GW274150, a potent and highly selective inhibitor of iNOS reduces experimental renal ischemia/reperfusion injury

Kidney International

Volumn 63, Issue 3, 2003, Pages 853-865

  Chatterjee, Prabal K ^a   Patel, Nimesh S A ^b   Sivarajah, Ahila ^b   Kvale, Espen O ^b   Dugo, Laura ^b   Cuzzocrea, Salvatore ^b   Brown, Paul A J ^b   Stewart, Keith N ^b   Mota Filipe, Helder ^b   Britti, Domenico ^b   Yaqoob, Muhammad M ^b   Thiemermann, Christoph ^b  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b NONE

Author keywords

Inducible nitric oxide synthase; Kidney; Malondialdehyde; Mouse; Myeloperoxidase; Nitric oxide; Oxidative stress; Peroxynitrite; Poly (ADP ribose) polymerase; Rat; Renal dysfunction; Reperfusion injury; Tubular injury

Indexed keywords

3 NITROTYROSINE; ADENOSINE DIPHOSPHATE RIBOSE; ASPARTATE AMINOTRANSFERASE; CREATININE; KIDNEY ENZYME; MALONALDEHYDE; MYELOPEROXIDASE; N ACETYL BETA GLUCOSAMINIDASE; NITRATE; NITRIC OXIDE SYNTHASE INHIBITOR; PEROXYNITRITE; S [2 (1 IMINOETHYLAMINO)ETHYL]HOMOCYSTEINE; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD ANALYSIS; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG EFFECT; DRUG POTENCY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; KIDNEY DISEASE; KIDNEY ISCHEMIA; LIPID PEROXIDATION; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; TISSUE SECTION; TUBULAR DYSFUNCTION; UREA BLOOD LEVEL; URINALYSIS; WILD TYPE;

EID: 0037337260     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2003.00802.x     Document Type: Article

References (67)

