메뉴 건너뛰기




Volumn 43, Issue 4, 2014, Pages 489-497

Comparative cancer risk associated with methotrexate, other non-biologic and biologic disease-modifying anti-rheumatic drugs

Author keywords

Cancer; DMARDs; Epidemiology; Methotrexate; Rheumatoid arthritis

Indexed keywords

CANCER; DMARDS; EPIDEMIOLOGY; METHOTREXATE; RHEUMATOID ARTHRITIS;

EID: 84894906316     PISSN: 00490172     EISSN: 1532866X     Source Type: Journal    
DOI: 10.1016/j.semarthrit.2013.08.003     Document Type: Article
Times cited : (97)

References (41)
  • 1
    • 0018110856 scopus 로고
    • Excess risk of lymphomas, leukemia and myeloma in patients with rheumatoid arthritis
    • Isomaki H.A., Hakulinen T., Joutsenlahti U. Excess risk of lymphomas, leukemia and myeloma in patients with rheumatoid arthritis. J Chronic Dis 1978, 31(11):691-696.
    • (1978) J Chronic Dis , vol.31 , Issue.11 , pp. 691-696
    • Isomaki, H.A.1    Hakulinen, T.2    Joutsenlahti, U.3
  • 2
    • 27744520447 scopus 로고    scopus 로고
    • Haematopoietic malignancies in rheumatoid arthritis: lymphoma risk and characteristics after exposure to tumour necrosis factor antagonists
    • Askling J., Fored C.M., Baecklund E., Brandt L., Backlin C., Ekbom A., et al. Haematopoietic malignancies in rheumatoid arthritis: lymphoma risk and characteristics after exposure to tumour necrosis factor antagonists. Ann Rheum Dis 2005, 64(10):1414-1420.
    • (2005) Ann Rheum Dis , vol.64 , Issue.10 , pp. 1414-1420
    • Askling, J.1    Fored, C.M.2    Baecklund, E.3    Brandt, L.4    Backlin, C.5    Ekbom, A.6
  • 3
    • 0032543858 scopus 로고    scopus 로고
    • Disease activity and risk of lymphoma in patients with rheumatoid arthritis: nested case-control study
    • Baecklund E., Ekbom A., Sparen P., Feltelius N., Klareskog L. Disease activity and risk of lymphoma in patients with rheumatoid arthritis: nested case-control study. Br Med J 1998, 317(7152):180-181.
    • (1998) Br Med J , vol.317 , Issue.7152 , pp. 180-181
    • Baecklund, E.1    Ekbom, A.2    Sparen, P.3    Feltelius, N.4    Klareskog, L.5
  • 4
    • 0036624739 scopus 로고    scopus 로고
    • Lymphomas in rheumatoid arthritis patients treated with methotrexate: a 3-year prospective study in France
    • Mariette X., Cazals-Hatem D., Warszawki J., Liote F., Balandraud N., Sibilia J., et al. Lymphomas in rheumatoid arthritis patients treated with methotrexate: a 3-year prospective study in France. Blood 2002, 99(11):3909-3915.
    • (2002) Blood , vol.99 , Issue.11 , pp. 3909-3915
    • Mariette, X.1    Cazals-Hatem, D.2    Warszawki, J.3    Liote, F.4    Balandraud, N.5    Sibilia, J.6
  • 5
    • 0017394305 scopus 로고
    • Methotrexate: clinical pharmacology, current status and therapeutic guidelines
    • Bleyer W.A. Methotrexate: clinical pharmacology, current status and therapeutic guidelines. Cancer Treat Rev 1977, 4(2):87-101.
    • (1977) Cancer Treat Rev , vol.4 , Issue.2 , pp. 87-101
    • Bleyer, W.A.1
  • 6
    • 0034735842 scopus 로고    scopus 로고
    • Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group
    • Lipsky P.E., van der Heijde D.M., Clair E.W., Furst D.E., Breedveld F.C., Kalden J.R., et al. Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group. N Engl J Med 2000, 343(22):1594-1602.
