Protection by inhibition of poly (ADP-ribose) synthetase against oxidant injury in cardiac myoblasts in vitro

Journal of Molecular and Cellular Cardiology

Volumn 29, Issue 9, 1997, Pages 2585-2597

  Gilad, Eli ^a   Zingarelli, Basilia ^a   Salzman, Andrew L ^a   Szabó, Csaba ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Cardiac myocytes; Heart; Hydroxyl radical; Nitric oxide; Peroxynitrite; Reperfusion; Superoxide

Indexed keywords

3 AMINOBENZAMIDE; DIETHYLTRIAMINE; FORMAZAN; HYDROGEN PEROXIDE; HYDROXYL RADICAL; N ACETYL S NITROSOPENICILLAMINE; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OXIDIZING AGENT; PEROXYNITRITE; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DAMAGE; CELL TYPE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA STRAND BREAKAGE; ENZYME ACTIVATION; ENZYME INHIBITION; FIBROBLAST CULTURE; HEART MUSCLE CELL; HYPOXIA; MACROPHAGE; MITOCHONDRIAL RESPIRATION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; REOXYGENATION; REPERFUSION INJURY; SMOOTH MUSCLE FIBER;

ANIMALIA;

EID: 0031239152     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.1997.0496     Document Type: Article

References (62)

