메뉴 건너뛰기




Volumn 82, Issue , 2016, Pages 109-118

Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat

Author keywords

Brain gut axis; Depression; Gut microbiota; Inflammation; Intestinal barrier; Tryptophan

Indexed keywords

C REACTIVE PROTEIN; CYTOKINE; HYDROCORTISONE; KYNURENINE; LIPOPOLYSACCHARIDE BINDING PROTEIN; RNA 16S; TRYPTOPHAN; CORTICOSTERONE; LIPOPOLYSACCHARIDE;

EID: 84979955472     PISSN: 00223956     EISSN: 18791379     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2016.07.019     Document Type: Article
Times cited : (1123)

References (66)
  • 1
    • 84890080017 scopus 로고    scopus 로고
    • Biological and psychological markers of stress in humans: focus on the trier social stress test
    • Allen, A.P., Kennedy, P.J., Cryan, J.F., Dinan, T.G., Clarke, G., Biological and psychological markers of stress in humans: focus on the trier social stress test. Neurosci. Biobehav. Rev. 38 (2014), 94–124.
    • (2014) Neurosci. Biobehav. Rev. , vol.38 , pp. 94-124
    • Allen, A.P.1    Kennedy, P.J.2    Cryan, J.F.3    Dinan, T.G.4    Clarke, G.5
  • 2
    • 84969504890 scopus 로고    scopus 로고
    • Human microbiota-associated mice: a model with challenges
    • Arrieta, M.C., Walter, J., Finlay, B.B., Human microbiota-associated mice: a model with challenges. Cell Host Microbe 19:5 (2016), 575–578.
    • (2016) Cell Host Microbe , vol.19 , Issue.5 , pp. 575-578
    • Arrieta, M.C.1    Walter, J.2    Finlay, B.B.3
  • 3
    • 0026100906 scopus 로고
    • Effects of acute paroxetine administration on tryptophan metabolism and disposition in the rat
    • Badawy, A.A., Morgan, C.J., Effects of acute paroxetine administration on tryptophan metabolism and disposition in the rat. Br. J. Pharmacol. 102:2 (1991), 429–433.
    • (1991) Br. J. Pharmacol. , vol.102 , Issue.2 , pp. 429-433
    • Badawy, A.A.1    Morgan, C.J.2
  • 4
    • 0025814863 scopus 로고
    • The effects of lofepramine and desmethylimipramine on tryptophan metabolism and disposition in the rat
    • Badawy, A.A., Morgan, C.J., Dacey, A., Stoppard, T., The effects of lofepramine and desmethylimipramine on tryptophan metabolism and disposition in the rat. Biochem. Pharmacol. 42:4 (1991), 921–929.
    • (1991) Biochem. Pharmacol. , vol.42 , Issue.4 , pp. 921-929
    • Badawy, A.A.1    Morgan, C.J.2    Dacey, A.3    Stoppard, T.4
  • 5
    • 79551681952 scopus 로고    scopus 로고
    • Exposure to a social stressor alters the structure of the intestinal microbiota: implications for stressor-induced immunomodulation
    • Bailey, M.T., Dowd, S.E., Galley, J.D., Hufnagle, A.R., Allen, R.G., Lyte, M., Exposure to a social stressor alters the structure of the intestinal microbiota: implications for stressor-induced immunomodulation. Brain, Behav. Immun. 25:3 (2011), 397–407.
    • (2011) Brain, Behav. Immun. , vol.25 , Issue.3 , pp. 397-407
    • Bailey, M.T.1    Dowd, S.E.2    Galley, J.D.3    Hufnagle, A.R.4    Allen, R.G.5    Lyte, M.6
  • 7
    • 31444441701 scopus 로고    scopus 로고
    • New approaches to antidepressant drug discovery: beyond monoamines
    • Berton, O., Nestler, E.J., New approaches to antidepressant drug discovery: beyond monoamines. Nat. Rev. Neurosci. 7:2 (2006), 137–151.
