NLRP3 inflammasome-driven pathways in depression: Clinical and preclinical findings

Brain, Behavior, and Immunity

Volumn 64, Issue , 2017, Pages 367-383

  Kaufmann, Fernanda N ^a   Costa, Ana Paula ^a   Ghisleni, Gabriele ^b   Diaz, Alexandre P ^c   Rodrigues, Ana Lúcia S ^a   Peluffo, Hugo ^d,e   Kaster, Manuella P ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^b CATHOLIC UNIVERSITY OF PELOTAS   (Brazil)

^c UNIVERSITY OF SOUTHERN SANTA CATARINA   (Brazil)

^d INSTITUT PASTEUR DE MONTEVIDEO   (Uruguay)

^e Faculty of Medicine   (Uruguay)

Author keywords

Cytokines; Depression; Inflammation; NLRP3; Stress

Indexed keywords

ANTIDEPRESSANT AGENT; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; PATTERN RECOGNITION RECEPTOR;

CENTRAL NERVOUS SYSTEM DISEASE; CHRONIC STRESS; CYTOKINE RELEASE; DRUG TARGETING; HUMAN; INTESTINE FLORA; MAJOR DEPRESSION; MICROGLIA; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PSYCHOLOGICAL RESILIENCE; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; COMPLICATION; ENCEPHALITIS; IMMUNOLOGY; MENTAL STRESS; METABOLISM; PHYSIOLOGY;

ANIMALS; DEPRESSIVE DISORDER, MAJOR; ENCEPHALITIS; GASTROINTESTINAL MICROBIOME; HUMANS; INFLAMMASOMES; MICROGLIA; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; RECEPTORS, PATTERN RECOGNITION; SIGNAL TRANSDUCTION; STRESS, PSYCHOLOGICAL;

EID: 85014687850     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2017.03.002     Document Type: Review

References (255)

