Inflammasome induction in Rasmussen's encephalitis: Cortical and associated white matter pathogenesis

Journal of Neuroinflammation

Volumn 10, Issue , 2013, Pages

  Ramaswamy, Vijay ^a,b   Walsh, John G ^a   Sinclair, D B ^a   Johnson, Edward ^a   Tang Wai, Richard ^a   Wheatley, B M ^a   Branton, William ^a   Maingat, Ferdinand ^a   Snyder, Thomas ^a   Gross, Donald W ^a   Power, Christopher ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Inflammasome; Innate immunity; Rasmussen's encephalitis; White matter

Indexed keywords

ALANINE; CASPASE INHIBITOR; CD3 ANTIGEN; CRYOPYRIN; CYCLOPHOSPHAMIDE; CYSTEINE; GLUCOCORTICOID; HLA DR ANTIGEN; IMMUNOGLOBULIN; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; METHOTREXATE; NLRP1 PROTEIN; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; SERINE; TACROLIMUS; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADOLESCENT; ARTICLE; ASTROCYTE; BONE MARROW CELL; BRAIN CORTEX; BRAIN CORTEX LESION; BRAIN TISSUE; CASE REPORT; CELL CULTURE; CELL INFILTRATION; CHILD; COGNITIVE DEFECT; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GLIOSIS; HEMISPHERECTOMY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOREACTIVITY; MALE; MICROGLIA; MONONUCLEAR CELL; NERVE CELL; NERVOUS SYSTEM INFLAMMATION; NEUROIMAGING; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOGENESIS; PRESCHOOL CHILD; PROTEIN EXPRESSION; RASMUSSEN SYNDROME; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHOOL CHILD; WESTERN BLOTTING; WHITE MATTER;

ADOLESCENT; BLOTTING, WESTERN; BRAIN; CHILD; CHILD, PRESCHOOL; ENCEPHALITIS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INFLAMMASOMES; MALE; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84889971629     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-10-152     Document Type: Article

References (29)