    • (2006) Nat. Rev. Neurosci. , vol.7 , Issue.2 , pp. 137-151
    • Berton, O.1    Nestler, E.J.2
  • 10
    • 0037411504 scopus 로고    scopus 로고
    • Characterization and functional significance of glucocorticoid receptors in patients with major depression: modulation by antidepressant treatment
    • Calfa, G., Kademian, S., Ceschin, D., Vega, G., Rabinovich, G.A., Volosin, M., Characterization and functional significance of glucocorticoid receptors in patients with major depression: modulation by antidepressant treatment. Psychoneuroendocrinology 28:5 (2003), 687–701.
    • (2003) Psychoneuroendocrinology , vol.28 , Issue.5 , pp. 687-701
    • Calfa, G.1    Kademian, S.2    Ceschin, D.3    Vega, G.4    Rabinovich, G.A.5    Volosin, M.6
  • 11
    • 61849182122 scopus 로고    scopus 로고
    • Tryptophan degradation in irritable bowel syndrome: evidence of indoleamine 2,3-dioxygenase activation in a male cohort
    • Clarke, G., Fitzgerald, P., Cryan, J.F., Cassidy, E.M., Quigley, E.M., Dinan, T.G., Tryptophan degradation in irritable bowel syndrome: evidence of indoleamine 2,3-dioxygenase activation in a male cohort. BMC Gastroenterol., 9, 2009, 6.
    • (2009) BMC Gastroenterol. , vol.9 , pp. 6
    • Clarke, G.1    Fitzgerald, P.2    Cryan, J.F.3    Cassidy, E.M.4    Quigley, E.M.5    Dinan, T.G.6
  • 12
    • 84878241830 scopus 로고    scopus 로고
    • The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner
    • Clarke, G., Grenham, S., Scully, P., Fitzgerald, P., Moloney, R.D., Shanahan, F., Dinan, T.G., Cryan, J.F., The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner. Mol. Psychiatry 18:6 (2013), 666–673.
    • (2013) Mol. Psychiatry , vol.18 , Issue.6 , pp. 666-673
    • Clarke, G.1    Grenham, S.2    Scully, P.3    Fitzgerald, P.4    Moloney, R.D.5    Shanahan, F.6    Dinan, T.G.7    Cryan, J.F.8
  • 13
    • 84866546211 scopus 로고    scopus 로고
    • Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
    • Cryan, J.F., Dinan, T.G., Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat. Rev. Neurosci. 13:10 (2012), 701–712.
    • (2012) Nat. Rev. Neurosci. , vol.13 , Issue.10 , pp. 701-712
    • Cryan, J.F.1    Dinan, T.G.2
  • 14
    • 84940897790 scopus 로고    scopus 로고
    • Gut microbiota: microbiota and neuroimmune signalling-Metchnikoff to microglia
    • Cryan, J.F., Dinan, T.G., Gut microbiota: microbiota and neuroimmune signalling-Metchnikoff to microglia. Nat. Rev. Gastroenterol. Hepatol. 12:9 (2015), 494–496.
    • (2015) Nat. Rev. Gastroenterol. Hepatol. , vol.12 , Issue.9 , pp. 494-496
    • Cryan, J.F.1    Dinan, T.G.2
  • 18
    • 77957142793 scopus 로고    scopus 로고
    • Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression
    • Desbonnet, L., Garrett, L., Clarke, G., Kiely, B., Cryan, J.F., Dinan, T.G., Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression. Neuroscience 170:4 (2010), 1179–1188.
    • (2010) Neuroscience , vol.170 , Issue.4 , pp. 1179-1188
    • Desbonnet, L.1    Garrett, L.2    Clarke, G.3    Kiely, B.4    Cryan, J.F.5    Dinan, T.G.6
  • 19
    • 57749193787 scopus 로고    scopus 로고
    • Inflammatory markers in depression
    • Dinan, T.G., Inflammatory markers in depression. Curr. Opin. Psychiatry 22:1 (2009), 32–36.