1. Adachi, O., Kawai, T., Takeda, K., Matsumoto, M., Tsutsui, H., Sakagami, M., Nakanishi, K., Akira, S., Targeted disruption of the MyD88 gene results in loss of IL-1 and IL-18 mediated function. Immunity 9 (1998), 143–150.
2. Afonina, I.S., Müller, C., Martin, S.J., Beyaert, R., Proteolytic processing of interleukin-1 family cytokines: variations on a common theme. Immunity 42 (2015), 991–1004.
3. Alboni, S., Cervia, D., Sugama, S., Conti, B., Interleukin 18 in the CNS. J. Neuroinflammation 7 (2010), 1–12.
4. Alcocer-Gómez, E., Cordero, M.D., NLRP3 inflammasome: a new target in major depressive disorder. CNS Neurosci. Ther. 20 (2014), 294–295.
5. Alcocer-Gómez, E., de Miguel, M., Casas-Barquero, N., Núñez-Vasco, J., Sánchez-Alcazar, J.A., Fernández-Rodríguez, A., Cordero, M.D., NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder. Brain Behav. Immun. 36 (2014), 111–117.
6. Alcocer-Gómez, E., Ulecia-Morón, C., Marín-Aguilar, F., Rybkina, T., Casas-Barquero, N., Ruiz-Cabello, J., Ryffel, B., Apetoh, L., Ghiringhelli, F., Bullón, P., Sánchez-Alcazar, J.A., Carrión, A.M., Cordero, M.D., Stress-induced depressive behaviors require a functional NLRP3 inflammasome. Mol. Neurobiol. 53 (2016), 4874–4882.
7. Ambrée, O., Bergink, V., Grosse, L., Alferink, J., Drexhage, H.A., Rothermundt, M., Arolt, V., Birkenhäger, T.K., S100B serum levels predict treatment response in patients with melancholic depression. Int. J. Neuropsychopharmacol., 19, 2015, pyv103.
8. Andoh, T., Kishi, H., Motoki, K., Nakanishi, K., Kuraishi, Y., Muraguchi, A., Protective effect of IL-18 on kainite- and IL-1 beta-induced cerebellar ataxia in mice. J. Immunol. 180 (2008), 2322–2328.
9. Anforth, H.R., Bluthé R.M., Bristow, A., Hopkins, S., Lenczowski, M.J., Luheshi, G., Lundkvist, J., Michaud, B., Mistry, Y., Van Dam, A.M., Zhen, C., Dantzer, R., Poole, S., Rothwell, N.J., Tilders, F.J., Wollman, E.E., Biological activity and brain actions of recombinant rat interleukin-1alpha and interleukin-1β. Eur. Cytokine Netw. 9 (1998), 279–288.
10. Anisman, H., Ravindran, A.V., Griffiths, J., Merali, Z., Endocrine and cytokine correlates of major depression and dysthymia with typical or atypical features. Mol. Psychiatry 4 (1999), 182–188.
11. Anisman, H., Gibb, J., Hayley, S., Influence of continuous infusion of interleukin-1β on depression-related processes in mice: corticosterone, circulating cytokines, brain monoamines, and cytokine mRNA expression. Psychopharmacology 199 (2008), 231–244.
12. Aries, A., Whitcomb, J., Shao, W., Komati, H., Saleh, M., Nemer, M., Caspase-1 cleavage of transcription factor GATA4 and regulation of cardiac cell fate. Cell Death Dis., 5, 2014, 1566.
13. Arolt, V., Peters, M., Erfurth, A., Wiesmann, M., Missler, U., Rudolf, S., Kirchner, H., Rothermundt, M., S100B and response to treatment in major depression: a pilot study. Eur. Neuropsychopharmacol. 13 (2003), 235–239.
14. Arrieta, M.C., Bistritz, L., Meddings, J.B., Alterations in intestinal permeability. Gut 55 (2006), 1512–1520.
15. Ataka, K., Asakawa, A., Nagaishi, K., Kaimoto, K., Sawada, A., Hayakawa, Y., Tatezawa, R., Inui, A., Fujimiya, M., Bone marrow-derived microglia infiltrate into the paraventricular nucleus of chronic psychological stress-loaded mice. PLoS One 8 (2013), 81744–81758.
16. Bailey, M.T., Engler, H., Powell, N.D., Padgett, D.A., Sheridan, J.F., Repeated social defeat increases the bactericidal activity of splenic macrophages through a Toll-like receptor-dependent pathway. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293 (2007), 1180–1190.
17. Basso, A.M., Bratcher, N.A., Harris, R.R., Jarvis, M.F., Decker, M.W., Rueter, L.E., Behavioral profile of P2X7 receptor knockout mice in animal models of depression and anxiety: relevance for neuropsychiatric disorders. Behav. Brain Res. 198 (2009), 83–90.
18. Bauernfeind, F.G., Horvath, G., Stutz, A., Alnemri, E.S., MacDonald, K., Speert, D., Fernandes-Alnemri, T., Wu, J., Monks, B.G., Fitzgerald, K.A., Hornung, V., Latz, E., Cutting edge: NF-kB activating pattern recognition and cytokine receptors licence NLRP3 inflammasome activation by regulating NLRP3 expression. J. Immunol. 183 (2009), 787–791.
19. Baune, B.T., Dannlowski, U., Domschke, K., Janssen, D.G., Jordan, M.A., Ohrmann, P., Bauer, J., Biros, E., Arolt, V., Kugel, H., Baxter, A.G., Suslow, T., The interleukin 1 beta (IL1B) gene is associated with failure to achieve remission and impaired emotion processing in major depression Biol. Psychiatry 67 (2010), 543–549.
20. Bayer, T.A., Buslei, R., Havas, L., Falkai, P., Evidence for activation of microglia in patients with psychiatric illnesses. Neurosci. Lett. 271 (1999), 126–128.
21. Bay-Richter, C., Linderholm, K.R., Lim, C.K., Samuelsson, M., Träskman-Bendz, L., Guillemin, G.J., Erhardt, S., Brundin, L.A., Role for inflammatory metabolites as modulators of the glutamate N-methyl-D-aspartate receptor in depression and suicidality. Brain Behav. Immun. 43 (2015), 110–117.
22. Bennett, M.L., Bennett, F.C., Liddelow, S.A., Ajami, B., Zamanian, J.L., Fernhoff, N.B., Mulinyawe, S.B., Bohlen, C.J., Adil, A., Tucker, A., Weissman, I.L., Chang, E.F., Li, G., Grant, G.A., Hayden Gephart, M.G., Barres, B.A., New tools for studying microglia in the mouse and human CNS. Proc. Natl. Acad. Sci. U.S.A. 113 (2016), 1738–1746.
23. Bercik, P., Denou, E., Collins, J., Jackson, W., Lu, J., Jury, J., Deng, Y., Blennerhassett, P., Macri, J., McCoy, K.D., Verdu, E.F., Collins, S.M., The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice. Gastroenterology 141 (2011), 599–609.
24. Beumer, W., Gibney, S.M., Drexhage, R.C., Pont-Lezica, L., Doorduin, J., Klein, H.C., Steiner, J., Connor, T.J., Harkin, A., Versnel, M.A., Drexhage, H.A., The immune theory of psychiatric diseases: a key role for activated microglia and circulating monocytes. J. Leukoc. Biol. 92 (2012), 959–975.
25. Biesmans, S., Meert, T.F., Bouwknecht, J.A., Acton, P.D., Davoodi, N., De Haes, P., Kuijlaars, J., Langlois, X., Matthews, L.J., Ver Donck, L., Hellings, N., Nuydens, R., Systemic immune activation leads to neuroinflammation and sickness behavior in mice. Mediators Inflamm., 2013, 2013, 271359.
26. Bluthé R.M., Walter, V., Parnet, P., Layé S., Lestage, J., Verrier, D., Poole, S., Stenning, B.E., Kelley, K.W., Dantzer, R., Lipopolysaccharide induces sickness behaviour in rats by a vagal mediated mechanism. C.R. Acad. Sci III 317 (1994), 499–503.
27. Bluthé R.M., Layé S., Michaud, B., Combe, C., Dantzer, R., Parnet, P., Role of interleukin-1β and tumour necrosis factor-alpha in lipopolysaccharide-induced sickness behavior: a study with interleukin-1 type I receptor-deficient mice. Eur. J. Neurosci. 12 (2000), 4447–4456.
28. Borkowska, P., Kucia, K., Rzezniczek, S., Paul-Samojedny, M., Kowalczyk, M., Owczarek, A., Suchanek, R., Medrala, T., Kowalski, J., Interleukin-1beta promoter (−31T/C and −511C/T) polymorphisms in major recurrent depression. J. Mol. Neurosci. 44 (2011), 12–16.
29. Borsini, A., Zunszain, P.A., Thuret, S., Pariante, C.M., The role of inflammatory cytokines as key modulators of neurogenesis. Trends Neurosci. 38 (2015), 145–157.
30. Bossaller, L., Chiang, P.I., Schimidt-Lauber, C., Ganesan, S., Kaiser, W.J., Rathinam, V.A., Mocarski, E.S., Subramanian, D., Green, D.R., Silverman, N., Fitzgerald, K.A., Marshak-Rothstein, A., Latz, E., Cutting edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 via caspase-8 in RIP3-independent manner. J. Immunol. 189 (2012), 5508–5512.
31. Bossù P., Salani, F., Cacciari, C., Picchetto, L., Cao, M., Bizzoni, F., Rasura, M., Caltagirone, C., Robinson, R.G., Orzi, F., Spalleta, G., Disease outcome, alexithymia and depression are differently associated with serum IL-18 levels in acute stroke. Curr. Neurovasc. Resour. 6 (2009), 163–170.
32. Brevet, M., Kojima, H., Asakawa, A., Atsuchi, K., Ushikai, M., Ataka, K., Inui, A., Kimura, H., Sevestre, H., Fujimiya, M., Chronic foot-shock stress potentiates the influx of bone marrow-derived microglia into hippocampus. J. Neurosci. Res. 88 (2010), 1890–1897.
33. Bufalino, C., Hepgul, N., Aguglia, E., Pariante, C.M., The role of immune genes in the association between depression and inflammation: a review of recent clinical studies. Brain Behav. Immun. 31 (2013), 31–47.
