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Volumn 48, Issue 1, 2013, Pages 190-204

Role of the toll like receptor (TLR) radical cycle in chronic inflammation: Possible treatments targeting the TLR4 pathway

Author keywords

Chronic fatigue; Cytokines; Depression; Inflammation; LPS; Oxidative and nitrosative stress; Toll like receptor

Indexed keywords

6 SHOGAOL; ACETYLCYSTEINE; ADJUVANT; ALUMINUM HYDROXIDE; CADMIUM; CHROMIUM; CINNAMON EXTRACT; COBALT; CURCUMIN; EPIGALLOCATECHIN GALLATE; ERITORAN; HYDROGEN; INTERLEUKIN 6; IRON; LIPOPOLYSACCHARIDE; MELATONIN; MYELOID DIFFERENTIATION FACTOR 88; NEUTROPHIL CYTOSOLIC FACTOR 1; NICKEL; OZONE; PROPOFOL; REACTIVE OXYGEN METABOLITE; RECOMBINANT FACTOR C; RECOMBINANT PROTEIN; SILVER NANOPARTICLE; TITANIUM DIOXIDE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLUENE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84880925130     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-013-8425-7     Document Type: Review
Times cited : (404)

References (138)
  • 1
    • 79955599141 scopus 로고    scopus 로고
    • Intrinsic and extrinsic regulation of innate immune receptors
    • 10.3349/ymj.2011.52.3.429 21488180 1:CAS:528:DC%2BC3MXovVKjtLk%3D 10.3349/ymj.2011.52.3.379
    • Jeong E, Lee JY (2011) Intrinsic and extrinsic regulation of innate immune receptors. Yonsei Med J 52(3):379-92. doi: 10.3349/ymj.2011.52.3.429
    • (2011) Yonsei Med J , vol.52 , Issue.3 , pp. 379-392
    • Jeong, E.1    Lee, J.Y.2
  • 2
    • 79951476391 scopus 로고    scopus 로고
    • Novel interactions of a microbial superantigen with TLR2 and TLR4 differentially regulate IL-17 and Th17-associated cytokines
    • 10.1111/j.1462-5822.2010.01540.x 20946245 1:CAS:528:DC%2BC3MXivF2ksb0%3D 10.1111/j.1462-5822.2010.01540.x
    • Mu HH, Hasebe A, Van Schelt A, Cole BC (2011) Novel interactions of a microbial superantigen with TLR2 and TLR4 differentially regulate IL-17 and Th17-associated cytokines. Cell Microbiol 13(3):374-87. doi: 10.1111/j.1462-5822.2010.01540.x
    • (2011) Cell Microbiol , vol.13 , Issue.3 , pp. 374-387
    • Mu, H.H.1    Hasebe, A.2    Van Schelt, A.3    Cole, B.C.4
  • 3
    • 84866991991 scopus 로고    scopus 로고
    • The role of TLR2 in infection and immunity
    • 10.3389/fimmu.00079 22566960 10.3389/fimmu.2012.00079
    • Oliveira-Nascimento L, Massari P, Wetzler LM (2012) The role of TLR2 in infection and immunity. Front Immunol 3:79. doi: 10.3389/fimmu.00079
    • (2012) Front Immunol , vol.3 , pp. 79
    • Oliveira-Nascimento, L.1    Massari, P.2    Wetzler, L.M.3
  • 5
    • 79958025243 scopus 로고    scopus 로고
    • Extra domain A of fibronectin primes leukotriene biosynthesis and stimulates neutrophil migration through activation of Toll-like receptor 4
    • 10.1002/art.30308 21360520 1:CAS:528:DC%2BC3MXmslOkurs%3D 10.1002/art.30308
    • Lefebvre JS, Lévesque T, Picard S, Paré G, Gravel A, Flamand L, Borgeat P (2011) Extra domain A of fibronectin primes leukotriene biosynthesis and stimulates neutrophil migration through activation of Toll-like receptor 4. Arthritis Rheum 63(6):1527-33. doi: 10.1002/art.30308
    • (2011) Arthritis Rheum , vol.63 , Issue.6 , pp. 1527-1533
    • Lefebvre, J.S.1    Lévesque, T.2    Picard, S.3    Paré, G.4    Gravel, A.5    Flamand, L.6    Borgeat, P.7
  • 6
    • 79958276436 scopus 로고    scopus 로고
    • Insight into the mechanisms regulating immune homeostasis in health and disease
    • 21560483 1:CAS:528:DC%2BC3MXmtV2jsro%3D
    • Sirisinha S (2011) Insight into the mechanisms regulating immune homeostasis in health and disease. Asian Pac J Allergy Immunol 29(1):1-14
    • (2011) Asian Pac J Allergy Immunol , vol.29 , Issue.1 , pp. 1-14
    • Sirisinha, S.1
  • 7
    • 77956050465 scopus 로고    scopus 로고
    • Toll-like receptor 2 and 4 genes influence susceptibility to adverse effects of traffic-related air pollution on childhood asthma
    • 10.1136/thx.2009.119636 20685742 1:STN:280:DC%2BC3cjis1CisQ%3D%3D 10.1136/thx.2009.119636
    • Kerkhof M, Postma DS, Brunekreef B, Reijmerink NE, Wijga AH, de Jongste JC, Gehring U, Koppelman GH (2010) Toll-like receptor 2 and 4 genes influence susceptibility to adverse effects of traffic-related air pollution on childhood asthma. Thorax 65(8):690-7. doi: 10.1136/thx.2009.119636
    • (2010) Thorax , vol.65 , Issue.8 , pp. 690-697
    • Kerkhof, M.1    Postma, D.S.2    Brunekreef, B.3    Reijmerink, N.E.4    Wijga, A.H.5    De Jongste, J.C.6    Gehring, U.7    Koppelman, G.H.8
  • 8
    • 84865583892 scopus 로고    scopus 로고
    • Toll-like receptor (TLR2 and TLR4) polymorphisms and chronic obstructive pulmonary disease
    • GLUCOLD study group 22952638 1:CAS:528:DC%2BC38Xht1yktb%2FF 10.1371/journal.pone.0043124
    • Budulac SE, Boezen HM, Hiemstra PS, Lapperre TS, Vonk JM, Timens W, Postma DS, GLUCOLD study group (2012) Toll-like receptor (TLR2 and TLR4) polymorphisms and chronic obstructive pulmonary disease. PLoS One 7(8):e43124
    • (2012) PLoS One , vol.7 , Issue.8 , pp. 43124
    • Budulac, S.E.1    Boezen, H.M.2    Hiemstra, P.S.3    Lapperre, T.S.4    Vonk, J.M.5    Timens, W.6    Postma, D.S.7
  • 10
    • 84861081512 scopus 로고    scopus 로고
    • The emerging role of TLR and innate immunity in cardiovascular disease
    • 10.1155/2012/181394 22577589
    • Spirig R, Tsui J, Shaw S (2012) The emerging role of TLR and innate immunity in cardiovascular disease. Cardiol Res Pract 2012:181394. doi: 10.1155/2012/181394
    • (2012) Cardiol Res Pract , vol.2012 , pp. 181394
    • Spirig, R.1    Tsui, J.2    Shaw, S.3
  • 12
    • 77954884148 scopus 로고    scopus 로고
    • Neural injury following stroke: Are Toll-like receptors the link between the immune system and the CNS?
    • 10.1111/j.1476-5381.2010.00864.x 20649586 1:CAS:528:DC%2BC3cXht1KjurzP 10.1111/j.1476-5381.2010.00864.x
    • Downes CE, Crack PJ (2010) Neural injury following stroke: are Toll-like receptors the link between the immune system and the CNS? Br J Pharmacol 160(8):1872-88. doi: 10.1111/j.1476-5381.2010.00864.x
    • (2010) Br J Pharmacol , vol.160 , Issue.8 , pp. 1872-1888
    • Downes, C.E.1    Crack, P.J.2
  • 14
    • 84878263657 scopus 로고    scopus 로고
    • Increased expression of toll-like receptor 4 and inflammatory cytokines, interleukin-6 in particular, in islets from a mouse model of obesity and type 2 diabetes
    • doi:. doi: 10.1111/apm.12018
    • Ladefoged M, Buschard K, Hansen AM (2013) Increased expression of toll-like receptor 4 and inflammatory cytokines, interleukin-6 in particular, in islets from a mouse model of obesity and type 2 diabetes. APMIS doi:. doi: 10.1111/apm.12018
    • (2013) APMIS
    • Ladefoged, M.1    Buschard, K.2    Hansen, A.M.3
  • 15
    • 84860485809 scopus 로고    scopus 로고
    • Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via Toll-like receptor-4 and NF-κB signalling
    • 10.1371/journal.pone.0036200 22558381 1:CAS:528:DC%2BC38XntFWktr8%3D 10.1371/journal.pone.0036200
    • Amyot J, Semache M, Ferdaoussi M, Fontés G, Poitout V (2012) Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via Toll-like receptor-4 and NF-κB signalling. PLoS One 7(4):e36200. doi: 10.1371/journal.pone.0036200
    • (2012) PLoS One , vol.7 , Issue.4 , pp. 36200
    • Amyot, J.1    Semache, M.2    Ferdaoussi, M.3    Fontés, G.4    Poitout, V.5
  • 16
    • 0037116641 scopus 로고    scopus 로고
    • Prevalence of the metabolic syndrome among US adults: Findings from the third National Health and Nutrition Examination Survey
    • 11790215 10.1001/jama.287.3.356
    • Ford ES, Giles WH, Dietz WH (2002) Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 287(3):356-9
    • (2002) JAMA , vol.287 , Issue.3 , pp. 356-359
    • Ford, E.S.1    Giles, W.H.2    Dietz, W.H.3
  • 17
    • 84862059730 scopus 로고    scopus 로고
    • Increased toll-like receptor activity in patients with metabolic syndrome
    • 10.2337/dc11-2375 22357188 1:CAS:528:DC%2BC38Xmt1Chtr8%3D 10.2337/dc11-2375
    • Jialal I, Huet BA, Kaur H, Chien A, Devaraj S (2012) Increased toll-like receptor activity in patients with metabolic syndrome. Diabetes Care 35(4):900-4. doi: 10.2337/dc11-2375
    • (2012) Diabetes Care , vol.35 , Issue.4 , pp. 900-904
    • Jialal, I.1    Huet, B.A.2    Kaur, H.3    Chien, A.4    Devaraj, S.5
  • 18
    • 80052334860 scopus 로고    scopus 로고