    • (2009) Curr. Opin. Psychiatry , vol.22 , Issue.1 , pp. 32-36
    • Dinan, T.G.1
  • 22
    • 43149091691 scopus 로고    scopus 로고
    • Population-based study of first onset and chronicity in major depressive disorder
    • Eaton, W.W., Shao, H., Nestadt, G., Lee, H.B., Bienvenu, O.J., Zandi, P., Population-based study of first onset and chronicity in major depressive disorder. Arch. General Psychiatry 65:5 (2008), 513–520.
    • (2008) Arch. General Psychiatry , vol.65 , Issue.5 , pp. 513-520
    • Eaton, W.W.1    Shao, H.2    Nestadt, G.3    Lee, H.B.4    Bienvenu, O.J.5    Zandi, P.6
  • 24
    • 84875238640 scopus 로고    scopus 로고
    • The microbiota and the gut-brain axis: insights from the temporal and spatial mucosal alterations during colonisation of the germfree mouse intestine
    • El Aidy, S., Kunze, W., Bienenstock, J., Kleerebezem, M., The microbiota and the gut-brain axis: insights from the temporal and spatial mucosal alterations during colonisation of the germfree mouse intestine. Benef. Microbes 3:4 (2012), 251–259.
    • (2012) Benef. Microbes , vol.3 , Issue.4 , pp. 251-259
    • El Aidy, S.1    Kunze, W.2    Bienenstock, J.3    Kleerebezem, M.4
  • 25
    • 0038147546 scopus 로고    scopus 로고
    • Diagnosis and definition of treatment-resistant depression
    • Fava, M., Diagnosis and definition of treatment-resistant depression. Biol. Psychiatry 53:8 (2003), 649–659.
    • (2003) Biol. Psychiatry , vol.53 , Issue.8 , pp. 649-659
    • Fava, M.1
  • 27
    • 0029951769 scopus 로고    scopus 로고
    • Intestinal transit in anxiety and depression
    • Gorard, D.A., Gomborone, J.E., Libby, G.W., Farthing, M.J., Intestinal transit in anxiety and depression. Gut 39:4 (1996), 551–555.
    • (1996) Gut , vol.39 , Issue.4 , pp. 551-555
    • Gorard, D.A.1    Gomborone, J.E.2    Libby, G.W.3    Farthing, M.J.4
  • 28
    • 84931094799 scopus 로고    scopus 로고
    • Depression and subsequent risk of Parkinson disease: a nationwide cohort study
    • Gustafsson, H., Nordstrom, A., Nordstrom, P., Depression and subsequent risk of Parkinson disease: a nationwide cohort study. Neurology 84:24 (2015), 2422–2429.
    • (2015) Neurology , vol.84 , Issue.24 , pp. 2422-2429
    • Gustafsson, H.1    Nordstrom, A.2    Nordstrom, P.3
  • 29
    • 0036185840 scopus 로고    scopus 로고
    • Are anxiety and depression related to gastrointestinal symptoms in the general population?
    • Haug, T.T., Mykletun, A., Dahl, A.A., Are anxiety and depression related to gastrointestinal symptoms in the general population?. Scand. J. Gastroenterology 37:3 (2002), 294–298.
    • (2002) Scand. J. Gastroenterology , vol.37 , Issue.3 , pp. 294-298
    • Haug, T.T.1    Mykletun, A.2    Dahl, A.A.3
  • 32
    • 84905028794 scopus 로고    scopus 로고
    • Association of metabolically healthy obesity with depressive symptoms: pooled analysis of eight studies
    • Jokela, M., Hamer, M., Singh-Manoux, A., Batty, G.D., Kivimaki, M., Association of metabolically healthy obesity with depressive symptoms: pooled analysis of eight studies. Mol. Psychiatry 19:8 (2014), 910–914.