    • (2000) N Engl J Med , vol.343 , Issue.22 , pp. 1594-1602
    • Lipsky, P.E.1    van der Heijde, D.M.2    Clair, E.W.3    Furst, D.E.4    Breedveld, F.C.5    Kalden, J.R.6
  • 7
    • 23644455857 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with the selective costimulation modulator abatacept: twelve-month results of a phase iib, double-blind, randomized, placebo-controlled trial
    • Kremer J.M., Dougados M., Emery P., Durez P., Sibilia J., Shergy W., et al. Treatment of rheumatoid arthritis with the selective costimulation modulator abatacept: twelve-month results of a phase iib, double-blind, randomized, placebo-controlled trial. Arthritis Rheum 2005, 52(8):2263-2271.
    • (2005) Arthritis Rheum , vol.52 , Issue.8 , pp. 2263-2271
    • Kremer, J.M.1    Dougados, M.2    Emery, P.3    Durez, P.4    Sibilia, J.5    Shergy, W.6
  • 8
    • 35648988128 scopus 로고    scopus 로고
    • New therapies for treatment of rheumatoid arthritis
    • Smolen J.S., Aletaha D., Koeller M., Weisman M.H., Emery P. New therapies for treatment of rheumatoid arthritis. Lancet 2007, 370(9602):1861-1874.
    • (2007) Lancet , vol.370 , Issue.9602 , pp. 1861-1874
    • Smolen, J.S.1    Aletaha, D.2    Koeller, M.3    Weisman, M.H.4    Emery, P.5
  • 9
    • 84894901637 scopus 로고    scopus 로고
    • FDA: Cancer Warnings Required for TNF Blockers
    • FDA, [cited 2011 December 23]; Available from
    • FDA: Cancer Warnings Required for TNF Blockers. FDA Note to Correspondents 2009, FDA, [cited 2011 December 23]; Available from http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm175803.htm.
    • (2009) FDA Note to Correspondents
  • 10
    • 33646696885 scopus 로고    scopus 로고
    • Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials
    • Bongartz T., Sutton A.J., Sweeting M.J., Buchan I., Matteson E.L., Montori V. Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials. JAMA 2006, 295(19):2275-2285.
    • (2006) JAMA , vol.295 , Issue.19 , pp. 2275-2285
    • Bongartz, T.1    Sutton, A.J.2    Sweeting, M.J.3    Buchan, I.4    Matteson, E.L.5    Montori, V.6
  • 11
    • 67549122368 scopus 로고    scopus 로고
    • Etanercept therapy in rheumatoid arthritis and the risk of malignancies: a systematic review and individual patient data meta-analysis of randomised controlled trials
    • Bongartz T., Warren F.C., Mines D., Matteson E.L., Abrams K.R., Sutton A.J. Etanercept therapy in rheumatoid arthritis and the risk of malignancies: a systematic review and individual patient data meta-analysis of randomised controlled trials. Ann Rheum Dis 2009, 68(7):1177-1183.
    • (2009) Ann Rheum Dis , vol.68 , Issue.7 , pp. 1177-1183
    • Bongartz, T.1    Warren, F.C.2    Mines, D.3    Matteson, E.L.4    Abrams, K.R.5    Sutton, A.J.6
  • 12
    • 79956215758 scopus 로고    scopus 로고
    • Tumor necrosis factor therapy and the risk of serious infection and malignancy in patients with early rheumatoid arthritis: a meta-analysis of randomized controlled trials
    • Thompson A.E., Rieder S.W., Pope J.E. Tumor necrosis factor therapy and the risk of serious infection and malignancy in patients with early rheumatoid arthritis: a meta-analysis of randomized controlled trials. Arthritis Rheum 2011, 63(6):1479-1485.
