Inhibition of Poly(ADP-Ribose) Polymerase-1 Protects Chronic Alcoholic Liver Injury

American Journal of Pathology

Volumn 186, Issue 12, 2016, Pages 3117-3130

  Zhang, Yanqing ^a   Wang, Cheng ^a   Tian, Yunli ^a   Zhang, Fengxiao ^a   Xu, Wenjing ^a   Li, Xiangrao ^a   Shu, Zhiping ^a   Wang, Yan ^a   Huang, Kai ^a   Huang, Dan ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ALANINE AMINOTRANSFERASE; BETA ACTIN; CHEMOKINE RECEPTOR CCR2; COLLAGEN TYPE 1; COMPLEMENTARY DNA; CONNECTIVE TISSUE GROWTH FACTOR; CYTOCHROME P450 2E1; FATTY ACID SYNTHASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HISTONE H3; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; N (5,6 DIHYDRO 6 OXO 2 PHENANTHRIDINYL) 2 DIMETHYLAMINOACETAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR; ALCOHOL; ENDOTOXIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PARP1 PROTEIN, MOUSE; PROTECTIVE AGENT;

ALCOHOLIC FATTY LIVER; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL ACTIVATION; CONDITIONED MEDIUM; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE DELETION; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; KUPFFER CELL; LIPOGENESIS; LIPOLYSIS; LIVER CELL CULTURE; LIVER PROTECTION; MACROPHAGE ACTIVATION; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PATHOGENESIS; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; TREATMENT OUTCOME; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; DISEASE MODEL; FATTY LIVER; HUMAN; INFLAMMATION; LIVER; LIVER CELL; LIVER DISEASES, ALCOHOLIC; METABOLISM; NEUTROPHIL; PATHOLOGY;

ANIMALS; APOPTOSIS; DISEASE MODELS, ANIMAL; ENDOTOXINS; ETHANOL; FATTY LIVER; HEPATOCYTES; HUMANS; INFLAMMATION; KUPFFER CELLS; LIVER; LIVER DISEASES, ALCOHOLIC; MALE; MICE; NEUTROPHILS; POLY (ADP-RIBOSE) POLYMERASE-1; POLY(ADP-RIBOSE) POLYMERASE INHIBITORS; PROTECTIVE AGENTS;

EID: 84995982172     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2016.08.016     Document Type: Article

References (41)