1. KONE BC: Nitric oxide in renal health and disease. Am J Kidney Dis 30:311-333, 1997
2. HILL-KAPTURCZAK N, KAPTURCZAK MH, MALINSKI T, GROSS P: Nitric oxide and nitric oxide synthase in the kidney: Potential roles in normal renal function and in renal dysfunction. Endothelium 3:253-299, 1995
3. LIANG M, KNOX FG: Production and functional roles of nitric oxide in the proximal tubule. Am J Physiol 278:R1117-R1124, 2000
4. CHATTERJEE PK, HAWKSWORTH GM, MCLAY JS: Cytokine-stimulated nitric oxide production in human renal proximal tubule and its modulation by natriuretic peptides: A novel immunomodulatory mechanism? Exp Nephrol 7:438-448, 1999
5. CHATTERJEE PK, BROWN PAJ, CUZZOCREA S, et al: Calpain inhibitor-1 reduces renal ischemia/reperfusion injury in the rat. Kidney Int 59:2073-2083, 2001
6. CHATTERJEE PK, PATEL NSA, KVALE EO, et al: Inhibition of inducible nitric oxide synthase reduces renal ischemia/reperfusion injury. Kidney Int 61:862-871, 2002
7. LIEBERTHAL W: Biology of ischemic and toxic renal tubular injury: Role of nitric oxide and the inflammatory response. Curr Opin Nephrol Hypertens 7:289-295, 1998
8. GOLIGORSKY MS, BRODSKY SV, NOIRI E: Nitric oxide in acute renal failure: NOS versus NOS. Kidney Int 61:855-861, 2002
9. WEIGHT SC, NICHOLSON ML: Nitric oxide and renal reperfusion injury: A review. Eur J Vasc Endovasc Surg 16:98-103, 1998
10. WEIGHT SC, FURNESS PN, NICHOLSON ML: Nitric oxide generation is increased in experimental renal warm ischaemia-reperfusion injury. Br J Surg 85:1663-1668, 1998
11. LING H, GENGARO PE, EDELSTEIN CL, et al: Effect of hypoxia on proximal tubules isolated from nitric oxide synthase knockout mice. Kidney Int 53:1642-1646, 1998
12. LING H, EDELSTEIN C, GENGARO P, et al: Attenuation of renal ischemia-reperfusion injury in inducible nitric oxide synthase knockout mice. Am J Physiol 277:F383-F390, 1999
13. NOIRI E, PERESIENI T, MILLER F, GOLIGORSKY MS: In vivo targeting of inducible NO synthase with oligodeoxynucleotides protects rat kidney against ischemia. J Clin Invest 97:2377-2383, 1996
14. PERESLENI T, NOIRI E, BAHOU W, GOLIGORSKY M: Antisense oligodeoxynucleotides to inducible NO synthase rescue epithelial cells from oxidative stress injury. Am J Physiol 270:F971-F977, 1996
15. 6-(1-iminoethyl)-lysine. J Pharmacol Exp Ther 295:417-422, 2000
16. WEIGHT SC, BELL PR, NICHOLSON ML: Renal ischaemia-reperfusion injury. Br J Surg 83:162-170, 1996
17. NATH KA, NORBY SM: Reactive oxygen species and acute renal failure. Am J Med 109:655-678, 2000
18. KADKHODAEE M, GOBÉ GC, WILLGOSS DA, ENDRE ZH: DNA fragmentation reduced by antioxidants following ischaemia-reperfusion in the isolated perfused rat kidney. Nephrol 4:163-175, 1998
19. CHATTERJEE PK, CUZZOCREA S, THIEMERMANN C: Inhibitors of poly (ADP-ribose) synthetase protect rat proximal tubular cells against oxidant stress. Kidney Int 56:973-984, 1999
20. CHATTERJEE PK, ZACHAROWSKI K, CUZZOCREA S, et al: Inhibitors of poly (ADP-ribose) synthetase reduce ischemia-reperfusion injury in the anesthetised rat in vivo. FASEB J 14:641-651, 2000
21. CHATTERJEE PK, CUZZOCREA S, BROWN PAJ, et al: Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat. Kidney Int 58:658-673, 2000
22. PRYOR W, SQUADRITO G: The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide. Am J Physiol 268:L699-L772, 1995
23. BECKMAN JS: Oxidative damage and tyrosine nitration from peroxynitrite. Chem Res Toxicol 9:836-844, 1996
24. BECKMAN JS, BECKMAN TW, CHEN J, et al: Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 87:1620-1624, 1990
25. CHINTALA MS, CHIU PJS, VEMULAPALLI S, et al: Inhibition of endothelial derived relaxing growth factor (EDGF) aggravates ischemic acute renal failure in anesthesized rats. Naunyn-Schmiedeberg's Arch Pharmacol 348:305-310, 1993
26. SPAIN DA, WILSON MA, GARRISON RN: Nitric oxide synthase inhibition exacerbates sepsis-induced renal hypoperfusion. Surgery 116:322-330, 1994
27. 6-(1-iminoethyl)-lysine: A selective inhibitor of inducible nitric oxide synthase. J Med Chem 37:3886-3888, 1994
28. GARVEY EP, OPLINGER JA, TANOURY GJ, et al: Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas. J Biol Chem 269:26669-26676, 1994
29. ALDERTON WK, COOPER CE, KNOWLES RG: Nitric oxide synthases: Structure, function and inhibition. Biochem J 357:593-615, 2001
30. THIEMERMANN C: Aminoethyl-isothiourea in Gram-positive shock: An inhibitor of inducible nitric oxide synthase or a jack-of-all-trades? Shock 15:453-454, 2001
31. THIEMERMANN C, RUETTEN H, Wu C-C, VANE JR: The multiple organ dysfunction syndrome caused by endotoxin in the rat: attenuation of liver dysfunction by inhibitors of nitric oxide synthase. Br J Pharmacol 116:2845-2851, 1995
32. SAETRE T, KAHLER H, FOSTER SJ, LYBERG T: Aminoethyl-isothiourea inhibits leukocyte production of reactive oxygen species and proinflammatory cytokines induced by streptococcal cell wall components in human whole blood. Shock 15:455-460, 2001
33. YOUNG RJ, BEAMS RM, CARTER K, et al: Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine. Bioorg Med Chem Lett 10:597-600, 2000