1. Andermann F, Farrell K. Early onset Rasmussen's syndrome: a malignant, often bilateral form of the disorder. Epilepsy Res 2006, 70(Suppl 1):S259-S262.
2. Rasmussen T, Olszewski J, Lloydsmith D. Focal seizures due to chronic localized encephalitis. Neurology 1958, 8:435-445. 10.1212/WNL.8.6.435, 13566382.
3. Freeman JM. Rasmussen's syndrome: progressive autoimmune multi-focal encephalopathy. Pediatr Neurol 2005, 32:295-299. 10.1016/j.pediatrneurol.2004.12.002, 15866428.
4. Bien CG. Pathogenesis, diagnosis and treatment of Rasmussen encephalitis: A European consensus statement. Brain 2005, 128:454-471. 10.1093/brain/awh415, 15689357.
5. Counce D, Limdi N, Kuzniecky R. Rasmussen's Encephalitis. Curr Treat Options Neurol 2001, 3:555-563. 10.1007/s11940-001-0018-5, 11581532.
6. Hart Y. Rasmussen's encephalitis. Epileptic Disord 2004, 6:133-144.
7. Ramaswamy V, Sinclair DB, Wheatley BM, Richer L, Snyder T. Epilepsiapartialis continua: acute disseminated encephalomyelitis or Rasmussen's encephalitis?. Pediatr Neurol 2005, 32:341-345. 10.1016/j.pediatrneurol.2005.01.001, 15866435.
8. Bien CG, Bauer J, Deckwerth TL, Wiendl H, Deckert M, Wiestler OD, Schramm J, Elger CE, Lassmann H. Destruction of neurons by cytotoxic T cells: A new pathogenic mechanism in rasmussen's encephalitis. Ann Neurol 2002, 51:311-318. 10.1002/ana.10100, 11891826.
9. Power C, Poland SD, Blume WT, Girvin JP, Rice GP. Cytomegalovirus and Rasmussen's encephalitis. Lancet 1990, 336:1282-1284. 10.1016/0140-6736(90)92965-K, 1978116.
10. Pardo CA, Vining EP, Guo L, Skolasky RL, Carson BS, Freeman JM. The pathology of Rasmussen syndrome: stages of cortical involvement and neuropathological studies in 45 hemispherectomies. Epilepsia 2004, 45:516-526. 10.1111/j.0013-9580.2004.33103.x, 15101833.
11. Hanamsagar R, Hanke ML, Kielian T. Toll-like receptor (TLR) and inflammasome actions in the central nervous system. Trends Immunol 2012, 33:333-342. 10.1016/j.it.2012.03.001, 3383346, 22521509.
12. Rathinam VA, Vanaja SK, Fitzgerald KA. Regulation of inflammasome signaling. Nat Immunol 2012, 13:333-332. 10.1038/ni.2237, 3523703, 22430786.
13. Gris D, Ye Z, Iocca HA, Wen H, Craven RR, Gris P, Huang M, Schneider M, Miller SD, Ting JP. NLRP3 plays a critical role in the development of experimental autoimmune encephalomyelitis by mediating Th1 and Th17 responses. J Immunol 2010, 185:974-981. 10.4049/jimmunol.0904145, 3593010, 20574004.
14. Hoegen T, Tremel N, Klein M, Angele B, Wagner H, Kirschning C, Pfister HW, Fontana A, Hammerschmidt S, Koedel U. The NLRP3 inflammasome contributes to brain injury in pneumococcal meningitis and is activated through ATP-dependent lysosomalcathepsin B release. J Immunol 2011, 187:5440-5451. 10.4049/jimmunol.1100790, 22003197.
15. Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng TC, Gelpi E, Halle A, Korte M, Latz E, Golenbock DT. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature 2013, 493:674-678. 3812809, 23254930.
16. Sinclair DB, Aronyk KE, Snyder TJ, Wheatley BM, McKean JD, Bhargava R, Hoskinson M, Hao C, Colmers WF, Berg M, Mak W. Pediatric epilepsy surgery at the University of Alberta: 1988-2000. Pediatr Neurol 2003, 29:302-311. 10.1016/S0887-8994(03)00307-2, 14643392.
17. Ellestad KK, Tsutsui S, Noorbakhsh F, Warren KG, Yong VW, Pittman QJ, Power C. Early life exposure to lipopolysaccharide suppresses experimental autoimmune encephalomyelitis by promoting tolerogenic dendritic cells and regulatory T cells. J Immunol 2009, 183:298-309. 10.4049/jimmunol.0803576, 19542441.
18. Power C, Kong PA, Crawford TO, Wesselingh S, Glass JD, McArthur JC, Trapp BD. Cerebral white matter changes in acquired immunodeficiency syndrome dementia: alterations of the blood-brain barrier. Ann Neurol 1993, 34:339-350. 10.1002/ana.410340307, 7689819.
19. Zhu Y, Vergote D, Pardo C, Noorbakhsh F, McArthur JC, Hollenberg MD, Overall CM, Power C. CXCR3 activation by lentivirus infection suppresses neuronal autophagy: neuroprotective effects of antiretroviral therapy. FASEB J 2009, 23:2928-2941. 10.1096/fj.08-128819, 2796902, 19380511.
20. Na H, Acharjee S, Jones G, Vivithanaporn P, Noorbakhsh F, McFarlane N, Maingat F, Ballanyi K, Pardo CA, Cohen EA, Power C. Interactions between human immunodeficiency virus (HIV)-1 Vpr expression and innate immunity influence neurovirulence. Retrovirology 2011, 8:44. 10.1186/1742-4690-8-44, 3123635, 21645334.
21. Polyak MJ, Vivithanaporn P, Maingat FG, Walsh JG, Branton W, Cohen EA, Meeker R, Power C. Differential type 1 interferon-regulated gene expression in the brain during AIDS: interactions with viral diversity and neurovirulence. FASEB J 2013, 27:2829-2844. 10.1096/fj.13-227868, 23608145.
22. Prayson RA, Frater JL. Rasmussen encephalitis: a clinicopathologic and immunohistochemical study of seven patients. Am J Clin Pathol 2002, 117:776-782. 10.1309/AD8R-560C-4V11-C5E2, 12090428.
23. Schwab N, Bien CG, Waschbisch A, Becker A, Vince GH, Dornmair K, Wiendl H. CD8+ T-cell clones dominate brain infiltrates in Rasmussen encephalitis and persist in the periphery. Brain 2009, 132:1236-1246. 10.1093/brain/awp003, 19179379.
24. Bauer J, Elger CE, Hans VH, Schramm J, Urbach H, Lassmann H, Bien CG. Astrocytes are a specific immunological target in Rasmussen's encephalitis. Ann Neurol 2007, 62:67-80. 10.1002/ana.21148, 17503512.
25. Cendes F, Andermann F, Silver K, Arnold DL. Imaging of axonal damage in vivo in Rasmussen's syndrome. Brain 1995, 118(Pt 3):753-758.
26. Aukema EJ, Caan MW, Oudhuis N, Majoie CB, Vos FM, Reneman L, Last BF, Grootenhuis MA, Schouten-van Meeteren AY. White matter fractional anisotropy correlates with speed of processing and motor speed in young childhood cancer survivors. Int J Radiat Oncol Biol Phys 2009, 74:837-843. 10.1016/j.ijrobp.2008.08.060, 19117694.
27. Patrick MK, Johnston JB, Power C. Lentiviral neuropathogenesis: comparative neuroinvasion, neurotropism, neurovirulence, and host neurosusceptibility. J Virol 2002, 76:7923-7931. 10.1128/JVI.76.16.7923-7931.2002, 155171, 12133996.
28. Deroide N, Li X, Lerouet D, Van Vré E, Baker L, Harrison J, Poittevin M, Masters L, Nih L, Margaill I, Iwakura Y, Ryffel B, Pocard M, Tedgui A, Kubis N, Mallat Z. MFGE8 inhibits inflammasome-induced IL-1beta production and limits postischemic cerebral injury. J Clin Invest 2013, 123:1176-1181. 10.1172/JCI65167, 3582131, 23454767.
29. Coll RC, ONeill LA. The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomes. PLoS One 2011, 6:e29539. 10.1371/journal.pone.0029539, 3245271, 22216309.