1. 1 Gramenzi, A., Caputo, F., Biselli, M., Kuria, F., Loggi, E., Andreone, P., Bernardi, M., Review article: alcoholic liver disease–pathophysiological aspects and risk factors. Aliment Pharmacol Ther 24 (2006), 1151–1161.
2. 2 Mathurin, P., Deng, Q.G., Keshavarzian, A., Choudhary, S., Holmes, E.W., Tsukamoto, H., Exacerbation of alcoholic liver injury by enteral endotoxin in rats. Hepatology 32 (2000), 1008–1017.
3. 3 Maraslioglu, M., Oppermann, E., Blattner, C., Weber, R., Henrich, D., Jobin, C., Schleucher, E., Marzi, I., Lehnert, M., Chronic ethanol feeding modulates inflammatory mediators, activation of nuclear factor-kappaB, and responsiveness to endotoxin in murine Kupffer cells and circulating leukocytes. Mediators Inflamm, 2014, 2014, 808695.
4. 4 Koop, D.R., Klopfenstein, B., Iimuro, Y., Thurman, R.G., Gadolinium chloride blocks alcohol-dependent liver toxicity in rats treated chronically with intragastric alcohol despite the induction of CYP2E1. Mol Pharmacol 51 (1997), 944–950.
5. 5 Lucey, M.R., Mathurin, P., Morgan, T.R., Alcoholic hepatitis. N Engl J Med 360 (2009), 2758–2769.
6. 6 Louvet, A., Teixeira-Clerc, F., Chobert, M.N., Deveaux, V., Pavoine, C., Zimmer, A., Pecker, F., Mallat, A., Lotersztajn, S., Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice. Hepatology 54 (2011), 1217–1226.
7. 7 Wan, J., Benkdane, M., Alons, E., Lotersztajn, S., Pavoine, C., M2 Kupffer cells promote hepatocyte senescence: an IL-6-dependent protective mechanism against alcoholic liver disease. Am J Pathol 184 (2014), 1763–1772.
8. 8 Wan, J., Benkdane, M., Teixeira-Clerc, F., Bonnafous, S., Louvet, A., Lafdil, F., Pecker, F., Tran, A., Gual, P., Mallat, A., Lotersztajn, S., Pavoine, C., M2 Kupffer cells promote M1 Kupffer cell apoptosis: a protective mechanism against alcoholic and nonalcoholic fatty liver disease. Hepatology 59 (2014), 130–142.
9. 9 Gibson, B.A., Kraus, W.L., New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs. Nat Rev Mol Cell Biol 13 (2012), 411–424.
10. 10 Pacher, P., Szabo, C., Role of the peroxynitrite-poly(ADP-ribose) polymerase pathway in human disease. Am J Pathol 173 (2008), 2–13.
11. 11 Kuhnle, S., Nicotera, P., Wendel, A., Leist, M., Prevention of endotoxin-induced lethality, but not of liver apoptosis in poly(ADP-ribose) polymerase-deficient mice. Biochem Biophys Res Commun 263 (1999), 433–438.
12. 12 Oliver, F.J., Menissier-de Murcia, J., Nacci, C., Decker, P., Andriantsitohaina, R., Muller, S., de la Rubia, G., Stoclet, J.C., de Murcia, G., Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice. EMBO J 18 (1999), 4446–4454.
13. 13 Hassa, P.O., Hottiger, M.O., A role of poly (ADP-ribose) polymerase in NF-kappaB transcriptional activation. Biol Chem 380 (1999), 953–959.
14. 14 Hassa, P.O., Covic, M., Hasan, S., Imhof, R., Hottiger, M.O., The enzymatic and DNA binding activity of PARP-1 are not required for NF-kappa B coactivator function. J Biol Chem 276 (2001), 45588–45597.
15. 15 Oumouna-Benachour, K., Hans, C.P., Suzuki, Y., Naura, A., Datta, R., Belmadani, S., Fallon, K., Woods, C., Boulares, A.H., Poly(ADP-ribose) polymerase inhibition reduces atherosclerotic plaque size and promotes factors of plaque stability in apolipoprotein E-deficient mice: effects on macrophage recruitment, nuclear factor-kappaB nuclear translocation, and foam cell death. Circulation 115 (2007), 2442–2450.
16. 16 Wang, C., Zhang, F., Wang, L., Zhang, Y., Li, X., Huang, K., Du, M., Liu, F., Huang, S., Guan, Y., Huang, D., Huang, K., Poly(ADP-ribose) polymerase 1 promotes oxidative-stress-induced liver cell death via suppressing farnesoid X receptor alpha. Mol Cell Biol 33 (2013), 4492–4503.
17. 17 Mukhopadhyay, P., Rajesh, M., Cao, Z., Horvath, B., Park, O., Wang, H., Erdelyi, K., Holovac, E., Wang, Y., Liaudet, L., Hamdaoui, N., Lafdil, F., Hasko, G., Szabo, C., Boulares, A.H., Gao, B., Pacher, P., Poly (ADP-ribose) polymerase-1 is a key mediator of liver inflammation and fibrosis. Hepatology 59 (2014), 1998–2009.
18. 18 Hassa, P.O., Hottiger, M.O., The functional role of poly(ADP-ribose)polymerase 1 as novel coactivator of NF-kappaB in inflammatory disorders. Cell Mol Life Sci 59 (2002), 1534–1553.
19. 19 Akinshola, B.E., Sharma, S., Potter, J.J., Mezey, E., Ethanol enhances ADP-ribosylation of protein in rat hepatocytes. Hepatology 15 (1992), 471–476.
20. 20 Nomura, F., Yaguchi, M., Itoga And, S., Noda, M., Effects of chronic alcohol consumption on hepatic poly-ADP-ribosylation in the rat. Alcohol Clin Exp Res 25 (2001), 35s–38s.