1. 3, in plasma after experimental myocardial infarction. J Mol Cell Cardiol 29: 1-9.
2. BANASIK M, KOMURA H, SHIMOYAMA M, UEDA K, 1992. Specific inhibitors of poly (ADP-ribose) synthetase and mono (ADP-ribosyl) transferase. J Biol Chem 267: 1569-1575.
3. BECKMAN JS, BECKMAN TW, CHEN J, MARSHALL PA, FREEMAN BA, 1990. Apparent hydroxyl radical production by peroxynitrite: implication for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 87: 1260-1264.
4. BECKMAN JS, CHEN J, ISCHIROPOULOS H, CROW JP, 1994. Oxidative chemistry of peroxynitrite. Meth Enzymol 233: 229-340.
5. BERGER NA, 1991. Oxidant-induced cytotoxicity: a challenge for metabolic modulation. Am J Respir Cell Mol Biol 4: 1-3.
6. BERRIDGE MV, TAN AS, 1993. Characterization of the cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reduction. Arch Biochem Biophys 303: 474-482.
7. CASSINA A, RADI R, 1996. Differential inhibitory action of nitric oxide and peroxynitrite on mitochondrial electron transport. Arch Biochem Biophys 328: 309-316.
8. COCHRANE CG, 1991. Mechanisms of oxidant injury of cells. Mol Aspects Med 12: 137-147.
9. CROW JP, BECKHAM JS, MCCORD J, 1995. Sensitivity of the essential zinc-thiolate moiety of yeast alcohol dehydrogenase to hypochlorite and peroxynitrite. Biochemistry 34: 3544-3552.
10. FERRARI F, 1994. Oxygen-free radicals at myocardial level: effects of ischaemia and reperfusion. Adv Exp Med Biol 366: 99-111.
11. FICI GJ, ALTHAUS JS, VONVOIGTLANDER PF, 1997. Effects of lazardoids and a peroxynitrite scavenger in a cell model of peroxynitrite toxicity. Free Rad Biol Med 22: 223-228.
12. HEADS RJ, YELLON DM, LATCHMAN DS, 1995. Differential cytoprotection against heat stress or hypoxia following expression of specific stress protein genes in myogenic cells. J Mol Cell Cardiol 27: 1669-1678.
13. HESCHELER J, MEYER R, PLANT S, KRAUTWURST D, ROSENTHAL W, SCHULTZ G, 1991. Morphological, biochemical, and electrophysiological characterization of a clonal cell (H9c2) line from rat heart. Circ Res 69: 1476-1486.
14. HELLER B, WANG ZQ, WAGNER EF, RADONS J, BURKL A, FEHSEL K, BURKART V, KOLB H, 1995. Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells. J Biol Chem 270: 11176-11180.
15. ISHIDA H, ICHIMORI K, HIROTA Y, FUKAORI M, NAKAZAWA H, 1996. Peroxynitrite-induced cardiac myocyte injury. Free Rad Biol Med 20: 343-350.
16. JANERO DR, HRENIUK D, SHARIF HM, PROUT KC, 1993. Hydroperoxide-induced oxidative stress alters pyridine nucleotide metaboism in neonatal heart muscle cells. Am J Physiol 264: C1401-1410.
17. KILGORE KS, FRIEDRICHS GS, JOHNSON C, SCHASTEEN CS, RILEY DP, WEIS RH, RYAN U, LUCCHESI BR, 1994. Protective effects of the SOD-mimetic SC-52608 against ischemia/reperfusion damage in the rabbit isolated heart. J Mol Cell Cardiol 26: 995-1006.
18. KIRKLAND JB, 1991. Lipid peroxidation, protein thiol oxidation and DNA damage in hydrogen peroxide-induced injury to endothelial cells: role of activation of poly(ADP-ribose)polymerase. Biochim Biophys Acta 1092: 319-325.
19. KIRSHENBAUM LA, SINGAL PK, 1992. Changes in anti-oxidant enzymes in isolated cardiac myocytes subjected to hypoxia-reoxygenation. Lab Invest 67: 796-803.
20. KUBES P, SUZUKI M, GRANGER DN, 1991. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA 88: 4651-4655.
21. LEFER AM, LEFER DJ, 1993. Pharmacology of the endothelium in ischemia-reperfusion and circulatory shock. Ann Rev Pharmacol Toxicol 33: 71-90.
22. MCCORD JM, 1988. Free radicals and myocardial ischaemia: overview and outlook. Free Rad Biol Med 4: 9-14.
23. MA XL, WEIRICH AS, LEFER DJ, LEFER AM, 1993. Diminished basal nitric oxide release after myocardial ischemia and reperfusion promotes neutrophil adherence to coronary endothelium. Circ Res 72: 403-412.
