the United States: a public health perspective. Nutr Rev 60:15-26
-
(2002)
Nutr Rev
, vol.60
, pp. 15-26
-
-
Backstrand, J.R.1
-
62
-
-
0036230697
-
B-vitamin intake, metabolic genes, and colorectal cancer risk (United States)
-
Le Marchand L, Donlon T, Hankin JH, Kolonel LN, Wilkens LR, Seifried A (2002) B-vitamin intake, metabolic genes, and colorectal cancer risk (United States). Cancer Causes Control 13:239-248
-
(2002)
Cancer Causes Control
, vol.13
, pp. 239-248
-
-
Le Marchand, L.1
Donlon, T.2
Hankin, J.H.3
Kolonel, L.N.4
Wilkens, L.R.5
Seifried, A.6
-
63
-
-
0033370552
-
Colorectal adenomas and the C677T MTHFR polymorphism: Evidence for gene-environment interaction?
-
Ulrich CM, Kampman E, Bigler J, Schwartz SM, Chen C, Bostick R, Fosdick L, Beresford SA, Yasui Y, Potter JD (1999) Colorectal adenomas and the C677T MTHFR polymorphism: evidence for gene-environment interaction? Cancer Epidemiol Biomarkers Prev 8:659-668
-
(1999)
Cancer Epidemiol Biomarkers Prev
, vol.8
, pp. 659-668
-
-
Ulrich, C.M.1
Kampman, E.2
Bigler, J.3
Schwartz, S.M.4
Chen, C.5
Bostick, R.6
Fosdick, L.7
Beresford, S.A.8
Yasui, Y.9
Potter, J.D.10
-
64
-
-
0035400131
-
Smoking, folate and methylenetetrahydrofolate reductase status as interactive determinants of adenomatous and hyperplastic polyps of colorectum
-
Ulvik A, Evensen ET, Lien EA, Hoff G, Vollset SE, Majak BM, Ueland PM (2001) Smoking, folate and methylenetetrahydrofolate reductase status as interactive determinants of adenomatous and hyperplastic polyps of colorectum. Am J Med Genet 101:246-254
-
(2001)
Am J Med Genet
, vol.101
, pp. 246-254
-
-
Ulvik, A.1
Evensen, E.T.2
Lien, E.A.3
Hoff, G.4
Vollset, S.E.5
Majak, B.M.6
Ueland, P.M.7
-
65
-
-
0033846460
-
Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene
-
Stern LL, Mason JB, Selhub J, Choi SW (2000) Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene. Cancer Epidemiol Biomarkers Prev 9: 849-853
-
(2000)
Cancer Epidemiol Biomarkers Prev
, vol.9
, pp. 849-853
-
-
Stern, L.L.1
Mason, J.B.2
Selhub, J.3
Choi, S.W.4
-
66
-
-
0037117501
-
A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status
-
Friso S, Choi SW, Girelli D, Mason JB, Dolnikowski GG, Bagley PJ, Olivieri O, Jacques PF, Rosenberg IH, Corrocher R, et al (2002) A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Nat Acad Sci USA 99:5606-5611
-
(2002)
Proc Nat Acad Sci USA
, vol.99
, pp. 5606-5611
-
-
Friso, S.1
Choi, S.W.2
Girelli, D.3
Mason, J.B.4
Dolnikowski, G.G.5
Bagley, P.J.6
Olivieri, O.7
Jacques, P.F.8
Rosenberg, I.H.9
Corrocher, R.10
-
67
-
-
4444371465
-
Methylenetetrahydrofolate reductase 677C→T polymorphism affects DNA methylation in response to controlled folate intake in young women
-
Shelnutt KP, Kauwell GPA, Gregory JF, Maneval DR, Quinlivan EP, Theriaque DW, Henderson GN, Bailey LB (2004) Methylenetetrahydrofolate reductase 677C→T polymorphism affects DNA methylation in response to controlled folate intake in young women. J Nutr Biochem 15:554-560
-
(2004)
J Nutr Biochem
, vol.15
, pp. 554-560
-
-
Shelnutt, K.P.1
Kauwell, G.P.A.2
Gregory, J.F.3
Maneval, D.R.4
Quinlivan, E.P.5
Theriaque, D.W.6
Henderson, G.N.7
Bailey, L.B.8
-
68
-
-
20144371859
-
Methylenetetrahydrofolate reductase 677C→T polymorphism and folate status affect one-carbon incorporation into human DNA deoxynucleosides
-
Quinlivan EP, Davis SR, Shelnutt KP, Henderson GN, Ghandour H, Shane B, Selhub J, Bailey LB, Stacpoole PW, Gregory JF (2005) Methylenetetrahydrofolate reductase 677C→T polymorphism and folate status affect one-carbon incorporation into human DNA deoxynucleosides. J Nutr 135:389-396
-
(2005)
J Nutr
, vol.135
, pp. 389-396
-
-
Quinlivan, E.P.1
Davis, S.R.2
Shelnutt, K.P.3
Henderson, G.N.4
Ghandour, H.5
Shane, B.6
Selhub, J.7
Bailey, L.B.8
Stacpoole, P.W.9
Gregory, J.F.10
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