    • (2011) Arthritis Rheum , vol.63 , Issue.6 , pp. 1479-1485
    • Thompson, A.E.1    Rieder, S.W.2    Pope, J.E.3
  • 13
    • 78751685797 scopus 로고    scopus 로고
    • Cancer risk with tumor necrosis factor alpha (TNF) inhibitors: meta-analysis of randomized controlled trials of adalimumab, etanercept, and infliximab using patient level data
    • Askling J., Fahrbach K., Nordstrom B., Ross S., Schmid C.H., Symmons D. Cancer risk with tumor necrosis factor alpha (TNF) inhibitors: meta-analysis of randomized controlled trials of adalimumab, etanercept, and infliximab using patient level data. Pharmacoepidemiol Drug Saf 2011, 20(2):119-130.
    • (2011) Pharmacoepidemiol Drug Saf , vol.20 , Issue.2 , pp. 119-130
    • Askling, J.1    Fahrbach, K.2    Nordstrom, B.3    Ross, S.4    Schmid, C.H.5    Symmons, D.6
  • 14
    • 67549117204 scopus 로고    scopus 로고
    • The safety of anti-tumour necrosis factor treatments in rheumatoid arthritis: meta and exposure-adjusted pooled analyses of serious adverse events
    • Leombruno J.P., Einarson T.R., Keystone E.C. The safety of anti-tumour necrosis factor treatments in rheumatoid arthritis: meta and exposure-adjusted pooled analyses of serious adverse events. Ann Rheum Dis 2009, 68(7):1136-1145.
    • (2009) Ann Rheum Dis , vol.68 , Issue.7 , pp. 1136-1145
    • Leombruno, J.P.1    Einarson, T.R.2    Keystone, E.C.3
  • 15
    • 34848893989 scopus 로고    scopus 로고
    • Biologic treatment of rheumatoid arthritis and the risk of malignancy: analyses from a large US observational study
    • Wolfe F., Michaud K. Biologic treatment of rheumatoid arthritis and the risk of malignancy: analyses from a large US observational study. Arthritis Rheum 2007, 56(9):2886-2895.
    • (2007) Arthritis Rheum , vol.56 , Issue.9 , pp. 2886-2895
    • Wolfe, F.1    Michaud, K.2
  • 17
    • 72249096209 scopus 로고    scopus 로고
    • Malignancies in the rheumatoid arthritis abatacept clinical development programme: an epidemiological assessment
    • Simon T.A., Smitten A.L., Franklin J., Askling J., Lacaille D., Wolfe F., et al. Malignancies in the rheumatoid arthritis abatacept clinical development programme: an epidemiological assessment. Ann Rheum Dis 2009, 68(12):1819-1826.
    • (2009) Ann Rheum Dis , vol.68 , Issue.12 , pp. 1819-1826
    • Simon, T.A.1    Smitten, A.L.2    Franklin, J.3    Askling, J.4    Lacaille, D.5    Wolfe, F.6
  • 19
    • 84865692521 scopus 로고    scopus 로고
    • Risk of malignancies in patients with rheumatoid arthritis treated with biologic therapy: a meta-analysis
    • Lopez-Olivo M.A., Tayar J.H., Martinez-Lopez J.A., Pollono E.N., Cueto J.P., Gonzales-Crespo M.R., et al. Risk of malignancies in patients with rheumatoid arthritis treated with biologic therapy: a meta-analysis. JAMA 2012, 308(9):898-908.
    • (2012) JAMA , vol.308 , Issue.9 , pp. 898-908
    • Lopez-Olivo, M.A.1    Tayar, J.H.2    Martinez-Lopez, J.A.3    Pollono, E.N.4    Cueto, J.P.5    Gonzales-Crespo, M.R.6
  • 20
    • 34447547659 scopus 로고    scopus 로고
    • Developments in post-marketing comparative effectiveness research
    • Schneeweiss S. Developments in post-marketing comparative effectiveness research. Clin Pharm Ther 2007, 82:143-156.