    • Enhanced peripheral toll-like receptor responses in psychosis: Further evidence of a pro-inflammatory phenotype
    • 10.1038/tp.2011.37 22832610 1:CAS:528:DC%2BC3MXht1KjsrrN 10.1038/tp.2011.37
    • McKernan DP, Dennison U, Gaszner G, Cryan JF, Dinan TG (2011) Enhanced peripheral toll-like receptor responses in psychosis: further evidence of a pro-inflammatory phenotype. Transl Psychiatry 1:e36. doi: 10.1038/tp.2011.37
    • (2011) Transl Psychiatry , vol.1 , pp. 36
    • McKernan, D.P.1    Dennison, U.2    Gaszner, G.3    Cryan, J.F.4    Dinan, T.G.5
  • 19
    • 71749094505 scopus 로고    scopus 로고
    • Differential monocyte responses to TLR ligands in children with autism spectrum disorders
    • Enstrom AM, Onore CE, Van de Water JA, Ashwood P 10.1016/j.bbi.2009.08. 001
    • Enstrom AM, Onore CE, Van de Water JA, Ashwood P (2010) Differential monocyte responses to TLR ligands in children with autism spectrum disorders. Brain BehavImmun 24(1):64-71. doi: 10.1016/j.bbi.2009.08.001
    • (2010) Brain BehavImmun , vol.24 , Issue.1 , pp. 64-71
  • 20
    • 62749162644 scopus 로고    scopus 로고
    • Cinnamon extract protects against acute alcohol-induced liver steatosis in mice
    • 10.3945/jn.108.100495 19126670 1:CAS:528:DC%2BD1MXjsFKitbo%3D 10.3945/jn.108.100495
    • Kanuri G, Weber S, Volynets V, Spruss A, Bischoff SC, Bergheim I (2009) Cinnamon extract protects against acute alcohol-induced liver steatosis in mice. J Nutr 139(3):482-7. doi: 10.3945/jn.108.100495
    • (2009) J Nutr , vol.139 , Issue.3 , pp. 482-487
    • Kanuri, G.1    Weber, S.2    Volynets, V.3    Spruss, A.4    Bischoff, S.C.5    Bergheim, I.6
  • 21
    • 42149093127 scopus 로고    scopus 로고
    • The gut-brain barrier in major depression: Intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression
    • 18283240
    • Maes M, Kubera M, Leunis JC (2008) The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression. Neuro Endocrinol Lett 29(1):117-24
    • (2008) Neuro Endocrinol Lett , vol.29 , Issue.1 , pp. 117-124
    • Maes, M.1    Kubera, M.2    Leunis, J.C.3
  • 22
    • 33847238471 scopus 로고    scopus 로고
    • Increased serum IgA and IgM against LPS of enterobacteria in chronic fatigue syndrome (CFS): Indication for the involvement of gram-negative enterobacteria in the etiology of CFS and for the presence of an increased gut-intestinal permeability
    • 17007934 1:CAS:528:DC%2BD2sXitFOhurs%3D 10.1016/j.jad.2006.08.021
    • Maes M, Mihaylova I, Leunis JC (2007) Increased serum IgA and IgM against LPS of enterobacteria in chronic fatigue syndrome (CFS): indication for the involvement of gram-negative enterobacteria in the etiology of CFS and for the presence of an increased gut-intestinal permeability. J Affect Disord 99(1-3):237-40
    • (2007) J Affect Disord , vol.99 , Issue.1-3 , pp. 237-240
    • Maes, M.1    Mihaylova, I.2    Leunis, J.C.3
  • 23
    • 84875300745 scopus 로고    scopus 로고
    • In depression, bacterial translocation may drive inflammatory responses, oxidative and nitrosative stress (O&NS), and autoimmune responses directed against O&NS-damaged neoepitopes
    • doi: 10.1111/j.1600-0447.2012.01908.x
    • Maes M, Kubera M, Leunis JC, Berk M, Geffard M, Bosmans E (2013) In depression, bacterial translocation may drive inflammatory responses, oxidative and nitrosative stress (O&NS), and autoimmune responses directed against O&NS-damaged neoepitopes. Acta Psychiatr Scand. doi: 10.1111/j.1600-0447. 2012.01908.x
    • (2013) Acta Psychiatr Scand
    • Maes, M.1    Kubera, M.2    Leunis, J.C.3    Berk, M.4    Geffard, M.5    Bosmans, E.6
  • 24
    • 0027225487 scopus 로고
    • Intestinal permeability and function in patients infected with human immunodeficiency virus. A comparison with coeliac disease
    • 8362208 1:STN:280:DyaK3szmvFGhsQ%3D%3D 10.3109/00365529309096090
    • Lim SG, Menzies IS, Lee CA, Johnson MA, Pounder RE (1993) Intestinal permeability and function in patients infected with human immunodeficiency virus. A comparison with coeliac disease. Scand J Gastroenterol 28(7):573-80
    • (1993) Scand J Gastroenterol , vol.28 , Issue.7 , pp. 573-580
    • Lim, S.G.1    Menzies, I.S.2    Lee, C.A.3    Johnson, M.A.4    Pounder, R.E.5
  • 25
    • 0020084730 scopus 로고
    • Influence of fasting on intestinal permeability and disease activity in patients with rheumatoid arthritis
    • 7063809 1:STN:280:DyaL387lt1Khuw%3D%3D 10.3109/03009748209098111
    • Sundqvist T, Lindström F, Magnusson KE, Sköldstam L, Stjernström I, Tagesson C (1982) Influence of fasting on intestinal permeability and disease activity in patients with rheumatoid arthritis. Scand J Rheumatol 11(1):33-8
    • (1982) Scand J Rheumatol , vol.11 , Issue.1 , pp. 33-38
    • Sundqvist, T.1    Lindström, F.2    Magnusson, K.E.3    Sköldstam, L.4    Stjernström, I.5    Tagesson, C.6
  • 26
    • 47849100075 scopus 로고    scopus 로고
    • Alzheimer's disease and peripheral infections: The possible contribution from periodontal infections, model and hypothesis
    • 18487851 1:CAS:528:DC%2BD1cXlsFGis78%3D
    • Kamer AR, Dasanayake AP, Craig RG, Glodzik-Sobanska L, Bry M, de Leon MJ (2008) Alzheimer's disease and peripheral infections: the possible contribution from periodontal infections, model and hypothesis. J Alzheimers Dis 13(4):437-49
    • (2008) J Alzheimers Dis , vol.13 , Issue.4 , pp. 437-449
    • Kamer, A.R.1    Dasanayake, A.P.2    Craig, R.G.3    Glodzik-Sobanska, L.4    Bry, M.5    De Leon, M.J.6
  • 28
    • 79952497372 scopus 로고    scopus 로고
    • Gut, bugs, and brain: Role of commensal bacteria in the control of central nervous system disease
    • 10.1002/ana.22344 21387369 10.1002/ana.22344 1:CAS:528: DC%2BC3MXktl2lsLw%3D
    • Ochoa-Repáraz J, Mielcarz DW, Begum-Haque S, Kasper LH (2011) Gut, bugs, and brain: role of commensal bacteria in the control of central nervous system disease. Ann Neurol 69(2):240-7. doi: 10.1002/ana.22344
    • (2011) Ann Neurol , vol.69 , Issue.2 , pp. 240-247
    • Ochoa-Repáraz, J.1    Mielcarz, D.W.2    Begum-Haque, S.3    Kasper, L.H.4
  • 29
    • 1042301128 scopus 로고    scopus 로고
    • Detection of the specific IgM and IgA circulating in sera of multiple sclerosis patients: Interest and perspectives
    • Geffard M, Bodet D, Martinet Y, Dabadie M-P (2002) Detection of the specific IgM and IgA circulating in sera of multiple sclerosis patients: interest and perspectives. Immuno-Analyse and Biol Spec 17:302-310
    • (2002) Immuno-Analyse and Biol Spec , vol.17 , pp. 302-310
    • Geffard, M.1    Bodet, D.2    Martinet, Y.3    Dabadie, M.-P.4
  • 30
    • 0027993341 scopus 로고
    • Current concepts of the pathogenesis of inflammatory bowel disease
    • 7843934 1:STN:280:DyaK2M7ks1ejtw%3D%3D 10.1007/BF02943022
    • Shanahan F (1994) Current concepts of the pathogenesis of inflammatory bowel disease. Ir J Med Sci 163(12):544-9
    • (1994) Ir J Med Sci , vol.163 , Issue.12 , pp. 544-549
    • Shanahan, F.1
  • 31
    • 27644438235 scopus 로고    scopus 로고
    • The importance of the gastrointestinal system in the pathogenesis of heart failure
    • 15980032 1:CAS:528:DC%2BD2MXhtlSisbvK 10.1093/eurheartj/ehi389
    • Krack A, Sharma R, Figulla HR, Anker SD (2005) The importance of the gastrointestinal system in the pathogenesis of heart failure. Eur Heart J 26(22):2368-74
    • (2005) Eur Heart J , vol.26 , Issue.22 , pp. 2368-2374
    • Krack, A.1    Sharma, R.2    Figulla, H.R.3    Anker, S.D.4
  • 33
    • 58149106232 scopus 로고    scopus 로고
    • The emerging role of the gut in chronic heart failure
    • 10.1097/MCO.0b013e32830a4c6e 18685461 10.1097/MCO.0b013e32830a4c6e
    • Sandek A, Rauchhaus M, Anker SD, von Haehling S (2008) The emerging role of the gut in chronic heart failure. Curr Opin Clin Nutr Metab Care 11(5):632-9. doi: 10.1097/MCO.0b013e32830a4c6e
    • (2008) Curr Opin Clin Nutr Metab Care , vol.11 , Issue.5 , pp. 632-639
    • Sandek, A.1    Rauchhaus, M.2    Anker, S.D.3    Von Haehling, S.4
  • 34
    • 34250768216 scopus 로고    scopus 로고
    • Role of bacterial endotoxin in chronic heart failure: The gut of the matter
    • 17510602 1:CAS:528:DC%2BD2sXotV2gt7g%3D 10.1097/shk.0b013e318033ebc5
    • Charalambous BM, Stephens RC, Feavers IM, Montgomery HE (2007) Role of bacterial endotoxin in chronic heart failure: the gut of the matter. Shock 28(1):15-23