34. MACMICKING JD, NATHAN C, HOM G, et al: Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 81:641-650, 1995
35. KELLY KJ, WILLIAMS WW JR, COLVIN RB, et al: Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury. J Clin Invest 97:1056-1063, 1996
36. CUZZOCREA S, CHATTERJEE PK, MAZZON E, et al: Role of induced nitric oxide in the initiation of the inflammatory response after post-ischemic injury. Shock 18:169-176, 2002
37. PALLER MS: The cell biology of reperfusion injury in the kidney. J Invest Med 42:632-639, 1994
38. SHERIDAN AM, BONVENTRE JV: Pathophysiology of ischemic acute renal failure. Contrib Nephrol 132:7-21, 2001
39. 3 segments. Kidney Int 14:31-49, 1978
40. MCCOMs PR, ROBERTS B: Acute renal failure following resection of abdominal aortic aneurysm. Surg Gynecol Obstet 148:175-178, 1979
41. ARONSON S, BLUMENTHAL R: Perioperative renal dysfunction and cardiovascular anesthesia: concerns and controversies. J Cardiothorac Vasc Anesth 17:117-130, 1998
42. BOOM H, MALLAT MJ, DE FIJTER JW, et al: Delayed graft function influences renal function, but not survival. Kidney Int 58:859-866, 2000
43. GONSKA T, HIRSCH JR, SCHLATTER E: Amino acid transport in the renal proximal tubule. Amino Acids 19:395-407, 2000
44. YOKOZAWA T, CHUNG HY, KIM DW, GOTO H: Involvement of superoxide and/or nitric oxide in renal tissue injury. Exp Toxicol Pathol 51:517-521, 1999
45. MILLAR CGM, THIEMERMANN C: Intrarenal haemodynamics and renal dysfunction in endotoxaemia: Effects of nitric oxide synthase inhibition. Br J Pharmacol 121:1824-1830, 1997
46. MCDONALD MC, MOTA-FILIPE H, PAUL A, et al: Calpain inhibitor I reduces the activation of nuclear factor-κB and organ injury/dysfunction in hemorrhagic shock. FASEB J 15:171-186, 2001
47. NOIRI E, NAKAO A, UCHIDA K, et al: Oxidative and nitrosative stress in acute renal ischemia. Am J Physiol 281:F948-F957, 2001
48. MORRISSEY JJ, MCCRACKEN R, KANETO H, et al: Location of an inducible nitric oxide synthase mRNA in the normal kidney. Kidney Int 45:998-1005, 1994
49. MAYEUX PR, GARNER HR, GIBSON JD, BEANUM VC: Effect of lipopolysaccharide on nitric oxide synthase activity in the rat proximal tubule. Biochem Pharmacol 49:115-118, 1995
50. TOJO A, GROSS SS, ZHANG L, et al: Immunocytochemical localisation of distinct isoforms of nitric oxide synthase in the juxtaglomerular apparatus of normal rat kidney. J Am Soc Nephrol 4:1438-1447, 1994
51. WALDER CE, THIEMERMANN C, VANE JR: The involvement of endothelium relaxing factor on the regulation of renal cortical blood flow in the rat. Br J Pharmacol 102:967-973, 1991
52. CRISTOL JP, THIEMERMANN C, MITCHELL JA, et al: Support of renal blood flow after ischaemic-reperfusion injury by endogenous formation of nitric oxide and of cyclo-oxygenase vasodilator metabolites. Br J Pharmacol 109:188-194, 1993
53. SHULTZ PJ, RAIJ L: Endogenously synthesised nitric oxide prevents endotoxin-induced glomerular thrombosis. J Clin Invest 90:1718-1725, 1992
54. THIEMERMANN C: The role of L-arginine: Nitric oxide pathway in circulatory shock. Adv Pharmacol 28:45-79, 1994
55. THIEMERMANN C: Nitric oxide and septic shock. Gen Pharmacol 29:159-166, 1997
56. BOOKE M, HINDER F, MCGUIRE R, et al: Nitric oxide synthase inhibition versus norepinephrine in ovine sepsis: Effects on regional blood flow. Shock 5:362-370, 1996
57. HINDER F, BOOKE M, TRABER LD, et al: Nitric oxide synthase inhibition during experimental sepsis improves renal excretory function in the presence of chronically increased atrial natriuretic peptide. Crit Care Med 24:131-136, 1996
58. HOFFEND J, CAVARAPE A, ENDLICH K, STAINHAUSEN M: Influence of endothelium-derived relaxing factor on renal microvessels and pressure-dependent vasodilatation. Am J Physiol 265:F285-F292, 1993
59. RADI R, PELUFFO G, ALVAREZ MN, et al: Unravelling peroxynitrite formation in biological systems. Free Rad Biol Med 30:463-488, 2001
60. EISERICH JP, HRISTOVA M, CROSS CE, et al: Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils. Nature 391:393-397, 1998
61. WANGSIRIPAISAN A, GENGARO P, NEMENOFF R, et al: Effect of nitric oxide donors on renal tubular epithelial cell-matrix adhesion. Kidney Int 55:2281-2288, 1999
62. SZABÓ C, DAWSON VL: Role of poly (ADP-ribose) synthetase in inflammation and ischaemia-reperfusion. Trends Pharmacol Sci 19:287-298, 1998
63. RABB H, O'MEARA YM, MADERNA P, et al: Leukocytes, cell adhesion molecules and ischemic acute renal failure. Kidney Int 51:1463-1468, 1997
64. LAURIAT S, LINAS SL: The role of neutrophils in acute renal failure. Semin Nephrol 18:498-504, 1998
65. JOHNSON JP, ROKAW MD: Sepsis or ischemia in experimental acute renal failure: What have we learned? New Horiz 3:608-614, 1995
66. HICKEY MJ: Role of inducible nitric oxide synthase in the regulation of leukocyte recruitment. Clin Sci 100:1-12, 2001
67. TASSIOPOULOS AK, HAKIM TS, FINCK CM, et al: Neutrophil sequestration in the lung following acute renal aortic occlusion starts during ischaemia and can be attenuated by tumour necrosis factor and nitric oxide blockade. Eur J Vasc Endovasc Surg 16:36-42, 1998