메뉴 건너뛰기




Volumn 18, Issue 2, 2012, Pages 92-100

Targeting poly(ADP-ribose) polymerase-1 as a promising approach for immunomodulation in multiple sclerosis?

Author keywords

[No Author keywords available]

Indexed keywords

NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; STRESS ACTIVATED PROTEIN KINASE;

EID: 84856651114     PISSN: 14714914     EISSN: 1471499X     Source Type: Journal    
DOI: 10.1016/j.molmed.2011.10.002     Document Type: Review
Times cited : (23)

References (95)
  • 1
    • 79955665687 scopus 로고    scopus 로고
    • Role of gender in multiple sclerosis: clinical effects and potential molecular mechanisms
    • Greer J.M., McCombe P.A. Role of gender in multiple sclerosis: clinical effects and potential molecular mechanisms. J. Neuroimmunol. 2011, 234:7-18.
    • (2011) J. Neuroimmunol. , vol.234 , pp. 7-18
    • Greer, J.M.1    McCombe, P.A.2
  • 2
    • 0029913882 scopus 로고    scopus 로고
    • Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis
    • Lublin F.D., Reingold S.C. Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology 1996, 46:907-911.
    • (1996) Neurology , vol.46 , pp. 907-911
    • Lublin, F.D.1    Reingold, S.C.2
  • 3
    • 77953394241 scopus 로고    scopus 로고
    • Multiple sclerosis: risk factors, prodromes, and potential causal pathways
    • Ramagopalan S.V., et al. Multiple sclerosis: risk factors, prodromes, and potential causal pathways. Lancet Neurol. 2010, 9:727-739.
    • (2010) Lancet Neurol. , vol.9 , pp. 727-739
    • Ramagopalan, S.V.1
  • 4
    • 34249049841 scopus 로고    scopus 로고
    • Antigen presentation in the CNS by myeloid dendritic cells drives progression of relapsing experimental autoimmune encephalomyelitis
    • Miller S.D., et al. Antigen presentation in the CNS by myeloid dendritic cells drives progression of relapsing experimental autoimmune encephalomyelitis. Ann. N. Y. Acad. Sci. 2007, 1103:179-191.
    • (2007) Ann. N. Y. Acad. Sci. , vol.1103 , pp. 179-191
    • Miller, S.D.1
  • 5
    • 77951214891 scopus 로고    scopus 로고
    • Role of the innate immune system in the pathogenesis of multiple sclerosis
    • Gandhi R., et al. Role of the innate immune system in the pathogenesis of multiple sclerosis. J. Neuroimmunol. 2010, 221:7-14.
    • (2010) J. Neuroimmunol. , vol.221 , pp. 7-14
    • Gandhi, R.1
  • 6
    • 33846485153 scopus 로고    scopus 로고
    • Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
    • Kim J.M., et al. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat. Immunol. 2007, 8:191-197.
    • (2007) Nat. Immunol. , vol.8 , pp. 191-197
    • Kim, J.M.1
  • 7
    • 77957374582 scopus 로고    scopus 로고
    • The multiple sclerosis market
    • Huynh T. The multiple sclerosis market. Nat. Rev. Drug Discov. 2010, 9:759-760.
    • (2010) Nat. Rev. Drug Discov. , vol.9 , pp. 759-760
    • Huynh, T.1
  • 8
    • 79951818195 scopus 로고    scopus 로고
    • Glatiramer acetate treatment of multiple sclerosis: an immunological perspective
    • Racke M.K., Lovett-Racke A.E. Glatiramer acetate treatment of multiple sclerosis: an immunological perspective. J. Immunol. 2011, 186:1887-1890.
    • (2011) J. Immunol. , vol.186 , pp. 1887-1890
    • Racke, M.K.1    Lovett-Racke, A.E.2
  • 9
    • 79955675946 scopus 로고    scopus 로고
    • Beta-interferon for multiple sclerosis
    • Rudick R.A., Goelz S.E. Beta-interferon for multiple sclerosis. Exp. Cell Res. 2011, 317:1301-1311.
    • (2011) Exp. Cell Res. , vol.317 , pp. 1301-1311
    • Rudick, R.A.1    Goelz, S.E.2
  • 10
    • 77956160606 scopus 로고    scopus 로고
    • Treatment options for multiple sclerosis: current and emerging therapies
    • Gawronski K.M., et al. Treatment options for multiple sclerosis: current and emerging therapies. Pharmacotherapy 2010, 30:916-927.
    • (2010) Pharmacotherapy , vol.30 , pp. 916-927
    • Gawronski, K.M.1
  • 11
    • 78649826782 scopus 로고    scopus 로고
    • Oral therapies for multiple sclerosis: a review of agents in phase III development or recently approved
    • Gold R. Oral therapies for multiple sclerosis: a review of agents in phase III development or recently approved. CNS Drugs 2011, 25:37-52.
