Biological activity and brain actions of recombinant rat interleukin-1α and interleukin-1β

European Cytokine Network

Volumn 9, Issue 3, 1998, Pages 279-288

  Anforth, Helen R ^a   Bluthe, Rose Marie ^b   Bristow, Adrian ^c   Hopkins, Steve ^a   Lenczowski, Marik J P ^d   Luheshi, Giamal ^a   Lundkvist, Johan ^e   Michaud, Bruno ^b   Mistry, Yogesh ^c   Van Dam, Anne Marie ^d   Zhen, Chai ^e   Dantzer, Robert ^b   Poole, Steeve ^c   Rothwell, Nancy J ^a   Tilders, Fred J H ^d   Wollman, Emmanuelle E ^b,f  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b INSERM   (France)

^c NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

^d VU UNIVERSITY AMSTERDAM   (Netherlands)

^e STOCKHOLM UNIVERSITY   (Sweden)

^f INSERM U 477 ^*  (France)

Author keywords

ACTH; Behaviour; Binding affinity; Corticosterone; Fever; IL 1 ; IL 1 ; Rat; TNF

Indexed keywords

CORTICOSTERONE; CORTICOTROPIN; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BLOOD LEVEL; BODY TEMPERATURE; BRAIN; CELL LINE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DRUG ACTIVITY; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INSULINOMA; INTRACEREBRAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; RAT; SOCIAL BEHAVIOR; SPECIES DIFFERENCE;

ANIMALS; BODY TEMPERATURE; BRAIN; CEREBRAL VENTRICLES; CLONING, MOLECULAR; ESCHERICHIA COLI; EXPLORATORY BEHAVIOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INJECTIONS, INTRAVENTRICULAR; INSULINOMA; INTERLEUKIN-1; MALE; MICE; PANCREATIC NEOPLASMS; PITUITARY-ADRENAL SYSTEM; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, INTERLEUKIN-1; RECOMBINANT PROTEINS; SOCIAL BEHAVIOR; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 7844225147     PISSN: 11485493     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Dinarello C A. 1996. Biologic basis for interleukin-1 in disease. (Review) Blood 87: 2095.
2. Hopkins S J, Rothwell N J. 1995. Cytokines and the nervous system I: expression and recognition. Trends Neurosci. 18: 83.
3. Rothwell N J, Hopkins S J. 1995. Cytokines and the nervous system II: Actions and mechanisms of action. Trends Neurosci. 18: 130.
4. Hart B L. 1988. Biological basis of the behavior of sick animals. Neurosci. Biobehav. Rev. 12: 123.
5. Dantzer R, Kelley K W. 1989. Stress and immunity: an integrated view of relationships between the brain and the immune system. Life Sci. 44: 1995.
6. Kent S, Bluthé R M, Dantzer R, Hardwick A J, Kelley K W, Rothwell N J, Vannice J L. 1992. Different receptor mechanisms mediate the pyrogenic and behavioral effects of interleukin-1. Proc. Natl. Acad Sci. USA 89: 9117.
7. Reddi K, Poole S, Nair S, Meghji S, Henderson B, Wilson M. 1995. Lipid A-associated proteins from periodontopathogenic bacteria induce interleukin-6 production by human gingival fibroblasts and monocytes. FEMS Immunol. Med. Microbiol. 11: 137.
8. Safieh-Garabedian B, Poole S, Allchorne A, Winter J, Woolf C J. 1995. Contribution of interleukin-1β to the inflammation-induced increase in nerve-growth factor levels and inflammatory hyperalgesia. Br. J. Pharmacol. 115: 1265.
9. Bristulf J, Gatti S, Malinowsky D, Bjork L, Sundgren A K, Bartfai T. 1994. Interleukin-1 stimulation of the expression of type I and type II interleukin-1 receptors in the rat insulinoma cell line Rinm5F; sequencing a rat type II interleukin-1 receptor cDNA. Eur. Cytokine Netw. 5:319.
10. Lenczowski M P J, Van Dam A M, Poole S, Larrick J W, Tilders F J. 1997. Role of circulating endotoxin and IL-6 in the ACTH and corticosterone response to intraperitoneal LPS. Am. J. Physiol. 273: R1870.
11. Bluthé R M, Parnet P, Dantzer R, Kelley K W. 1991. Interleukin-1 receptor antagonist blocks effects of IL-1α and IL-1β on social behaviour and body weight in mice. Neurosci. Res. Commun. 15: 151.
12. Schotanus K, Tilders F J, Berkenbosch F. 1993. Human recombinant IL-1 receptor antagonist prevents adrenocorticotropin but not IL-6 responses to bacterial endotoxin in rats. Endocrinology 133: 2461.
13. Schotanus K, Holtkamp G M, Meloen R H, Puij W C, Berkenbosch F, Tilders F J. 1995. Domains of rat interleukin-1β involved in type I receptor binding. Endocrinology 136: 332.
14. Rothwell N J, Dantzer R, eds. 1992. Interleukin-1 in the Brain. Oxford: Pergamon.
15. Sims J E, Giri J G, Dower S K. 1994. The two interleukin-1 receptors play different roles in IL-1 actions. Clin. Immunol. Immunopathol. 72: 9.
16. Busbridge N J, Dascombe M J, Tilders F J, van Oerst J W A M, Linton E A, Rothwell N J. 1989. Central activation of thermogenesis and fever by interleukin-1β and interleukin-1α involves different mechanisms. Biochem. Biophys. Res. Comm. 162: 591.
17. Kluger M J, Leon L R, Kozak W, Soszynski D, Conn C A. 1996. Cytokine actions on fever. In: Rothwell N J, ed. Cytokines in the Nervous System. Austin: Landes, 73.
18. Besedovsky H O, del Rey A. 1996. Immune-neuro-endocrine interactions: facts and hypotheses. (Review) Endocr. Rev. 17: 64.
19. Uehara A, Gottschall P E, Dahl R K, Arimura A. 1988. Stimulation of ACTH release by human interleukin-1beta, but not by interleukin-1alpha, in conscious, freely moving rats. Biochem. Biophys. Res. Commun. 146: 1286.
20. Dantzer R, Bluthé R M, Aubert A, Goodall G, Bret-Dibat J L, Kent S, Goujon E, Lavé S, Parnet P, Kelley K W. 1996. Cytokine actions on behavior. In: Rothwell N J, ed. Cytokines in the Nervous System. Austin: Landes, 117.
21. Van der Meer M J, Sweep C G, Rijnkels C E, Pesman G J, Tilders F J, Kloppenborg P W, Hermus A R. 1996. Acute stimulation of the pituitary-adrenal axis by IL-1β, TNF-α and IL-6: a dose-response study. J. Endocrinol. Invest. 19: 175.
22. Rothwell N J. 1989. CRF is involved in the pyrogenic and thermogenic effects of interleukin-1β in the rat. Am. J. Physiol. 256: E111.
23. Bluthé R M, Dantzer R, Kelley K W. 1989. Corticotropin releasing hormone is not involved in the behavioral effects of peripherally injected interleukin-1 in the rat. Neurosci. Res. Commun. 5: 149.