    • (2007) Shock , vol.28 , Issue.1 , pp. 15-23
    • Charalambous, B.M.1    Stephens, R.C.2    Feavers, I.M.3    Montgomery, H.E.4
  • 35
    • 10944234609 scopus 로고    scopus 로고
    • Neurotoxic effects of lipopolysaccharide on nigral dopaminergic neurons are mediated by microglial activation, interleukin-1beta, and expression of caspase-11 in mice
    • 1:CAS:528:DC%2BD2cXhtVaqs7nE
    • Arai H, Furuya T, Yasuda T, Miura M, Mizuno Y, Mochizuki H (2004) Neurotoxic effects of lipopolysaccharide on nigral dopaminergic neurons are mediated by microglial activation, interleukin-1beta, and expression of caspase-11 in mice. J BiolChem 279(49):51647-53
    • (2004) J BiolChem , vol.279 , Issue.49 , pp. 51647-51653
    • Arai, H.1    Furuya, T.2    Yasuda, T.3    Miura, M.4    Mizuno, Y.5    Mochizuki, H.6
  • 36
    • 0344120248 scopus 로고    scopus 로고
    • Pathophysiology of psoriasis: Coping endotoxins with bile acid therapy
    • 14643904 1:CAS:528:DC%2BD3sXpt1Sgt7s%3D 10.1016/j.pathophys.2003.07.001
    • Gyurcsovics K, Bertók L (2003) Pathophysiology of psoriasis: coping endotoxins with bile acid therapy. Pathophysiology 10(1):57-61
    • (2003) Pathophysiology , vol.10 , Issue.1 , pp. 57-61
    • Gyurcsovics, K.1    Bertók, L.2
  • 37
    • 34447115943 scopus 로고    scopus 로고
    • Ozone and pulmonary innate immunity
    • 17607006 10.1513/pats.200701-023AW 1:CAS:528:DC%2BD2sXptVSrtL8%3D
    • Hollingsworth JW, Kleeberger SR, Foster WM (2007) Ozone and pulmonary innate immunity. Proc Am Thorac Soc 4(3):240-6
    • (2007) Proc Am Thorac Soc , vol.4 , Issue.3 , pp. 240-246
    • Hollingsworth, J.W.1    Kleeberger, S.R.2    Foster, W.M.3
  • 40
    • 84857293874 scopus 로고    scopus 로고
    • Ozone-induced lung injury and sterile inflammation. Role of toll-like receptor 4
    • 10.1016/j.yexmp.2012.01.004 22300504 1:CAS:528:DC%2BC38Xktleqtbo%3D 10.1016/j.yexmp.2012.01.004
    • Connor AJ, Laskin JD, Laskin DL (2012) Ozone-induced lung injury and sterile inflammation. Role of toll-like receptor 4. Exp Mol Pathol 92(2):229-35. doi: 10.1016/j.yexmp.2012.01.004
    • (2012) Exp Mol Pathol , vol.92 , Issue.2 , pp. 229-235
    • Connor, A.J.1    Laskin, J.D.2    Laskin, D.L.3
  • 42
    • 80455145158 scopus 로고    scopus 로고
    • Hyaluronan signaling during ozone-induced lung injury requires TLR4, MyD88, and TIRAP
    • 10.1371/journal.pone.0027137 22073274 1:CAS:528:DC%2BC3MXhsFejsr%2FP 10.1371/journal.pone.0027137
    • Li Z, Potts-Kant EN, Garantziotis S, Foster WM, Hollingsworth JW (2011) Hyaluronan signaling during ozone-induced lung injury requires TLR4, MyD88, and TIRAP. PLoS One 6(11):e27137. doi: 10.1371/journal.pone.0027137
    • (2011) PLoS One , vol.6 , Issue.11 , pp. 27137
    • Li, Z.1    Potts-Kant, E.N.2    Garantziotis, S.3    Foster, W.M.4    Hollingsworth, J.W.5
  • 43
    • 80051471752 scopus 로고    scopus 로고
    • Pathways of cholesterol oxidation via non-enzymatic mechanisms
    • 10.1016/j.chemphyslip.2011.06.006 1:CAS:528:DC%2BC3MXpvFCntbs%3D 10.1016/j.chemphyslip.2011.06.006
    • Iuliano L (2011) Pathways of cholesterol oxidation via non-enzymatic mechanisms. ChemPhys Lipids 164(6):457-68. doi: 10.1016/j.chemphyslip.2011.06. 006
    • (2011) ChemPhys Lipids , vol.164 , Issue.6 , pp. 457-468
    • Iuliano, L.1
  • 44
    • 34548349078 scopus 로고    scopus 로고
    • Measurements of fine and ultrafine particles formation in photocopy centers in Taiwan
    • org/10.1016/j.atmosenv.2007.04.016 1:CAS:528:DC%2BD2sXpsl2jtrc%3D 10.1016/j.atmosenv.2007.04.016
    • Lee C-W, Hsu D-J (2007) Measurements of fine and ultrafine particles formation in photocopy centers in Taiwan. Atmospheric Environment 41(3):6598-09. doi: org/10.1016/j.atmosenv.2007.04.016
    • (2007) Atmospheric Environment , vol.41 , Issue.3 , pp. 6598-6609
    • Lee, C.-W.1    Hsu, D.-J.2
  • 47
    • 81855194081 scopus 로고    scopus 로고
    • The innate and adaptive immune response induced by alveolar macrophages exposed to ambient particulate matter
    • 10.1016/j.taap.2011.09.007 21951342 1:CAS:528:DC%2BC3MXhsV2mtLnN 10.1016/j.taap.2011.09.007
    • Miyata R, van Eeden SF (2011) The innate and adaptive immune response induced by alveolar macrophages exposed to ambient particulate matter. Toxicol Appl Pharmacol 257(2):209-26. doi: 10.1016/j.taap.2011.09.007
    • (2011) Toxicol Appl Pharmacol , vol.257 , Issue.2 , pp. 209-226
    • Miyata, R.1    Van Eeden, S.F.2
  • 48
    • 79953068798 scopus 로고    scopus 로고
    • The role of long-lived reactive oxygen intermediates in the reaction of ozone with aerosol particles
    • 10.1038/nchem.988 21430687 1:CAS:528:DC%2BC3MXjvVKru74%3D 10.1038/nchem.988
    • Shiraiwa M, Sosedova Y, Rouvière A, Yang H, Zhang Y, Abbatt JP, Ammann M, Pöschl U (2011) The role of long-lived reactive oxygen intermediates in the reaction of ozone with aerosol particles. Nat Chem 3(4):291-5. doi: 10.1038/nchem.988
    • (2011) Nat Chem , vol.3 , Issue.4 , pp. 291-295
    • Shiraiwa, M.1    Sosedova, Y.2    Rouvière, A.3    Yang, H.4    Zhang, Y.5    Abbatt, J.P.6    Ammann, M.7    Pöschl, U.8
  • 50
    • 1342267646 scopus 로고    scopus 로고
    • Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles
    • 14600271 1:CAS:528:DC%2BD2cXht1Kluro%3D 10.1093/toxsci/kfh019
    • Bermudez E, Mangum JB, Wong BA, Asgharian B, Hext PM, Warheit DB, Everitt JI (2004) Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles. Toxicol Sci 77(2):347-57
    • (2004) Toxicol Sci , vol.77 , Issue.2 , pp. 347-357
    • Bermudez, E.1    Mangum, J.B.2    Wong, B.A.3    Asgharian, B.4    Hext, P.M.5    Warheit, D.B.6    Everitt, J.I.7
  • 51
    • 79960815264 scopus 로고    scopus 로고
    • Development of sensor cells using NF-κB pathway activation for detection of nanoparticle-induced inflammation
    • 10.3390/s110707219 1:CAS:528:DC%2BC3MXhtVeht7jO 10.3390/s110707219
    • Chen P, Migita S, Kanehira K, Sonezaki S, Taniguchi A (2011) Development of sensor cells using NF-κB pathway activation for detection of nanoparticle-induced inflammation. Sensors (Basel) 11(7):7219-30. doi: 10.3390/s110707219
    • (2011) Sensors (Basel) , vol.11 , Issue.7 , pp. 7219-7230
    • Chen, P.1    Migita, S.2    Kanehira, K.3    Sonezaki, S.4    Taniguchi, A.5
  • 52
    • 78649604711 scopus 로고    scopus 로고
    • Signaling pathway of inflammatory responses in the mouse liver caused by TiO2 nanoparticles
    • 10.1002/jbm.a.32976 21105171
    • Cui Y, Liu H, Zhou M, Duan Y, Li N, Gong X, Hu R, Hong M, Hong F (2011) Signaling pathway of inflammatory responses in the mouse liver caused by TiO2 nanoparticles. J Biomed Mater Res A 96(1):221-9. doi: 10.1002/jbm.a.32976
    • (2011) J Biomed Mater Res A , vol.96 , Issue.1 , pp. 221-229
    • Cui, Y.1    Liu, H.2    Zhou, M.3    Duan, Y.4    Li, N.5    Gong, X.6    Hu, R.7    Hong, M.8    Hong, F.9
  • 53
    • 0037235805 scopus 로고    scopus 로고
    • The role of free radicals in the toxic and inflammatory effects of four different ultrafine particle types
    • 12476359 1:CAS:528:DC%2BD38XpslGlsL4%3D 10.1080/08958370304454
    • Dick CA, Brown DM, Donaldson K, Stone V (2003) The role of free radicals in the toxic and inflammatory effects of four different ultrafine particle types. Inhal Toxicol 15(1):39-52
    • (2003) Inhal Toxicol , vol.15 , Issue.1 , pp. 39-52
    • Dick, C.A.1    Brown, D.M.2    Donaldson, K.3    Stone, V.4
  • 54
    • 40649085539 scopus 로고    scopus 로고
    • Hydroxyl radicals (*OH) are associated with titanium dioxide (TiO(2)) nanoparticle-induced cytotoxicity and oxidative DNA damage in fish cells
    • 10.1016/j.mrfmmm.2007.12.010 18258270 1:CAS:528:DC%2BD1cXjsVSgtb8%3D
    • Reeves JF, Davies SJ, Dodd NJ, Jha AN (2008) Hydroxyl radicals (*OH) are associated with titanium dioxide (TiO(2)) nanoparticle-induced cytotoxicity and oxidative DNA damage in fish cells. Mutat Res 640(1-2):113-22. doi: 10.1016/j.mrfmmm.2007.12.010
    • (2008) Mutat Res , vol.640 , Issue.1-2 , pp. 113-122
    • Reeves, J.F.1    Davies, S.J.2    Dodd, N.J.3    Jha, A.N.4
  • 55
    • 35348906164 scopus 로고    scopus 로고
    • Gold nanoparticle-initiated free radical oxidations and halogen abstractions
    • 17943210 1:CAS:528:DC%2BD2sXhtFOjurrN 10.1039/b711573c
    • Ionita P, Conte M, Gilbert BC, Chechik V (2007) Gold nanoparticle- initiated free radical oxidations and halogen abstractions. Org Biomol Chem 5(21):3504-9