    • (2014) Mol. Psychiatry , vol.19 , Issue.8 , pp. 910-914
    • Jokela, M.1    Hamer, M.2    Singh-Manoux, A.3    Batty, G.D.4    Kivimaki, M.5
  • 33
    • 84908383256 scopus 로고    scopus 로고
    • Review article: intestinal barrier dysfunction and central nervous system disorders–a controversial association
    • Julio-Pieper, M., Bravo, J.A., Aliaga, E., Gotteland, M., Review article: intestinal barrier dysfunction and central nervous system disorders–a controversial association. Aliment. Pharmacol. Ther. 40:10 (2014), 1187–1201.
    • (2014) Aliment. Pharmacol. Ther. , vol.40 , Issue.10 , pp. 1187-1201
    • Julio-Pieper, M.1    Bravo, J.A.2    Aliaga, E.3    Gotteland, M.4
  • 34
    • 84944446673 scopus 로고    scopus 로고
    • Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders
    • Kelly, J.R., Kennedy, P.J., Cryan, J.F., Dinan, T.G., Clarke, G., Hyland, N.P., Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders. Front. Cell. Neurosci., 9, 2015, 392.
    • (2015) Front. Cell. Neurosci. , vol.9 , pp. 392
    • Kelly, J.R.1    Kennedy, P.J.2    Cryan, J.F.3    Dinan, T.G.4    Clarke, G.5    Hyland, N.P.6
  • 35
    • 84962485820 scopus 로고    scopus 로고
    • Brain-gut-microbiota axis: challenges for translation in psychiatry
    • Kelly, J.R., Clarke, G., Cryan, J.F., Dinan, T.G., Brain-gut-microbiota axis: challenges for translation in psychiatry. Ann. Epidemiol 26:5 (2016), 366–372.
    • (2016) Ann. Epidemiol , vol.26 , Issue.5 , pp. 366-372
    • Kelly, J.R.1    Clarke, G.2    Cryan, J.F.3    Dinan, T.G.4
  • 36
    • 84904131824 scopus 로고    scopus 로고
    • Expression of toll-like receptors in peripheral blood mononuclear cells and response to cognitive-behavioral therapy in major depressive disorder
    • Keri, S., Szabo, C., Kelemen, O., Expression of toll-like receptors in peripheral blood mononuclear cells and response to cognitive-behavioral therapy in major depressive disorder. Brain, Behav. Immun. 40 (2014), 235–243.
    • (2014) Brain, Behav. Immun. , vol.40 , pp. 235-243
    • Keri, S.1    Szabo, C.2    Kelemen, O.3
  • 38
    • 84862769027 scopus 로고    scopus 로고
    • New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates–Nrf2 activators and GSK-3 inhibitors
    • Maes, M., Fisar, Z., Medina, M., Scapagnini, G., Nowak, G., Berk, M., New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates–Nrf2 activators and GSK-3 inhibitors. Inflammopharmacology 20:3 (2012), 127–150.
    • (2012) Inflammopharmacology , vol.20 , Issue.3 , pp. 127-150
    • Maes, M.1    Fisar, Z.2    Medina, M.3    Scapagnini, G.4    Nowak, G.5    Berk, M.6
  • 39
    • 42149093127 scopus 로고    scopus 로고
    • The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression
    • Maes, M., Kubera, M., Leunis, J.C., The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression. Neuro Endocrinol. Lett. 29:1 (2008), 117–124.
    • (2008) Neuro Endocrinol. Lett. , vol.29 , Issue.1 , pp. 117-124
    • Maes, M.1    Kubera, M.2    Leunis, J.C.3
  • 40
    • 84875300745 scopus 로고    scopus 로고
    • In depression, bacterial translocation may drive inflammatory responses, oxidative and nitrosative stress (O&NS), and autoimmune responses directed against O&NS-damaged neoepitopes
    • Maes, M., Kubera, M., Leunis, J.C., Berk, M., Geffard, M., Bosmans, E., In depression, bacterial translocation may drive inflammatory responses, oxidative and nitrosative stress (O&NS), and autoimmune responses directed against O&NS-damaged neoepitopes. Acta Psychiatr. Scand. 127:5 (2013), 344–354.