    • (2007) Clin Pharm Ther , vol.82 , pp. 143-156
    • Schneeweiss, S.1
  • 21
    • 28744446260 scopus 로고    scopus 로고
    • The CORRONA database
    • Kremer J.M. The CORRONA database. Autoimmun Rev 2006, 5(1):46-54.
    • (2006) Autoimmun Rev , vol.5 , Issue.1 , pp. 46-54
    • Kremer, J.M.1
  • 23
    • 33644804877 scopus 로고    scopus 로고
    • The Simplified Disease Activity Index (SDAI) and the Clinical Disease Activity Index (CDAI): a review of their usefulness and validity in rheumatoid arthritis
    • 5 Suppl 39
    • Aletaha D., Smolen J. The Simplified Disease Activity Index (SDAI) and the Clinical Disease Activity Index (CDAI): a review of their usefulness and validity in rheumatoid arthritis. Clin Exp Rheumatol 2005, 23(5 Suppl 39):S100-S108.
    • (2005) Clin Exp Rheumatol , vol.23
    • Aletaha, D.1    Smolen, J.2
  • 24
    • 0035025404 scopus 로고    scopus 로고
    • Which HAQ is best? A comparison of the HAQ, MHAQ and RA-HAQ, a difficult 8 item HAQ (DHAQ), and a rescored 20 item HAQ (HAQ20): analyses in 2,491 rheumatoid arthritis patients following leflunomide initiation
    • Wolfe F. Which HAQ is best? A comparison of the HAQ, MHAQ and RA-HAQ, a difficult 8 item HAQ (DHAQ), and a rescored 20 item HAQ (HAQ20): analyses in 2,491 rheumatoid arthritis patients following leflunomide initiation. J Rheumatol 2001, 28(5):982-989.
    • (2001) J Rheumatol , vol.28 , Issue.5 , pp. 982-989
    • Wolfe, F.1
  • 25
    • 77951622706 scopus 로고
    • The central role of the propensity score in observational studies for causal effects
    • Rosenbaum P.R., Rubin D.B. The central role of the propensity score in observational studies for causal effects. Biometrika 1983, 70:41-55.
    • (1983) Biometrika , vol.70 , pp. 41-55
    • Rosenbaum, P.R.1    Rubin, D.B.2
  • 26
    • 33645210305 scopus 로고    scopus 로고
    • Indications for propensity scores and review of their use in pharmacoepidemiology
    • Glynn R.J., Schneeweiss S., Sturmer T. Indications for propensity scores and review of their use in pharmacoepidemiology. Basic Clin Pharmacol Toxicol 2006, 98(3):253-259.
    • (2006) Basic Clin Pharmacol Toxicol , vol.98 , Issue.3 , pp. 253-259
    • Glynn, R.J.1    Schneeweiss, S.2    Sturmer, T.3
  • 27
    • 33745466638 scopus 로고    scopus 로고
    • A comparison of propensity score methods: a case-study estimating the effectiveness of post-AMI statin use
    • Austin P.C., Mamdani M.M. A comparison of propensity score methods: a case-study estimating the effectiveness of post-AMI statin use. Stat Med 2006, 25(12):2084-2106.
    • (2006) Stat Med , vol.25 , Issue.12 , pp. 2084-2106
    • Austin, P.C.1    Mamdani, M.M.2
  • 28
    • 70350548170 scopus 로고    scopus 로고
    • Cancer risk in patients with rheumatoid arthritis treated with anti-tumor necrosis factor alpha therapies: does the risk change with the time since start of treatment?
    • Askling J., van Vollenhoven R.F., Granath F., Raaschou P., Fored C.M., Baecklund E., et al. Cancer risk in patients with rheumatoid arthritis treated with anti-tumor necrosis factor alpha therapies: does the risk change with the time since start of treatment?. Arthritis Rheum 2009, 60(11):3180-3189.