    • (2011) CNS Drugs , vol.25 , pp. 37-52
    • Gold, R.1
  • 12
    • 80053312105 scopus 로고    scopus 로고
    • Monoclonal antibodies and progressive multifocal leukoencephalopathy
    • Keene D.L., et al. Monoclonal antibodies and progressive multifocal leukoencephalopathy. Can. J. Neurol. Sci. 2011, 38:565-571.
    • (2011) Can. J. Neurol. Sci. , vol.38 , pp. 565-571
    • Keene, D.L.1
  • 13
    • 77954274504 scopus 로고    scopus 로고
    • The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets
    • Krishnakumar R., Kraus W.L. The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets. Mol. Cell 2010, 39:8-24.
    • (2010) Mol. Cell , vol.39 , pp. 8-24
    • Krishnakumar, R.1    Kraus, W.L.2
  • 14
    • 77951023118 scopus 로고    scopus 로고
    • Toward a unified nomenclature for mammalian ADP-ribosyltransferases
    • Hottiger M.O., et al. Toward a unified nomenclature for mammalian ADP-ribosyltransferases. Trends Biochem. Sci. 2010, 35:208-219.
    • (2010) Trends Biochem. Sci. , vol.35 , pp. 208-219
    • Hottiger, M.O.1
  • 15
    • 77950023283 scopus 로고    scopus 로고
    • PARP inhibition: PARP1 and beyond
    • Rouleau M., et al. PARP inhibition: PARP1 and beyond. Nat. Rev. Cancer 2010, 10:293-301.
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 293-301
    • Rouleau, M.1
  • 16
    • 33745867638 scopus 로고    scopus 로고
    • Poly(ADP-ribose): novel functions for an old molecule
    • Schreiber V., et al. Poly(ADP-ribose): novel functions for an old molecule. Nat. Rev. Mol. Cell Biol. 2006, 7:517-528.
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 517-528
    • Schreiber, V.1
  • 17
    • 58749112769 scopus 로고    scopus 로고
    • Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes
    • Gagne J.P., et al. Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes. Nucleic Acids Res. 2008, 36:6959-6976.
    • (2008) Nucleic Acids Res. , vol.36 , pp. 6959-6976
    • Gagne, J.P.1
  • 18
    • 38049064044 scopus 로고    scopus 로고
    • Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins
    • Ahel I., et al. Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins. Nature 2008, 451:81-85.
    • (2008) Nature , vol.451 , pp. 81-85
    • Ahel, I.1
  • 19
    • 69949133036 scopus 로고    scopus 로고
    • A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation
    • Timinszky G., et al. A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation. Nat. Struct. Mol. Biol. 2009, 16:923-929.
    • (2009) Nat. Struct. Mol. Biol. , vol.16 , pp. 923-929
    • Timinszky, G.1
  • 20
    • 0035977206 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase: a guardian angel protecting the genome and suppressing tumorigenesis
    • Tong W.M., et al. Poly(ADP-ribose) polymerase: a guardian angel protecting the genome and suppressing tumorigenesis. Biochim. Biophys. Acta 2001, 1552:27-37.
    • (2001) Biochim. Biophys. Acta , vol.1552 , pp. 27-37
    • Tong, W.M.1
  • 21
    • 0036499892 scopus 로고    scopus 로고
    • PARP-1: killer or conspirator? The suicide hypothesis revisited
    • Chiarugi A. PARP-1: killer or conspirator? The suicide hypothesis revisited. Trends Pharmacol. Sci 2002, 23:122-129.
    • (2002) Trends Pharmacol. Sci , vol.23 , pp. 122-129
    • Chiarugi, A.1
  • 22
    • 67649526000 scopus 로고    scopus 로고
    • Poly(ADP-ribose) signals to mitochondrial AIF: a key event in parthanatos
    • Wang Y., et al. Poly(ADP-ribose) signals to mitochondrial AIF: a key event in parthanatos. Exp. Neurol. 2009, 218:193-202.
    • (2009) Exp. Neurol. , vol.218 , pp. 193-202
    • Wang, Y.1
  • 23
    • 34247127355 scopus 로고    scopus 로고
    • The role of poly(ADP-ribose) polymerase-1 in CNS disease
    • Kauppinen T.M., Swanson R.A. The role of poly(ADP-ribose) polymerase-1 in CNS disease. Neuroscience 2007, 145:1267-1272.
    • (2007) Neuroscience , vol.145 , pp. 1267-1272
    • Kauppinen, T.M.1    Swanson, R.A.2
  • 24
    • 34250777695 scopus 로고    scopus 로고
    • Multiple roles for poly(ADP-ribose)polymerase-1 in neurological disease
    • Kauppinen T.M. Multiple roles for poly(ADP-ribose)polymerase-1 in neurological disease. Neurochem. Int. 2007, 50:954-958.
    • (2007) Neurochem. Int. , vol.50 , pp. 954-958
    • Kauppinen, T.M.1
  • 25
    • 17144423943 scopus 로고    scopus 로고
    • Specific binding of poly(ADP-ribose) polymerase-1 to cruciform hairpins
    • Potaman V.N., et al. Specific binding of poly(ADP-ribose) polymerase-1 to cruciform hairpins. J. Mol. Biol. 2005, 348:609-615.
