Association of MTHFR C677T with total homocysteine plasma levels and susceptibility to Parkinson’s disease: a meta-analysis

Neurological Sciences

Volumn 36, Issue 6, 2015, Pages 945-951

  Zhu, Ying ^a   Zhu, Rui Xia ^a   He, Zhi Yi ^a   Liu, Xu ^a   Liu, He Nan ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Homocysteine; Meta analysis; MTHFR C677T; Parkinson s disease

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); HOMOCYSTEINE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MTHFR PROTEIN, HUMAN;

ALLELE; ARTICLE; ASIAN; COCHRANE LIBRARY; EMBASE; EUROPEAN; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HUMAN; MEDLINE; META ANALYSIS; PARKINSON DISEASE; RISK FACTOR; SYSTEMATIC REVIEW; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD; CAUCASIAN; CHINA; GENETIC PREDISPOSITION; GENETICS; SINGLE NUCLEOTIDE POLYMORPHISM;

ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC PREDISPOSITION TO DISEASE; HOMOCYSTEINE; HUMANS; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); PARKINSON DISEASE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 84930374860     PISSN: 15901874     EISSN: 15903478     Source Type: Journal    
DOI: 10.1007/s10072-014-2052-6     Document Type: Article

References (33)

1. Postuma RB, Lang AE (2004) Homocysteine and levodopa: should Parkinson disease patients receive preventative therapy? Neurology 63(5):886–891
2. de Lau LM, Breteler MM (2006) Epidemiology of Parkinson’s disease. Lancet Neurol 5(6):525–535
3. Yasui K, Kowa H, Nakaso K, Takeshima T, Nakashima K (2000) Plasma homocysteine and MTHFR C677T genotype in levodopa-treated patients with PD. Neurology 55(3):437–439
4. Duan W, Ladenheim B, Cutler RG, Kruman II, Cadet JL, Mattson MP (2002) Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson’s disease. J Neurochem 80(1):101–110
5. Födinger M, Buchmayer H, Heinz G, Papagiannopoulos M, Kletzmayr J, Rasoul-Rockenschaub S, Hörl WH, Sunder-Plassmann G (2000) Effect of MTHFR 1298A → C and MTHFR 677C → T genotypes on total homocysteine, folate, and vitamin B(12) plasma concentrations in kidney graft recipients. J Am Soc Nephrol 11(10):1918–1925
6. Białecka M, Robowski P, Honczarenko K, Roszmann A, Sławek J (2009) Genetic and environmental factors for hyperhomocysteinaemia and its clinical implications in Parkinson’s disease. Neurol Neurochir Pol 43(3):272–285
7. Białecka M, Kurzawski M, Roszmann A, Robowski P, Sitek EJ, Honczarenko K, Gorzkowska A, Budrewicz S, Mak M, Jarosz M, Gołąb-Janowska M, Koziorowska-Gawron E, Droździk M, Sławek J (2012) Association of COMT, MTHFR, and SLC19A1(RFC-1) polymorphisms with homocysteine blood levels and cognitive impairment in Parkinson’s disease. Pharmacogenet Genomics 22(10):716–724. doi:10.1097/FPC.0b013e32835693f7
8. Gorgone G, Currò M, Ferlazzo N, Parisi G, Parnetti L, Belcastro V, Tambasco N, Rossi A, Pisani F, Calabresi P, Ientile R, Caccamo D (2012) Coenzyme Q10, hyperhomocysteinemia and MTHFR C677T polymorphism in levodopa-treated Parkinson’s disease patients. Neuromolecular Med 14(1):84–90. doi:10.1007/s12017-012-8174-1
9. Fong CS, Shyu HY, Shieh JC, Fu YP, Chin TY, Wang HW, Cheng CW (2010) Association of MTHFR, MTR, and MTRR polymorphisms with Parkinson’s disease among ethnic Chinese in Taiwan. Clin Chim Acta 412(3–4):332–338. doi:10.1016/j.cca.2010.11.004
10. Rodriguez-Oroz MC, Lage PM, Sanchez-Mut J, Lamet I, Pagonabarraga J, Toledo JB, García-Garcia D, Clavero P, Samaranch L, Irurzun C, Matsubara JM, Irigoien J, Bescos E, Kulisevsky J, Pérez-Tur J, Obeso JA (2009) Homocysteine and cognitive impairment in Parkinson’s disease: a biochemical, neuroimaging, and genetic study. Mov Disord 24(10):1437–1444. doi:10.1002/mds.22522
11. Camicioli RM, Bouchard TP, Somerville MJ (2009) Homocysteine is not associated with global motor or cognitive measures in nondemented older Parkinson’s disease patients. Mov Disord 24(2):176–182. doi:10.1002/mds.22227
