Glutamine contributes to ameliorate inflammation after renal ischemia/reperfusion injury in rats

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 383, Issue 5, 2011, Pages 493-508

  Esposito, Emanuela ^a,b   Mondello, Stefania ^c   Di Paola, Rosanna ^a   Mazzon, Emanuela ^a   Italiano, Domenico ^c   Paterniti, Irene ^b   Mondello, Patrizia ^c   Aloisi, Carmela ^c   Cuzzocrea, Salvatore ^a,b  

^a IRCCS CENTRO NEUROLESI BONINO PULEJO   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

^c UNIVERSITY OF MESSINA   (Italy)

Author keywords

Glutamine; Inflammation; Oxidative stress; Renal I R; ROS

Indexed keywords

3 NITROTYROSINE; ANGIOTENSIN 1 RECEPTOR; ASPARTATE AMINOTRANSFERASE; CREATININE; CYCLOOXYGENASE 2; FAS LIGAND; GAMMA GLUTAMYLTRANSFERASE; GLUTAMINE; I KAPPA B ALPHA; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERCELLULAR ADHESION MOLECULE 1; MALONALDEHYDE; MYELOPEROXIDASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PADGEM PROTEIN; PROTEIN BAX; PROTEIN BCL 2; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL INFILTRATION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; ENZYME ACTIVITY; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HISTOPATHOLOGY; KIDNEY DYSFUNCTION; KIDNEY FUNCTION; KIDNEY ISCHEMIA; LIPID PEROXIDATION; MALE; NONHUMAN; POLYMORPHONUCLEAR CELL; PROTEIN EXPRESSION; RAT; RENAL PROTECTION; REPERFUSION INJURY; UREA BLOOD LEVEL;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; GLUTAMINE; IMMUNOHISTOCHEMISTRY; KIDNEY; KIDNEY FUNCTION TESTS; MALE; NEPHRITIS; RATS; RATS, WISTAR; REPERFUSION INJURY;

EID: 79955702894     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-011-0610-5     Document Type: Article

References (60)