    • (2005) J. Mol. Biol. , vol.348 , pp. 609-615
    • Potaman, V.N.1
  • 26
    • 33750932728 scopus 로고    scopus 로고
    • Novel modulators of poly(ADP-ribose) polymerase
    • Szabo C., et al. Novel modulators of poly(ADP-ribose) polymerase. Trends Pharmacol. Sci. 2006, 27:626-630.
    • (2006) Trends Pharmacol. Sci. , vol.27 , pp. 626-630
    • Szabo, C.1
  • 27
    • 44649130038 scopus 로고    scopus 로고
    • Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation
    • Kraus W.L. Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation. Curr. Opin. Cell Biol. 2008, 20:294-302.
    • (2008) Curr. Opin. Cell Biol. , vol.20 , pp. 294-302
    • Kraus, W.L.1
  • 28
    • 0344721492 scopus 로고    scopus 로고
    • Resistance to endotoxic shock as a consequence of defective NF-κB activation in poly(ADP-ribose) polymerase-1 deficient mice
    • Oliver F.J., et al. Resistance to endotoxic shock as a consequence of defective NF-κB activation in poly(ADP-ribose) polymerase-1 deficient mice. EMBO J. 1999, 18:4446-4454.
    • (1999) EMBO J. , vol.18 , pp. 4446-4454
    • Oliver, F.J.1
  • 29
    • 0035824647 scopus 로고    scopus 로고
    • The enzymatic and DNA binding activity of PARP-1 are not required for NF-kappaB coactivator function
    • Hassa P.O., et al. The enzymatic and DNA binding activity of PARP-1 are not required for NF-kappaB coactivator function. J. Biol. Chem. 2001, 276:45588-45597.
    • (2001) J. Biol. Chem. , vol.276 , pp. 45588-45597
    • Hassa, P.O.1
  • 30
    • 0035861675 scopus 로고    scopus 로고
    • The sequence specific DNA binding of NF-κB is reversibly regulated by the automodification reaction of PARP-1
    • Chang W.J., Alvarez-Gonzalez R. The sequence specific DNA binding of NF-κB is reversibly regulated by the automodification reaction of PARP-1. J. Biol. Chem. 2001, 276:47664-47670.
    • (2001) J. Biol. Chem. , vol.276 , pp. 47664-47670
    • Chang, W.J.1    Alvarez-Gonzalez, R.2
  • 31
    • 0037387772 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase-1 activity promotes NF-kappaB-driven transcription and microglial activation: implication for neurodegenerative disorders
    • Chiarugi A., Moskowitz M.A. Poly(ADP-ribose) polymerase-1 activity promotes NF-kappaB-driven transcription and microglial activation: implication for neurodegenerative disorders. J. Neurochem. 2003, 85:306-317.
    • (2003) J. Neurochem. , vol.85 , pp. 306-317
    • Chiarugi, A.1    Moskowitz, M.A.2
  • 32
    • 70350011787 scopus 로고    scopus 로고
    • NF-kappa B, a potential therapeutic target for the treatment of multiple sclerosis
    • Yan J., Greer J.M. NF-kappa B, a potential therapeutic target for the treatment of multiple sclerosis. CNS Neurol. Disord. Drug Targets 2008, 7:536-557.
    • (2008) CNS Neurol. Disord. Drug Targets , vol.7 , pp. 536-557
    • Yan, J.1    Greer, J.M.2
  • 33
    • 0036855413 scopus 로고    scopus 로고
    • Inhibitors of poly(ADP-ribose) polymerase-1 suppress transcriptional activation in lymphocytes and ameliorate autoimmune encephalomyelitis in rats
    • Chiarugi A. Inhibitors of poly(ADP-ribose) polymerase-1 suppress transcriptional activation in lymphocytes and ameliorate autoimmune encephalomyelitis in rats. Br. J. Pharmacol. 2002, 137:761-770.
    • (2002) Br. J. Pharmacol. , vol.137 , pp. 761-770
    • Chiarugi, A.1
  • 34
    • 0037022627 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in glia
    • Ha H.C., et al. Poly(ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in glia. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:3270-3275.
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 3270-3275
    • Ha, H.C.1
  • 35
    • 39149088997 scopus 로고    scopus 로고
    • Regulation of NFAT by poly(ADP-ribose) polymerase activity in T cells
    • Valdor R., et al. Regulation of NFAT by poly(ADP-ribose) polymerase activity in T cells. Mol. Immunol. 2008, 45:1863-1871.
    • (2008) Mol. Immunol. , vol.45 , pp. 1863-1871
    • Valdor, R.1
  • 36
    • 0035937826 scopus 로고    scopus 로고
    • A role for poly(ADP-ribose) polymerase (PARP) in the transcriptional regulation of the melanoma growth stimulatory activity (CXCL1) gene expression
    • Nirodi C., et al. A role for poly(ADP-ribose) polymerase (PARP) in the transcriptional regulation of the melanoma growth stimulatory activity (CXCL1) gene expression. J. Biol. Chem. 2001, 276:9366-9374.
