PARP-1 inhibition attenuates neuronal loss, microglia activation and neurological deficits after traumatic brain injury

Journal of Neurotrauma

Volumn 31, Issue 8, 2014, Pages 758-772

  Stoica, Bogdan A ^a   Loane, David J ^a   Zhao, Zaorui ^a   Kabadi, Shruti V ^a   Hanscom, Marie ^a   Byrnes, Kimberly R ^b   Faden, Alan I ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

controlled cortical impact; microglial activation; neuroprotection; PARP 1; PJ34

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; METHYLNITRONITROSOGUANIDINE; N (5,6 DIHYDRO 6 OXO 2 PHENANTHRIDINYL) 2 DIMETHYLAMINOACETAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CELL CULTURE; BRAIN CORTEX; CELL ACTIVATION; CELL LOSS; COGNITION; CONTROLLED CORTICAL IMPACT; CONTROLLED STUDY; EMBRYO; ENZYME INHIBITION; HIPPOCAMPUS; MALE; MICROGLIA; MICROGLIAL ACTIVATION; MORRIS WATER MAZE TEST; MOTOR PERFORMANCE; MOUSE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; RAT; REPEATED DRUG DOSE; SINGLE DRUG DOSE; SPATIAL LEARNING; SPATIAL MEMORY; STEREOMETRY; THALAMUS; THERAPY EFFECT; TRAUMATIC BRAIN INJURY;

ANIMALS; BLOTTING, WESTERN; BRAIN INJURIES; CELL DEATH; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; MALE; MICE; MICE, INBRED C57BL; MICROGLIA; NEURONS; NEUROPROTECTIVE AGENTS; PHENANTHRENES; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION;

EID: 84897464560     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.2013.3194     Document Type: Article

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