Peroxynitrite-mediated DNA strand breakage activates poly-adenosine diphosphate ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide

Journal of Immunology

Volumn 156, Issue 1, 1996, Pages 350-358

  Zingarelli, Basilia ^a   O'Connor, Michael ^a   Wong, Hector ^a   Salzman, Andrew L ^a   Szabó, Csaba ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINOBENZAMIDE; BACTERIUM LIPOPOLYSACCHARIDE; FREE RADICAL; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; SUPEROXIDE;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DAMAGE; CELL ENERGY; CONTROLLED STUDY; CYTOTOXICITY; DNA REPAIR; DNA STRAND BREAKAGE; ENDOTOXEMIA; INFLAMMATION; MITOCHONDRIAL RESPIRATION; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; RAT;

ADENOSINE DIPHOSPHATE RIBOSE; ANIMALS; CELL LINE; DNA DAMAGE; ENERGY METABOLISM; ENZYME ACTIVATION; HYDROGEN PEROXIDE; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES, PERITONEAL; MALE; NITRATES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXIDATION-REDUCTION; RATS; RATS, WISTAR; RHODAMINES; RNA LIGASE (ATP); SUPEROXIDES;

EID: 0030026515     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (60)

1. Nathan, C. 1992. Nitric oxide as a secretory product of mammalian cells. FASEB J. 6 3051
2. Green, S J, and C. A Nacy. 1993 Antimicrobial and immunopathologic effects of cytokine induced nitric oxide synthesis. Curr Opin. Infect. Dis 6:384
3. Szabó, C. 1994 Alterations in the production of nitric oxide in various forms of circulatory shock New Horizons 3:3.
4. Murrell, G., D. Jang, and R. Williams 1995. Nitric oxide activates metalloprotease enzymes in articular cartilage. Biochem. Biophys. Res. Commun. 206:15.
5. Ribbons, K., X. Zhang, J. Thompson, S. Greenberg, W. Moore, C Kommeier, M. Currie, N Lerche, J Blanchard, D Clark, and M. Miller. 1995 Potential role of nitric oxide in a model of chronic colitis in rhesus macaques. Gastroenterology 108:705.
6. Worrall, N, W Lazenby, T. Misko, T. Lin, C. Rodi, P. Manning, R. Tilton, J. Williamson, and T. Ferguson, Jr. 1995. Modulation of in vivo alloreactivity by inhibition of inducible nitric oxide synthase. J. Exp Med 181 63.
7. Narita, I, W. Border, M Ketteler, and N. Noble. 1995. Nitric oxide mediates immunologic injury to kidney mesangium in experimental glomerulonephritis. Lab. Invest. 72:17.
8. + depletion. Biochem. Biophys. Res. Commun. 199:1270.
9. Inada, C., K Yamada, N. Takane, and K. Nonaka 1995. Poly(ADP-ribose) synthesis induced by nitric oxide in a mouse β-cell line. Life Sci 56:1467.
10. Heller, B., Z.-Q. Wang, E. Wagner, J. Radons, A. Burkle, K Fehsel, V. Burkart, and H Kolb. 1995. Inactivation of the poly (ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells. J. Biol. Chem 270:11176.
11. Zhang, J., V. Dawson, T. Dawson, and S. Snyder. 1994 Nitric oxide activation of poly (ADP-ribose) synthetase in neurotoxicity Science 263:687.
12. Schraufstatter, I, P Hyslop, D. Hinshaw, R. Spragg, L. Sklar, and C Cochrane 1986. Hydrogen peroxide-induced injury cells and its prevention by inhibitors of poly (ADP-ribose) polymerase. Proc Natl Acad. Sci. USA 83:4908.
13. Schraufstatter, I., D. Hinshaw, P Hyslop, R Spragg, and C. Cochrane. 1986 Oxidant injury of cells. DNA strand breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide. J. Clin. Invest 77:1312
14. Schraufstatter, I. P. Hyslop, J. Jackson, and C. Cochrane. 1988 Oxidant-induced DNA damage of target cells. J. Clin Invest. 82:1040.
15. Junod, A. F., L Jornot, and H. Petersen 1989 Differential effects of hyperoxia and hydrogen peroxide on DNA damage, polyadenosine diphosphate-ribose polymerase activity, and nicotinamide adenine dinucleotide and adenosine triphosphate contents in cultured endothelial cells and fibroblasts J. Cell Physiol 140: 177.
16. Cochrane, C. 1991. Mechanisms of oxidant injury of cells. Mol. Aspects Med. 12:137.
17. Kirkland, J 1991. Lipid peroxidation, protein thiol oxidation and DNA damage in hydrogen peroxide-induced injury to endothelial cells, role of activation of poly(ADP-ribose) polymerase Biochim. Biophys. Acta 1092:319