    • (2001) J. Biol. Chem. , vol.276 , pp. 9366-9374
    • Nirodi, C.1
  • 37
    • 34250838558 scopus 로고    scopus 로고
    • A key role for poly(ADP-ribose) polymerase-1 activity during human dendritic cell maturation
    • Aldinucci A., et al. A key role for poly(ADP-ribose) polymerase-1 activity during human dendritic cell maturation. J. Immunol. 2007, 179:305-312.
    • (2007) J. Immunol. , vol.179 , pp. 305-312
    • Aldinucci, A.1
  • 38
    • 79959493209 scopus 로고    scopus 로고
    • PARP-1 inhibition prevents CNS migration of dendritic cells during EAE, suppressing the encephalitogenic response and relapse severity
    • Cavone L., et al. PARP-1 inhibition prevents CNS migration of dendritic cells during EAE, suppressing the encephalitogenic response and relapse severity. Mult. Scler. 2011, 17:794-807.
    • (2011) Mult. Scler. , vol.17 , pp. 794-807
    • Cavone, L.1
  • 39
    • 0035202873 scopus 로고    scopus 로고
    • Regulation of microglial expression of integrins by poly(ADP-ribose) polymerase-1
    • Ullrich O., et al. Regulation of microglial expression of integrins by poly(ADP-ribose) polymerase-1. Nat. Cell Biol. 2001, 3:1035-1042.
    • (2001) Nat. Cell Biol. , vol.3 , pp. 1035-1042
    • Ullrich, O.1
  • 40
    • 23844531504 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase-1 activation in a primate model of multiple sclerosis
    • Kauppinen T.M., et al. Poly(ADP-ribose) polymerase-1 activation in a primate model of multiple sclerosis. J. Neurosci. Res. 2005, 81:190-198.
    • (2005) J. Neurosci. Res. , vol.81 , pp. 190-198
    • Kauppinen, T.M.1
  • 41
    • 4844220063 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) glycohydrolase by gallotannin selectively up-regulates expression of proinflammatory genes
    • Rapizzi E., et al. Inhibition of poly(ADP-ribose) glycohydrolase by gallotannin selectively up-regulates expression of proinflammatory genes. Mol. Pharmacol. 2004, 66:890-898.
    • (2004) Mol. Pharmacol. , vol.66 , pp. 890-898
    • Rapizzi, E.1
  • 42
    • 13544277675 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase-1 promotes microglial activation, proliferation, and matrix metalloproteinase-9-mediated neuron death
    • Kauppinen T.M., Swanson R.A. Poly(ADP-ribose) polymerase-1 promotes microglial activation, proliferation, and matrix metalloproteinase-9-mediated neuron death. J. Immunol. 2005, 174:2288-2296.
    • (2005) J. Immunol. , vol.174 , pp. 2288-2296
    • Kauppinen, T.M.1    Swanson, R.A.2
  • 43
    • 43449100054 scopus 로고    scopus 로고
    • Transcriptional regulation by poly(ADP-ribose) polymerase-1 during T cell activation
    • Saenz L., et al. Transcriptional regulation by poly(ADP-ribose) polymerase-1 during T cell activation. BMC Genomics 2008, 9:171.
    • (2008) BMC Genomics , vol.9 , pp. 171
    • Saenz, L.1
  • 44
    • 0029073251 scopus 로고
    • Immunosuppressive activities of 6(5)-phenanthridinone, a new poly(ADP-ribose) polymerase inhibitor
    • Weltin D., et al. Immunosuppressive activities of 6(5)-phenanthridinone, a new poly(ADP-ribose) polymerase inhibitor. Int. J. Immunopharmacol. 1995, 17:265-271.
    • (1995) Int. J. Immunopharmacol. , vol.17 , pp. 265-271
    • Weltin, D.1
  • 45
    • 1342327619 scopus 로고    scopus 로고
    • Transcription regulation of TNF-alpha-early response genes by poly(ADP-ribose) polymerase-1 in murine heart endothelial cells
    • Carrillo A., et al. Transcription regulation of TNF-alpha-early response genes by poly(ADP-ribose) polymerase-1 in murine heart endothelial cells. Nucleic Acids Res. 2004, 32:757-766.
    • (2004) Nucleic Acids Res. , vol.32 , pp. 757-766
    • Carrillo, A.1
  • 46
    • 0038523790 scopus 로고    scopus 로고
    • Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis
    • Bettelli E., et al. Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. J. Exp. Med. 2003, 197:1073-1081.
    • (2003) J. Exp. Med. , vol.197 , pp. 1073-1081
    • Bettelli, E.1
  • 47
    • 4444247999 scopus 로고    scopus 로고
    • Constitutive expression of a costimulatory ligand on antigen-presenting cells in the nervous system drives demyelinating disease
    • Zehntner S.P., et al. Constitutive expression of a costimulatory ligand on antigen-presenting cells in the nervous system drives demyelinating disease. FASEB J. 2003, 17:1910-1912.