1. Aravindan N, Natarajan M, Shaw AD (2006) Fenoldopam inhibits nuclear translocation of nuclear factor kappa B in a rat model of surgical ischemic acute renal failure. J Cardiothorac Vasc Anesth 20:179-186
2. Bonegio R, Lieberthal W (2002) Role of apoptosis in the pathogenesis of acute renal failure. Curr Opin Nephrol Hypertens 11:301-308 (Pubitemid 34496778)
3. Bonventre JV, Weinberg JM (2003) Recent advances in the pathophysiology of ischemic acute renal failure. J Am Soc Nephrol 14:2199-2210 (Pubitemid 36909930)
4. Bonventre JV, Zuk A (2004) Ischemic acute renal failure: an inflammatory disease? Kidney Int 66:480-485
5. Boonstra JG, van der Woude FJ, Wever PC, Laterveer JC, Daha MR, van Kooten C (1997) Expression and function of Fas (CD95) on human renal tubular epithelial cells. J Am Soc Nephrol 8:1517-1524 (Pubitemid 27496469)
6. Chatterjee PK, Zacharowski K, Cuzzocrea S, Otto M, Thiemermann C (2000) Inhibitors of poly (ADP-ribose) synthetase reduce renal ischemia-reperfusion injury in the anesthetized rat in vivo. FASEB J 14:641-651 (Pubitemid 30198563)
7. Cheng HF, Wang JL, Zhang MZ, McKanna JA, Harris RC (2000) Nitric oxide regulates renal cortical cyclooxygenase-2 expression. Am J Physiol Renal Physiol 279:F122-F129 (Pubitemid 30619553)
8. Conjard A, Brun V, Martin M, Baverel G, Ferrier B (2002) Effect of starvation on glutamine ammoniagenesis and gluconeogenesis in isolated mouse kidney tubules. Biochem J 368:301-308 (Pubitemid 35463433)
9. Curi R, Newsholme P, Pithon-Curi TC, Pires-de-Melo M, Garcia C, Homem-de-Bittencourt Junior PI, Guimaraes AR (1999) Metabolic fate of glutamine in lymphocytes, macrophages and neutrophils. Braz J Med Biol Res [Rev Bras Pesquisas Med Biol], vol 32. Sociedade Brasileira de Biofisica et al, pp 15-21
10. Daemen MA, van't Veer C, Denecker G, Heemskerk VH, Wolfs TG, Clauss M, Vandenabeele P, Buurman WA (1999) Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation. J Clin Invest 104:541-549
11. de Souza HM, Borba-Murad GR, Ceddia RB, Curi R, Vardanega- Peicher M, Bazotte RB (2001) Rat liver responsiveness to gluconeogenic substrates during insulin-induced hypoglycemia. Braz J Med Biol Res [Rev Bras Pesquisas Med Biol], vol 34. Sociedade Brasileira de Biofisica, pp 771-777
12. Devarajan P (2006) Update on mechanisms of ischemic acute kidney injury. J Am Soc Nephrol 17:1503-1520
13. Dunn MJ, Scharschmidt LA (1987) Prostaglandins modulate the glomerular actions of angiotensin II. Kidney Int Suppl 20:S95-S101 (Pubitemid 17072335)
14. Elia M, Lunn PG (1997) The use of glutamine in the treatment of gastrointestinal disorders in man. Nutrition (Burbank, Los Angeles County, Calif) 13:743-747 (Pubitemid 27347184)
15. Faubion WA, Guicciardi ME, Miyoshi H, Bronk SF, Roberts PJ, Svingen PA, Kaufmann SH, Gores GJ (1999) Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas. J Clin Invest 103:137-145 (Pubitemid 29031172)
16. Feldenberg LR, Thevananther S, del Rio M, de Leon M, Devarajan P (1999) Partial ATP depletion induces Fas- and caspase-mediated apoptosis in MDCK cells. Am J Physiol 276:F837-F846 (Pubitemid 29323557)
17. Ferdinandy P, Schulz R (2003) Nitric oxide, superoxide, and peroxynitrite in myocardial ischaemia-reperfusion injury and preconditioning. Br J Pharmacol 138:532-543 (Pubitemid 36315301)
18. Friedewald JJ, Rabb H (2004) Inflammatory cells in ischemic acute renal failure. Kidney Int 66:486-491 (Pubitemid 38981983)
19. Giris M, Erbil Y, Oztezcan S, Olgac V, Barbaros U, Deveci U, Kirgiz B, Uysal M, Toker GA (2006) The effect of heme oxygenase-1 induction by glutamine on radiation-induced intestinal damage: the effect of heme oxygenase-1 on radiation enteritis. Am J Surg 191:503-509 (Pubitemid 43384147)
20. Gonzalez-Cuadrado S, Lopez-Armada MJ, Gomez-Guerrero C, Subira D, Garcia-Sahuquillo A, Ortiz-Gonzalez A, Neilson EG, Egido J, Ortiz A (1996) Anti-Fas antibodies induce cytolysis and apoptosis in cultured human mesangial cells. Kidney Int 49:1064-1070 (Pubitemid 26124365)