34. Buffington, S.A., Di Prisco, G.V., Auchtung, T.A., Ajami, N.J., Petrosino, J.F., Costa-Mattioli, M., Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring. Cell 165 (2016), 1762–1775.
35. Buret, A.G., How stress induces intestinal hypersensitivity. Am. J. Pathol. 168 (2006), 3–5.
36. Butovsky, O., Jedrychowski, M.P., Moore, C.S., Cialic, R., Lanser, A.J., Gabriely, G., Koeglsperger, T., Dake, B., Wu, P.M., Doykan, C.E., Fanek, Z., Liu, L., Chen, Z., Rothstein, J.D., Ransohoff, R.M., Gygi, S.P., Antel, J.P., Weiner, H.L., Identification of a unique TGF-β-dependent molecular and functional signature in microglia. Nat. Neurosci. 17 (2014), 131–143.
37. Carvalho, F.A., Aitken, J.D., Vijay-Kumar, M., Gewirtz, A.T., Toll-like receptor-gut microbiota interactions: perturb at your own risk!. Annu. Rev. Physiol. 74 (2012), 177–198.
38. Cayrol, C., Girard, J.P., The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1. Proc. Natl. Acad. Sci. U.S.A. 106 (2009), 9021–9026.
39. Chalkiadaki, A., Guarente, L., High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction. Cell Metab. 16 (2012), 180–188.
40. Chen, S.K., Tvrdik, P., Peden, E., Cho, S., Wu, S., Spangrude, G., Capecchi, M.R., Hematopoietic origin of pathological grooming in Hoxb8 mutant mice. Cell 141 (2010), 775–785.
41. Chen, Y., Zhang, Z., Xu, Z., Pu, M., Geng, L., Influence of interleukin-1 beta gene polymorphism and childhood maltreatment on antidepressant treatment. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 32 (2015), 801–804.
42. Cheng, Y., Pardo, M., Armini Rde, S., Martinez, A., Mouhsine, H., Zagury, J.F., Jope, R.S., Beurel, E., Stress-induced neuroinflammation is mediated by GSK3-dependent TLR4 signaling that promotes susceptibility to depression-like behavior. Brain Behav. Immun. 53 (2016), 207–222.
43. Chi, M.H., Lee, S.Y., Chang, H.H., Yang, Y.K., Lin, E., Chen, P.S., Comparison of antidepressant efficacy-related SNPs among Taiwanese and four populations in the HapMap database. J. Formos. Med. Assoc. 110 (2011), 478–482.
44. Cho, K.S., Lee, E.J., Kim, J.N., Choi, J.W., Kim, H.Y., Han, S.H., Ryu, J.H., Cheong, J.H., Shin, C.Y., Kwon, K.J., Proteinase 3 induces neuronal cell death through microglial activation. Neurochem. Res. 40 (2015), 2242–2251.
45. Choi, A.J., Ryter, S.W., Inflammasomes: molecular regulation and implications for metabolic and cognitive diseases. Mol. Cells 37 (2014), 441–448.
46. Coeshott, C., Ohnemus, C., Pilyavskaya, A., Ross, S., Wieczorek, M., Kroona, H., Leimer, A.H., Cheronis, J., Converting enzyme-independent release of tumor necrosis factor alpha and IL-1beta from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3. Proc. Natl. Acad. Sci. U.S.A. 96 (1999), 6261–6266.
47. Coll, R.C., Robertson, A.A., Chae, J.J., Higgins, S.C., Muñoz-Planillo, R., Inserra, M.C., Vetter, I., Dungan, L.S., Monks, B.G., Stutz, A., Croker, D.E., Butler, M.S., Haneklaus, M., Sutton, C.E., Núñez, G., Latz, E., Kastner, D.L., Mills, K.H., Masters, S.L., Schroder, K., Cooper, M.A., O'Neill, L.A., A small molecule inhibitor of the NLRP3 inflammasome is a potential therapeutic for inflammatory diseases. Nat. Med. 21 (2015), 248–255.
48. Conti, B., Park, L.C., Calingasan, N.Y., Kim, Y., Kim, H., Bae, Y., Gibson, G.E., Joh, T.H., Cultures of astrocytes and microglia express interleukin-18. Brain Res. Mol. Brain Res. 67 (1999), 46–52.
49. Coombes, J.L., Powrie, F., Dendritic cells in intestinal immune regulation. Nat. Rev. Immunol. 8 (2008), 435–446.
50. Cryan, J.F., Dinan, T.G., Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat. Rev. Neurosci. 13 (2012), 701–712.
51. Culhane, A.C., Hall, M.D., Rothwell, N.J., Luheshi, G.N., Cloning of rat brain interleukin-18 cDNA. Mol. Psychiatry 3 (1998), 362–366.
52. Dantzer, R., Walker, A.K., Is there a role for glutamate-mediated excitotoxicity in inflammation-induced depression?. J. Neural Transm. 121 (2014), 925–932.
53. Dantzer, R., O'Connor, J.C., Freund, G.G., Johnson, R.W., Kelley, K.W., From inflammation to sickness and depression: when the immune system subjugates the brain. Nat. Rev. Neurosci. 9 (2008), 46–56.
54. de Rivero Vaccari, J.P., Dietrich, W.D., Keane, R.W., Activation and regulation of cellular inflammasomes: gaps in our knowledge for central nervous system injury. J. Cereb. Blood Flow Metab. 34 (2014), 369–375.
55. Deng, X.Y., Li, H.Y., Chen, J.J., Li, R.P., Qu, R., Fu, Q., Ma, S.P., Thymol produces an antidepressant-like effect in a chronic unpredictable mild stress model of depression in mice. Behav. Brain Res. 291 (2015), 12–19.
56. Deng, X.Y., Xue, J.S., Li, H.Y., Ma, Z.Q., Fu, Q., Qu, R., Ma, S.P., Geraniol produces antidepressant-like effects in a chronic unpredictable mild stress mice model. Physiol. Behav. 152 (2015), 264–271.
57. Dinan, T.G., Cryan, J.F., Melancholic microbes: a link between gut microbiota and depression?. Neurogastroenterol. Motil. 25 (2013), 713–719.
58. Dinarello, C.A., The role of the interleukin-1-receptor antagonist in blocking inflammation mediated by interleukin-1. N. Engl. J. Med. 343 (2000), 732–734.
59. Dinarello, C.A., IL-1: discoveries, controversies and future directions. Eur. J. Immunol. 40 (2010), 599–606.
60. Dinarello, C.A., Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood 117 (2011), 3720–3732.
61. Dinarello, C.A., Fantuzzi, G., Interleukin-18 and host defense against infection. J. Infect. Dis., 15, 2003, 187.
62. Douglas-Escobar, M., Elliott, E., Neu, J., Effect of intestinal microbial ecology on the developing brain. JAMA Pediatr. 167 (2013), 374–379.
63. Dowlati, Y., Hermann, N., Swardfager, W., Liu, H., Sham, L., Reim, E.K., Lanctôt, K.L., A meta-analysis of cytokines in major depression. Biol. Psychiatry 67 (2010), 446–457.
64. Du, R.H., Tan, J., Sun, X.Y., Lu, M., Ding, J.H., Hu, G., Fluoxetine inhibits NLRP3 inflammasome activation: implication in depression. Int. J. Neuropsychopharmacol. 19 (2016), 1–9.
65. Engelhardt, B., Regulation of immune cell entry into the central nervous system. Results Probl. Cell Differ. 43 (2006), 259–280.
66. Engler, H., Bailey, M.T., Engler, A., Sheridan, J.F., Effects of repeated social stress on leukocyte distribution in bone marrow, peripheral blood and spleen. J. Neuroimmunol. 148 (2004), 106–115.
67. Ericsson, A., Liu, C., Hart, R.P., Sawchenko, P.E., Type 1 interleukin-1 receptor in the rat brain: distribution, regulation, and relationship to sites of IL-1-induced cellular activation. J. Comp. Neurol. 361 (1995), 681–698.
68. Erny, D., Hrabě de Angelis, A.L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., Schwierzeck, V., Utermöhlen, O., Chun, E., Garrett, W.S., McCoy, K.D., Diefenbach, A., Staeheli, P., Stecher, B., Amit, I., Prinz, M., Host microbiota constantly control maturation and function of microglia in the CNS. Nat. Neurosci. 18 (2015), 965–977.
69. Esposito, P., Gheorghe, D., Kandere, K., Pang, X., Connolly, R., Jacobson, S., Theoharides, T.C., Acute stress increases permeability of the blood-brain-barrier through activation of brain mast cells. Brain Res. 888 (2001), 117–127.
70. Esposito, P., Chandler, N., Kandere, K., Basu, S., Jacobson, S., Connolly, R., Tutor, D., Theoharides, T.C., Corticotropin-releasing hormone and brain mast cells regulate blood-brain-barrier permeability induced by acute stress. J. Pharmacol. Exp. Ther. 303 (2002), 1061–1066.
71. Fagarasan, S., Kawamoto, S., Kanagawa, O., Suzuki, K., Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis. Annu. Rev. Immunol. 28 (2010), 243–273.
72. Fang, Y., Xiao, S.F., Zhang, S.Y., Qiu, Q., Wang, T., Li, X., Increased plasma S100β level in patients with major depressive disorder. CNS Neurosci. Ther. 22 (2016), 248–250.
73. Fantuzzi, G., Ku, G., Harding, M.W., Livingston, D.J., Sipe, J.D., Kuida, K., Flavell, R.A., Dinarello, C.A., Response to local inflammation of IL-1 beta-converting enzyme-deficient mice. J. Immunol. 158 (1997), 1818–1824.
74. Fleshner, M., Stress-evoked sterile inflammation, danger associated molecular patterns (DAMPs), microbial associated molecular patterns (MAMPs) and the inflammasome. Brain Behav. Immun. 27 (2012), 1–7.
