Minocycline inhibits poly(ADP-ribose) polymerase-1 at nanomolar concentrations

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 25, 2006, Pages 9685-9690

  Alano, Conrad C ^a   Kauppinen, Tiina M ^a   Valls, Andreu Viader ^a   Swanson, Raymond A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Death; Doxycycline; Inflammation; Neuron

Indexed keywords

3,4 DIHYDRO 5 [4 (1 PIPERIDINYL)BUTOXY] 1(2H) ISOQUINOLINONE; CHLORTETRACYCLINE; DEMECLOCYCLINE; DOXYCYCLINE; ENZYME INHIBITOR; ISOQUINOLINE DERIVATIVE; LINSIDOMINE; METHYLNITRONITROSOGUANIDINE; MINOCYCLINE; N (5,6 DIHYDRO 6 OXO 2 PHENANTHRIDINYL) 2 DIMETHYLAMINOACETAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; POLY(ADENOSINE DIPHOSPHATE RIBOSE); TETRACYCLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CULTURE MEDIUM; DRUG EFFECT; DRUG POTENCY; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; EVALUATION; IC 50; MOUSE; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; MICE; MINOCYCLINE; MOLECULAR STRUCTURE; NEURONS; POLY(ADP-RIBOSE) POLYMERASES; RECOMBINANT PROTEINS; TETRACYCLINE;

EID: 33745457705     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0600554103     Document Type: Article

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