21. 21 Hritz, I., Mandrekar, P., Velayudham, A., Catalano, D., Dolganiuc, A., Kodys, K., Kurt-Jones, E., Szabo, G., The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88. Hepatology 48 (2008), 1224–1231.
22. 22 Zhou, J., Zhai, Y., Mu, Y., Gong, H., Uppal, H., Toma, D., Ren, S., Evans, R.M., Xie, W., A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway. J Biol Chem 281 (2006), 15013–15020.
23. 23 Souza, M.H., Troncon, L.E., Cunha, F.Q., Oliveira, R.B., Decreased gastric tone and delayed gastric emptying precede neutrophil infiltration and mucosal lesion formation in indomethacin-induced gastric damage in rats. Braz J Med Biol Res 36 (2003), 1383–1390.
24. 24 Roychowdhury, S., McMullen, M.R., Pisano, S.G., Liu, X., Nagy, L.E., Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury. Hepatology 57 (2013), 1773–1783.
25. 25 Wieser, V., Tymoszuk, P., Adolph, T.E., Grander, C., Grabherr, F., Enrich, B., Pfister, A., Lichtmanegger, L., Gerner, R., Drach, M., Moser, P., Zoller, H., Weiss, G., Moschen, A.R., Theurl, I., Tilg, H., Lipocalin 2 drives neutrophilic inflammation in alcoholic liver disease. J Hepatol 64 (2016), 872–880.
26. 26 Cohen, J.I., Roychowdhury, S., DiBello, P.M., Jacobsen, D.W., Nagy, L.E., Exogenous thioredoxin prevents ethanol-induced oxidative damage and apoptosis in mouse liver. Hepatology 49 (2009), 1709–1717.
27. 27 Pastorino, J.G., Shulga, N., Hoek, J.B., TNF-alpha-induced cell death in ethanol-exposed cells depends on p38 MAPK signaling but is independent of Bid and caspase-8. Am J Physiol Gastrointest Liver Physiol 285 (2003), G503–G516.
28. 28 McVicker, B.L., Tuma, D.J., Kubik, J.L., Tuma, P.L., Casey, C.A., Ethanol-induced apoptosis in polarized hepatic cells possibly through regulation of the Fas pathway. Alcohol Clin Exp Res 30 (2006), 1906–1915.
29. 29 Masutani, M., Nakagama, H., Sugimura, T., Poly(ADP-ribosyl)ation in relation to cancer and autoimmune disease. Cell Mol Life Sci 62 (2005), 769–783.
30. 30 Mota, R.A., Sanchez-Bueno, F., Saenz, L., Hernandez-Espinosa, D., Jimeno, J., Tornel, P.L., Martinez-Torrano, A., Ramirez, P., Parrilla, P., Yelamos, J., Inhibition of poly(ADP-ribose) polymerase attenuates the severity of acute pancreatitis and associated lung injury. Lab Invest 85 (2005), 1250–1262.
31. 31 Pacher, P., Szabo, C., Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors. Cardiovasc Drug Rev 25 (2007), 235–260.
32. 32 Shevalye, H., Stavniichuk, R., Xu, W., Zhang, J., Lupachyk, S., Maksimchyk, Y., Drel, V.R., Floyd, E.Z., Slusher, B., Obrosova, I.G., Poly(ADP-ribose) polymerase (PARP) inhibition counteracts multiple manifestations of kidney disease in long-term streptozotocin-diabetic rat model. Biochem Pharmacol 79 (2010), 1007–1014.
33. 33 Underhill, C., Toulmonde, M., Bonnefoi, H., A review of PARP inhibitors: from bench to bedside. Ann Oncol 22 (2011), 268–279.
34. 34 Nanji, A.A., Khettry, U., Sadrzadeh, S.M., Yamanaka, T., Severity of liver injury in experimental alcoholic liver disease: correlation with plasma endotoxin, prostaglandin E2, leukotriene B4, and thromboxane B2. Am J Pathol 142 (1993), 367–373.
35. 35 Virag, L., Szabo, C., Purines inhibit poly(ADP-ribose) polymerase activation and modulate oxidant-induced cell death. FASEB J 15 (2001), 99–107.
36. 36 You, M., Fischer, M., Deeg, M.A., Crabb, D.W., Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP). J Biol Chem 277 (2002), 29342–29347.
37. 37 Yu, S., Rao, S., Reddy, J.K., Peroxisome proliferator-activated receptors, fatty acid oxidation, steatohepatitis and hepatocarcinogenesis. Curr Mol Med 3 (2003), 561–572.
38. 38 Wagner, M., Zollner, G., Trauner, M., Nuclear receptors in liver disease. Hepatology 53 (2011), 1023–1034.
39. 39 Erener, S., Mirsaidi, A., Hesse, M., Tiaden, A.N., Ellingsgaard, H., Kostadinova, R., Donath, M.Y., Richards, P.J., Hottiger, M.O., ARTD1 deletion causes increased hepatic lipid accumulation in mice fed a high-fat diet and impairs adipocyte function and differentiation. FASEB J 26 (2012), 2631–2638.
40. 40 Nath, B., Szabo, G., Alcohol-induced modulation of signaling pathways in liver parenchymal and nonparenchymal cells: implications for immunity. Semin Liver Dis 29 (2009), 166–177.
41. 41 Higuchi, H., Kurose, I., Kato, S., Miura, S., Ishii, H., Ethanol-induced apoptosis and oxidative stress in hepatocytes. Alcohol Clin Exp Res 20 (1996), 340a–346a.