Iptakalim confers an antidepressant effect in a chronic mild stress model of depression through regulating neuro-inflammation and neurogenesis

International Journal of Neuropsychopharmacology

Volumn 17, Issue 9, 2014, Pages 1501-1510

  Lu, Ming ^a   Yang, Jing Zhe ^a   Geng, Fan ^a   Ding, Jian Hua ^a   Hu, Gang ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Chronic mild stress; hippocampal neurogenesis; Iptakalim; major depression; neuro inflammation

Indexed keywords

CORTICOSTERONE; CRYOPYRIN; FLUOXETINE; INFLAMMASOME; INSULIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; IPTAKALIM; NOD LIKE RECEPTOR PROTEIN 3; SUCROSE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIDEPRESSANT AGENT; BROXURIDINE; CYTOKINE; N-(1-METHYLETHYL)-1,1,2-TRIMETHYLPROPYLAMINE; PROPYLAMINE; SWEETENING AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDEPRESSANT ACTIVITY; ARTICLE; BEHAVIOR CHANGE; BODY WEIGHT; BRAIN TISSUE; CELL DIFFERENTIATION; CELL PROLIFERATION; CHRONIC MILD STRESS; CHRONIC STRESS; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DENTATE GYRUS; DEPRESSION; DISEASE COURSE; FORCED SWIM TEST; HIPPOCAMPUS; MALE; MICROGLIA; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NERVOUS SYSTEM INFLAMMATION; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SUCROSE PREFERENCE TEST; TAIL SUSPENSION TEST; UPREGULATION; WESTERN BLOTTING; ANIMAL; BLOOD; C57BL MOUSE; CATALEPSY; CELL COUNT; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; FOOD PREFERENCE; GENETICS; IMMOBILIZATION; MENTAL STRESS; METABOLISM; PATHOLOGY; PSYCHOLOGY; SWIMMING;

ANIMALS; ANTIDEPRESSIVE AGENTS; BODY WEIGHT; BROMODEOXYURIDINE; CELL COUNT; CORTICOSTERONE; CYTOKINES; DEPRESSION; DISEASE MODELS, ANIMAL; FOOD PREFERENCES; FREEZING REACTION, CATALEPTIC; HINDLIMB SUSPENSION; HIPPOCAMPUS; MALE; MICE; MICE, INBRED C57BL; NEUROGENESIS; PROPYLAMINES; STRESS, PSYCHOLOGICAL; SWEETENING AGENTS; SWIMMING;

EID: 84904877341     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1017/S1461145714000285     Document Type: Article

References (33)