    • (2007) Org Biomol Chem , vol.5 , Issue.21 , pp. 3504-3509
    • Ionita, P.1    Conte, M.2    Gilbert, B.C.3    Chechik, V.4
  • 56
    • 79951813476 scopus 로고    scopus 로고
    • Effects of nano-scale TiO2, ZnO and their bulk counterparts on zebrafish: Acute toxicity, oxidative stress and oxidative damage
    • 10.1016/j.scitotenv.2011.01.015 21296382 1:CAS:528:DC%2BC3MXisFWrs74%3D 10.1016/j.scitotenv.2011.01.015
    • Xiong D, Fang T, Yu L, Sima X, Zhu W (2011) Effects of nano-scale TiO2, ZnO and their bulk counterparts on zebrafish: acute toxicity, oxidative stress and oxidative damage. Sci Total Environ 409(8):1444-52. doi: 10.1016/j.scitotenv.2011.01.015
    • (2011) Sci Total Environ , vol.409 , Issue.8 , pp. 1444-1452
    • Xiong, D.1    Fang, T.2    Yu, L.3    Sima, X.4    Zhu, W.5
  • 57
    • 33746255334 scopus 로고    scopus 로고
    • Titanium dioxide (P25) produces reactive oxygen species in immortalized brain microglia (BV2): Implications for nanoparticle neurotoxicity
    • 16903269 1:CAS:528:DC%2BD28Xlt1yqtLw%3D 10.1021/es060589n
    • Long TC, Saleh N, Tilton RD, Lowry GV, Veronesi B (2006) Titanium dioxide (P25) produces reactive oxygen species in immortalized brain microglia (BV2): implications for nanoparticle neurotoxicity. Environ Sci Technol 40(14):4346-52
    • (2006) Environ Sci Technol , vol.40 , Issue.14 , pp. 4346-4352
    • Long, T.C.1    Saleh, N.2    Tilton, R.D.3    Lowry, G.V.4    Veronesi, B.5
  • 58
    • 77956012861 scopus 로고    scopus 로고
    • Neurotoxicological effects and the impairment of spatial recognition memory in mice caused by exposure to TiO2 nanoparticles
    • 10.1016/j.biomaterials.2010.07.011 20692697 1:CAS:528:DC%2BC3cXhtVyit77O 10.1016/j.biomaterials.2010.07.011
    • Hu R, Gong X, Duan Y, Li N, Che Y, Cui Y, Zhou M, Liu C, Wang H, Hong F (2010) Neurotoxicological effects and the impairment of spatial recognition memory in mice caused by exposure to TiO2 nanoparticles. Biomaterials 31(31):8043-50. doi: 10.1016/j.biomaterials.2010.07.011
    • (2010) Biomaterials , vol.31 , Issue.31 , pp. 8043-8050
    • Hu, R.1    Gong, X.2    Duan, Y.3    Li, N.4    Che, Y.5    Cui, Y.6    Zhou, M.7    Liu, C.8    Wang, H.9    Hong, F.10
  • 59
    • 56549115351 scopus 로고    scopus 로고
    • Potential neurological lesion after nasal instillation of TiO(2) nanoparticles in the anatase and rutile crystal phases
    • 10.1016/j.toxlet.2008.10.001 18992307 1:CAS:528:DC%2BD1cXhsVCmsb7I 10.1016/j.toxlet.2008.10.001
    • Wang J, Chen C, Liu Y, Jiao F, Li W, Lao F, Li Y, Li B, Ge C, Zhou G, Gao Y, Zhao Y, Chai Z (2008) Potential neurological lesion after nasal instillation of TiO(2) nanoparticles in the anatase and rutile crystal phases. Toxicol Lett 183:72-80. doi: 10.1016/j.toxlet.2008.10.001
    • (2008) Toxicol Lett , vol.183 , pp. 72-80
    • Wang, J.1    Chen, C.2    Liu, Y.3    Jiao, F.4    Li, W.5    Lao, F.6    Li, Y.7    Li, B.8    Ge, C.9    Zhou, G.10    Gao, Y.11    Zhao, Y.12    Chai, Z.13
  • 60
    • 84863990988 scopus 로고    scopus 로고
    • Inflammasome formation and IL-1β release by human blood monocytes in response to silver nanoparticles
    • 10.1016/j.biomaterials.2012.06.016 22770526 1:CAS:528: DC%2BC38Xps1Klsrw%3D 10.1016/j.biomaterials.2012.06.016
    • Yang EJ, Kim S, Kim JS, Choi IH (2012) Inflammasome formation and IL-1β release by human blood monocytes in response to silver nanoparticles. Biomaterials 33(28):6858-67. doi: 10.1016/j.biomaterials.2012.06.016
    • (2012) Biomaterials , vol.33 , Issue.28 , pp. 6858-6867
    • Yang, E.J.1    Kim, S.2    Kim, J.S.3    Choi, I.H.4
  • 62
    • 84862315735 scopus 로고    scopus 로고
    • Silver nanoparticles modify VEGF signaling pathway and mucus hypersecretion in allergic airway inflammation
    • 10.2147/IJN.S27159 22457593 1:CAS:528:DC%2BC38XkslamsLo%3D
    • Jang S, Park JW, Cha HR, Jung SY, Lee JE, Jung SS, Kim JO, Kim SY, Lee CS, Park HS (2012) Silver nanoparticles modify VEGF signaling pathway and mucus hypersecretion in allergic airway inflammation. Int J Nanomedicine 7:1329-43. doi: 10.2147/IJN.S27159
    • (2012) Int J Nanomedicine , vol.7 , pp. 1329-1343
    • Jang, S.1    Park, J.W.2    Cha, H.R.3    Jung, S.Y.4    Lee, J.E.5    Jung, S.S.6    Kim, J.O.7    Kim, S.Y.8    Lee, C.S.9    Park, H.S.10
  • 63
    • 84863330423 scopus 로고    scopus 로고
    • Impact of emerging pollutants on pulmonary inflammation in asthmatic rats: Ethanol vapors and agglomerated TiO2 nanoparticles
    • 10.3109/08958378.2012.696741 22746402 1:CAS:528:DC%2BC38XpsVahsrk%3D 10.3109/08958378.2012.696741
    • Scarino A, Noël A, Renzi PM, Cloutier Y, Vincent R, Truchon G, Tardif R, Charbonneau M (2012) Impact of emerging pollutants on pulmonary inflammation in asthmatic rats: ethanol vapors and agglomerated TiO2 nanoparticles. Inhal Toxicol 24(8):528-38. doi: 10.3109/08958378.2012.696741
    • (2012) Inhal Toxicol , vol.24 , Issue.8 , pp. 528-538
    • Scarino, A.1    Noël, A.2    Renzi, P.M.3    Cloutier, Y.4    Vincent, R.5    Truchon, G.6    Tardif, R.7    Charbonneau, M.8
  • 64
    • 79251602398 scopus 로고    scopus 로고
    • Mucin secretion induced by titanium dioxide nanoparticles
    • 10.1371/journal.pone.0016198 21283816 1:CAS:528:DC%2BC3MXht1Kkt7Y%3D 10.1371/journal.pone.0016198
    • Chen EY, Garnica M, Wang YC, Chen CS, Chin WC (2011) Mucin secretion induced by titanium dioxide nanoparticles. PLoS One 6(1):e16198. doi: 10.1371/journal.pone.0016198
    • (2011) PLoS One , vol.6 , Issue.1 , pp. 16198
    • Chen, E.Y.1    Garnica, M.2    Wang, Y.C.3    Chen, C.S.4    Chin, W.C.5
  • 66
    • 84870576417 scopus 로고    scopus 로고
    • Metal allergens nickel and cobalt facilitate TLR4 homodimerization independently of MD2
    • 10.1038/embor.2012.155 23059983 1:CAS:528:DC%2BC38XhsV2rtr7K 10.1038/embor.2012.155
    • Raghavan B, Martin SF, Esser PR, Goebeler M, Schmidt M (2012) Metal allergens nickel and cobalt facilitate TLR4 homodimerization independently of MD2. EMBO Rep 13(12):1109-15. doi: 10.1038/embor.2012.155
    • (2012) EMBO Rep , vol.13 , Issue.12 , pp. 1109-1115
    • Raghavan, B.1    Martin, S.F.2    Esser, P.R.3    Goebeler, M.4    Schmidt, M.5
  • 67
    • 80053280235 scopus 로고    scopus 로고
    • Nickel allergy-promoting effects of microbial or inflammatory substances at the sensitization step in mice
    • 10.1016/j.intimp.2011.05.010 21621645 1:CAS:528:DC%2BC3MXht1anur%2FO 10.1016/j.intimp.2011.05.010
    • Takahashi H, Kinbara M, Sato N, Sasaki K, Sugawara S, Endo Y (2011) Nickel allergy-promoting effects of microbial or inflammatory substances at the sensitization step in mice. Int Immunopharmacol 11(10):1534-40. doi: 10.1016/j.intimp.2011.05.010
    • (2011) Int Immunopharmacol , vol.11 , Issue.10 , pp. 1534-1540
    • Takahashi, H.1    Kinbara, M.2    Sato, N.3    Sasaki, K.4    Sugawara, S.5    Endo, Y.6
  • 68
    • 84855820668 scopus 로고    scopus 로고
    • Aluminum as an adjuvant in Crohn's disease induction
    • 10.1177/0961203311430090 22235058 1:CAS:528:DC%2BC38XjsFCgt7c%3D 10.1177/0961203311430090
    • Lerner A (2012) Aluminum as an adjuvant in Crohn's disease induction. Lupus 21(2):231-8. doi: 10.1177/0961203311430090
    • (2012) Lupus , vol.21 , Issue.2 , pp. 231-238
    • Lerner, A.1
  • 69
    • 84055200070 scopus 로고    scopus 로고
    • Advances in carcinogenic metal toxicity and potential molecular markers
    • 10.3390/ijms12129576 22272150 1:CAS:528:DC%2BC38XptF2guw%3D%3D 10.3390/ijms12129576
    • Koedrith P, Seo YR (2011) Advances in carcinogenic metal toxicity and potential molecular markers. Int J Mol Sci 12(12):9576-95. doi: 10.3390/ijms12129576
    • (2011) Int J Mol Sci , vol.12 , Issue.12 , pp. 9576-9595
    • Koedrith, P.1    Seo, Y.R.2
  • 70
    • 78549240952 scopus 로고    scopus 로고
    • Neurotoxins: Free radical mechanisms and melatonin protection
    • 10.2174/157015910792246236 21358970 1:CAS:528:DC%2BC3cXhtl2mtrvI 10.2174/157015910792246236
    • Reiter RJ, Manchester LC, Tan DX (2010) Neurotoxins: free radical mechanisms and melatonin protection. Curr Neuropharmacol 8(3):194-210. doi: 10.2174/157015910792246236
    • (2010) Curr Neuropharmacol , vol.8 , Issue.3 , pp. 194-210
    • Reiter, R.J.1    Manchester, L.C.2    Tan, D.X.3
  • 71
    • 34247106805 scopus 로고    scopus 로고
