Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation

Science

Volumn 353, Issue 6294, 2016, Pages 45-50

  Gibson, Bryan A ^a   Zhang, Yajie ^b   Jiang, Hong ^c,f   Hussey, Kristine M ^d   Shrimp, Jonathan H ^c,g   Lin, Hening ^c   Schwede, Frank ^e   Yu, Yonghao ^b   Kraus, W Lee ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c Department of Molecular Biology and Genetics   (United States)

^d AVI BIOPHARMA INC   (United States)

^e BIOLOG Life Science Institute   (Germany)

^f SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

^g NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; ELONGATION FACTOR; NEGATIVE ELONGATION FACTOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 2; PROTEOME; RNA POLYMERASE II; UNCLASSIFIED DRUG; ADENOSINE DIPHOSPHATE; CELL CYCLE PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PARP1 PROTEIN, HUMAN; PARP2 PROTEIN, HUMAN; PARP3 PROTEIN, HUMAN; POSITIVE TRANSCRIPTION ELONGATION FACTOR B; RIBOSE; TRANSCRIPTION FACTOR;

ENZYME ACTIVITY; INHIBITION; MUTATION; PROTEIN; PROTEOMICS; RNA;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ARTICLE; CYCLOADDITION; ENZYME SUBSTRATE; INTRACELLULAR SIGNALING; MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEPLETION; TRANSCRIPTION ELONGATION; ANIMAL; CHEMISTRY; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; MOUSE;

ADENOSINE DIPHOSPHATE; ANIMALS; CELL CYCLE PROTEINS; HEK293 CELLS; HUMANS; MICE; NAD; POLY(ADP-RIBOSE) POLYMERASES; POSITIVE TRANSCRIPTIONAL ELONGATION FACTOR B; RIBOSE; RNA POLYMERASE II; TRANSCRIPTION ELONGATION, GENETIC; TRANSCRIPTION FACTORS;

EID: 84974575150     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaf7865     Document Type: Article

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