    • (2009) Arthritis Rheum , vol.60 , Issue.11 , pp. 3180-3189
    • Askling, J.1    van Vollenhoven, R.F.2    Granath, F.3    Raaschou, P.4    Fored, C.M.5    Baecklund, E.6
  • 29
    • 33749346419 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha antagonist use and cancer in patients with rheumatoid arthritis. [erratum appears in Arthritis Rheum. 2006 Oct;54(10):3134]
    • Setoguchi S., Solomon D.H., Weinblatt M.E., Katz J.N., Avorn J., Glynn R.J., et al. Tumor necrosis factor alpha antagonist use and cancer in patients with rheumatoid arthritis. [erratum appears in Arthritis Rheum. 2006 Oct;54(10):3134]. Arthritis Rheum 2006, 54(9):2757-2764.
    • (2006) Arthritis Rheum , vol.54 , Issue.9 , pp. 2757-2764
    • Setoguchi, S.1    Solomon, D.H.2    Weinblatt, M.E.3    Katz, J.N.4    Avorn, J.5    Glynn, R.J.6
  • 30
    • 34248547187 scopus 로고    scopus 로고
    • The effect of methotrexate and anti-tumor necrosis factor therapy on the risk of lymphoma in rheumatoid arthritis in 19,562 patients during 89,710 person-years of observation
    • Wolfe F., Michaud K. The effect of methotrexate and anti-tumor necrosis factor therapy on the risk of lymphoma in rheumatoid arthritis in 19,562 patients during 89,710 person-years of observation. Arthritis Rheum 2007, 56(5):1433-1439.
    • (2007) Arthritis Rheum , vol.56 , Issue.5 , pp. 1433-1439
    • Wolfe, F.1    Michaud, K.2
  • 31
    • 0021991135 scopus 로고
    • Incidence of neoplasms in patients with rheumatoid arthritis exposed to different treatment regimens
    • Hazleman B. Incidence of neoplasms in patients with rheumatoid arthritis exposed to different treatment regimens. Am J Med 1985, 78(1A):39-43.
    • (1985) Am J Med , vol.78 , Issue.1 A , pp. 39-43
    • Hazleman, B.1
  • 32
    • 0026644291 scopus 로고
    • Association of methotrexate, rheumatoid arthritis and lymphoma: report of 2 cases and literature review
    • Kingsmore S.F., Hall B.D., Allen N.B., Rice J.R., Caldwell D.S. Association of methotrexate, rheumatoid arthritis and lymphoma: report of 2 cases and literature review. J Rheumatol 1992, 19(9):1462-1465.
    • (1992) J Rheumatol , vol.19 , Issue.9 , pp. 1462-1465
    • Kingsmore, S.F.1    Hall, B.D.2    Allen, N.B.3    Rice, J.R.4    Caldwell, D.S.5
  • 33
    • 0029922581 scopus 로고    scopus 로고
    • Non-Hodgkin's lymphoma in patients with rheumatoid arthritis treated with low dose methotrexate
    • Usman A.R., Yunus M.B. Non-Hodgkin's lymphoma in patients with rheumatoid arthritis treated with low dose methotrexate. J Rheumatol 1996, 23(6):1095-1097.
    • (1996) J Rheumatol , vol.23 , Issue.6 , pp. 1095-1097
    • Usman, A.R.1    Yunus, M.B.2
  • 34
    • 0030915936 scopus 로고    scopus 로고
    • Is methotrexate oncogenic in patients with rheumatoid arthritis?
    • Kremer J.M. Is methotrexate oncogenic in patients with rheumatoid arthritis?. Semin Arthritis Rheum 1997, 26(6):785-787.