    • Aluminum hydroxide adjuvants activate caspase-1 and induce IL-1beta and IL-18 release
    • 17404311 1:CAS:528:DC%2BD2sXjslWjtLo%3D
    • Li H, Nookala S, Re F (2007) Aluminum hydroxide adjuvants activate caspase-1 and induce IL-1beta and IL-18 release. J Immunol 178(8):5271-6
    • (2007) J Immunol , vol.178 , Issue.8 , pp. 5271-5276
    • Li, H.1    Nookala, S.2    Re, F.3
  • 73
    • 0032873079 scopus 로고    scopus 로고
    • Role of reactive oxygen metabolites in organophosphate-bidrin-induced renal tubular cytotoxicity
    • 10446942 1:CAS:528:DyaK1MXlt1Wqsbg%3D
    • Poovala VS, Huang H, Salahudeen AK (1999) Role of reactive oxygen metabolites in organophosphate-bidrin-induced renal tubular cytotoxicity. J Am Soc Nephrol 10(8):1746-52
    • (1999) J Am Soc Nephrol , vol.10 , Issue.8 , pp. 1746-1752
    • Poovala, V.S.1    Huang, H.2    Salahudeen, A.K.3
  • 74
    • 34248682962 scopus 로고    scopus 로고
    • Diazinon immunotoxicity in mice: Modulation of cytokines level and their gene expression
    • 17499902 1:CAS:528:DC%2BD2sXlvVyitrY%3D 10.1016/j.tox.2007.04.004
    • Alluwaimi AM, Hussein Y (2007) Diazinon immunotoxicity in mice: modulation of cytokines level and their gene expression. Toxicology 236(1-2):123-31
    • (2007) Toxicology , vol.236 , Issue.1-2 , pp. 123-131
    • Alluwaimi, A.M.1    Hussein, Y.2
  • 75
    • 11144253604 scopus 로고    scopus 로고
    • Lipopolysaccharide (LPS) induced activation of the immune system in control rats and rats chronically exposed to a low level of the organothiophosphate insecticide, acephate
    • 15697179 1:CAS:528:DC%2BD2MXpslClug%3D%3D 10.1191/0748233703th181oa
    • Singh AK, Jiang Y (2003) Lipopolysaccharide (LPS) induced activation of the immune system in control rats and rats chronically exposed to a low level of the organothiophosphate insecticide, acephate. Toxicol Ind Health 19(2-6):93-108
    • (2003) Toxicol Ind Health , vol.19 , Issue.2-6 , pp. 93-108
    • Singh, A.K.1    Jiang, Y.2
  • 76
    • 33745796133 scopus 로고    scopus 로고
    • Toll-like receptor priming sensitizes macrophages to proinflammatory cytokine gene induction by deoxynivalenol and other toxicants
    • 16687389 1:CAS:528:DC%2BD28Xms1Ohu7c%3D 10.1093/toxsci/kfl012
    • Pestka J, Zhou HR (2006) Toll-like receptor priming sensitizes macrophages to proinflammatory cytokine gene induction by deoxynivalenol and other toxicants. Toxicol Sci 92(2):445-55
    • (2006) Toxicol Sci , vol.92 , Issue.2 , pp. 445-455
    • Pestka, J.1    Zhou, H.R.2
  • 77
    • 40949145643 scopus 로고    scopus 로고
    • Newspapers and newspaper ink contain agonists for the ah receptor
    • 10.1093/toxsci/kfn011 18203687 1:CAS:528:DC%2BD1cXjtFOntbw%3D 10.1093/toxsci/kfn011
    • Bohonowych JE, Zhao B, Timme-Laragy A, Jung D, Di Giulio RT, Denison MS (2008) Newspapers and newspaper ink contain agonists for the ah receptor. Toxicol Sci 102(2):278-90. doi: 10.1093/toxsci/kfn011
    • (2008) Toxicol Sci , vol.102 , Issue.2 , pp. 278-290
    • Bohonowych, J.E.1    Zhao, B.2    Timme-Laragy, A.3    Jung, D.4    Di Giulio, R.T.5    Denison, M.S.6
  • 78
    • 80053453758 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor negatively regulates LPS-induced IL-6 production through suppression of histamine production in macrophages
    • 10.1093/intimm/dxr072 21930594 1:CAS:528:DC%2BC3MXht1Ght7jI 10.1093/intimm/dxr072
    • Masuda K, Kimura A, Hanieh H, Nguyen NT, Nakahama T, Chinen I, Otoyo Y, Murotani T, Yamatodani A, Kishimoto T (2011) Aryl hydrocarbon receptor negatively regulates LPS-induced IL-6 production through suppression of histamine production in macrophages. Int Immunol 23(10):637-45. doi: 10.1093/intimm/dxr072
    • (2011) Int Immunol , vol.23 , Issue.10 , pp. 637-645
    • Masuda, K.1    Kimura, A.2    Hanieh, H.3    Nguyen, N.T.4    Nakahama, T.5    Chinen, I.6    Otoyo, Y.7    Murotani, T.8    Yamatodani, A.9    Kishimoto, T.10
  • 79
    • 67449107326 scopus 로고    scopus 로고
    • Potential mechanism for pentachlorophenol-induced carcinogenicity: A novel mechanism for metal-independent production of hydroxyl radicals
    • 10.1021/tx900030v 19408893 1:CAS:528:DC%2BD1MXlt12mt78%3D 10.1021/tx900030v
    • Zhu BZ, Shan GQ (2009) Potential mechanism for pentachlorophenol-induced carcinogenicity: a novel mechanism for metal-independent production of hydroxyl radicals. Chem Res Toxicol 22(6):969-77. doi: 10.1021/tx900030v
    • (2009) Chem Res Toxicol , vol.22 , Issue.6 , pp. 969-977
    • Zhu, B.Z.1    Shan, G.Q.2
  • 80
    • 39049152967 scopus 로고    scopus 로고
    • Effects of possible endocrine disruptors on MyD88-independent TLR4 signaling
    • 10.1111/j.1574-695X.2007.00355.x 18177342 1:CAS:528:DC%2BD1cXjt1CmsLc%3D 10.1111/j.1574-695X.2007.00355.x
    • Ohnishi T, Yoshida T, Igarashi A, Muroi M, Tanamoto K (2008) Effects of possible endocrine disruptors on MyD88-independent TLR4 signaling. FEMS Immunol Med Microbiol 52(2):293-5. doi: 10.1111/j.1574-695X.2007.00355.x
    • (2008) FEMS Immunol Med Microbiol , vol.52 , Issue.2 , pp. 293-295
    • Ohnishi, T.1    Yoshida, T.2    Igarashi, A.3    Muroi, M.4    Tanamoto, K.5
  • 81
    • 1842609942 scopus 로고    scopus 로고
    • In vitro activation of murine peritoneal macrophages by ultraviolet B radiation: Upregulation of CD18, production of NO, proinflammatory cytokines and a signal transduction pathway
    • 15072850 1:CAS:528:DC%2BD2cXivFGgsLs%3D 10.1016/j.molimm.2004.01.001
    • Sethi G, Sodhi A (2004) In vitro activation of murine peritoneal macrophages by ultraviolet B radiation: upregulation of CD18, production of NO, proinflammatory cytokines and a signal transduction pathway. Mol Immunol 40(18):1315-23
    • (2004) Mol Immunol , vol.40 , Issue.18 , pp. 1315-1323
    • Sethi, G.1    Sodhi, A.2
  • 82
    • 0038312244 scopus 로고    scopus 로고
    • Characteristic cytokine generation patterns in cancer cells and infiltrating lymphocytes in oral squamous cell carcinomas and the influence of chemoradiation combined with immunotherapy on these patterns
    • 12759539 1:CAS:528:DC%2BD3sXktVyhtLY%3D 10.1159/000070300
    • Yamamoto T, Kimura T, Ueta E, Tatemoto Y, Osaki T (2003) Characteristic cytokine generation patterns in cancer cells and infiltrating lymphocytes in oral squamous cell carcinomas and the influence of chemoradiation combined with immunotherapy on these patterns. Oncology 64(4):407-15
    • (2003) Oncology , vol.64 , Issue.4 , pp. 407-415
    • Yamamoto, T.1    Kimura, T.2    Ueta, E.3    Tatemoto, Y.4    Osaki, T.5
  • 83
    • 33847646709 scopus 로고    scopus 로고
    • Ionizing radiation stimulates secretion of pro-inflammatory cytokines: Dose-response relationship, mechanisms and implications
    • 17072632 1:CAS:528:DC%2BD2sXisVejsrg%3D 10.1007/s00411-006-0076-x
    • Shan YX, Jin SZ, Liu XD, Liu Y, Liu SZ (2007) Ionizing radiation stimulates secretion of pro-inflammatory cytokines: dose-response relationship, mechanisms and implications. Radiat Environ Biophys 46(1):21-9
    • (2007) Radiat Environ Biophys , vol.46 , Issue.1 , pp. 21-29
    • Shan, Y.X.1    Jin, S.Z.2    Liu, X.D.3    Liu, Y.4    Liu, S.Z.5
  • 84
    • 84868271201 scopus 로고    scopus 로고
    • Evaluation of systemic markers of inflammation in atomic-bomb survivors with special reference to radiation and age effects
    • 10.1096/fj.12-215228 22872680 1:CAS:528:DC%2BC38Xhs1Cju7zK 10.1096/fj.12-215228
    • Hayashi T, Morishita Y, Khattree R, Misumi M, Sasaki K, Hayashi I, Yoshida K, Kajimura J, Kyoizumi S, Imai K, Kusunoki Y, Nakachi K (2012) Evaluation of systemic markers of inflammation in atomic-bomb survivors with special reference to radiation and age effects. FASEB J 26(11):4765-73. doi: 10.1096/fj.12-215228
    • (2012) FASEB J , vol.26 , Issue.11 , pp. 4765-4773
    • Hayashi, T.1    Morishita, Y.2    Khattree, R.3    Misumi, M.4    Sasaki, K.5    Hayashi, I.6    Yoshida, K.7    Kajimura, J.8    Kyoizumi, S.9    Imai, K.10    Kusunoki, Y.11    Nakachi, K.12
  • 85
    • 77949867992 scopus 로고    scopus 로고
    • Reactive oxygen species and the pathogenesis of radiocontrast-induced nephropathy
    • 10.1097/RLI.0b013e3181d2eed8 20195159 10.1097/RLI.0b013e3181d2eed8
    • Heyman SN, Rosen S, Khamaisi M, Idée JM, Rosenberger C (2010) Reactive oxygen species and the pathogenesis of radiocontrast-induced nephropathy. Invest Radiol 45(4):188-95. doi: 10.1097/RLI.0b013e3181d2eed8