12. Yuan RY, Sheu JJ, Yu JM, Hu CJ, Tseng IJ, Ho CS, Yeh CY, Hung YL, Chiang TR (2009) Methylenetetrahydrofolate reductase polymorphisms and plasma homocysteine in levodopa-treated and non-treated Parkinson’s disease patients. J Neurol Sci 287(1–2):64–68. doi:10.1016/j.jns.2009.09.007
13. Caccamo D, Gorgone G, Currò M, Parisi G, Di Iorio W, Menichetti C, Belcastro V, Parnetti L, Rossi A, Pisani F, Ientile R, Calabresi P (2007) Effect of MTHFR polymorphisms on hyperhomocysteinemia in levodopa-treated Parkinsonian patients. Neuromolecular Med 9(3):249–254
14. Dorszewska J, Florczak J, Rozycka A, Kempisty B, Jaroszewska-Kolecka J, Chojnacka K, Trzeciak WH, Kozubski W (2007) Oxidative DNA damage and level of thiols as related to polymorphisms of MTHFR, MTR, MTHFD1 in Alzheimer’s and Parkinson’s diseases. Acta Neurobiol Exp (Wars) 67(2):113–129
15. Lin JJ, Yueh KC, Liu CS, Liu JT, Lin SZ (2007) 5,10-methylenetetrahydrofolate reductase C677T gene polymorphism can influence age at onset of Parkinson’s disease. Acta Neurol Taiwan 16(3):150–157
16. Religa D, Czyzewski K, Styczynska M, Peplonska B, Lokk J, Chodakowska-Zebrowska M, Stepien K, Winblad B, Barcikowska M (2006) Hyperhomocysteinemia and methylenetetrahydrofolate reductase polymorphism in patients with Parkinson’s disease. Neurosci Lett 404(1–2):56–60
17. Todorović Z, Dzoljić E, Novaković I, Mirković D, Stojanović R, Nesić Z, Krajinović M, Prostran M, Kostić V (2006) Homocysteine serum levels and MTHFR C677T genotype in patients with Parkinson’s disease, with and without levodopa therapy. J Neurol Sci 248(1–2):56–61
18. Wüllner U, Kölsch H, Linnebank M (2005) Methylenetetrahydrofolate reductase in Parkinson’s disease. Ann Neurol 58(6):972–973
19. de Lau LM, Koudstaal PJ, van Meurs JB, Uitterlinden AG, Hofman A, Breteler MM (2005) Methylenetetrahydrofolate reductase C677T genotype and PD. Ann Neurol 57(6):927–930
20. Harmon DL, Ramsbottom D, Whitehead AS, Ben-Shlomo Y, Davey-Smith G (1997) The thermolabile variant of 5,10-methylenetetrahydrofolate reductase is not associated with Parkinson’s disease. J Neurol Neurosurg Psychiatry 62(6):671
21. Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA, Thacker SB (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 283(15):2008–2012
22. Mantel N, Haenszel W (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22(4):719–748
23. DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7(3):177–188
24. Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50(4):1088–1101
25. Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315(7109):629–634
26. Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992) Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55(3):181–184
27. Benabid AL (2010) Gene therapy for Parkinson’s disease: do we have the cure? Lancet Neurol 9(12):1142–1143. doi:10.1016/S1474-4422(10)70256-8
28. Obeid R, Schadt A, Dillmann U, Kostopoulos P, Fassbender K, Herrmann W (2009) Methylation status and neurodegenerative markers in Parkinson disease. Clin Chem 55(10):1852–1860. doi:10.1373/clinchem.2009.125021
29. Imamura K, Takeshima T, Nakaso K, Nakashima K (2007) Homocysteine is toxic for dopaminergic neurons in primary mesencephalic culture. NeuroReport 18(13):1319–1322
30. Liao Q, Li NN, Mao XY, Chang XL, Zhao DM, Zhang JH, Yu WJ, Tan EK, Peng R (2014) MTHFR C677T variant reduces risk of sporadic Parkinson’s disease in ethnic Chinese. Acta Neurol Scand 130(1):e30–e34. doi:10.1111/ane.12245
31. Chao N, Sun L, Yu HY, Zhao LJ, Zeng XY, Gu WH, Yang Z, Qin B (2014) Association between methylenetetrahydrofolate reductase gene C677T polymorphism and Parkinson’s disease combined with hyperhomocysteinemia. Chin J Geriatr 33(2):121–125. doi:10.3760/cma.j.issn.0254-9026.2014.02.003
32. Zhu ZG, Ai QL, Wang WM, Xiao ZC (2013) Meta-analysis supports association of a functional SNP (rs1801133) in the MTHFR gene with Parkinson’s disease. Gene 531(1):78–83. doi:10.1016/j.gene.2013.07.034
33. Iacobazzi V, Castegna A, Infantino V, Andria G (2013) Mitochondrial DNA methylation as a next-generation biomarker and diagnostic tool. Mol Genet Metab 110(1–2):25–34. doi:10.1016/j.ymgme.2013.07.012