    • (2003) FASEB J. , vol.17 , pp. 1910-1912
    • Zehntner, S.P.1
  • 48
    • 70149122373 scopus 로고    scopus 로고
    • Pathogenic CD8(+) T cells in multiple sclerosis
    • Friese M.A., Fugger L. Pathogenic CD8(+) T cells in multiple sclerosis. Ann. Neurol. 2009, 66:132-141.
    • (2009) Ann. Neurol. , vol.66 , pp. 132-141
    • Friese, M.A.1    Fugger, L.2
  • 49
    • 0035796895 scopus 로고    scopus 로고
    • Role of poly(ADP-ribose) synthetase activation in the development of experimental allergic encephalomyelitis
    • Scott G.S., et al. Role of poly(ADP-ribose) synthetase activation in the development of experimental allergic encephalomyelitis. J. Neuroimmunol. 2001, 117:78-86.
    • (2001) J. Neuroimmunol. , vol.117 , pp. 78-86
    • Scott, G.S.1
  • 50
    • 4243068535 scopus 로고    scopus 로고
    • The therapeutic effects of PJ34 [N-(6-oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide.HCl], a selective inhibitor of poly(ADP-ribose) polymerase, in experimental allergic encephalomyelitis are associated with immunomodulation
    • Scott G.S., et al. The therapeutic effects of PJ34 [N-(6-oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide.HCl], a selective inhibitor of poly(ADP-ribose) polymerase, in experimental allergic encephalomyelitis are associated with immunomodulation. J. Pharmacol. Exp. Ther. 2004, 310:1053-1061.
    • (2004) J. Pharmacol. Exp. Ther. , vol.310 , pp. 1053-1061
    • Scott, G.S.1
  • 51
    • 69049084375 scopus 로고    scopus 로고
    • Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE
    • Farez M.F., et al. Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE. Nat. Immunol. 2009, 10:958-964.
    • (2009) Nat. Immunol. , vol.10 , pp. 958-964
    • Farez, M.F.1
  • 52
    • 70350005154 scopus 로고    scopus 로고
    • PARP-1 deficiency increases the severity of disease in a mouse model of multiple sclerosis
    • Selvaraj V., et al. PARP-1 deficiency increases the severity of disease in a mouse model of multiple sclerosis. J. Biol. Chem. 2009, 284:26070-26084.
    • (2009) J. Biol. Chem. , vol.284 , pp. 26070-26084
    • Selvaraj, V.1
  • 53
    • 77949363999 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis in the mouse
    • (Chapter 15, Unit 15.1)
    • Miller S.D., et al. Experimental autoimmune encephalomyelitis in the mouse. Curr. Protoc. Immunol. 2010, 1-20. (Chapter 15, Unit 15.1).
    • (2010) Curr. Protoc. Immunol. , pp. 1-20
    • Miller, S.D.1
  • 54
    • 0029737874 scopus 로고    scopus 로고
    • Active and passive experimental autoimmune encephalomyelitis in strain 129/J (H-2b) mice
    • Fritz R.B., Zhao M.L. Active and passive experimental autoimmune encephalomyelitis in strain 129/J (H-2b) mice. J. Neurosci. Res. 1996, 45:471-474.
    • (1996) J. Neurosci. Res. , vol.45 , pp. 471-474
    • Fritz, R.B.1    Zhao, M.L.2
  • 55
    • 0037440373 scopus 로고    scopus 로고
    • Peroxynitrite-induced oligodendrocyte toxicity is not dependent on poly(ADP-ribose) polymerase activation
    • Scott G.S., et al. Peroxynitrite-induced oligodendrocyte toxicity is not dependent on poly(ADP-ribose) polymerase activation. Glia 2003, 41:105-116.
    • (2003) Glia , vol.41 , pp. 105-116
    • Scott, G.S.1
  • 56
    • 0024361208 scopus 로고
    • Differential role for ADP-ribosylation in gene expression during the activation of T lymphocytes by various stimuli
    • King S.L., et al. Differential role for ADP-ribosylation in gene expression during the activation of T lymphocytes by various stimuli. Immunology 1989, 67:258-262.
    • (1989) Immunology , vol.67 , pp. 258-262
    • King, S.L.1
  • 57
    • 0036481263 scopus 로고    scopus 로고
    • Epitope spreading in immune-mediated diseases: implications for immunotherapy
    • Vanderlugt C.L., Miller S.D. Epitope spreading in immune-mediated diseases: implications for immunotherapy. Nat. Rev. Immunol. 2002, 2:85-95.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 85-95
    • Vanderlugt, C.L.1    Miller, S.D.2
  • 58
    • 16244417773 scopus 로고    scopus 로고
    • Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis
    • McMahon E.J., et al. Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis. Nat. Med. 2005, 11:335-339.
    • (2005) Nat. Med. , vol.11 , pp. 335-339
    • McMahon, E.J.1
  • 59
    • 0027141893 scopus 로고
    • Inhibitors of poly(ADP-ribose) polymerase increase antibody class switching
    • Shockett P., Stavnezer J. Inhibitors of poly(ADP-ribose) polymerase increase antibody class switching. J. Immunol. 1993, 151:6962-6976.