18. Junod, A F., L. Jornot, and H Petersen. 1989 Differential effects of hyperoxia and hydrogen peroxide on DN \damage PARS activity, NAD and ADP and ATP content in cultured endothelial cells and fibroblasts. J. Cell Physiol. 140:177.
19. Agarwal, S., B -E. Drysdale, and H. S. Shin. 1988. Tumor necrosis factor mediated cytotoxicity involves ADP-ribosylation. J. Immunol 140:4187.
20. Yamamoto, K, K Tsukidate, and J. Farber. 1993 Differing effects of the inhibition of poly (ADP-ribose) polymerase on the course of oxidative cell injury in hepatocytes and fibroblasts. Biochem. Pharmacol. 46:483.
21. Thies, R., and A. Autor. 1991. Reactive oxygen injury to cultured pulmonary artery endothelial cells: mediation by poly(ADP-ribose) polymerase activation causing NAD depletion and altered energy balance. Arch. Biochem. Biophys 2:353.
22. Uchigata, V., H. Yamamoto, A. Kawamura, and H. Okamoto. 1982. Protection by Superoxide dismutase, catalase, and poly(ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis. J. Biol. Chem. 257:6084
23. Beckman, J., J. Chen, J. Crow, and Y. Ye. 1994. Reactions of nitric oxide, superoxide and peroxynitrite with superoxide dismutase in neurodegeneration. Prog Brain Res. 103:371.
24. Fagni, L., M Lafon-Czal, G Rondoin, O. Manzoni, M. Lerner-Natoli, and J. Bockaert. 1994. The role of free radicals in NMDA-dependent neurotoxicity Prog. Brain Res. 103:381.
25. Amano, F., and Y. Akamatsu 1991. A lipopolysaccharide (LPS) resistant mutant isolated from a macrophage-like cell line. J774.1, exhibits an altered activated macrophage phenotype in response to LPS. Infect. Immun. 59:2166
26. Beckman, J., T. Beckman, J. Chen, P. Marshall, and B. Freeman. 1990. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and Superoxide. Proc. Natl. Acad. Sci. USA 87:1620
27. Pryor, W., and G Squadrito. 1995. The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide Am J Physiol 268:L699.
28. Beckman, J S., J. Chen, H. Ischiropoulos, and J. Crow. 1994. Oxidative chemistry of peroxynitrite Methods Enzymol. 233:229
29. Radi, R., M. Rodriguez, L. Castro, and R. Telleri. 1994. Inhibition of mitochondrial electron transport by peroxynitrite Arch. Biochem. Biophys 308:89.
30. Hu, P., H. Ischiropoulos, J. S Beckman, and S. Matalon. 1994. Peroxymtrite inhibition of oxygen consumption and sodium transport in alveolar type II cells. Am. J. Physiol. 266:L628
31. Hausladen, A., and I. Fridovich. 1994. Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not. J. Biol. Chem. 269:9405.
32. Castro, L., M. Rodriguez, and R. Radi. 1994. Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide. J. Biol. Chem 269:29409.
33. Brunelh, L, J. Crow, and J. Beckman. 1995. The comparative toxicity of nitric oxide and peroxynitrite to Escherichia coli Arch. Biochem. Biophys 316:327
34. Szabó, C, B Zingarelli, M. O'Connor, and A L Salzman. 1995. Peroxynitrite, but not nitric oxide or superoxide, causes DNA strand breakage, activates poly-ADP ribosyl synthetase, and depletes cellular energy stores in J774 macrophages and rat aortic smooth muscle cells in vitro. Endothelium 3(Suppl).46.
35. Szabó, C., G J. Southan, C. Thiemermann, and J. R. Vane 1994. Aldehyde metabolites account for the inhibitory effect of polyamines on the induction of nitric oxide synthase. Br. J. Pharmacol. 113:757.
36. Zingarelli, B, P. Halushka, A. Caputi, and J. Cook. 1995. Increased nitric oxide synthesis during the development of endotoxin tolerance Shock 3:102.
37. Matsubara, T, and M. Ziff. 1986. Superoxide anion release by human endothelial cells, synergism between a phorbol ester and a calcium ionophore. J Cell. Physiol. 127:207.
38. Kooy, N., J Royall, H Ischiropoulos, and J. Beckman. 1994. Peroxynitrite-mediated oxidation of dihydrorhodamine 123 Free Radical Biol. Med. 16:149.
39. Hinz, M., N. Katsilambros, V. Maier, H. Schatz, and E. F. Pfeiffer. 1973. Significance of streptozotocin induced nicotinamide-adenine-dinucleotide (NAD) degradation in mouse pancreatic islets FEBS Lett. 30:225.