75. Fleshner, M., Frank, M., Maier, S.F., Danger signals and inflammasomes: stress-evoked sterile inflammation in mood disorders. Neuropsychopharmacology 42 (2017), 36–45.
76. Frank, M.G., Thompson, B.M., Watkins, L.R., Maier, S.F., Glucocorticoids mediate stress-induced priming of microglial pro-inflammatory responses. Brain Behav. Immun. 26 (2012), 337–345.
77. Frank, M.G., Adhikary, S., Sobesky, J.L., Weber, M.D., Watkins, L.R., Maier, S.F., The danger-associated molecular pattern HMGB1 mediates the neuroinflammatory effects of methamphetamine. Brain Behav. Immun. 51 (2015), 99–108.
78. Frick, L.R., Williams, K., Pittenger, C., Microglial dysregulation in psychiatric disease. Clin. Dev. Immunol., 2013, 2013, 608654.
79. Fröhlich, E.E., Farzi, A., Mayerhofer, R., Reichmann, F., Jacan, A., Wagner, B., Zinser, E., Bordag, N., Magnes, C., Fröhlich, E., Kashofer, K., Gorkiewicz, G., Holzer, P., Cognitive impairment by antibiotic-induced gut dysbiosis: analysis of gut microbiota-brain communication. Brain Behav. Immun. 56 (2016), 140–155.
80. Gadani, S.P., Walsh, J.T., Lukens, J.R., Kipnis, J., Dealing with danger in the CNS: the response of the immune system to injury. Neuron 87 (2015), 47–62.
81. Gareau, M.G., Microbiota-gut-brain axis and cognitive function. Adv. Exp. Med. Biol. 817 (2014), 357–371.
82. Garlanda, C., Dinarello, C.A., Mantovani, A., The interleukin-1 family: back to the future. Immunity 39 (2013), 1003–1018.
83. Garrido-Mesa, N., Zarzuelo, A., Gávez, J., Minocycline: far beyond an antibiotic. Br. J. Pharmacol. 169 (2013), 337–352.
84. Gautier, E.L., Shay, T., Miller, J., Greter, M., Jakubzick, C., Ivanov, S., Helft, J., Chow, A., Elpek, K.G., Gordonov, S., Mazloom, A.R., Ma'ayan, A., Chua, W.J., Hansen, T.H., Turley, S.J., Merad, M., Randolph, G.J., Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages. Immunological Genome Consortium. Nat. Immunol. 13 (2012), 1118–1128.
85. Giedraitis, V., He, B., Huang, X.Y., Hillert, J., Cloning and mutation analysis of the human IL-18 promoter: a possible role of polymorphisms in expression regulation. J. Neuroimmunol. 112 (2001), 146–152.
86. Goldsmith, D.R., Rapaport, M.H., Miller, B.J., A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression. Mol. Psychiatry 21 (2016), 1696–1709.
87. Gos, T., Schroeter, M.L., Lessel, W., Bernstein, H.G., Dobrowolny, H., Schiltz, K., Bogerts, B., Steiner, J., S100B-immunopositive astrocytes and oligodendrocytes in the hippocampus are differentially afflicted in unipolar and bipolar depression: a postmortem study. J. Psychiatr. Res. 47 (2013), 1694–1699.
88. Goshen, I., Yirmiya, R., Interleukin-1 (IL-1): a central regulator of stress responses. Front. Neuroendocrinol. 30 (2009), 30–45.
89. Goshen, I., Kreisel, T., Ben-Menachem-Zidon, O., Licht, T., Weidenfeld, J., Ben-Hur, T., Yirmiya, R., Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression. Mol. Psychiatry 13 (2008), 717–728.
90. Greter, M., Lelios, I., Croxford, A.L., Microglia versus myeloid cell nomenclature during brain inflammation. Front. Immunol., 6, 2015, 249.
91. Gross, O., Yazdi, A.S., Thomas, C.J., Masin, M., Heinz, L.X., Guarda, G., Quadroni, M., Drexler, S.K., Tschopp, J., Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase 1. Immunity 36 (2012), 388–400.
92. Guerreiro, R., Wojtas, A., Bras, J., Carrasquillo, M., Rogaeva, E., Majounie, E., Cruchaga, C., Sassi, C., Kauwe, J.S., Younkin, S., Hazrati, L., Collinge, J., Pocock, J., Lashley, T., Williams, J., Lambert, J.C., Amouyel, P., Goate, A., Rademakers, R., Morgan, K., Powell, J., St George-Hyslop, P., Singleton, A., Hardy, J., Alzheimer Genetic Analysis Group. TREM2 variants in Alzheimer's disease. N. Engl. J. Med. 368 (2013), 117–127.
93. Guma, M., Ronacher, L., Liu-Bryan, R., Takai, S., Karin, M., Corr, M., Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation. Arthritis Rheum. 60 (2009), 3642–3650.
94. Gurung, P., Lukens, J.R., Kanneganti, T.D., Mitochondria: diversity in the regulation of the NLRP3 inflammasome. Trends Mol. Med. 21 (2014), 193–201.
95. Haack, M., Plasma levels of cytokines and soluble cytokine receptors in psychiatric patients upon hospital admission: effects of confounding factors and diagnosis. J. Psychiatr. Res. 33 (1999), 407–418.
96. Haastrup, E., Bukh, J.D., Bock, C., Vinberg, M., Thørner, L.W., Hansen, T., Werge, T., Kessing, L.V., Ullum, H., Promoter variants in IL18 are associated with onset of depression in patients previously exposed to stressful-life events. J. Affect. Disord. 136 (2012), 134–138.
97. Halle, A., Hornung, V., Petzold, G.C., Stewart, C.R., Monks, B.G., Reinheckel, T., Fitzgerald, K.A., Latz, E., Moore, K.J., Golenbock, D.T., The NALP3 inflammasome is involved in the innate immune response to amyloid-β. Nat. Immunol. 9 (2008), 857–865.
98. Hanamsagar, R., Hanke, M.L., Kielian, T., Toll-like receptor (TLR) and inflammasome actions in the central nervous system. Trends Immunol. 33 (2012), 333–342.
99. Hannestad, J., DellaGioia, N., Bloch, M., The effect of antidepressant medication treatment on serum levels of inflammatory cytokines: a meta-analysis. Neuropsychopharmacology 36 (2011), 2452–2459.
100. Hartwell, K.J., Moran-Santa Maria, M.M., Twal, W.O., Shaftman, S., DeSantis, S.M., McRae-Clark, A.L., Brady, K.T., Association of elevated cytokines with childhood adversity in a sample of healthy adults. J. Psychiatr. Res. 47 (2013), 604–610.
101. Hazuda, D.J., Strickler, J., Kueppers, F., Simon, P.L., Young, P.R., Processing of precursor interleukin 1 beta and inflammatory disease. J. Biol. Chem. 265 (1990), 6318–6322.
102. He, F., Doucet, J.A., Stephens, J.M., Caspase-mediated degradation of PPARδ proteins in adipocytes. Obesity 16 (2008), 1735–1741.
103. Herzog, C., Haun, R.S., Kaushal, V., Mayeux, P.R., Shah, S.V., Kaushal, G.P., Meprin A and meprin alpha generate biologically functional IL-1beta from pro-IL-1beta. Biochem. Biophys. Commun. 379 (2009), 904–908.
104. Hickman, S.E., Kingery, N.D., Ohsumi, T.K., Borowsky, M.L., Wang, L.C., Means, T.K., El Khoury, J., The microglial sensome revealed by direct RNA sequencing. Nat. Neurosci. 16 (2013), 1896–1905.
105. Hinwood, M., Tynan, R.J., Charnley, J.L., Beynon, S.B., Day, T.A., Walker, F.R., Chronic stress induced remodeling of the prefrontal cortex: structural re-organization of microglia and the inhibitory effect of minocycline. Cereb. Cortex 23 (2013), 1784–1797.
106. Hoffman, H.M., Mueller, J.L., Broide, D.H., Wanderer, A.A., Kolodner, R.D., Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat. Genet. 29 (2001), 301–305.
107. Hwang, J.P., Tsai, S.J., Hong, C.J., Yang, C.H., Hsu, C.D., Liou, Y.J., Interleukin-1 beta −511C/T genetic polymorphism is associated with age of onset of geriatric depression. Neuromolecular Med. 11 (2009), 322–327.
108. Insel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D.S., Quinn, K., Sanislow, C., Wang, P., Research domain criteria (RDoC): toward a new classification framework for research on mental disorders. Am. J. Psychiatry 167 (2010), 748–751.
109. Iwata, M., Ota, K.Y., Duman, R.S., The inflammasome: pathways linking stress, depression, and systemic illnesses. Brain Behav. Immun. 31 (2013), 105–114.
110. Iwata, M., Ota, K.T., Li, X.Y., Sakaue, F., Li, N., Dutheil, S., Banasr, M., Duric, V., Yamanashi, T., Kaneko, K., Rasmussen, K., Glasebrook, A., Koester, A., Song, D., Jones, K.A., Zorn, S., Smagin, G., Duman, R.S., Psychological stress activates the inflammasome via release of adenosine triphosphate and stimulation of the purinergic type 2X7 receptor. Biol. Psychiatry 80 (2016), 12–22.
111. Jiang, H., Ling, Z., Zhang, Y., Mao, H., Ma, Z., Yin, Y., Wang, W., Tang, W., Tan, Z., Shi, J., Li, L., Ruan, B., Altered fecal microbiota composition in patients with major depressive disorder. Brain Behav. Immun. 48 (2015), 186–194.
112. Kaestner, F., Hettich, M., Peters, M., Sibrowski, W., Hetzel, G., Ponath, G., Arolt, V., Cassens, U., Rothermundt, M., Different activation patterns of proinflammatory cytokines in melancholic and non-melancholic major depression are associated with HPA axis activity. J. Affect. Disord. 87 (2005), 305–311.