    • (1997) Semin Arthritis Rheum , vol.26 , Issue.6 , pp. 785-787
    • Kremer, J.M.1
  • 36
    • 66149084485 scopus 로고    scopus 로고
    • Anti-tumour necrosis factor therapy in rheumatoid arthritis and risk of malignant lymphomas: relative risks and time trends in the Swedish Biologics Register
    • Askling J., Baecklund E., Granath F., Geborek P., Fored M., Backlin C., et al. Anti-tumour necrosis factor therapy in rheumatoid arthritis and risk of malignant lymphomas: relative risks and time trends in the Swedish Biologics Register. Ann Rheum Dis 2009, 68(5):648-653.
    • (2009) Ann Rheum Dis , vol.68 , Issue.5 , pp. 648-653
    • Askling, J.1    Baecklund, E.2    Granath, F.3    Geborek, P.4    Fored, M.5    Backlin, C.6
  • 37
    • 38649126529 scopus 로고    scopus 로고
    • Lung cancer after exposure to disease modifying anti-rheumatic drugs
    • Bernatsky S., Clarke A., Suissa S. Lung cancer after exposure to disease modifying anti-rheumatic drugs. Lung Cancer 2008, 59(2):266-269.
    • (2008) Lung Cancer , vol.59 , Issue.2 , pp. 266-269
    • Bernatsky, S.1    Clarke, A.2    Suissa, S.3
  • 38
    • 40449106365 scopus 로고    scopus 로고
    • Hematologic malignant neoplasms after drug exposure in rheumatoid arthritis
    • Bernatsky S., Clarke A.E., Suissa S. Hematologic malignant neoplasms after drug exposure in rheumatoid arthritis. Arch Intern Med 2008, 168(4):378-381.
    • (2008) Arch Intern Med , vol.168 , Issue.4 , pp. 378-381
    • Bernatsky, S.1    Clarke, A.E.2    Suissa, S.3
  • 39
    • 27744499707 scopus 로고    scopus 로고
    • Skin cancer, rheumatoid arthritis, and tumor necrosis factor inhibitors
    • Chakravarty E.F., Michaud K., Wolfe F. Skin cancer, rheumatoid arthritis, and tumor necrosis factor inhibitors. J Rheumatol 2005, 32(11):2130-2135.
    • (2005) J Rheumatol , vol.32 , Issue.11 , pp. 2130-2135
    • Chakravarty, E.F.1    Michaud, K.2    Wolfe, F.3
  • 40
    • 17644374819 scopus 로고    scopus 로고
    • Tumour necrosis factor blockers do not increase overall tumour risk in patients with rheumatoid arthritis, but may be associated with an increased risk of lymphomas.[see comment]
    • Geborek P., Bladstrom A., Turesson C., Gulfe A., Petersson I.F., Saxne T., et al. Tumour necrosis factor blockers do not increase overall tumour risk in patients with rheumatoid arthritis, but may be associated with an increased risk of lymphomas.[see comment]. Ann Rheum Dis 2005, 64(5):699-703.
    • (2005) Ann Rheum Dis , vol.64 , Issue.5 , pp. 699-703
    • Geborek, P.1    Bladstrom, A.2    Turesson, C.3    Gulfe, A.4    Petersson, I.F.5    Saxne, T.6
  • 41
    • 77953103015 scopus 로고    scopus 로고
    • Influence of anti-tumor necrosis factor therapy on cancer incidence in patients with rheumatoid arthritis who have had a prior malignancy: results from the British Society for Rheumatology Biologics Register
    • Dixon W.G., Watson K.D., Lunt M., Mercer L.K., Hyrich K.L., Symmons D.P. Influence of anti-tumor necrosis factor therapy on cancer incidence in patients with rheumatoid arthritis who have had a prior malignancy: results from the British Society for Rheumatology Biologics Register. Arthritis Care Res (Hoboken) 2010, 62(6):755-763.
    • (2010) Arthritis Care Res (Hoboken) , vol.62 , Issue.6 , pp. 755-763
    • Dixon, W.G.1    Watson, K.D.2    Lunt, M.3    Mercer, L.K.4    Hyrich, K.L.5    Symmons, D.P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.