40. Lemasters, J. J, and C. R. Hackenbrock 1979. Continuous measurement of adenosine triphosphate with firefly luciferase luminescence. Methods Enzymol. 56: 530
41. Chomczynski, P., and N. Sacchi. 1987. Single step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156.
42. Lowenstein, C. J., C S. Glatt, D. S. Bredt, and S. H. Snyder. 1992. Cloned and expressed macrophage nitric oxide synthase contrasts with brain enzyme. Proc. Natl. Acad. Sci. USA 89:6711
43. Banasik, M., H Komura, M. Shimoyama, and K Ueda. 1992. Specific inhibitors of poly (ADP-ribose) synthetase and mono (ADP-ribosyl) transferase. J Biol Chem. 267:1569
44. Berton, G., C. Sorio, C. Laudanna, M. Menegazzi, A. Arcereri De Prati, and H. Suzuki. 1991. Activation of human monocyte-derived macrophages by interferon gamma is accompanied by increase of poly(ADP-ribose) polymerase activity. Biochim. Biophys. Acta 1091:101.
45. Lichtenstein, A., J Gera, J. Andrews, J Berenson, and C. F. Ware. 1991. Inhibitors of ADP-ribose polymerase decrease the resistance of HER2/neu-expressing cancer cells to the cytotoxic effects of tumor necrosis factor. J. Immunol. 140: 4187.
46. Szabó, C., G. J. Southan, and C. Thiemermann. 1994. Beneficial effects and improved survival in rodent models of septic shock with S-methyl-isothiourea sulfate, a novel, potent and selective inhibitor of inducible nitric oxide synthase. Proc. Natl Acad. Sci. USA 91:12472.
47. Szabó, C., and A. L. Salzman 1995. Endogenous peroxynitrite is involved in the inhibition of cellular respiration in immuno-stimulated J774.2 macrophages. Biochem Biophys. Res Commun. 209:739.
48. Haddad, I., J Crow, P Hu, Y. Ye, J. Beckman, and S. Matalon. 1994. Concurrent generation of nitric oxide and superoxide damages surfactant protein A. Am J. Physiol 267:L242.
49. Heales, S J. R, J. P. Bolanos, J. M Land, and J. B Clark. 1994 Trolox protects mitochondrial complex IV from nitric oxide-mediated damage in astrocytes Brain Res. 668:234.
50. Ohkuma, S, M. Katsura, J. Guo, T. Hasegawa, and K Kuriyama. 1995. Participation of peroxynitrite in acetylcholine release induced by nitric oxide generators. Neurosci. Lett. 183:151
51. Hibbs, J. B, R. R. Taintor, and Z. Vavrin. 1987. Macrophage cytotoxicity: a role for L-arginine deiminase activity and imino nitrogen oxidation to nitrite. Science 235:473.
52. Redegeld, F., S. Chatterjee, N, Berger, and M. Sitkovsky. 1992 Poly-(ADP-ribose) polymerase partially contributes to target cell death triggered by cytolytic T lymphocytes J Immunol 149:3509.
53. Ischiropoulos, H, L. Zhu, and J. Beckman. 1992. Peroxynitrite formation from macrophage-derived nitric oxide. Arch. Biochem. Biophys 2:446.
54. Ródenas, J., M. Mitjavila, and T. Carbonel. 1995. Simultaneous generation of nitric oxide and Superoxide by inflammatory cells in rats. Free Radical Biol Med 18:869.
55. Carreras, M. C., G. A Pargement, S. D. Catz, J. J. Poderoso, and A, Boverine. 1994. Kinetics of nitric oxide and hydrogen peroxide production and formation of peroxynitrite during the respiratory burst of human neutrophils. FEBS Lett. 341 65.
56. 2 in cultured endothelial cells. Arch Biochem. Biophys. 302:348.
57. Hauschildt, S., P Scheipers, W. Bessler, and A Mülsch 1992. Induction nitric oxide synthase in L929 cells by tumour-necrosis factor alpha is prevented by inhibitors of poly(ADP-ribose) polymerase. Biochem. J. 288:255.
58. Cetkovic-Cvlje, M, S. Sandler, and D. Eizirik. 1993. Nicotinamide and dexamethasone inhibit interleukin-1-induced nitric oxide production by RTNm5F cells without decreasing messenger ribonucleic acid expression for nitric oxide synthase. Endocrinology 133:1739
59. Pellat-Deceunynck, C, J., Wietzerbin, and J Drapier. 1994. Nicotinamide inhibits nitric oxide synthase mRNA induction in activated macrophages Biochem J. 297:53.
60. Dierenfeldt, S. M., C. T. Warnick, and H M. Lazarus. 1987. In vivo ischemia and storage injury cause alterations in the activity of poly (adenosine diphosphate ribose) synthetase. Biochem. Med. Metab. Biol. 38:88.