    • (2013) Acta Psychiatr. Scand. , vol.127 , Issue.5 , pp. 344-354
    • Maes, M.1    Kubera, M.2    Leunis, J.C.3    Berk, M.4    Geffard, M.5    Bosmans, E.6
  • 41
    • 79953160733 scopus 로고    scopus 로고
    • Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects
    • Messaoudi, M., Lalonde, R., Violle, N., Javelot, H., Desor, D., Nejdi, A., Bisson, J.F., Rougeot, C., Pichelin, M., Cazaubiel, M., Cazaubiel, J.M., Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. Br. J. Nutr. 105:5 (2011), 755–764.
    • (2011) Br. J. Nutr. , vol.105 , Issue.5 , pp. 755-764
    • Messaoudi, M.1    Lalonde, R.2    Violle, N.3    Javelot, H.4    Desor, D.5    Nejdi, A.6    Bisson, J.F.7    Rougeot, C.8    Pichelin, M.9    Cazaubiel, M.10    Cazaubiel, J.M.11
  • 44
    • 84920404296 scopus 로고    scopus 로고
    • How informative is the mouse for human gut microbiota research?
    • Nguyen, T.L.A., Vieira-Silva, S., Liston, A., Raes, J., How informative is the mouse for human gut microbiota research?. Dis. Models Mech. 8:1 (2015), 1–16.
    • (2015) Dis. Models Mech. , vol.8 , Issue.1 , pp. 1-16
    • Nguyen, T.L.A.1    Vieira-Silva, S.2    Liston, A.3    Raes, J.4
  • 45
    • 65349135346 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice
    • O'Connor, J.C., Lawson, M.A., Andre, C., Moreau, M., Lestage, J., Castanon, N., Kelley, K.W., Dantzer, R., Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice. Mol. Psychiatry 14:5 (2009), 511–522.
    • (2009) Mol. Psychiatry , vol.14 , Issue.5 , pp. 511-522
    • O'Connor, J.C.1    Lawson, M.A.2    Andre, C.3    Moreau, M.4    Lestage, J.5    Castanon, N.6    Kelley, K.W.7    Dantzer, R.8
  • 47
    • 58149291318 scopus 로고    scopus 로고
    • Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses
    • O'Mahony, S.M., Marchesi, J.R., Scully, P., Codling, C., Ceolho, A.-M., Quigley, E.M.M., Cryan, J.F., Dinan, T.G., Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses. Biol. Psychiatry 65:18723164 (2009), 263–267.
    • (2009) Biol. Psychiatry , vol.65 , Issue.18723164 , pp. 263-267
    • O'Mahony, S.M.1    Marchesi, J.R.2    Scully, P.3    Codling, C.4    Ceolho, A.-M.5    Quigley, E.M.M.6    Cryan, J.F.7    Dinan, T.G.8
  • 50
    • 0035280252 scopus 로고    scopus 로고
    • Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
    • Pariante, C.M., Miller, A.H., Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment. Biol. Psychiatry 49:5 (2001), 391–404.
    • (2001) Biol. Psychiatry , vol.49 , Issue.5 , pp. 391-404
    • Pariante, C.M.1    Miller, A.H.2
  • 54
    • 84937636483 scopus 로고    scopus 로고
    • Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers
    • Schmidt, K., Cowen, P.J., Harmer, C.J., Tzortzis, G., Errington, S., Burnet, P.W., Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers. Psychopharmacology 232:10 (2015), 1793–1801.
    • (2015) Psychopharmacology , vol.232 , Issue.10 , pp. 1793-1801
    • Schmidt, K.1    Cowen, P.J.2    Harmer, C.J.3    Tzortzis, G.4    Errington, S.5    Burnet, P.W.6
  • 55
    • 34250161829 scopus 로고    scopus 로고
    • Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse
    • Schroeder, F.A., Lin, C.L., Crusio, W.E., Akbarian, S., Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse. Biol. Psychiatry 62:1 (2007), 55–64.
