Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease

Journal of Neuroscience

Volumn 22, Issue 5, 2002, Pages 1752-1762

  Kruman, Inna I ^a   Kumaravel, T S ^a   Lohani, Althaf ^a   Pedersen, Ward A ^a   Cutler, Roy G ^a   Kruman, Yuri ^a   Haughey, Norman ^a   Lee, Jaewon ^a   Evans, Michele ^a   Mattson, Mark P ^a,b  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Comet assay; Glycosylase; Oxidative stress; Transgenic; Uracil

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; DNA BASE; DNA GLYCOSYLTRANSFERASE; FOLIC ACID; HOMOCYSTEINE; METHOTREXATE; URACIL DERIVATIVE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CELL CULTURE; CELL DEATH; COMET ASSAY; CONTROLLED STUDY; DEGENERATIVE DISEASE; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; ENZYME LINKED IMMUNOSORBENT ASSAY; FOLIC ACID DEFICIENCY; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MOUSE; NERVE DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; TRANSGENIC MOUSE;

EID: 0036523032     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-05-01752.2002     Document Type: Article

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