113. Kang, H.J., Bae, K.Y., Kim, S.W., Kim, J.T., Park, M.S., Cho, K.H., Kim, J.M., Effects of interleukin-6, interleukin-18, and statin use, evaluated at acute stroke, on post-stroke depression during 1-year follow-up. Psychoneuroendocrinology 72 (2016), 156–160.
114. Katsuura, G., Gottschall, P.E., Arimura, A., Identification of a high affinity receptor for interleukin-1β in rat brain. Biochem. Biophys. Res. Commun. 156 (1988), 61–67.
115. Kelly, J.R., Borre, Y., O’ Brien, C., Patterson, E., El Aidy, S., Deane, J., Kennedy, P.J., Beers, S., Scott, K., Moloney, G., Hoban, A.E., Scott, L., Fitzgerald, P., Ross, P., Stanton, C., Clarke, G., Cryan, J.F., Dinan, T.G., Transferring the blues: depression-associated gut microbiota induces neurobehavioural changes in the rat. J. Psychiatr. Res. 82 (2016), 109–118.
116. Kennedy, P.S., Cryan, J.F., Dinan, T.G., Clarke, G., Kynurenine pathway metabolism and microbiota-gut-brain axis. Neuropharmacology 112 (2017), 399–412.
117. Kigerl, K.A., de Rivero Vaccari, J.P., Dietrich, W.D., Popovich, P.G., Keane, R.W., Pattern recognition receptors and central nervous system repair. Exp. Neurol. 258 (2014), 5–16.
118. Kim, J.M., Stewart, R., Kim, S.W., Shin, I.S., Kim, J.T., Park, M.S., Park, S.W., Kim, Y.H., Cho, K.H., Yoon, J.S., Associations of cytokine gene polymorphisms with post-stroke depression. World J. Biol. Psychiatry 13 (2011), 579–587.
119. Kim, H.K., Andreazza, A.C., Elmi, N., Chen, W., Young, L.T., Nod-like receptor pyrin containing 3 (NLRP3) in the post-mortem frontal cortex from patients with bipolar disorder: a potential mediator between mitochondria and immune-activation. J. Psychiatr. Res. 72 (2016), 43–50.
120. Kokai, M., Kashiwamura, S., Okamura, H., Ohara, K., Morita, Y., Plasma Interleukin-18 levels in patients with psychiatric disorder. J. Immunother. 25 (2002), 68–71.
121. Konsman, J.P., Veeneman, J., Combe, C., Poole, S., Luheshi, G.N., Dantzer, R., Central nervous action of interleukin-1 mediates activation of limbic structures and behavioural depression in response to peripheral administration of bacterial lipopolysaccharide. Eur. J. Neurosci. 28 (2008), 2499–2510.
122. Koo, J.W., Duman, R.S., IL-1β is an essential mediator of the antinuerogenic and anhedonic effects of stress. Proc. Natl. Acad. Sci. U.S.A. 105 (2008), 751–756.
123. Koo, J.W., Duman, R.S., Evidence for IL-1 receptor blockade as a therapeutic strategy for the treatment of depression. Curr. Opin. Invest. Drugs 10 (2009), 664–671.
124. Kreisel, T., Frank, M.G., Licht, T., Reshef, R., Ben-Menachem-Zidon, O., Baratta, M.V., Maier, S.F., Yirmiya, R., Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis. Mol. Psychiatry 19 (2014), 699–709.
125. Krishnan, V., Nestler, E.J., The molecular neurobiology of depression. Nature 455 (2008), 894–902.
126. Kroes, R.A., Panksepp, J., Burgdorf, J., Otto, N.J., Moskal, J.R., Modeling depression: social dominance-submission gene expression patterns in rat neocortex. Neuroscience 137 (2006), 37–49.
127. Kumar, S., Hanning, C.R., Brigham-Burke, M.R., Rieman, D.J., Lehr, R., Khandekar, S., Kirkpatrick, R.B., Scott, G.F., Lee, J.C., Lynch, F.J., Gao, W., Gambotto, A., Lotze, M.T., Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production. Cytokine 18 (2002), 61–71.
128. Lamkanfi, M., Dixit, V.M., Inflammasomes and their roles in health and disease. Annu. Rev. Cell Dev. Biol. 28 (2012), 137–161.
129. Lamkanfi, M., Dixit, V.M., Mechanisms and functions of inflammasomes. Cell 157 (2014), 1012–1022.
130. Lanquillon, S., Krieg, J.C., Bening-Abu-Shach, U., Vedder, H., Cytokine production and treatment response in major depressive disorder. Neuropsychopharmacology 22 (2000), 370–379.
131. Lechtenberg, B.C., Mace, P.D., Riedl, S.J., Structural mechanisms in NLR inflammasome signaling. Curr. Opin. Struct. Biol. 29 (2014), 17–25.
132. Lehmann, M.L., Cooper, H.A., Maric, D., Herkenham, M., Social defeat induces depressive-like states and microglial activation without involvement of peripheral macrophages. J. Neuroinflammation, 13, 2016, 224.
133. Levine, J., Cerebrospinal cytokine levels in patients with acute depression. Neuropsychobiology 40 (1999), 171–176.
134. Levkovich, T., Poutahidis, T., Smillie, C., Varian, B.J., Ibrahim, Y.M., Lakritz, J.R., Alm, E.J., Erdman, S.E., Probiotic bacteria induce a ‘glow of health’. PLoS One, 8, 2013, 53867.
135. Li, R., Wang, X., Qin, T., Qu, R., Ma, S., Apigenin ameliorates chronic mild stress-induced depressive behavior by inhibiting interleukin-1β production and NLRP3 inflammasome activation in the rat brain. Behav. Brain Res. 296 (2016), 318–325.
136. Lian, Y.J., Gong, H., Su, W.J., Zhang, Y., Yang, Y.Y., Peng, W., Zhang, T., Zhou, J.R., Jiang, C.L., Wang, Y.X., Ds-HMGB1 and fr-HMGB induce depressive behavior through neuroinflammation in contrast to monoxide-HMGB1. Brain Behav. Immun. 59 (2017), 322–332.
137. Lindqvist, D., Fernström, J., Grudet, C., Ljunggren, L., Träskman-Bendz, L., Ohlsson, L., Westrin, A., Increased plasma levels of circulating cell-free mitochondrial DNA in suicide attempters: associations with HPA-axis hyperactivity. Transl. Psychiatry, 6, 2016, e971.
138. Liu, B., Xu, C., Wu, X., Liu, F., Du, Y., Sun, J., Tao, J., Dong, J., Icariin exerts an antidepressant effect in an unpredictable chronic mild stress model of depression in rats and is associated with the regulation of hippocampal neuroinflammation. Neuroscience 294 (2015), 193–205.
139. Lu, M., Yang, J.Z., Geng, F., Ding, J.H., Hu, G., Iptakalim confers an antidepressant effect in a chronic mild stress model of depression through regulating neuro-inflammation and neurogenesis. Int. J. Neuropsychopharmacol. 17 (2014), 1501–1510.
140. Lucas, K., Maes, M., Role of the Toll Like receptor (TLR) radical cycle in chronic inflammation: possible treatments targeting the TLR4 pathway. Mol. Neurobiol. 48 (2013), 190–204.
141. Luciano, M., Houlihan, L.M., Harris, S.E., Gow, A.J., Hayward, C., Starr, J.M., Deary, I.J., Association of existing and new candidate genes for anxiety, depression and personality traits in older people. Behav. Genet. 40 (2010), 518–532.
142. Ma, M., Ren, Q., Zhang, J.C., Hashimoto, K., Effects of brilliant blue G on serum tumor necrosis factor-α levels and depression-like behavior in mice after lipopolysaccharide administration. Clin. Psychopharmacol. Neurosci. 12 (2014), 31–36.
143. Maes, M., Evidence for an immune response in major depression: a review and hypothesis. Prog. Neuropsychopharmacol. Biol. Psychiatry 19 (1995), 11–38.
144. Maes, M., Song, C., Yirmiya, R., Targeting IL-1 in depression. Expert Opin. Ther. Targets 16 (2012), 1097–1112.
145. Mariathasan, S., Weiss, D.S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W.P., Weinrauch, Y., Monack, D.M., Dixit, V.M., Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440 (2006), 228–232.
146. Marques-Deak, A.H., Neto, F.L., Dominguez, W.V., Solis, A.C., Kurcgant, D., Sato, F., Ross, J.M., Prado, E.B., Cytokine profiles in women with different subtypes of major depressive disorder. J. Psychiatr. Res. 41 (2005), 152–159.
147. Martinon, F., Burns, K., Tschopp, J., The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of pro-IL-1β. Mol. Cell 10 (2002), 417–446.
148. Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., Tschopp, J., Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440 (2006), 237–241.
149. Maslanik, T., Mahaffey, L., Tannura, K., Beninson, L., Greenwood, B.N., Fleshner, M., The inflammasome and danger associated molecular patterns (DAMPs) are implicated in cytokine and chemokines responses following stressor exposure. Brain Behav. Immun. 28 (2013), 54–62.
150. McCulley, M.C., Day, I.N., Holmes, C., Association between interleukin 1-beta promoter (−511) polymorphism and depressive symptoms in Alzheimer's disease. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 124B (2004), 50–53.
151. Mechawar, N., Savitz, J., Neuropathology of mood disorders: do we see the stigmata of inflammation?. Transl. Psychiatry, 6, 2016, e946.
152. Ménard, C., Pfau, M.L., Hodes, G.E., Russo, S.J., Immune and neuroendocrine mechanisms of stress vulnerability and resilience. Neuropsychopharmacology 42 (2017), 62–80.