24. MATHEIS G, SHERMAN MP, BUCKBERG GD, HAYBRON DM, YOUNG HH, IGNARRO LJ, 1992. Role of L-arginine-nitric oxide pathway in myocardial reoxygenation injury. Am J Physiol 262: H616-620.
25. MEHTA JL, NICHOLS WW, DONNELLY WH, LAWSON DL, THOMPSON L, RIET M, SALDEEN TG, 1989. Protection by superoxide dismutase from myocardial dysfunction and attenuation of vasodilator reserve after coronary occlusion and reperfusion in dog. Circ Res 65: 1283-1295.
26. MESTRIL R, CHI SH, SAYEN MR, O'REILLY K, DILLMANN WH, 1994. Expression of inducible stress protein 70 in rat heart myogenic cells confers protection against simulated ischemia-induced injury. J Clin Invest 93: 759-767.
27. MILES AM, BOHL DS, GLASSBRENNER PA, HANSERT B, WINK DA, GRISHAM MB, 1996. Modulation of superoxide-dependent oxidation and hydroxylation reactions by nitric oxide. J Biol Chem 271: 40-47.
28. G-nitro-L-arginiune improves myocardial function following ischemia/reperfusion in isolated perfused rat heart. J Mol Cell Cardiol 27: 419-426.
29. ODDIS CV, FINKEL MS, 1995. Cytokine-stimulated nitric oxide production inhibits mitochondrial activity in cardiac myocytes. Biochem Biophys Res Comm 213: 1002-1009.
30. PACKER L, 1994. Oxygen radicals in biological systems. Meth Enzymol 234: 1-642.
31. QUAIFE RA, KOHMOTO O, BARRY WH, 1991. Mechanisms of reoxygenation injury in cultured ventricular myocytes. Circulation 83: 566-577.
32. RADONS J, HELLER B, BURKLE A, HARTMANN B, RODRIGUEZ ML, 1994. NO toxicity in islet cells involves polyADP-polymerase activation and concomitant NAD depletion Biochem Biophys Res Comm 199: 1270-1277.
33. RUBBO H, RADI R, TRUJILLO M, TELLERI R, KALYANARAMAN B, BARNES B, KIRK M, FREEMAN BA, 1994. Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives. J Biol Chem 269: 26066-26075.
34. SALGO MG, BERMUDEZ E, SQUADRITO G, PRYOR W, 1995. DNA damage and oxidation of thiols peroxynitrite causes in rat thymocytes. Arch Biochem Biophys 322: 500-505.
35. SAMAJA M, MOTTERLINI R, SANTORO F, DELL'ANTONIO G, CORNO A, 1994. Oxidative injury in reoxygenated and reperfused hearts. Free Rad Biol Med 16: 255-262.
36. SCHRAUESTATTER I, HYSLOP P, HINSHAW D, SPRAGG R, SKLAR L, COCHRANE C, 1986a. Hydrogen peroxide-induced injury cells and its prevention by inhibitors of poly (ADP-ribose) polymerase. Proc Natl Acad Sci USA 83: 4908-4912.
37. SCHRAUFSTATTER I, HINSHAW D, HYSLOP P, SPRAGG RG, COCHRANE C, 1986b. Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide. J Clin Invest 77: 1312-1320.
38. SCHULZ R, WAMBOLT R, 1995. Inhibition of nitric oxide synthesis protects the isolated working rabbit heart from ischemia-reperfusion injury. Cardiovasc Res 30: 432-439.
39. SCHULZ R, DODGE KL, LOPASSCHUK GD, CLANACHAN AS, 1995. Peroxynitrite depresses cardiac efficiency in the isolated working heart. Circulation 92: I-45 (Abstract).
40. SILVERMAN HS, 1993. Mitochondrial free calcium regulation in hypoxia and reoxygenation: relation to cellular injury. Basic Res Cardiol 88: 483-494.
41. SUN JZ, KAUR H, HALLIWELL B, LI XY, BOLLI R, 1993. Use of aromatic hydroxylation of phenylalanine to measure production of hydroxyl radicals after myocardial ischemia in vivo. Direct evidence for a pathogenetic role of the hydroxyl radical in myocardial stunning. Circ Res 73: 534-549.
42. SZABÓ C, 1996a. The role of peroxynitrite in the pathophysiology of shock, inflammation and ischemia-reperfusion injury. Shock 6: 79-88.
43. SZABÓ C, 1996b. DNA strand breakage and activation of poly-ADP ribosyltransferase: a cytotoxic pathway triggered by peroxynitrite. Free Rad Biol Med 21: 855-869.
44. SZABÓ C, SALZMAN AL, 1995. Endogenous peroxynitrite is involved in the inhibition of cellular respiration in immuno-stimulated J774.2 macrophages. Biochem Biophys Res Comm 209: 739-743.