    • (1993) J. Immunol. , vol.151 , pp. 6962-6976
    • Shockett, P.1    Stavnezer, J.2
  • 60
    • 34250792144 scopus 로고    scopus 로고
    • Contribution of poly(ADP-ribose) polymerase to postischemic blood-brain barrier damage in rats
    • Lenzser G., et al. Contribution of poly(ADP-ribose) polymerase to postischemic blood-brain barrier damage in rats. J. Cereb. Blood Flow Metab. 2007, 27:1318-1326.
    • (2007) J. Cereb. Blood Flow Metab. , vol.27 , pp. 1318-1326
    • Lenzser, G.1
  • 61
    • 77951634464 scopus 로고    scopus 로고
    • Increased Foxp3+ regulatory T cells in poly(ADP-ribose) polymerase-1 deficiency
    • Nasta F., et al. Increased Foxp3+ regulatory T cells in poly(ADP-ribose) polymerase-1 deficiency. J. Immunol. 2010, 184:3470-3477.
    • (2010) J. Immunol. , vol.184 , pp. 3470-3477
    • Nasta, F.1
  • 62
    • 76249094369 scopus 로고    scopus 로고
    • Disturbed regulatory T cell homeostasis in multiple sclerosis
    • Venken K., et al. Disturbed regulatory T cell homeostasis in multiple sclerosis. Trends Mol. Med. 2010, 16:58-68.
    • (2010) Trends Mol. Med. , vol.16 , pp. 58-68
    • Venken, K.1
  • 63
    • 77649290565 scopus 로고    scopus 로고
    • Neuroprotection, regeneration and immunomodulation: broadening the therapeutic repertoire in multiple sclerosis
    • Aktas O., et al. Neuroprotection, regeneration and immunomodulation: broadening the therapeutic repertoire in multiple sclerosis. Trends Neurosci. 2010, 33:140-152.
    • (2010) Trends Neurosci. , vol.33 , pp. 140-152
    • Aktas, O.1
  • 64
    • 77950862182 scopus 로고    scopus 로고
    • Multiple sclerosis - candidate mechanisms underlying CNS atrophy
    • Siffrin V., et al. Multiple sclerosis - candidate mechanisms underlying CNS atrophy. Trends Neurosci. 2010, 33:202-210.
    • (2010) Trends Neurosci. , vol.33 , pp. 202-210
    • Siffrin, V.1
  • 65
    • 77953611373 scopus 로고    scopus 로고
    • The link between inflammation, synaptic transmission and neurodegeneration in multiple sclerosis
    • Centonze D., et al. The link between inflammation, synaptic transmission and neurodegeneration in multiple sclerosis. Cell Death Differ. 2010, 17:1083-1091.
    • (2010) Cell Death Differ. , vol.17 , pp. 1083-1091
    • Centonze, D.1
  • 66
    • 0037418615 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase as a key player in excitotoxicity and post-ischemic brain damage
    • Meli E., et al. Poly(ADP-ribose) polymerase as a key player in excitotoxicity and post-ischemic brain damage. Toxicol. Lett. 2003, 139:153-162.
    • (2003) Toxicol. Lett. , vol.139 , pp. 153-162
    • Meli, E.1
  • 67
    • 26444460818 scopus 로고    scopus 로고
    • Intrinsic mechanisms of poly(ADP-ribose) neurotoxicity: three hypotheses
    • Chiarugi A. Intrinsic mechanisms of poly(ADP-ribose) neurotoxicity: three hypotheses. Neurotoxicology 2005, 26:847-855.
    • (2005) Neurotoxicology , vol.26 , pp. 847-855
    • Chiarugi, A.1
  • 68
    • 33846472053 scopus 로고    scopus 로고
    • CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4+ T(H)-17 cells in relapsing EAE
    • Bailey S.L., et al. CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4+ T(H)-17 cells in relapsing EAE. Nat. Immunol. 2007, 8:172-180.
    • (2007) Nat. Immunol. , vol.8 , pp. 172-180
    • Bailey, S.L.1
  • 69
    • 33748162638 scopus 로고    scopus 로고
    • Tolerogenic dendritic cells: cytokine modulation comes of age
    • Rutella S., et al. Tolerogenic dendritic cells: cytokine modulation comes of age. Blood 2006, 108:1435-1440.
    • (2006) Blood , vol.108 , pp. 1435-1440
    • Rutella, S.1
  • 70
    • 79957765659 scopus 로고    scopus 로고
    • Interferon-beta exacerbates Th17-mediated inflammatory disease
    • Axtell R.C., et al. Interferon-beta exacerbates Th17-mediated inflammatory disease. Trends Immunol. 2011, 32:272-277.
    • (2011) Trends Immunol. , vol.32 , pp. 272-277
    • Axtell, R.C.1
  • 71
    • 33745728404 scopus 로고    scopus 로고
    • How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis
    • Steinman L., Zamvil S.S. How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis. Ann. Neurol. 2006, 60:12-21.
