Nuclear enrichment of folate cofactors and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) protect de novo thymidylate biosynthesis during folate deficiency

Journal of Biological Chemistry

Volumn 289, Issue 43, 2014, Pages 29642-29650

  Field, Martha S ^a   Kamynina, Elena ^a   Agunloye, Olufunmilayo C ^a   Liebenthal, Rebecca P ^a   Lamarre, Simon G ^b   Brosnan, Margaret E ^b   Brosnan, John T ^b   Stover, Patrick J ^a  

^a Department of Molecular Biology and Genetics   (United States)

^b MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; CELL CULTURE; MAMMALS; METABOLISM;

CARBON METABOLISM; DE NOVO SYNTHESIS; DNA BASIS; HOMOCYSTEINES; HUMAN CELL LINES; INTERCONNECTED PATHWAYS; METABOLIC NETWORK; MOUSE LIVER;

BIOSYNTHESIS;

ADENOSINE TRIPHOSPHATE; FOLIC ACID; FORMIC ACID; METHYLENETETRAHYDROFOLATE DEHYDROGENASE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE 1; METHYLENETETRAHYDROFOLIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THYMIDINE PHOSPHATE; UNCLASSIFIED DRUG; COENZYME; DNA; FORMIC ACID DERIVATIVE; GLYCINE HYDROXYMETHYLTRANSFERASE; METHIONINE; PURINE DERIVATIVE; SHMT1 PROTEIN, MOUSE; URACIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE S PHASE; CELL NUCLEUS; CONTROLLED STUDY; CYTOSOL; ENZYME BLOOD LEVEL; ENZYME SYNTHESIS; FEMALE; FOLIC ACID DEFICIENCY; HELA CELL LINE; HUMAN; HUMAN CELL; MALE; MCF 7 CELL LINE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN FUNCTION; ANIMAL; BIOSYNTHESIS; BLOOD; C57BL MOUSE; CELL CYCLE CHECKPOINT; CELL LINE; COENZYME; DIET; ENZYMOLOGY; GENE SILENCING; LIVER; METABOLISM; PATHOLOGY; PROTEIN TRANSPORT;

ANIMALS; CELL CYCLE CHECKPOINTS; CELL LINE; CELL NUCLEUS; COENZYMES; DIET; DNA; FEMALE; FOLIC ACID; FOLIC ACID DEFICIENCY; FORMATES; GENE KNOCKDOWN TECHNIQUES; GLYCINE HYDROXYMETHYLTRANSFERASE; HUMANS; LIVER; MALE; METHIONINE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP); MICE; MICE, INBRED C57BL; PROTEIN TRANSPORT; PURINES; S PHASE; THYMIDINE MONOPHOSPHATE; URACIL;

EID: 84908191332     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.599589     Document Type: Article

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