21. Griendling KK, Ushio-Fukai M (2000) Reactive oxygen species as mediators of angiotensin II signaling. Regul Pept 91:21-27
22. Haller H, Dragun D, Miethke A, Park JK, Weis A, Lippoldt A, Gross V, Luft FC (1996) Antisense oligonucleotides for ICAM-1 attenuate reperfusion injury and renal failure in the rat. Kidney Int 50:473-480 (Pubitemid 26274374)
23. Harris RC, Cheng H, Wang J, Zhang M, McKanna JA (2000) Interactions of the renin-angiotensin system and neuronal nitric oxide synthase in regulation of cyclooxygenase-2 in the macula densa. Acta Physiol Scand 168:47-51 (Pubitemid 30128667)
24. Hestin D, Johns EJ (1999) The influence of allopurinol on kidney haemodynamic and excretory responses to renal ischaemia in anaesthetized rats. Br J Pharmacol 128:255-261 (Pubitemid 29425293)
25. Imig JD (2000) Eicosanoid regulation of the renal vasculature. Am J Physiol Renal Physiol 279:F965-F981
26. Kelly KJ, Williams WW Jr, Colvin RB, Bonventre JV (1994) Antibody to intercellular adhesion molecule 1 protects the kidney against ischemic injury. Proc Natl Acad Sci USA 91:812-816 (Pubitemid 24041492)
27. Kelly KJ, Williams WW Jr, Colvin RB, Meehan SM, Springer TA, Gutierrez-Ramos JC, Bonventre JV (1996) Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury. J Clin Invest 97:1056-1063
28. Khogali SE, Pringle SD, Weryk BV, Rennie MJ (2002) Is glutamine beneficial in ischemic heart disease? Nutrition (Burbank, Los Angeles County, Calif) 18:123-126
29. Klahr S, Morrissey J (2002) Obstructive nephropathy and renal fibrosis. Am J Physiol Renal Physiol 283:F861-F875 (Pubitemid 35192452)
30. Kwiatkowski A, Wszola M, Perkowska-Ptasinska A, Ostrowski K, Domagala P, Fesolowicz S, Trzebicki J, Durlik M, Paczek L, Rowinski W, Chmura A (2009) Influence of preservation method on histopathological lesions of kidney allografts. Ann Transplant 14:10-13
31. Lien YH, Lai LW, Silva AL (2003) Pathogenesis of renal ischemia/ reperfusion injury: lessons from knockout mice. Life Sci 74:543-552
32. Lima AA, Carvalho GH, Figueiredo AA, Gifoni AR, Soares AM, Silva EA, Guerrant RL (2002) Effects of an alanyl-glutamine-based oral rehydration and nutrition therapy solution on electrolyte and water absorption in a rat model of secretory diarrhea induced by cholera toxin. Nutrition (Burbank, Los Angeles County, Calif) 18:458-462 (Pubitemid 34586800)
33. Lopez R, Roig F, Llinas MT, Salazar FJ (2003) Role of cyclooxygenase-2 in the control of renal haemodynamics and excretory function. Acta Physiol Scand 177:429-435 (Pubitemid 36411580)
34. Lorz C, Ortiz A, Justo P, Gonzalez-Cuadrado S, Duque N, Gomez- Guerrero C, Egido J (2000) Proapoptotic Fas ligand is expressed by normal kidney tubular epithelium and injured glomeruli. J Am Soc Nephrol 11:1266-1277 (Pubitemid 30416223)
35. Mates JM, Perez-Gomez C, Nunez de Castro I, Asenjo M, Marquez J (2002) Glutamine and its relationship with intracellular redox status, oxidative stress and cell proliferation/death. Int J Biochem Cell Biol 34:439-458 (Pubitemid 34242758)
36. Matsuyama M, Yoshimura R, Hase T, Kawahito Y, Sano H, Nakatani T (2005) Study of cyclooxygenase-2 in renal ischemia-reperfusion injury. Transplant Proc 37:370-372 (Pubitemid 40459789)
37. Mondello S, Galuppo M, Mazzon E, Domenico I, Mondello P, Carmela A, Cuzzocrea S (2010) Glutamine treatment attenuates the development of ischaemia/reperfusion injury of the gut. Eur J Pharmacol 643:304-315
38. Mullane KM, Kraemer R, Smith B (1985) Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium. J Pharmacol Methods 14:157-167 (Pubitemid 15241170)
39. Nakao N, Yoshimura A, Morita H, Takada M, Kayano T, Ideura T (2003) Combination treatment of angiotensin-II receptor blocker and angiotensin-converting-enzyme inhibitor in non-diabetic renal disease (COOPERATE): a randomised controlled trial. Lancet 361:117-124 (Pubitemid 36092015)
40. Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351-358 (Pubitemid 9194347)
