Icariin exerts an antidepressant effect in an unpredictable chronic mild stress model of depression in rats and is associated with the regulation of hippocampal neuroinflammation

Neuroscience

Volumn 294, Issue , 2015, Pages 193-205

  Liu, B ^a   Xu, C ^a,b   Wu, X ^a   Liu, F ^a   Du, Y ^a   Sun, J ^a   Tao, J ^c   Dong, J ^a  

^a FUDAN UNIVERSITY   (China)

^b HANGZHOU NORMAL UNIVERSITY   (China)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Depression; Hippocampus; Icariin; NLRP3 inflammasome; Unpredictable chronic mild stress

Indexed keywords

CATALASE; CRYOPYRIN; FLUOXETINE; ICARIIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MALONALDEHYDE; MESSENGER RNA; NITRITE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA; ANTIDEPRESSANT AGENT; FLAVONOID; INFLAMMASOME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDEPRESSANT ACTIVITY; ARTICLE; BRAIN HOMOGENATE; CHRONIC STRESS; CONTROLLED STUDY; CYTOKINE RELEASE; DEPRESSION; DRUG EXPOSURE; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FORCED SWIM TEST; GENE EXPRESSION; HIPPOCAMPUS; MALE; MOLECULAR MECHANICS; NERVOUS SYSTEM INFLAMMATION; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SUCROSE PREFERENCE TEST; WESTERN BLOTTING; ANIMAL; BLOOD BRAIN BARRIER; COMPLICATION; DEPRESSIVE DISORDER; DISEASE MODEL; DRUG EFFECTS; MENTAL STRESS; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIDEPRESSIVE AGENTS; BLOOD-BRAIN BARRIER; DEPRESSION; DEPRESSIVE DISORDER; DISEASE MODELS, ANIMAL; FLAVONOIDS; HIPPOCAMPUS; INFLAMMASOMES; NF-KAPPA B; RATS, SPRAGUE-DAWLEY; STRESS, PSYCHOLOGICAL;

EID: 84925715644     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2015.02.053     Document Type: Article

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