    • (2010) Invest Radiol , vol.45 , Issue.4 , pp. 188-195
    • Heyman, S.N.1    Rosen, S.2    Khamaisi, M.3    Idée, J.M.4    Rosenberger, C.5
  • 86
    • 0344121650 scopus 로고    scopus 로고
    • IL-1beta, TNFalpha and IL-6 induction in the rat brain after partial-body irradiation: Role of vagal afferents
    • 14630536 1:CAS:528:DC%2BD3sXptVOnu7s%3D 10.1080/09553000310001610998
    • Marquette C, Linard C, Galonnier M, Van Uye A, Mathieu J, Gourmelon P, Clarençon D (2003) IL-1beta, TNFalpha and IL-6 induction in the rat brain after partial-body irradiation: role of vagal afferents. Int J Radiat Biol 79(10):777-85
    • (2003) Int J Radiat Biol , vol.79 , Issue.10 , pp. 777-785
    • Marquette, C.1    Linard, C.2    Galonnier, M.3    Van Uye, A.4    Mathieu, J.5    Gourmelon, P.6    Clarençon, D.7
  • 87
    • 72949118144 scopus 로고    scopus 로고
    • Top-down and bottom-up mechanisms in mind-body medicine: Development of an integrative framework for psychophysiological research
    • 10.1016/j.explore.2009.10.004 10.1016/j.explore.2009.10.004
    • Taylor AG, Goehler LE, Galper DI, Innes KE, Bourguignon C (2010) Top-down and bottom-up mechanisms in mind-body medicine: development of an integrative framework for psychophysiological research. Explore (NY) 6(1):29-41. doi: 10.1016/j.explore.2009.10.004
    • (2010) Explore (NY) , vol.6 , Issue.1 , pp. 29-41
    • Taylor, A.G.1    Goehler, L.E.2    Galper, D.I.3    Innes, K.E.4    Bourguignon, C.5
  • 88
    • 70249121385 scopus 로고    scopus 로고
    • Psychosocial interventions for reducing fatigue during cancer treatment in adults
    • doi: 10.1002/14651858.CD006953.pub2
    • Goedendorp MM, Gielissen MF, Verhagen CA, Bleijenberg G (2009) Psychosocial interventions for reducing fatigue during cancer treatment in adults. Cochrane Database Syst Rev(1):CD006953. doi: 10.1002/14651858.CD006953. pub2
    • (2009) Cochrane Database Syst Rev , Issue.1
    • Goedendorp, M.M.1    Gielissen, M.F.2    Verhagen, C.A.3    Bleijenberg, G.4
  • 89
    • 84874377185 scopus 로고    scopus 로고
    • A neuro-immune model of myalgic encephalomyelitis/chronic fatigue syndrome
    • doi: 10.1007/s11011-012-9324-8
    • Morris G, Maes M (2012) A neuro-immune model of myalgic encephalomyelitis/chronic fatigue syndrome. Metab Brain Dis doi: 10.1007/s11011-012-9324-8
    • (2012) Metab Brain Dis
    • Morris, G.1    Maes, M.2
  • 91
    • 84856182267 scopus 로고    scopus 로고
    • Hyaluronic acid is radioprotective in the intestine through a TLR4 and COX-2-mediated mechanism
    • 10.1152/ajpgi.00248.2011 22038822 10.1152/ajpgi.00248.2011 1:CAS:528:DC%2BC38XjsFKgtrk%3D
    • Riehl TE, Foster L, Stenson WF (2011) Hyaluronic acid is radioprotective in the intestine through a TLR4 and COX-2-mediated mechanism. Am J Physiol Gastrointest Liver Physiol 302(3):G309-16. doi: 10.1152/ajpgi.00248.2011
    • (2011) Am J Physiol Gastrointest Liver Physiol , vol.302 , Issue.3 , pp. 309-316
    • Riehl, T.E.1    Foster, L.2    Stenson, W.F.3
  • 92
    • 33644833719 scopus 로고    scopus 로고
    • Neuroimaging in drug and substance abuse part II: Opioids and solvents
    • 16340648 10.1097/01.rmr.0000192154.34563.6b
    • Borne J, Riascos R, Cuellar H, Vargas D, Rojas R (2005) Neuroimaging in drug and substance abuse part II: opioids and solvents. Top Magn Reson Imaging 16(3):239-45
    • (2005) Top Magn Reson Imaging , vol.16 , Issue.3 , pp. 239-245
    • Borne, J.1    Riascos, R.2    Cuellar, H.3    Vargas, D.4    Rojas, R.5
  • 93
    • 80053192293 scopus 로고    scopus 로고
    • Role of hippocampal TLR4 in neurotoxicity in mice following toluene exposure
    • 10.1016/j.ntt.2011.07.005 21802510 1:CAS:528:DC%2BC3MXht1ejtr%2FP 10.1016/j.ntt.2011.07.005
    • Win-Shwe TT, Kunugita N, Yoshida Y, Fujimaki H (2011) Role of hippocampal TLR4 in neurotoxicity in mice following toluene exposure. Neurotoxicol Teratol 33(5):598-602. doi: 10.1016/j.ntt.2011.07.005
    • (2011) Neurotoxicol Teratol , vol.33 , Issue.5 , pp. 598-602
    • Win-Shwe, T.T.1    Kunugita, N.2    Yoshida, Y.3    Fujimaki, H.4
  • 95
    • 34548379424 scopus 로고    scopus 로고
    • Repeated social defeat increases the bactericidal activity of splenic macrophages through a Toll-like receptor-dependent pathway
    • 17596326 1:CAS:528:DC%2BD2sXhtVOqt7%2FJ 10.1152/ajpregu.00307.2007
    • Bailey MT, Engler H, Powell ND, Padgett DA, Sheridan JF (2007) Repeated social defeat increases the bactericidal activity of splenic macrophages through a Toll-like receptor-dependent pathway. Am J Physiol Regul Integr Comp Physiol 293(3):R1180-90
    • (2007) Am J Physiol Regul Integr Comp Physiol , vol.293 , Issue.3 , pp. 1180-1190
    • Bailey, M.T.1    Engler, H.2    Powell, N.D.3    Padgett, D.A.4    Sheridan, J.F.5
  • 96
    • 41549112494 scopus 로고    scopus 로고
    • Stress mediators regulate brain prostaglandin synthesis and peroxisome proliferator-activated receptor-gamma activation after stress in rats
    • 18079203 10.1210/en.2007-0482 1:CAS:528:DC%2BD1cXktVeqsbk%3D
    • García-Bueno B, Madrigal JL, Pérez-Nievas BG, Leza JC (2008) Stress mediators regulate brain prostaglandin synthesis and peroxisome proliferator-activated receptor-gamma activation after stress in rats. Endocrinology 149(4):1969-78
    • (2008) Endocrinology , vol.149 , Issue.4 , pp. 1969-1978
    • García-Bueno, B.1    Madrigal, J.L.2    Pérez-Nievas, B.G.3    Leza, J.C.4
  • 97
    • 41149112041 scopus 로고    scopus 로고
    • Toll-like receptor 4 is involved in subacute stress-induced neuroinflammation and in the worsening of experimental stroke
    • 10.1161/STROKEAHA.107.498212 18309167 1:CAS:528:DC%2BD1cXjtlSqsbo%3D 10.1161/STROKEAHA.107.498212
    • Caso JR, Pradillo JM, Hurtado O, Leza JC, Moro MA, Lizasoain I (2008) Toll-like receptor 4 is involved in subacute stress-induced neuroinflammation and in the worsening of experimental stroke. Stroke 39(4):1314-20. doi: 10.1161/STROKEAHA.107.498212
    • (2008) Stroke , vol.39 , Issue.4 , pp. 1314-1320
    • Caso, J.R.1    Pradillo, J.M.2    Hurtado, O.3    Leza, J.C.4    Moro, M.A.5    Lizasoain, I.6
  • 98
    • 34548358816 scopus 로고    scopus 로고
    • Toll-like receptors modulate adult hippocampal neurogenesis
    • 17704767 1:CAS:528:DC%2BD2sXpslGju7w%3D 10.1038/ncb1629
    • Rolls A, Shechter R, London A, Ziv Y, Ronen A, Levy R, Schwartz M (2007) Toll-like receptors modulate adult hippocampal neurogenesis. Nat Cell Biol 9(9):1081-8
    • (2007) Nat Cell Biol , vol.9 , Issue.9 , pp. 1081-1088
    • Rolls, A.1    Shechter, R.2    London, A.3    Ziv, Y.4    Ronen, A.5    Levy, R.6    Schwartz, M.7
  • 99
    • 77956332289 scopus 로고    scopus 로고
    • Substance P primes lipoteichoic acid- and Pam3CysSerLys4-mediated activation of human mast cells by up-regulating Toll-like receptor 2
    • 10.1111/j.1365-2567.2010.03296.x 20497485 1:CAS:528:DC%2BC3cXht1CmsLrO 10.1111/j.1365-2567.2010.03296.x
    • Tancowny BP, Karpov V, Schleimer RP, Kulka M (2010) Substance P primes lipoteichoic acid- and Pam3CysSerLys4-mediated activation of human mast cells by up-regulating Toll-like receptor 2. Immunology 131(2):220-30. doi: 10.1111/j.1365-2567.2010.03296.x
    • (2010) Immunology , vol.131 , Issue.2 , pp. 220-230
    • Tancowny, B.P.1    Karpov, V.2    Schleimer, R.P.3    Kulka, M.4
  • 100
    • 4344591766 scopus 로고    scopus 로고
    • Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene
    • 15310853 1:CAS:528:DC%2BD2cXnsVentrk%3D 10.1073/pnas.0403831101
    • Hultqvist M, Olofsson P, Holmberg J, Bäckström BT, Tordsson J, Holmdahl R (2004) Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene. Proc Natl Acad Sci U S A 101(34):12646-51
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.34 , pp. 12646-12651
    • Hultqvist, M.1    Olofsson, P.2    Holmberg, J.3    Bäckström, B.T.4    Tordsson, J.5    Holmdahl, R.6
  • 101
    • 80054751966 scopus 로고    scopus 로고
    • Oxidized phospholipid-induced inflammation is mediated by Toll-like receptor 2
    • 10.1016/j.freeradbiomed.2011.08.026 21925592 1:CAS:528:DC%2BC3MXhtlejsLjJ 10.1016/j.freeradbiomed.2011.08.026
    • Kadl A, Sharma PR, Chen W, Agrawal R, Meher AK, Rudraiah S, Grubbs N, Sharma R, Leitinger N (2011) Oxidized phospholipid-induced inflammation is mediated by Toll-like receptor 2. Free Radic Biol Med 51(10):1903-9. doi: 10.1016/j.freeradbiomed.2011.08.026