153. Merendino, R.A., Di Rosa, A.E., Di Pasquale, G., Minciullo, P.L., Mangraviti, C., Constantino, A., Ruello, A., Gangemi, S., Interleukin-18 and CD30 serum levels in patients with moderate-severe depression. Mediators Inflamm. 11 (2002), 265–267.
154. Miller, A.H., Raison, C.L., The role of inflammation in depression: from evolutionary imperative to modern treatment target. Nat. Rev. Immunol. 16 (2016), 22–34.
155. Miller, A.H., Maletic, V., Raison, C.L., Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol. Psychiatry 65 (2009), 732–741.
156. Minkiewicz, J., de Rivero Vaccari, J.P., Keane, R.W., Human astrocytes express a novel NLRP2 inflammasome. Glia 61 (2013), 1113–1121.
157. Misener, V.L., Gomez, L., Wigg, K.G., Luca, P., King, N., Kiss, E., Daróczi, G., Kapornai Tamas, Z., Mayer, L., Gádoros, J., Baji, I., Kennedy, J.L., Kovacs, M., Vetró A., Barr, C.L., Cytokine Genes TNF, IL1A, IL1B, IL6, IL1RN and IL10, and childhood-onset mood disorders. Neuropsychobiology 58 (2008), 71–80.
158. Misener, V.L., Gomez, L., Wigg, K.G., King, N., Kiss, E., Daroczi, G., Kapornai, K., Tamáz, Z., Mayer, L., Gádoros, J., Baji, I., Kennedy, J.L., Kovacs, M., Vetró A., Barr, C.L., Tagging SNP association study of the IL-1beta gene (IL1B) and childhood-onset mood disorders. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 150B (2009), 653–659.
159. Mizel, S.B., The interleukins. FASEB J. 3 (1989), 2379–2388.
160. Mota, R., Gazal, M., Acosta, B.A., de Leon, P.B., Jansen, K., Pinheiro, R.T., Souza, L.D., Silva, R.A., Oses, J.P., Quevedo, L., Lara, D.R., Ghisleni, G., Kaster, M.P., Interleukin-1β is associated with depressive episode in major depression but not in bipolar disorder. J. Psychiatr. Res. 47 (2013), 2011–2014.
161. Murray, C.J., Atkinson, C., Bhalla, K., Birbeck, G., Burstein, R., Chou, D., Dellavalle, R., Danaei, G., Ezzati, M., Fahimi, A., Flaxman, D., Foreman Gabriel, S., Gakidou, E., Kassebaum, N., Khatibzadeh, S., Lim, S., Lipshultz, S.E., London, S., Lopez MacIntyre, M.F., Mokdad, A.H., Moran, A., Moran, A.R., Mozaffarian, D., Murphy, T., Naghavi, M., Pope, C., Roberts, T., Salomon, J., Schwebel, D.C., Shahraz, S., Sleet, D.A., Murray Abraham, J., Ali, M.K., Atkinson, C., Bartels, D.H., Bhalla, K., Birbeck, G., Burstein, R., Chen, H., Criqui, M.H., Ding, E.L., Dorsey, E.R., Ebel, B.E., Ezzati, M., Flaxman, S., Flaxman, A.D., Gonzalez-Medina, D., Grant, B., Hagan, H., Hoffaman, H., Kassebaum, N., Khatibzadeh, S., Leasher, J.L., Lin, J., Lipshultz, S.E., Lozano, R., Lu, Y., Mallinger, L., McDermott, M.M., Micha, R., Miller, T.R., Mokdad, A.A., Mokdad, A.H., Mozaffarian, D., Naghavi, M., Narayan, K.M., Omer, S.B., Pelizzari, P.M., Phillips, D., Ranganathan, D., Rivara, F.P., Roberts, T., Sampson, U., Sanman, E., Sapkota, A., Schwebel, D.C., Sharaz, S., Shivakoti, R., Singh, G.M., Singh, D., Tavakkoli, M., Towbin, J.A., Wilkinson, J.D., Zabetian, A., Murray, J., Abraham, J., Ali, M.K., Alvardo, M., Atkinson, C., Baddour, L.M., Benjamin, E.J., Bhalla, K., kirbeck, G., Bolliger, R., Burstein, R., Carnahan, E., Chou, D., Chugh, S.S., Cohen, A., Colson, K.E., Cooper, L.T., Couser, W., Criqui, M.H., Dabhadkar, K.C., Dellavalle, R.P., Jarlais, Dicker, D., Dorsey, E.R., Duber, H., Ebel, B.E., Engell, R.E., Ezzati, M, Felson, D.T., Finucane, M.M., Flaxman, S, Flaxman, A.D., Fleming, T., Foreman, Forouzanfar, M.H., Freedman, G., Freedman, M.K., Gakidou, E., Gillum, R.F., Gonzalez-Medina, D., Gosselin, R, Gutierrez, H.R., Hagan, H., Havmoeller, R., Hoffman, H., Jacobsen, K.H., James, S.L., Jasrasaria, R., Jayarman, S., Johns, N., Kassebaum, N., Khatibzadeh, S., Lan, Q., Leasher, J.L., Lim, S., Lipshultz, S.E., London, S., Lopez, Lozano, R., Lu, Y, Mallinger, L., Meltzer, M., Mensah, G.A., Michaud, C., Miller, T.R., Mock, C., Moffitt, T.E., Mokdad, A.A., Mokdad, A.H., Moran, A., Naghavi, M., Narayan, K.M., Nelson, R.G., Olives, C., Omer, S.B., Ortblad, K., Ostro, B., Pelizzari, P.M., Phillips, D., Raju, M., Razavi, H., Ritz, B., Roberts, T., Sacco, R.L., Salomon, J., Sampson, U., Schwebel, D.C., Shahraz, S., Shibuya, K., Silberberg, D., Singh, J.A., Steenland, K., Taylor, J.A., Thurston, G.D., Vavilala, M.S., Vos, T., Wagner, G.R., Weinstock, M.A., Weisskopf, M.G., Wulf, S, Murray, U.S., The state of US health, 1990–2010: burden of diseases, injuries, and risk factors. JAMA 310 (2013), 591–608.
162. Najjar, S., Pearlman, D.M., Alper, K., Najjar, A., Devinsky, O., Neuroinflammation and psychiatric illness. J. Neuroinflammation, 10, 2013, 43.
163. Netea, M.G., van de Veerdonk, F.L., van der Meer, J.W., Dinarello, C.A., Joosten, L.A., Inflammasome-independent regulation of IL-1 family cytokines. Annu. Rev. Immunol. 33 (2015), 49–77.
164. Noverr, M.C., Huffnagle, G.B., Does the microbiota regulate immune responses outside the gut?. Trends Microbiol. 12:12 (2004), 562–568.
165. Ohland, C.L., Kish, L., Bell, H., Thiesen, A., Hotte, N., Pankiv, E., Madsen, K.L., Effects of Lactobacillus helveticus on murine behavior are dependent on diet and genotype and correlate with alterations in the gut microbiome. Psychoneuroendocrinology 38 (2013), 1738–1747.
166. Owen, B.M., Eccleston, D., Ferrier, I.N., Young, A.H., Raised levels of plasma interleukin-1β in major and postviral depression. Acta Psychiatr. Scand. 103 (2001), 226–228.
167. Paloneva, J., Manninen, T., Christman, G., Hovanes, K., Mandelin, J., Adolfsson, R., Bianchin, M., Bird, T., Miranda, R., Salmaggi, A., Tranebjaerg, L., Konttinen, Y., Peltonen, L., Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype. Am. J. Hum. Genet. 71 (2002), 656–662.
168. Pan, Y., Chen, X.Y., Zhang, Q.Y., Kong, L.D., Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats. Brain Behav. Immun. 41 (2014), 90–100.
169. Papakostas, G.I., Ionescu, D.F., Towards new mechanisms: an update on therapeutics for treatment-resistant major depressive disorder Mol. Psychiatry 20 (2015), 1142–1150.
170. Park, A.J., Collins, J., Blennerhassett, P.A., Ghia, J.E., Verdu, E.F., Bercik, P., Collins, S.M., Altered colonic function and microbiota profile in a mouse model of chronic depression. Neurogastroenterol. Motil. 25 (2013), e733–e775.
171. Park, H., Shim, H.S., An, K., Starkweather, A., Kim, K.S., Shim, I., IL-4 inhibits IL-1β-induced depressive-like behavior and central neurotransmitter alterations. Mediators Inflamm., 2015, 2015, 941413.
172. Peng, Y.F., Xiang, Y., Wei, Y.S., The significance of routine biochemical markers in patients with major depressive disorder. Sci. Rep., 6, 2016, 34402.
173. Perry, V.H., Stress primes microglia to the presence of systemic inflammation: implications for environmental influences on the brain. Brain Behav. Immun. 21 (2007), 45–46.
174. Picard, M., Juster, R.P., McEwen, B.S., Mitochondrial allostatic load puts the ‘gluc’ back in glucocorticoids. Nat. Rev. Endocrinol. 10 (2014), 303–310.
175. Piletz, J.E., Aricioglu, F., Cheng, J.T., Fairbanks, C.A., Gilad, V.H., Haenisch, B., Halaris, A., Hong, S., Lee, J.E., Li, J., Liu, O., Molderings, G.J., Rodrigues, A.L., Satriano, J., Seong, G.J., Wilcox, G., Wu, N., Gilad, G.M., Agmatine: clinical implications after 100 years in translation. Drug Discov. Today 18 (2013), 880–893.
176. Powell, N.D., Bailey, M.T., Mays, J.W., Stiner-Jones, L.M., Hanke, M.L., Padgett, D.A., Sheridan, J.F., Repeated social defeat activates dendritic cells and enhances Toll-like receptor dependent cytokine secretion. Brain Behav. Immun. 23 (2009), 225–231.
177. Powell, N.D., Sloan, E.K., Bailey, M.T., Arevalo, J.M., Miller, G.E., Chen, E., Kobor, M.S., Reader, B.F., Sheridan, J.F., Cole, S.W., Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via β-adrenergic induction of myelopoiesis. Proc. Natl. Acad. Sci. U.S.A. 110 (2013), 16574–16579.
178. Proell, M., Gerlic, M., Mace, P.D., Reed, J.C., Riedl, S.J., The CARD plays a critical role in ASC foci formation and inflammasome signalling. Biochem. J. 449 (2013), 613–621.
179. Puren, A.J., Fantuzzi, G., Dinarello, C.A., Gene expression, synthesis, an secretion of interleukin-18 and interleukin-1β are differentially regulated in human blood mononuclear cells and mouse spleen cells. Proc. Natl. Acad. Sci. U.S.A. 96 (1999), 2256–2261.
180. Raison, C.L., Miller, A.H., Malaise, melancholia and madness: the evolutionary legacy of an inflammatory bias. Brain Behav. Immun. 31 (2013), 1–8.
