PARP inhibitors in clinical use induce genomic instability in normal human cells

PLoS ONE

Volumn 11, Issue 7, 2016, Pages

  Ito, Shuhei ^a,b   Murphy, Conleth G ^a,c   Doubrovina, Ekaterina ^a   Jasin, Maria ^a   Moynahan, Mary Ellen ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b KYUSHU UNIVERSITY   (Japan)

^c BON SECOURS HOSPITAL   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OLAPARIB; VELIPARIB; BENZIMIDAZOLE DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PHTHALAZINE DERIVATIVE; PIPERAZINE DERIVATIVE;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ANIMAL CELL; ARTICLE; CHROMOSOME ANALYSIS; CONTROLLED STUDY; DRUG DETERMINATION; DRUG EFFICACY; DRUG EXPOSURE; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; IC50; MOUSE; NONHUMAN; NORMAL HUMAN; SISTER CHROMATID EXCHANGE; CHROMOSOME ABERRATION; DNA DAMAGE; DNA REPAIR; DOSE RESPONSE; DRUG EFFECTS; DRUG POTENTIATION; FEMALE; GENE EXPRESSION; GENETICS; HOMOLOGOUS RECOMBINATION; KARYOTYPING; METABOLISM;

BENZIMIDAZOLES; CHROMOSOME ABERRATIONS; CISPLATIN; DNA DAMAGE; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; FEMALE; GENE EXPRESSION; GENOMIC INSTABILITY; HOMOLOGOUS RECOMBINATION; HUMANS; KARYOTYPING; PHTHALAZINES; PIPERAZINES; POLY(ADP-RIBOSE) POLYMERASE INHIBITORS; POLY(ADP-RIBOSE) POLYMERASES; SISTER CHROMATID EXCHANGE;

EID: 84979247551     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0159341     Document Type: Article

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