    • (2011) Free Radic Biol Med , vol.51 , Issue.10 , pp. 1903-1909
    • Kadl, A.1    Sharma, P.R.2    Chen, W.3    Agrawal, R.4    Meher, A.K.5    Rudraiah, S.6    Grubbs, N.7    Sharma, R.8    Leitinger, N.9
  • 103
    • 34548449911 scopus 로고    scopus 로고
    • Recombinant factor C competes against LBP to bind lipopolysaccharide and neutralizes the endotoxicity
    • 17621557 1:CAS:528:DC%2BD2sXptV2ms78%3D 10.1177/0968051907079573
    • Li P, Ho B, Ding JL (2007) Recombinant factor C competes against LBP to bind lipopolysaccharide and neutralizes the endotoxicity. J Endotoxin Res 13(3):150-7
    • (2007) J Endotoxin Res , vol.13 , Issue.3 , pp. 150-157
    • Li, P.1    Ho, B.2    Ding, J.L.3
  • 104
    • 84874418376 scopus 로고    scopus 로고
    • TLR4 antagonist reduces early-stage atherosclerosis in diabetic apolipoprotein E-deficient mice
    • 23060524 1:CAS:528:DC%2BC3sXhvFalu74%3D 10.1530/JOE-12-0338
    • Lu Z, Zhang X, Li Y, Jin J, Huang Y (2013) TLR4 antagonist reduces early-stage atherosclerosis in diabetic apolipoprotein E-deficient mice. J Endocrinol 216(1):61-71
    • (2013) J Endocrinol , vol.216 , Issue.1 , pp. 61-71
    • Lu, Z.1    Zhang, X.2    Li, Y.3    Jin, J.4    Huang, Y.5
  • 105
    • 81055156707 scopus 로고    scopus 로고
    • Spinal TLR4 mediates the transition to a persistent mechanical hypersensitivity after the resolution of inflammation in serum-transferred arthritis
    • 10.1016/j.pain.2011.09.020 22019135 1:CAS:528:DC%2BC3MXhsVOlt7fM 10.1016/j.pain.2011.09.020
    • Christianson CA, Dumlao DS, Stokes JA, Dennis EA, Svensson CI, Corr M, Yaksh TL (2011) Spinal TLR4 mediates the transition to a persistent mechanical hypersensitivity after the resolution of inflammation in serum-transferred arthritis. Pain 152(12):2881-91. doi: 10.1016/j.pain.2011.09.020
    • (2011) Pain , vol.152 , Issue.12 , pp. 2881-2891
    • Christianson, C.A.1    Dumlao, D.S.2    Stokes, J.A.3    Dennis, E.A.4    Svensson, C.I.5    Corr, M.6    Yaksh, T.L.7
  • 106
    • 74049125175 scopus 로고    scopus 로고
    • Phase 2 trial of eritorantetrasodium (E5564), a toll-like receptor 4 antagonist, in patients with severe sepsis
    • Eritoran Sepsis Study Group 10.1097/CCM.0b013e3181b07b78 10.1097/CCM.0b013e3181b07b78 1:CAS:528:DC%2BD1MXhsFyhsL7F
    • Tidswell M, Tillis W, Larosa SP, Lynn M, Wittek AE, Kao R, Wheeler J, Gogate J, Opal SM; Eritoran Sepsis Study Group (2010) Phase 2 trial of eritorantetrasodium (E5564), a toll-like receptor 4 antagonist, in patients with severe sepsis. Crit Care Med 38(1):72-83. doi: 10.1097/CCM.0b013e3181b07b78
    • (2010) Crit Care Med , vol.38 , Issue.1 , pp. 72-83
    • Tidswell, M.1    Tillis, W.2    Larosa, S.P.3    Lynn, M.4    Wittek, A.E.5    Kao, R.6    Wheeler, J.7    Gogate, J.8    Opal, S.M.9
  • 107
    • 33745041451 scopus 로고    scopus 로고
    • A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression
    • 16717116 1:CAS:528:DC%2BD28XmtVantrw%3D 10.1084/jem.20060136
    • Macagno A, Molteni M, Rinaldi A, Bertoni F, Lanzavecchia A, Rossetti C, Sallusto F (2006) A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression. J Exp Med 203(6):1481-92
    • (2006) J Exp Med , vol.203 , Issue.6 , pp. 1481-1492
    • MacAgno, A.1    Molteni, M.2    Rinaldi, A.3    Bertoni, F.4    Lanzavecchia, A.5    Rossetti, C.6    Sallusto, F.7
  • 108
    • 84855721698 scopus 로고    scopus 로고
    • Therapeutic targeting of innate immunity with Toll-like receptor 4 (TLR4) antagonists
    • 10.1016/j.biotechadv.2011.05.014 21664961 1:CAS:528: DC%2BC38XpsFynsg%3D%3D 10.1016/j.biotechadv.2011.05.014
    • Peri F, Piazza M (2012) Therapeutic targeting of innate immunity with Toll-like receptor 4 (TLR4) antagonists. Biotechnol Adv 30(1):251-60. doi: 10.1016/j.biotechadv.2011.05.014
    • (2012) Biotechnol Adv , vol.30 , Issue.1 , pp. 251-260
    • Peri, F.1    Piazza, M.2
  • 109
    • 33748189399 scopus 로고    scopus 로고
    • Suppression of MyD88- and TRIF-dependent signaling pathways of Toll-like receptor by (-)-epigallocatechin-3-gallate, a polyphenol component of green tea
    • 16890209 1:CAS:528:DC%2BD28XptVGmtrw%3D 10.1016/j.bcp.2006.06.021
    • Youn HS, Lee JY, Saitoh SI, Miyake K, Kang KW, Choi YJ, Hwang DH (2006) Suppression of MyD88- and TRIF-dependent signaling pathways of Toll-like receptor by (-)-epigallocatechin-3-gallate, a polyphenol component of green tea. Biochem Pharmacol 72(7):850-9
    • (2006) Biochem Pharmacol , vol.72 , Issue.7 , pp. 850-859
    • Youn, H.S.1    Lee, J.Y.2    Saitoh, S.I.3    Miyake, K.4    Kang, K.W.5    Choi, Y.J.6    Hwang, D.H.7
  • 110
    • 84855579653 scopus 로고    scopus 로고
    • Effects of intrathecalepigallocatechingallate, an inhibitor of Toll-like receptor 4, on chronic neuropathic pain in rats
    • 10.1016/j.ejphar.2011.11.037 22173123 1:CAS:528:DC%2BC38Xks1Gmtg%3D%3D 10.1016/j.ejphar.2011.11.037
    • Kuang X, Huang Y, Gu HF, Zu XY, Zou WY, Song ZB, Guo QL (2012) Effects of intrathecalepigallocatechingallate, an inhibitor of Toll-like receptor 4, on chronic neuropathic pain in rats. Eur J Pharmacol 676(1-3):51-6. doi: 10.1016/j.ejphar.2011.11.037
    • (2012) Eur J Pharmacol , vol.676 , Issue.1-3 , pp. 51-56
    • Kuang, X.1    Huang, Y.2    Gu, H.F.3    Zu, X.Y.4    Zou, W.Y.5    Song, Z.B.6    Guo, Q.L.7
  • 111
    • 68649096651 scopus 로고    scopus 로고
    • TBK1-targeted suppression of TRIF-dependent signaling pathway of Toll-like receptors by 6-shogaol, an active component of ginger
    • 19584560 1:CAS:528:DC%2BD1MXps1ylsbk%3D 10.1271/bbb.80738
    • Park SJ, Lee MY, Son BS, Youn HS (2009) TBK1-targeted suppression of TRIF-dependent signaling pathway of Toll-like receptors by 6-shogaol, an active component of ginger. Biosci Biotechnol Biochem 73(7):1474-8
    • (2009) Biosci Biotechnol Biochem , vol.73 , Issue.7 , pp. 1474-1478
    • Park, S.J.1    Lee, M.Y.2    Son, B.S.3    Youn, H.S.4
  • 112
    • 44449179744 scopus 로고    scopus 로고
    • Salvianolic acid B inhibits hydrogen peroxide-induced endothelial cell apoptosis through regulating PI3K/Akt signaling
    • 18091994 10.1371/journal.pone.0001321 1:CAS:528:DC%2BD1cXhtVSls7s%3D
    • Liu CL, Xie LX, Li M, Durairajan SS, Goto S, Huang JD (2007) Salvianolic acid B inhibits hydrogen peroxide-induced endothelial cell apoptosis through regulating PI3K/Akt signaling. PLoS One 2(12):e1321
    • (2007) PLoS One , vol.2 , Issue.12 , pp. 1321
    • Liu, C.L.1    Xie, L.X.2    Li, M.3    Durairajan, S.S.4    Goto, S.5    Huang, J.D.6
  • 113
    • 79957508060 scopus 로고    scopus 로고
    • Differential cardioprotective effects of salvianolic acid and tanshinone on acute myocardial infarction are mediated by unique signaling pathways
    • 10.1016/j.jep.2011.03.070 21497648 1:CAS:528:DC%2BC3MXmsFWgtbg%3D 10.1016/j.jep.2011.03.070
    • Wang X, Wang Y, Jiang M, Zhu Y, Hu L, Fan G, Wang Y, Li X, Gao X (2011) Differential cardioprotective effects of salvianolic acid and tanshinone on acute myocardial infarction are mediated by unique signaling pathways. J Ethnopharmacol 135(3):662-71. doi: 10.1016/j.jep.2011.03.070
    • (2011) J Ethnopharmacol , vol.135 , Issue.3 , pp. 662-671
    • Wang, X.1    Wang, Y.2    Jiang, M.3    Zhu, Y.4    Hu, L.5    Fan, G.6    Wang, Y.7    Li, X.8    Gao, X.9
  • 114
    • 33744526702 scopus 로고    scopus 로고
    • Inhibition of homodimerization of Toll-like receptor 4 by curcumin
    • 16678799 1:CAS:528:DC%2BD28Xltl2gt7c%3D 10.1016/j.bcp.2006.03.022
    • Youn HS, Saitoh SI, Miyake K, Hwang DH (2006) Inhibition of homodimerization of Toll-like receptor 4 by curcumin. Biochem Pharmacol 72(1):62-9
    • (2006) Biochem Pharmacol , vol.72 , Issue.1 , pp. 62-69
    • Youn, H.S.1    Saitoh, S.I.2    Miyake, K.3    Hwang, D.H.4
  • 115
    • 84864408767 scopus 로고    scopus 로고
    • Therapeutic inhibition of pro-inflammatory signaling and toxicity to staphylococcal enterotoxin B by a synthetic dimeric BB-loop mimetic of MyD88
    • 10.1371/journal.pone.0040773 22848400 1:CAS:528:DC%2BC38XhtFCgu73J 10.1371/journal.pone.0040773
    • Kissner TL, Ruthel G, Alam S, Mann E, Ajami D, Rebek M, Larkin E, Fernandez S, Ulrich RG, Ping S, Waugh DS, Rebek J Jr, Saikh KU (2012) Therapeutic inhibition of pro-inflammatory signaling and toxicity to staphylococcal enterotoxin B by a synthetic dimeric BB-loop mimetic of MyD88. PLoS One 7(7):e40773. doi: 10.1371/journal.pone.0040773
