Minocycline blocks asthma-associated inflammation in part by interfering with the t cell receptor-nuclear factorkB-GATA-3-IL-4 axis without a prominent effect on poly(ADP-ribose) polymerase

Journal of Biological Chemistry

Volumn 288, Issue 3, 2013, Pages 1458-1468

  Naura, Amarjit S ^a   Kim, Hogyoung ^a   Ju, Jihang ^a   Rodriguez, Paulo C ^a   Jordan, Joaquin ^b   Catling, Andrew D ^a   Rezk, Bashir M ^c   Abd Elmageed, Zakaria Y ^a   Pyakurel, Kusma ^a   Tarhuni, Abdelmetalab F ^a   Abughazleh, Mohammad Q ^a   Errami, Youssef ^a   Zerfaoui, Mourad ^a   Ochoa, Augusto C ^a   Boulares, A Hamid ^a  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CASTILLA LA MANCHA   (Spain)

^c SOUTHERN UNIVERSITY AT NEW ORLEANS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADP-RIBOSE; ANIMAL MODEL; B CELLS; CYTOKINE PRODUCTION; EX-VIVO; HYPERSECRETION; IMMUNOREACTIVITIES; MECHANISM OF ACTION; MINOCYCLINE; MRNA LEVEL; OXIDATIVE DNA DAMAGE; P38 MAPK; POLY POLYMERASE; SIGNALING PATHWAYS; T CELLS; T-CELL RECEPTORS; THERAPEUTIC POTENTIALS;

ALLERGIES; ANTIBIOTICS; CELL MEMBRANES; MAMMALS; NUCLEIC ACIDS; PHOSPHORYLATION; TRANSCRIPTION FACTORS;

DISEASES;

GLYCOGEN SYNTHASE KINASE 3; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HYDROGEN PEROXIDE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12P70; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; METHYLNITRONITROSOGUANIDINE; MINOCYCLINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OVALBUMIN; PROTEIN TYROSINE KINASE; STAT6 PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFAT1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA DAMAGE; EX VIVO STUDY; GENE EXPRESSION; IMMUNOGLOBULIN PRODUCTION; LOEFFLER PNEUMONIA; MACROPHAGE; MALE; MOUSE; MUCUS SECRETION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RESPIRATORY TRACT ALLERGY;

ANIMALS; ASTHMA; GATA3 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; IMMUNOGLOBULIN E; IMMUNOLOGIC FACTORS; INFLAMMATION; INTERLEUKIN-4; MALE; MICE; MICE, INBRED C57BL; MINOCYCLINE; NF-KAPPA B; POLY(ADP-RIBOSE) POLYMERASES; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION;

ANIMALIA; MUS;

EID: 84872708384     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.419580     Document Type: Article

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