    • (2006) Ann. Neurol. , vol.60 , pp. 12-21
    • Steinman, L.1    Zamvil, S.S.2
  • 72
    • 77955844059 scopus 로고    scopus 로고
    • Emerging concepts in autoimmune encephalomyelitis beyond the CD4/T(H)1 paradigm
    • Batoulis H., et al. Emerging concepts in autoimmune encephalomyelitis beyond the CD4/T(H)1 paradigm. Ann. Anat. 2010, 192:179-193.
    • (2010) Ann. Anat. , vol.192 , pp. 179-193
    • Batoulis, H.1
  • 73
    • 34248633160 scopus 로고    scopus 로고
    • Molecular mimicry in multiple sclerosis
    • Libbey J.E., et al. Molecular mimicry in multiple sclerosis. Int. Rev. Neurobiol. 2007, 79:127-147.
    • (2007) Int. Rev. Neurobiol. , vol.79 , pp. 127-147
    • Libbey, J.E.1
  • 74
    • 69149108015 scopus 로고    scopus 로고
    • Molecular and immunogenic features of myelin lipids: incitants or modulators of multiple sclerosis?
    • Podbielska M., Hogan E.L. Molecular and immunogenic features of myelin lipids: incitants or modulators of multiple sclerosis?. Mult. Scler. 2009, 15:1011-1029.
    • (2009) Mult. Scler. , vol.15 , pp. 1011-1029
    • Podbielska, M.1    Hogan, E.L.2
  • 75
    • 0031025835 scopus 로고    scopus 로고
    • Autoimmune pathogenesis of multiple sclerosis: role of autoreactive T lymphocytes and new immunotherapeutic strategies
    • Stinissen P., et al. Autoimmune pathogenesis of multiple sclerosis: role of autoreactive T lymphocytes and new immunotherapeutic strategies. Crit. Rev. Immunol. 1997, 17:33-75.
    • (1997) Crit. Rev. Immunol. , vol.17 , pp. 33-75
    • Stinissen, P.1
  • 76
    • 56649117451 scopus 로고    scopus 로고
    • Multiple sclerosis and regulatory T cells
    • Costantino C.M., et al. Multiple sclerosis and regulatory T cells. J. Clin. Immunol. 2008, 28:697-706.
    • (2008) J. Clin. Immunol. , vol.28 , pp. 697-706
    • Costantino, C.M.1
  • 77
    • 0037434789 scopus 로고    scopus 로고
    • Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    • Cua D.J., et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 2003, 421:744-748.
    • (2003) Nature , vol.421 , pp. 744-748
    • Cua, D.J.1
  • 78
    • 79955636935 scopus 로고    scopus 로고
    • IL-17 receptor signaling and T helper 17-mediated autoimmune demyelinating disease
    • Zepp J., et al. IL-17 receptor signaling and T helper 17-mediated autoimmune demyelinating disease. Trends Immunol. 2011, 32:232-239.
    • (2011) Trends Immunol. , vol.32 , pp. 232-239
    • Zepp, J.1
  • 79
    • 40449089827 scopus 로고    scopus 로고
    • Differential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cells
    • Stromnes I.M., et al. Differential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cells. Nat. Med. 2008, 14:337-342.
    • (2008) Nat. Med. , vol.14 , pp. 337-342
    • Stromnes, I.M.1
  • 80
    • 77954202847 scopus 로고    scopus 로고
    • Pro-inflammatory effects of interleukin-17A on vascular smooth muscle cells involve NAD(P)H-oxidase derived reactive oxygen species
    • Pietrowski E., et al. Pro-inflammatory effects of interleukin-17A on vascular smooth muscle cells involve NAD(P)H-oxidase derived reactive oxygen species. J. Vasc. Res. 2011, 48:52-58.
    • (2011) J. Vasc. Res. , vol.48 , pp. 52-58
    • Pietrowski, E.1
  • 81
    • 65749103989 scopus 로고    scopus 로고
    • Regulatory lymphocytes and intestinal inflammation
    • Izcue A., et al. Regulatory lymphocytes and intestinal inflammation. Annu. Rev. Immunol. 2009, 27:313-338.
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 313-338
    • Izcue, A.1
  • 82
    • 35649015342 scopus 로고    scopus 로고
    • CD4+CD25+FoxP3+ regulatory T cells in autoimmune diseases
    • Valencia X., Lipsky P.E. CD4+CD25+FoxP3+ regulatory T cells in autoimmune diseases. Nat. Clin. Pract. Rheumatol. 2007, 3:619-626.
    • (2007) Nat. Clin. Pract. Rheumatol. , vol.3 , pp. 619-626
    • Valencia, X.1    Lipsky, P.E.2
  • 83
    • 50349102854 scopus 로고    scopus 로고
    • B cells and autoantibodies in the pathogenesis of multiple sclerosis and related inflammatory demyelinating diseases
    • McLaughlin K.A., Wucherpfennig K.W. B cells and autoantibodies in the pathogenesis of multiple sclerosis and related inflammatory demyelinating diseases. Adv. Immunol. 2008, 98:121-149.
    • (2008) Adv. Immunol. , vol.98 , pp. 121-149
    • McLaughlin, K.A.1    Wucherpfennig, K.W.2
  • 84
    • 1442354894 scopus 로고    scopus 로고
    • Multiple sclerosis: brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood
    • Skulina C., et al. Multiple sclerosis: brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:2428-2433.