    • (2007) Biol. Psychiatry , vol.62 , Issue.1 , pp. 55-64
    • Schroeder, F.A.1    Lin, C.L.2    Crusio, W.E.3    Akbarian, S.4
  • 56
    • 84862603083 scopus 로고    scopus 로고
    • Kynurenines in the mammalian brain: when physiology meets pathology
    • Schwarcz, R., Bruno, J.P., Muchowski, P.J., Wu, H.Q., Kynurenines in the mammalian brain: when physiology meets pathology. Nat. Rev. Neurosci. 13:7 (2012), 465–477.
    • (2012) Nat. Rev. Neurosci. , vol.13 , Issue.7 , pp. 465-477
    • Schwarcz, R.1    Bruno, J.P.2    Muchowski, P.J.3    Wu, H.Q.4
  • 57
    • 84929369869 scopus 로고    scopus 로고
    • A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood
    • Steenbergen, L., Sellaro, R., van Hemert, S., Bosch, J.A., Colzato, L.S., A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood. Brain, Behav. Immun. 48 (2015), 258–264.
    • (2015) Brain, Behav. Immun. , vol.48 , pp. 258-264
    • Steenbergen, L.1    Sellaro, R.2    van Hemert, S.3    Bosch, J.A.4    Colzato, L.S.5
  • 58
    • 79951514630 scopus 로고    scopus 로고
    • Depression and hypothalamic-pituitary-adrenal activation: a quantitative summary of four decades of research
    • Stetler, C., Miller, G.E., Depression and hypothalamic-pituitary-adrenal activation: a quantitative summary of four decades of research. Psychosom. Med. 73:2 (2011), 114–126.
    • (2011) Psychosom. Med. , vol.73 , Issue.2 , pp. 114-126
    • Stetler, C.1    Miller, G.E.2
  • 59
    • 84938150375 scopus 로고    scopus 로고
    • Microbes & neurodevelopment–Absence of microbiota during early life increases activity-related transcriptional pathways in the amygdala
    • Stilling, R.M., Ryan, F.J., Hoban, A.E., Shanahan, F., Clarke, G., Claesson, M.J., Dinan, T.G., Cryan, J.F., Microbes & neurodevelopment–Absence of microbiota during early life increases activity-related transcriptional pathways in the amygdala. Brain, Behav. Immun. 50 (2015), 209–220.
    • (2015) Brain, Behav. Immun. , vol.50 , pp. 209-220
    • Stilling, R.M.1    Ryan, F.J.2    Hoban, A.E.3    Shanahan, F.4    Clarke, G.5    Claesson, M.J.6    Dinan, T.G.7    Cryan, J.F.8
  • 60
    • 4043161248 scopus 로고    scopus 로고
    • Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice
    • Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X.N., Kubo, C., Koga, Y., Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice. J. Physiology 558:Pt 1 (2004), 263–275.
    • (2004) J. Physiology , vol.558 , pp. 263-275
    • Sudo, N.1    Chida, Y.2    Aiba, Y.3    Sonoda, J.4    Oyama, N.5    Yu, X.N.6    Kubo, C.7    Koga, Y.8
  • 62
    • 84897412061 scopus 로고    scopus 로고
    • Role of monocarboxylate transporters in drug delivery to the brain
    • Vijay, N., Morris, M.E., Role of monocarboxylate transporters in drug delivery to the brain. Curr. Pharm. Des. 20:10 (2014), 1487–1498.
    • (2014) Curr. Pharm. Des. , vol.20 , Issue.10 , pp. 1487-1498
    • Vijay, N.1    Morris, M.E.2
  • 64
    • 54149090275 scopus 로고    scopus 로고
    • The Global Burden of Disease 2004 Update
    • WHO, The Global Burden of Disease 2004 Update. 2008.
    • (2008)
    • WHO1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.