Antisense oligonucleotides to poly(ADP-ribose) polymerase-2 ameliorate colitis in interleukin-10-deficient mice

Journal of Pharmacology and Experimental Therapeutics

Volumn 303, Issue 3, 2002, Pages 1145-1154

  Popoff, Ian ^a,c   Jijon, Humberto ^a   Monia, Brett ^b   Tavernini, Michele ^a   Ma, Michael ^a   McKay, Rob ^b   Madsen, Karen ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b ISIS PHARMACEUTICALS   (United States)

^c AGOURON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CARBACHOL; CYTOKINE; FORSKOLIN; INTERLEUKIN 10; ISIS 110251; ISIS 110261; ISIS 110262; ISIS 113529; ISIS 113530; ISIS 113531; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NITRIC OXIDE SYNTHASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CHRONIC INFLAMMATION; COLITIS; COLON MUCOSA; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE MODEL; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION REGULATION; INTESTINE FUNCTION; LIVER LEVEL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN DETERMINATION; TISSUE CULTURE;

ANIMALS; COLITIS; COLON; DOSE-RESPONSE RELATIONSHIP, DRUG; INTERLEUKIN-10; LIVER; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; OLIGONUCLEOTIDES, ANTISENSE; POLY(ADP-RIBOSE) POLYMERASES; RNA, MESSENGER;

EID: 0036897243     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.039768     Document Type: Article

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