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 2428-2433
    • Skulina, C.1
  • 85
    • 79953284305 scopus 로고    scopus 로고
    • Role of CD8 regulatory T-cells in multiple sclerosis
    • Kreft K.L., et al. Role of CD8 regulatory T-cells in multiple sclerosis. Ann. Neurol. 2011, 69:593-594.
    • (2011) Ann. Neurol. , vol.69 , pp. 593-594
    • Kreft, K.L.1
  • 86
    • 0342906187 scopus 로고    scopus 로고
    • Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination
    • Lucchinetti C., et al. Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann. Neurol. 2000, 47:707-717.
    • (2000) Ann. Neurol. , vol.47 , pp. 707-717
    • Lucchinetti, C.1
  • 87
    • 0032522185 scopus 로고    scopus 로고
    • Costimulatory CD80 (B7-1) and CD86 (B7-2) on cerebrospinal fluid cells in multiple sclerosis
    • Sellebjerg F., et al. Costimulatory CD80 (B7-1) and CD86 (B7-2) on cerebrospinal fluid cells in multiple sclerosis. J. Neuroimmunol. 1998, 84:179-187.
    • (1998) J. Neuroimmunol. , vol.84 , pp. 179-187
    • Sellebjerg, F.1
  • 88
    • 18944390248 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors
    • Jagtap P., Szabo C. Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat. Rev. Drug Discov. 2005, 4:421-440.
    • (2005) Nat. Rev. Drug Discov. , vol.4 , pp. 421-440
    • Jagtap, P.1    Szabo, C.2
  • 89
    • 0036733355 scopus 로고    scopus 로고
    • The therapeutic potential of poly(ADP-ribose) polymerase inhibitors
    • Virag L., Szabo C. The therapeutic potential of poly(ADP-ribose) polymerase inhibitors. Pharmacol. Rev. 2002, 54:375-429.
    • (2002) Pharmacol. Rev. , vol.54 , pp. 375-429
    • Virag, L.1    Szabo, C.2
  • 90
    • 79551652531 scopus 로고    scopus 로고
    • The clinical development of inhibitors of poly(ADP-ribose) polymerase
    • Calvert H., Azzariti A. The clinical development of inhibitors of poly(ADP-ribose) polymerase. Ann. Oncol. 2011, 22(Suppl. 1):i53-i59.
    • (2011) Ann. Oncol. , vol.22 , Issue.SUPPL. 1
    • Calvert, H.1    Azzariti, A.2
  • 91
    • 79951821948 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase (PARP) inhibitors: exploiting a synthetic lethal strategy in the clinic
    • Yap T.A., et al. Poly(ADP-ribose) polymerase (PARP) inhibitors: exploiting a synthetic lethal strategy in the clinic. CA Cancer J. Clin. 2011, 61:31-49.
    • (2011) CA Cancer J. Clin. , vol.61 , pp. 31-49
    • Yap, T.A.1
  • 92
    • 78751610848 scopus 로고    scopus 로고
    • Iniparib plus chemotherapy in metastatic triple-negative breast cancer
    • O'Shaughnessy J., et al. Iniparib plus chemotherapy in metastatic triple-negative breast cancer. N. Engl. J. Med. 2011, 364:205-214.
    • (2011) N. Engl. J. Med. , vol.364 , pp. 205-214
    • O'Shaughnessy, J.1
  • 93
    • 79957511957 scopus 로고    scopus 로고
    • Progress in the function and regulation of ADP-ribosylation
    • Hottiger M.O., et al. Progress in the function and regulation of ADP-ribosylation. Sci. Signal. 2011, 4:mr5.
    • (2011) Sci. Signal. , vol.4
    • Hottiger, M.O.1
  • 94
    • 67349272283 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial to evaluate the tolerability, safety, pharmacokinetics, and pharmacodynamics of a potent inhibitor of poly(ADP-ribose) polymerase (INO-1001) in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: results of the TIMI 37 trial
    • Morrow D.A., et al. A randomized, placebo-controlled trial to evaluate the tolerability, safety, pharmacokinetics, and pharmacodynamics of a potent inhibitor of poly(ADP-ribose) polymerase (INO-1001) in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: results of the TIMI 37 trial. J. Thromb. Thrombolysis 2009, 27:359-364.
    • (2009) J. Thromb. Thrombolysis , vol.27 , pp. 359-364
    • Morrow, D.A.1
  • 95
    • 0033881017 scopus 로고    scopus 로고
    • Increased resistance to anticancer therapy of mouse cells lacking the poly(ADP-ribose) polymerase attributable to up-regulation of the multidrug resistance gene product P-glycoprotein
    • Wurzer G., et al. Increased resistance to anticancer therapy of mouse cells lacking the poly(ADP-ribose) polymerase attributable to up-regulation of the multidrug resistance gene product P-glycoprotein. Cancer Res. 2000, 60:4238-4244.
    • (2000) Cancer Res. , vol.60 , pp. 4238-4244
    • Wurzer, G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.