1. Baudry A, Mouillet-Richard S, Schneider B, Launay JM, Kellermann O (2010) miR-16 targets the serotonin transporter: a new facet for adaptive responses to antidepressants. Science 329:1537-1541.
2. Baune BT, Dannlowski U, Domschke K, Janssen DG, Jordan MA, Ohrmann P, Bauer J, Biros E, Arolt V, Kugel H, Baxter AG, Suslow T (2010) The interleukin 1 beta (IL1B) gene is associated with failure to achieve remission and impaired emotion processing in major depression. Biol Psychiatry 67:543-549.
3. Cassano P, Fava M (2004) Tolerability issues during long-term treatment with antidepressants. Ann Clin Psychiatry 16:15-25.
4. Dandona P, Aljada A, Bandyopadhyay A (2004) Inflammation: the link between insulin resistance, obesity and diabetes. Trends Immunol 25:4-7.
5. Deng W, Aimone JB, Gage FH (2010) New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? Nat Rev Neurosci 11:339-350.
6. Dunbar JA, Reddy P, Davis-Lameloise N, Philpot B, Laatikainen T, Kilkkinen A, Bunker SJ, Best JD, Vartiainen E, Kai Lo S, Janus ED (2008) Depression: an important comorbidity with metabolic syndrome in a general population. Diabetes Care 31:2368-2373.
7. Dutta S, Singh G, Sreejith S, Mamidi MK, Husin JM, Datta I, Pal R, Das AK (2013) Cell therapy: the final frontier for treatment of neurological diseases. CNS Neurosci Therap 19:5-11.
8. Ekdahl CT, Kokaia Z, Lindvall O (2009) Brain inflammation and adult neurogenesis: the dual role of microglia. Neuroscience 158:1021-1029.
9. Gelfo F, Tirassa P, De Bartolo P, Croce N, Bernardini S, Caltagirone C, Petrosini L, Angelucci F (2012) NPY intraperitoneal injections produce antidepressant-like effects and downregulate BDNF in the rat hypothalamus. CNS Neurosci Therap 18:487-492.
10. Goshen I, Yirmiya R (2009) Interleukin-1 (IL-1): a central regulator of stress responses. Front Neuroendocrinol 30:30-45.
11. Hu YS, Long N, Pigino G, Brady ST, Lazarov O (2013) Molecular mechanisms of environmental enrichment: impairments in Akt/GSK3beta, neurotrophin-3 and CREB signaling. PloS ONE 8:e64460.
12. Hurtado-Chong A, Yusta-Boyo MJ, Vergano-Vera E, Bulfone A, de Pablo F, Vicario-Abejon C (2009) IGF-I promotes neuronal migration and positioning in the olfactory bulb and the exit of neuroblasts from the subventricular zone. Eur J Neurosci 30:742-755.
13. Hwang J, Zheng LT, Ock J, Lee MG, Kim SH, Lee HW, Lee WH, Park HC, Suk K (2008) Inhibition of glial inflammatory activation and neurotoxicity by tricyclic antidepressants. Neuropharmacology 55:826-834.
14. Kheirbek MA, Klemenhagen KC, Sahay A, Hen R (2012) Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders. Nat Neurosci 15:1613-1620.
15. Kong H, Sha LL, Fan Y, Xiao M, Ding JH, Wu J, Hu G (2009) Requirement of AQP4 for antidepressive efficiency of fluoxetine: implication in adult hippocampal neurogenesis. Neuropsychopharmacology 34:1263-1276.
16. Kuzumaki N, Ikegami D, Imai S, Narita M, Tamura R, Yajima M, Suzuki A, Miyashita K, Niikura K, Takeshima H, Ando T, Ushijima T, Suzuki T (2010) Enhanced IL-1beta production in response to the activation of hippocampal glial cells impairs neurogenesis in aged mice. Synapse 64:721-728.
17. Lu XY, Kim CS, Frazer A, Zhang W (2006) Leptin: a potential novel antidepressant. Proc Natl Acad Sci U S A 103:1593-1598.
18. Masi G, Brovedani P (2011) The hippocampus, neurotrophic factors and depression: possible implications for the pharmacotherapy of depression. CNS Drugs 25:913-931.
19. McElroy SL, Kotwal R, Malhotra S, Nelson EB, Keck PE, Nemeroff CB (2004) Are mood disorders and obesity related? A review for the mental health professional. J Clin Psychiatry 65:634-651, quiz 730.
20. Ming GL, Song H (2011) Adult neurogenesis in the mammalian brain: significant answers and significant questions. Neuron 70:687-702.
21. Nichols CG (2006) KATP channels as molecular sensors of cellular metabolism. Nature 440:470-476.
22. Ogura Y, Sutterwala FS, Flavell RA (2006) The inflammasome: first line of the immune response to cell stress. Cell 126:659-662.
23. Sahay A, Hen R (2007) Adult hippocampal neurogenesis in depression. Nat Neurosci 10:1110-1115.
24. Saxe MD, Malleret G, Vronskaya S, Mendez I, Garcia AD, Sofroniew MV, Kandel ER, Hen R (2007) Paradoxical influence of hippocampal neurogenesis on working memory. Proc Natl Acad Sci U S A 104:4642-4646.
25. Schroder K, Tschopp J (2010) The inflammasomes. Cell 140:821-832.
26. Schroder K, Zhou R, Tschopp J (2010) The NLRP3 inflammasome: a sensor for metabolic danger? Science 327:296-300.
27. Serafini G, Pompili M, Hansen KF, Obrietan K, Dwivedi Y, Shomron N, Girardi P (2014) The involvement of MicroRNAs in major depression, suicidal behavior, and related disorders: a focus on miR-185 and miR-491-3p. Cell Mol Neurobiol 34:17-30.
28. Snyder JS, Soumier A, Brewer M, Pickel J, Cameron HA (2011) Adult hippocampal neurogenesis buffers stress responses and depressive behaviour. Nature 476:458-461.
29. Soskin DP, Carl JR, Alpert J, Fava M (2012) Antidepressant effects on emotional temperament: toward a biobehavioral research paradigm for major depressive disorder. CNS Neurosci Therap 18:441-451.
30. Yang JZ, Huang X, Zhao FF, Xu Q, Hu G (2012) Iptakalim enhances adult mouse hippocampal neurogenesis via opening Kir6.1-composed K-ATP channels expressed in neural stem cells. CNS Neurosci Therap 18:737-744.
31. Zhang Y, Liu L, Peng YL, Liu YZ, Wu TY, Shen XL, Zhou JR, Sun DY, Huang AJ, Wang X, Wang YX, Jiang CL (2014) Involvement of inflammasome activation in lipopolysaccharide-induced mice depressive-like behaviors. CNS Neurosci Therap 20:119-124.
32. Zhou F, Wu JY, Sun XL, Yao HH, Ding JH, Hu G (2007) Iptakalim alleviates rotenone-induced degeneration of dopaminergic neurons through inhibiting microglia-mediated neuroinflammation. Neuropsychopharmacology 32:2570-2580.
33. Zingman LV, Hodgson DM, Bast PH, Kane GC, Perez-Terzic C, Gumina RJ, Pucar D, Bienengraeber M, Dzeja PP, Miki T, Seino S, Alekseev AE, Terzic A (2002) Kir6.2 is required for adaptation to stress. Proc Natl Acad Sci U S A 99:13278-13283.