181. Ramaswamy, V., Walsh, J.G., Sinclair, D.B., Johnson, E., Tang-Wai, R., Wheatley, B.M., Branton, W., Maingat, F., Snyder, T., Gross, D.W., Power, C., Inflammasome induction in Rasmussen's encephalitis: cortical and associated white matter pathogenesis. J. Neuroinflammation, 10, 2013, 152.
182. Ramirez, K., Fornaguera-Trías, J., Sheridan, J.F., Stress-induced microglia activation and monocyte trafficking to the brain underlie the development of anxiety and depression. Curr. Top. Behav. Neurosci. 31 (2017), 155–172.
183. Réus, G.Z., Jansen, K., Titus, S., Carvalho, A.F., Gabbay, V., Quevedo, J., Kynurenine pathway dysfunction in the pathophysiology and treatment of depression: Evidences from animal and human studies. J. Psychiatr. Res. 68 (2015), 316–328.
184. Rivera-Escalera, F., Matousek, S.B., Ghosh, S., Olschowka, J.A., O'Banion, M.K., Interleukin-1β mediated amyloid plaque clearance is independent of CCR2 signaling in the APP/PS1 mouse model of Alzheimer's disease. Neurobiol. Dis. 69 (2014), 124–133.
185. Rodrigues, R.J., Tomé A.R., Cunha, R.A., ATP as a multi-target danger signal in the brain. Front. Neurosci., 9, 2015, 148.
186. Rosa, A., Peralta, V., Papiol, S., Cuesta, M.J., Serrano, F., Martinez-Larrea, A., Fananas, L., Interleukin-1beta (IL-1beta) gene and increased risk for the depressive symptom-dimension in schizophrenia spectrum disorders. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 124 (2004), 10–14.
187. Rothermundt, M., Arolt, V., Peters, M., Gutbrodt, H., Fenker, J., Kersting, A., Kirchner, H., Inflammatory markers in major depression and melancholia. J. Affect. Disord. 63 (2001), 93–102.
188. Rothwell, N.J., Luheshi, G.N., Interleukin 1 in the brain: biology, pathology and therapeutic target. Trends Neurosci. 23 (2000), 618–625.
189. Sahin, C., Albayrak, O., Akdeniz, T.F., Akbulut, Z., Yanikkaya Demirel, G., Aricioglu, F., Agmatine reverses sub-chronic stress-induced nod-like receptor protein 3 (NLRP3) activation and cytokine response in rats. Basic Clin. Pharmacol. Toxicol. 119 (2016), 367–375.
190. Sahraei, Z., Eshraghi, A., Eslami, N., Mehdizadeh, M., Assessment of depression prevalence and its relation with interleukin 18 one year after renal transplantation. Am. J.Ther. 23 (2015), e1579–e1585.
191. Santos, M., Carvalho, S., Lima, L., Mota-Pereira, J., Pimentel, P., Maia, D., Correia, D., Gomes, S., Cruz, A., Medeiros, R., The role of IL18-607C>A and IL18-137G>C promoter polymorphisms in antidepressant treatment phenotypes: A preliminary report. Neurosci. Lett. 622 (2016), 107–112.
192. Sanz, J.M., Di Virgilio, F., Kinetics and mechanism of ATP-dependent IL-1 beta release from microglial cells. J. Immunol. 164 (2000), 4893–4898.
193. Schenk, G.J., de Vries, H.E., Altered blood-brain barrier transport in neuro-inflammatory disorders. Drug Discov. Today Technol. 20 (2016), 5–11.
194. Schiepers, O.J., Wichers, M.C., Maes, M., Cytokines and major depression. Prog. Neuropsychopharmacol. Biol. Psychiatry 29 (2005), 201–217.
195. Schmidt, K., Cowen, P.J., Harmer, C.J., Tzortzis, G., Errington, S., Burnet, P.W., Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers. Psychopharmacology 232 (2015), 1793–1801.
196. Schwieler, L., Samuelsson, M., Frye, M.A., Bhat, M., Schuppe-Koistinen, I., Jungholm, O., Johansson, A.G., Landén, M., Sellgren, C.M., Erhardt, S., Electroconvulsive therapy suppresses the neurotoxic branch of the kynurenic pathway in treatment-resistant depressed patients. J. Neuroinflammation, 13, 2016, 51.
197. Seguin, J.A., Brennan, J., Mangano, E., Hayley, S., Proinflammatory cytokines differentially influence adult hippocampal cell proliferation depending upon the route and chronicity of administration. Neuropsychiatr. Dis. Treat. 5 (2009), 5–14.
198. Setiwan, E., Wilson, A.A., Mizrahi, R., Rusjan, P.M., Miler, L., Rajkowska, G., Suridjan, I., Kennedy, J.L., Rekkas, P.V., Houle, S., Meyer, J.H., Role of translocator protein density, a marker of neuroinflammation, in the brain during major depressive episodes. JAMA Psychiatry 72 (2015), 268–275.
199. Shaftel, S.S., Carlson, T.J., Olschowka, J.A., Kyrkanides, S., Matousek, S.B., O'Banion, M.K., Chronic interleukin-1beta expression in mouse brain leads to leukocyte infiltration and neutrophil-independent blood brain barrier permeability without overt neurodegeneration. J. Neurosci. 27 (2007), 9301–9309.
200. Shaftel, S.S., Griffin, W.S., O'Banion, M.K., The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective. J. Neuroinflammation, 5, 2008, 7.
201. Sharon, G., Sampson, T.R., Geschwind, D.H., Mazmanian, S.K., The central nervous system and the gut microbiome. Cell 167 (2016), 915–932.
202. Shen, J., Yin, Y., Mai, J., Xiong, X., Pansuria, M., Liu, J., Maley, E., Saqib, N.U., Wang, H., Yang, X.F., Caspase-1 recognizes extended cleavage sites in its natural substrates. Atherosclerosis 210 (2010), 422–429.
203. Sims, J.E., Smith, D.E., The IL-1 family: regulators of immunity. Nat. Rev. Immunol. 10 (2010), 89–102.
204. Singhal, G., Jaehne, E.J., Corrigan, F., Toben, C., Baune, B.T., Inflammasomes in neuroinflammation and changes in brain function: a focused review. Front. Neurosci., 8, 2014, 315.
205. Slusarczyk, J., Trojan, E., Glombik, K., Budziszewska, B., Kubera, M., Lasón, W., Popiolek-Barczyk, K., Mika, J., Wedzony, K., Basta-kaim, A., Prenatal stress is a vulnerability factor for the altered morphology and biological activity of microglial cells. Front. Cell. Neurosci., 9, 2015, 82.
206. Ślusarczyk, J., Trojan, E., Wydra, K., Glombic, K., Chamera, K., Kucharczyk, M., Budziszewska, B., Kubera, M., Lasoń W., Filip, M., Basta-Kaim, A., Beneficial impact of intracerebroventricular fractalkine administration on behavioral and biochemical changes induced by prenatal stress in adult rats: possible role of NLRP3 inflammasome pathway. Biochem. Pharmacol. 113 (2016), 45–56.
207. Söderlund, J., Olsson, S.K., Samuelsson, M., Walther-Jallow, L., Johansson, C., Erhardt, S., Landén, M., Engberg, G., Elevation of cerebrospinal fluid interleukin-1ß in bipolar disorder. J. Psychiatry Neurosci. 36 (2011), 114–118.
208. Sollberger, G., Strittmatter, G.E., Garstkiewicz, M., Sand, J., Beer, H.D., Caspase-1: the inflammasome and beyond. Innate Immun. 20 (2014), 115–125.
209. Soragna, D., Papi, L., Ratti, M.T., Sestini, R., Tupler, R., Montalbetti, L., An Italian family affected by Nasu-Hakola disease with a novel genetic mutation in the TREM2 gene. J. Neurol. Neurosurg. Psychiatry 74 (2003), 825–826.
210. Sorrells, S.F., Sapolsky, R.M., An inflammatory review of glucocorticoid actions in the CNS. Brain Behav. Immun. 21 (2007), 259–272.
211. Steiner, J., Bielau, H., Brish, R., Danos, P., Ullrich, O., Mawrin, C., Bernstein, H.G., Bogerts, B., Immunological aspects in the neurobiology of suicide: elevated microglial density in schizophrenia and depression is associated with suicide. J. Psychiatr. Res. 42 (2008), 151–157.
212. Steiner, J., Walter, M., Gos, T., Guillemin, G.J., Bernstein, H.G., Sarnyai, Z., Mawrin, C., Brisch, R., Bielau, H., Meyer zu Schwabedissen, L., Bogerts, B., Myint, A.M., Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission?. J. Neuroinflammation, 8, 2011, 94.
213. Steptoe, A., Lack of association between depressive symptoms and markers of immune and vascular inflammation in middle-aged men and women. Psychol. Med. 33 (2003), 667–674.
214. Stoffels, M., Zaal, R., Kok, N., van der Meer, J.W., Dinarello, C.A., Simon, A., ATP-induced IL-1β specific secretion: true under stringent conditions. Front. Immunol., 6, 2015, 54.
215. Stroth, N., Svenningsson, P., S100B interacts with the serotonin 5-HT7 receptor to regulate a depressive-like behavior. Eur. Neuropsychopharmacol. 25 (2015), 2372–2380.
216. Sugama, S., Conti, B., Interleukin-18 and stress. Brain Res. Rev. 58 (2008), 85–95.
217. Sugama, S., Cho, B.P., Baker, H., Joh, T.H., Lucero, J., Conti, B., Neurons of the superior nucleus of the medial habenula and ependymal cells express IL-18 in rat CNS. Brain Res. 958 (2002), 1–9.
218. Swartz, J.R., Prather, A.A., Di Iorio, C.R., Bogdan, R., Hariri, A.R., A functional interleukin-18 haplotype predicts depression and anxiety through increased threat-related amygdala reactivity in women but not men. Neuropsychopharmacology 2 (2017), 419–426.