41. Ortiz MC, Atucha NM, Lahera V, Vargas F, Quesada T, Garcia-Estan J (1996) Importance of nitric oxide and prostaglandins in the control of rat renal papillary blood flow. Hypertension 27:377-381 (Pubitemid 26083055)
42. Padanilam BJ (2003) Cell death induced by acute renal injury: a perspective on the contributions of apoptosis and necrosis. Am J Physiol Renal Physiol 284:F608-F627
43. Patel NS, Cuzzocrea S, Collino M, Chaterjee PK, Mazzon E, Britti D, Yaqoob MM, Thiemermann C (2007) The role of cycloxygenase- 2 in the rodent kidney following ischaemia/reperfusion injury in vivo. Eur J Pharmacol 562:148-154 (Pubitemid 46466766)
44. Pithon-Curi TC, Schumacher RI, Freitas JJ, Lagranha C, Newsholme P, Palanch AC, Doi SQ, Curi R (2003) Glutamine delays spontaneous apoptosis in neutrophils. Am J Physiol 284:C1355-C1361 (Pubitemid 36583376)
45. Rabb H, O'Meara YM, Maderna P, Coleman P, Brady HR (1997) Leukocytes, cell adhesion molecules and ischemic acute renal failure. Kidney Int 51:1463-1468 (Pubitemid 27239898)
46. Roth E, Oehler R, Manhart N, Exner R, Wessner B, Strasser E, Spittler A (2002) Regulative potential of glutamine - relation to glutathione metabolism. Nutrition (Burbank, Los Angeles County, Calif) 18:217-221 (Pubitemid 34204130)
47. Shi Q, Feng YN, Fang J, Xu K (2009) Pretreatment with glutamine attenuates anoxia/reoxygenation injury of human proximal renal tubular epithelial cells via induction of heme oxygenase-1. Pharmacology 84:1-8
48. Singleton KD, Wischmeyer PE (2006) Oral glutamine enhances heat shock protein expression and improves survival following hyperthermia. Shock 25:295-299
49. Sorenson CM, Rogers SA, Korsmeyer SJ, Hammerman MR (1995) Fulminant metanephric apoptosis and abnormal kidney development in bcl-2-deficient mice. Am J Physiol 268:F73-F81 (Pubitemid 124005462)
50. Stein JH, Lifschitz MD, Barnes LD (1978) Current concepts on the pathophysiology of acute renal failure. Am J Physiol 234:F171-F181 (Pubitemid 9158652)
51. Therland KL, Stubbe J, Thiesson HC, Ottosen PD, Walter S, Sorensen GL, Skott O, Jensen BL (2004) Cycloxygenase-2 is expressed in vasculature of normal and ischemic adult human kidney and is colocalized with vascular prostaglandin E2 EP4 receptors. J Am Soc Nephrol 15:1189-1198 (Pubitemid 38526000)
52. Traynor TR, Schnermann J (1999) Renin-angiotensin system dependence of renal hemodynamics in mice. J Am Soc Nephrol 10 (Suppl 11):S184-S188 (Pubitemid 29038185)
53. Umeda K, Takahashi T, Inoue K, Shimizu H, Maeda S, Morimatsu H, Omori E, Akagi R, Katayama H, Morita K (2009) Prevention of hemorrhagic shock-induced intestinal tissue injury by glutamine via heme oxygenase-1 induction. Shock 31:40-49
54. Weitzel LR, Wischmeyer PE (2010) Glutamine in critical illness: the time has come, the time is now. Crit Care Clin 26:515-525, ix-x
55. Whelton A, Hamilton CW (1991) Nonsteroidal anti-inflammatory drugs: effects on kidney function. J Clin Pharmacol 31:588-598
56. Williams P, Lopez H, Britt D, Chan C, Ezrin A, Hottendorf R (1997) Characterization of renal ischemia-reperfusion injury in rats. J Pharmacol Toxicol Methods 37:1-7 (Pubitemid 27150639)
57. Wischmeyer PE, Musch MW, Madonna MB, Thisted R, Chang EB (1997) Glutamine protects intestinal epithelial cells: role of inducible HSP70. Am J Physiol 272:G879-G884
58. Wischmeyer PE, Jayakar D, Williams U, Singleton KD, Riehm J, Bacha EA, Jeevanandam V, Christians U, Serkova N (2003) Single dose of glutamine enhances myocardial tissue metabolism, glutathione content, and improves myocardial function after ischemia-reperfusion injury. JPEN J Parenter Enteral Nutr 27:396-403 (Pubitemid 38133103)
59. Zhang Y, Zou Z, Li YK, Yuan HB, Shi XY (2009) Glutamine-induced heat shock protein protects against renal ischaemia-reperfusion injury in rats. Nephrol Carlton 14:573-580
60. Ziegler TR, Ogden LG, Singleton KD, Luo M, Fernandez-Estivariz C, Griffith DP, Galloway JR, Wischmeyer PE (2005) Parenteral glutamine increases serum heat shock protein 70 in critically ill patients. Intensive Care Med 31:1079-1086 (Pubitemid 41125339)