45. SZABÓ C, SALZMAN AL, ISCHIROPOULOS H, 1995. Peroxynitrite-mediated oxidation of dihydrorhodamine 123 occurs in early stages of endotoxic and hemorrhagic shock and ischemia-reperfusion injury. FEBS Lett 372: 229-232.
46. SZABÓ C, ZINGARELLI B, SALZMAN AL, 1996a. Role of poly-ADP ribosyltransferase activation in the nitric oxide-and peroxynitrite-induced vascular failure. Circ Res 78: 1051-1063.
47. SZABÓ C, ZINGARELLI B, O'CONNOR M, SALZMAN AL, 1996b. DNA strand leakage, activation of poly-ADP ribosyl synthetase, and cellular energy depletion are involved in the cytotoxicity in macrophages and smooth muscle cells exposed to peroxynitrite. Proc Natl Acad Sci USA 93: 1753-1758.
48. SZABÓ C, SAUNDERS C, O'CONNOR M, SALZMAN AL, 1997a. Peroxynitrite causes energy depletion and increases permeability via activation of poly-ADP ribosyl synthetase in pulmonary epithelial cells. Am J Mol Cell Rdspir Biol 16: 105-109.
49. SZABÓ C, CUZZOCREA S, ZINGARELLI B, O'CONNOR M, SALZMAN AL, 1997b. Endothelial dysfunction in endotoxic shock: importance of the activation of poly (ADP ribose) synthetase (PARS) by peroxynitrite. J Clin Invest 100: 723-735.
50. SZABÓ C, WONG HR, BAUER PI, KIRSTEN E, O'CONNOR M, ZINGARELLI B, MENDELEYEV J, HASKO G, VIZI ES, SALZMAN AL, KUN E, 1997c. Regulation of components of the inflammatory response by 5-iodo-6-amino-1,2-benzopyrone, and inhibitor of poly (ADP-ribose) synthetase and pleiotropic modifier of cellular signal pathways. Int J Oncol 10: 1093-1101.
51. THIEMERMANN C, BOWES J, MYINT FP, VANE JR, 1997. Inhibition of the activity of poly(ADP ribose) synthase reduces ischemia-reperfusion injury in the heart and skeletal muscle. Proc Natl Acad Sci USA 94: 679-683.
52. THIES RL, AUTOR AP, 1991. Reactive oxygen injury to cultured pulmonary artery endothelial cells: mediation by poly ADP-ribose polymerase activation causing NAD depletion and altered energy balance. Arch Biochem Biophys 286: 353-363.
53. VILLA LM, SALAS E, DARLEY-USMAR V, RADOMSKI M, MONCADA S, 1994. Peroxynitrite induces both vaso-dilatation and impaired vascular relaxation in the isolated perfused rat heart. Proc Natl Acad Sci USA 19: 12383-12387.
54. 2+-ATPase by peroxynitrite. Free Rad Res 24: 243-259.
55. XIE YW, WOLIN MS, 1996. Role of nitric oxide and its interaction with superoxide in the suppression of cardiac muscle mitochondrial respiration. Circulation 94: 2580-2586.
56. WANG P, ZWEIER JL, 1996. Measurement of nitric oxide and peroxynitrite generation in the postischemic heart. J Biol Chem 271: 29223-29230.
57. WANG ZQ, AUER B, STINGL L, BERGHAMMER H, HAIDACHER D, SCHWEIGER M, WAGNER EF, 1995. Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease. Genes Develop 9: 510-520.
58. WU ML, TSAI KL, WANG SM, WU JC, WANG BS, LEE YT, 1996. Mechanism of hydrogen peroxide and hydroxyl free radical-induced intracellular acidification in cultured rat cardiac myoblasts. Circ Res 78: 564-572.
59. ZHANG J, DAWSON VL, DAWSON TM, SNYDER SH, 1994. Nitric oxide activation of poly (ADP-ribose) synthetase in neurotoxicity. Science 263: 687-689.
60. ZINGARELLI B, O'CONNOR M, SALZMAN AL, SZABÓ C, 1996. Peroxynitrite-mediated DNA strand breakage activates poly-ADP ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide. J Immunol 156: 350-358.
61. ZINGARELLI B, CUZZOCREA S, O'CONNOR M, ZSENGELLER Z, SALZMAN AL, SZABÓ C, 1997a. Poly (ADP-ribose) synthetase activation induced by peroxynitrite mediates myocardial ischemia and reperfusion injury. In: Faist E(ed.). The Immune Consequences of Trauma, Shock and Sepsis: Mechanisms and Therapeutic Approaches. Bologna: Monduzzi Editore, 681-685.
62. ZINGARELLI B, CUZZOCREA S, ZSENGELLER Z, SALZMAN AL, SZABÓ C, 1997b. Beneficial effect of inhibition of poly-ADP ribose synthetase activity in myocardial ischemia-reperfusion injury. Cardiovasc Res (in press).