219. Tadic, A., Rujescu, D., Müller, M.J., Kohnen, R., Stassen, H.H., Szegedi, A., Dahmen, N., Association analysis between variants of the interleukin-1beta and the interleukin-1 receptor antagonist gene and antidepressant treatment response in major depression. Neuropsychiatr. Dis. Treat. 4 (2008), 269–276.
220. Takisawa, T., Shibata, M., Kayama, Y., Shimizu, T., Toriumi, H., Ebine, T., Unekawa, M., Koh, A., Yoshimura, A., Suzuki, N., High-mobility group box 1 is an important mediator of microglial activation induced by cortical spreading depression. J. Cereb. Blood Flow Metab., 2016 (in press).
221. Tao, R., Li, H., High serum uric acid level in adolescent depressive patients. J. Affect. Disord. 174 (2015), 464–466.
222. Tartter, M., Hammen, C., Bower, J.E., Brennan, P.A., Cole, S., Effects of chronic interpersonal stress exposure on depressive symptoms are moderated by genetic variation at IL6 and IL1β in youth. Brain Behav. Immun. 46 (2015), 104–111.
223. Tsuchiya, K., Hara, H., The inflammasome and its regulation. Crit. Rev. Immunol. 34 (2014), 41–80.
224. Tynan, R.J., Naicker, S., Hinwood, M., Nalivaiko, E., Buller, K.M., Pow, D.V., Day, T.A., Walker, F.R., Chronic stress alters the density and morphology of microglia in a subset of stress-responsive brain regions. Brain Behav. Immun. 24 (2010), 1058–1068.
225. Tyrka, A.R., Parade, S.H., Price, L.H., Kao, H.T., Porton, B., Phillip, N.S., Welch, E.S., Carpenter, L.L., Alterations of mitochondrial DNA copy number and telomere length with early adversity and psychopathology. Biol. Psychiatry 79 (2016), 78–86.
226. van Buel, E.M., Bosker, F.J., van Drunen, J., Strijker, J., Douwenga, W., Klein, H.C., Eisel, U.L., Electroconvulsive seizures (ECS) do not prevent LPS-induced behavioral alterations and microglial activation. J. Neuroinflammation, 12, 2015, 232.
227. Vitkovic, L., Konsman, J.P., Bockaert, J., Dantzer, R., Homburger, V., Jacque, C., Cytokine signals propagate through the brain. Mol. Psychiatry 5 (2000), 604–615.
228. Walsh, J.G., Muruve, D.A., Power, C., Inflammasomes in the CNS. Nat. Rev. Neurosci. 15 (2014), 84–97.
229. Wang, N., Sugama, S., Conti, B., Teramoto, A., Shibasaki, T., Interleukin-18 mRNA expression in the rat pituitary gland. J. Neuroimmunol. 173 (2006), 117–125.
230. Wang, L., Wang, W., Zhang, L., Dai, P., Wang, K., Hui, H., Rao, W., Peng, C., Yang, J., Yan, Z., Fei, Z., Oxygen-glucose deprivation inducing B1 RNA inhibits neuronal cells metabolic activity by NLRP3 and associated proinflammatory cytokines production. Neurosci. Lett. 588 (2015), 147–153.
231. Wang, Y., Xu, Y., Sheng, H., Ni, X., Lu, J., Exercise amelioration of depressive-like behavior in OVX mice is associated with suppression of NLRP3 inflammasome activation in hippocampus. Brain Behav. Res. 307 (2016), 18–24.
232. Weber, M.D., Godbout, J.P., Sheridan, J.F., Repeated social defeat, neuroinflammation, and behavior: monocytes carry the signal. Neuropsychopharmacology 42 (2017), 46–61.
233. Wen, H., Miao, E.A., Ting, J.P., Mechanisms of NOD-like receptor-associated inflammasome activation. Immunity 39 (2013), 432–441.
234. Wheeler, R.D., Culhane, A.C., Hall, M.D., Pickering-Brown, S., Rothwell, N.J., Luheshi, G.N., Detection of the interleukin 18 family in rat brain by RT-PCR. Brain Res. Mol. Brain Res. 77 (2000), 290–293.
235. Wilson, E.H., Weninger, W., Hunter, C.A., Trafficking of immune cells in the central nervous system. J. Clin. Invest. 120 (2010), 1368–1379.
236. Wohleb, E.S., Hanke, M.L., Corona, A.W., Powell, N.D., Stiner, L.M., Bailey, M.T., Nelson, R.J., Godbout, J.P., Sheridan, J.F., β-Adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat. J. Neurosci. 31 (2011), 6277–6288.
237. Wohleb, E.S., Powell, N.D., Godbout, J.P., Sheridan, J.F., Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior. J. Neurosci. 33 (2013), 13820–13833.
238. Wohleb, E.S., McKim, D.B., Sheridan, J.F., Godbout, J.P., Monocyte trafficking to the brain with stress and inflammation: a novel axis of immune-to-brain communication that influences mood and behavior. Front. Neurosci. 8 (2015), 447–464.
239. Wohleb, E.S., Franklin, T., Iwata, M., Duman, R.S., Integrating neuroimmune systems in the neurobiology of depression. Nat. Rev. Neurosci. 17 (2016), 497–511.
240. Wu, T.Y., Liu, L., Zhang, Y., Liu, Y.Z., Shen, X.L., Gong, H., Yang, Y.Y., Bi, X.Y., Jiang, C.L., Wang, Y.X., High-mobility group box 1 was released actively and involved in LPS induced depressive-like behavior. J. Psychiatry Res. 64 (2015), 99–106.
241. Xu, Y., Sheng, H., Bao, Q., Wang, Y., Lu, J., Ni, X., NLRP3 inflammasome activation mediates estrogen deficiency-induced depression- and anxiety-like behavior and hippocampal inflammation in mice. Brain Behav. Immun. 56 (2016), 175–186.
242. Xue, J., Li, H., Deng, X., Ma, Z., Fu, Q., Ma, S., L-Menthone confers antidepressant-like effects in an unpredictable chronic mild stress mouse model via NLRP3 inflammasome-mediated inflammatory cytokines and central neurotransmitters. Pharmacol. Biochem. Behav. 134 (2015), 42–48.
243. Yamanaka, R., Yajima, N., Tsuchiya, N., Honma, J., Tanaka, R., Ramsey, J., Blaese, M., Xanthopoulos, K.G., Administration of interleukin-12 and -18 enhancing the antitumor immunity of genetically modified dendritic cells that had been pulsed with Semliki forest virus-mediated tumor complementary DNA. J. Neurosurg. 97 (2002), 1184–1190.
244. Yanik, M., Erel, O., Kati, M., The relationship between potency of oxidative stress and severity of depression. Acta Neuropsychiatr. 16 (2004), 200–203.
245. Yirmiya, R., Rimmerman, N., Reshef, R., Depression as a microglial disease. Trends Neurosci. 38 (2015), 637–658.
246. Youm, Y.H., Nguyen, K.Y., Grant, R.W., Goldberg, E.L., Bodogai, M., Kim, D., D'Agostino, D., Planavsky, N., Lupfer, C., Kanneganti, T.D., Kang, S., Horvath, T.L., Fahmy, T.M., Crawford, P.A., Biragyn, A., Alnemru, E., Dixit, V.D., The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat. Med. 21 (2015), 263–269.
247. Yu, Y.W., Chen, T.J., Hong, C.J., Chen, H.M.S.J, Association study of the interleukin-1 beta (C-511T) genetic polymorphism with major depressive disorder, associated symptomatology, and antidepressant response. Neuropsychopharmacology 28 (2003), 1182–1185.
248. Zendedel, A., Johann, S., Mehrabi, S., Joghataei, M.T., Hassanzadeh, G., Kipp, M., Beyer, C., Activation and regulation of NLRP3 inflammasome by intrathecal application of SDF-1a in a spinal cord injury model. Mol. Neurobiol. 53 (2016), 3063–3075.
249. Zhang, W., Zhang, X.A., A novel urinary metabolite signature for non-invasive post-stroke depression diagnosis. Cell Biochem. Biophys. 72 (2015), 661–667.
250. Zhang, Y., Chen, K., Sloan, S.A., Bennett, M.L., Scholze, A.R., O'Keeffe, S., Phatnani, H.P., Guarnieri, P., Caneda, C., Ruderisch, N., Deng, S., Liddelow, S.A., Zhang, C., Daneman, R., Maniatis, T., Barres, B.A., Wu, J.Q., An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J. Neurosci. 34 (2014), 11929–11947.
251. Zhang, Y., Liu, L., Peng, Y.L., Liu, Y.Z., Wu, T.Y., Shen, X.L., Zhou, J.R., Sun, D.Y., Huang, A.J., Wang, X., Wang, Y.X., Jiang, C.L., Involvement of inflammasome activation in lipopolysaccharide-induced mice depressive-like behaviors. CNS Neurosci. Ther. 20 (2014), 119–124.
252. Zhang, Y., Liu, L., Liu, Y.Z., Shen, X.L., Wu, T.Y., Zhang, T., Wang, W., Wang, Y.X., Jiang, C.L., NLRP3 inflammasome mediates chronic mild stress-induced depression in mice via neuroinflammation. Int. J. Neuropsychopharmacol., 18, 2015, Pyv006.
253. Zheng, P., Zeng, B., Zhou, C., Liu, M., Fang, Z., Xu, X., Zeng, L., Chen, J., Fan, S., Du, X., Zhang, X., Yang, D., Yang, Y., Meng, H., Li, W., Melgiri, N.D., Licinio, J., Wei, H., Xie, P., Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host's metabolism. Mol. Psychiatry 21 (2016), 786–796.
254. Zhou, R., Tardivel, A., Thorens, B., Choi, I., Tschopp, J., Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat. Immunol. 11 (2010), 136–140.
255. Zhou, J., Ping, F.F., Lv, W.T., Feng, J.Y., Shang, J., Interleukin-18 directly protects neurons by activating PI3K/AKT/NF-κβ/CREB pathways. Cytokine 69 (2014), 29–38.