    • (2012) PLoS One , vol.7 , Issue.7 , pp. 40773
    • Kissner, T.L.1    Ruthel, G.2    Alam, S.3    Mann, E.4    Ajami, D.5    Rebek, M.6    Larkin, E.7    Fernandez, S.8    Ulrich, R.G.9    Ping, S.10    Waugh, D.S.11    Rebek, Jr.J.12    Saikh, K.U.13
  • 116
    • 79952412498 scopus 로고    scopus 로고
    • Anesthetic propofol reduces endotoxic inflammation by inhibiting reactive oxygen species-regulated Akt/IKKβ/NF-κB signaling
    • 10.1371/journal.pone.0017598 21408125 1:CAS:528:DC%2BC3MXjsFGku7k%3D 10.1371/journal.pone.0017598
    • Hsing CH, Lin MC, Choi PC, Huang WC, Kai JI, Tsai CC, Cheng YL, Hsieh CY, Wang CY, Chang YP, Chen YH, Chen CL, Lin CF (2011) Anesthetic propofol reduces endotoxic inflammation by inhibiting reactive oxygen species-regulated Akt/IKKβ/NF-κB signaling. PLoS One 6(3):e17598. doi: 10.1371/journal.pone.0017598
    • (2011) PLoS One , vol.6 , Issue.3 , pp. 17598
    • Hsing, C.H.1    Lin, M.C.2    Choi, P.C.3    Huang, W.C.4    Kai, J.I.5    Tsai, C.C.6    Cheng, Y.L.7    Hsieh, C.Y.8    Wang, C.Y.9    Chang, Y.P.10    Chen, Y.H.11    Chen, C.L.12    Lin, C.F.13
  • 117
    • 70249119956 scopus 로고    scopus 로고
    • Propofol inhibits lipoteichoic acid-induced iNOS gene expression in macrophages possibly through downregulation of toll-like receptor 2-mediated activation of Raf-MEK1/2-ERK1/2-IKK-NFkappaB
    • 10.1016/j.cbi.2009.06.011 19573522 1:CAS:528:DC%2BD1MXhtFGksrrJ 10.1016/j.cbi.2009.06.011
    • Chiu WT, Lin YL, Chou CW, Chen RM (2009) Propofol inhibits lipoteichoic acid-induced iNOS gene expression in macrophages possibly through downregulation of toll-like receptor 2-mediated activation of Raf-MEK1/2-ERK1/2-IKK-NFkappaB. Chem Biol Interact 181(3):430-9. doi: 10.1016/j.cbi.2009.06.011
    • (2009) Chem Biol Interact , vol.181 , Issue.3 , pp. 430-439
    • Chiu, W.T.1    Lin, Y.L.2    Chou, C.W.3    Chen, R.M.4
  • 118
    • 84864089849 scopus 로고    scopus 로고
    • Ketamine inhibits lipopolysaccharide-induced astrocytes activation by suppressing TLR4/NF-Ä̧B pathway
    • 10.1159/000341442 22832327 1:CAS:528:DC%2BC38XhtF2jurzM 10.1159/000341442
    • Wu Y, Li W, Zhou C, Lu F, Gao T, Liu Y, Cao J, Zhang Y, Zhang Y, Zhou C (2012) Ketamine inhibits lipopolysaccharide-induced astrocytes activation by suppressing TLR4/NF-Ä̧B pathway. Cell Physiol Biochem 30(3):609-17. doi: 10.1159/000341442
    • (2012) Cell Physiol Biochem , vol.30 , Issue.3 , pp. 609-617
    • Wu, Y.1    Li, W.2    Zhou, C.3    Lu, F.4    Gao, T.5    Liu, Y.6    Cao, J.7    Zhang, Y.8    Zhang, Y.9    Zhou, C.10
  • 119
    • 84860918905 scopus 로고    scopus 로고
    • Molecular mechanisms of hypertension-reactive oxygen species and antioxidants: A basic science update for the clinician
    • 10.1016/j.cjca.2012.01.017 22445098 1:CAS:528:DC%2BC38XhtVCmu77F 10.1016/j.cjca.2012.01.017
    • Montezano AC, Touyz RM (2012) Molecular mechanisms of hypertension-reactive oxygen species and antioxidants: a basic science update for the clinician. Can J Cardiol 28(3):288-95. doi: 10.1016/j.cjca.2012.01.017
    • (2012) Can J Cardiol , vol.28 , Issue.3 , pp. 288-295
    • Montezano, A.C.1    Touyz, R.M.2
  • 120
    • 49749109893 scopus 로고    scopus 로고
    • N-acetyl cysteine for depressive symptoms in bipolar disorder - A double-blind randomized placebo-controlled trial
    • 10.1016/j.biopsych.2008.04.022 18534556 1:CAS:528:DC%2BD1cXhtVensr7J 10.1016/j.biopsych.2008.04.022
    • Berk M, Copolov DL, Dean O, Lu K, Jeavons S, Schapkaitz I, Anderson-Hunt M, Bush AI (2008) N-acetyl cysteine for depressive symptoms in bipolar disorder - a double-blind randomized placebo-controlled trial. Biol Psychiatry 64(6):468-75. doi: 10.1016/j.biopsych.2008.04.022
    • (2008) Biol Psychiatry , vol.64 , Issue.6 , pp. 468-475
    • Berk, M.1    Copolov, D.L.2    Dean, O.3    Lu, K.4    Jeavons, S.5    Schapkaitz, I.6    Anderson-Hunt, M.7    Bush, A.I.8
  • 123
    • 84880919496 scopus 로고    scopus 로고
    • N-acetylcysteine reduces inflammation in the small intestine by regulating redox, EGF and TLR4 signaling
    • in press
    • Hou Y, Wang L, Yi D, Ding B, Yang Z, Li J, Chen X, Qiu Y, Wu G (2013) N-acetylcysteine reduces inflammation in the small intestine by regulating redox, EGF and TLR4 signaling. Amino Acids (in press)
    • (2013) Amino Acids
    • Hou, Y.1    Wang, L.2    Yi, D.3    Ding, B.4    Yang, Z.5    Li, J.6    Chen, X.7    Qiu, Y.8    Wu, G.9
  • 124
    • 84867097988 scopus 로고    scopus 로고
    • α-Lipoic acid prevents non-alcoholic fatty liver disease in OLETF rats
    • 10.1111/j.1478-3231.2012.02857.x 22863080 1:CAS:528: DC%2BC3sXktlalug%3D%3D 10.1111/j.1478-3231.2012.02857.x
    • Jung TS, Kim SK, Shin HJ, Jeon BT, Hahm JR, Roh GS (2012) α-Lipoic acid prevents non-alcoholic fatty liver disease in OLETF rats. Liver Int 32(10):1565-73. doi: 10.1111/j.1478-3231.2012.02857.x
    • (2012) Liver Int , vol.32 , Issue.10 , pp. 1565-1573
    • Jung, T.S.1    Kim, S.K.2    Shin, H.J.3    Jeon, B.T.4    Hahm, J.R.5    Roh, G.S.6
  • 125
    • 83555164917 scopus 로고    scopus 로고
    • Lipoic acid attenuates innate immune infiltration and activation in the visceral adipose tissue of obese insulin resistant mice
    • 10.1007/s11745-011-3603-8 21861137 1:CAS:528:DC%2BC3MXhsVCksbfI 10.1007/s11745-011-3603-8
    • Deiuliis JA, Kampfrath T, Ying Z, Maiseyeu A, Rajagopalan S (2011) Lipoic acid attenuates innate immune infiltration and activation in the visceral adipose tissue of obese insulin resistant mice. Lipids 46(11):1021-1032. doi: 10.1007/s11745-011-3603-8
    • (2011) Lipids , vol.46 , Issue.11 , pp. 1021-1032
    • Deiuliis, J.A.1    Kampfrath, T.2    Ying, Z.3    Maiseyeu, A.4    Rajagopalan, S.5
  • 126
    • 84860917437 scopus 로고    scopus 로고
    • α-Lipoic acid prevents mild portal endotoxaemia-induced hepatic inflammation and β cell dysfunction
    • 10.1111/j.1365-2362.2011.02630.x 22121883 1:CAS:528:DC%2BC38XhtFSqsrjL 10.1111/j.1365-2362.2011.02630.x
    • Tian YF, Hsieh CH, Hsieh YJ, Chen YT, Peng YJ, Hsieh PS (2012) α-Lipoic acid prevents mild portal endotoxaemia-induced hepatic inflammation and β cell dysfunction. Eur J Clin Invest 42(6):637-48. doi: 10.1111/j.1365-2362.2011.02630.x
    • (2012) Eur J Clin Invest , vol.42 , Issue.6 , pp. 637-648
    • Tian, Y.F.1    Hsieh, C.H.2    Hsieh, Y.J.3    Chen, Y.T.4    Peng, Y.J.5    Hsieh, P.S.6
  • 127
    • 84861933674 scopus 로고    scopus 로고
    • Glycyrrhizin and isoliquiritigenin suppress the LPS sensor toll-like receptor 4/MD-2 complex signaling in a different manner
    • 10.1189/jlb.0112038 22422925 1:CAS:528:DC%2BC38XotlWrt7w%3D 10.1189/jlb.0112038
    • Honda H, Nagai Y, Matsunaga T, Saitoh S, Akashi-Takamura S, Hayashi H, Fujii I, Miyake K, Muraguchi A, Takatsu K (2012) Glycyrrhizin and isoliquiritigenin suppress the LPS sensor toll-like receptor 4/MD-2 complex signaling in a different manner. J Leukoc Biol 91(6):967-76. doi: 10.1189/jlb.0112038
    • (2012) J Leukoc Biol , vol.91 , Issue.6 , pp. 967-976
    • Honda, H.1    Nagai, Y.2    Matsunaga, T.3    Saitoh, S.4    Akashi-Takamura, S.5    Hayashi, H.6    Fujii, I.7    Miyake, K.8    Muraguchi, A.9    Takatsu, K.10
  • 128
    • 79955675928 scopus 로고    scopus 로고
    • A resveratrol and polyphenol preparation suppresses oxidative and inflammatory stress response to a high-fat, high-carbohydrate meal
    • 10.1210/jc.2010-1812 21289251 1:CAS:528:DC%2BC3MXmsVWns7k%3D 10.1210/jc.2010-1812
    • Ghanim H, Sia CL, Korzeniewski K, Lohano T, Abuaysheh S, Marumganti A, Chaudhuri A, Dandona P (2011) A resveratrol and polyphenol preparation suppresses oxidative and inflammatory stress response to a high-fat, high-carbohydrate meal. J Clin Endocrinol Metab 96(5):1409-14. doi: 10.1210/jc.2010-1812
    • (2011) J Clin Endocrinol Metab , vol.96 , Issue.5 , pp. 1409-1414
    • Ghanim, H.1    Sia, C.L.2    Korzeniewski, K.3    Lohano, T.4    Abuaysheh, S.5    Marumganti, A.6    Chaudhuri, A.7    Dandona, P.8
  • 129
    • 84855440646 scopus 로고    scopus 로고
    • Effect of baicalin on toll-like receptor 4-mediated ischemia/reperfusion inflammatory responses in alcoholic fatty liver condition
    • 10.1016/j.taap.2011.10.005 22019745 1:CAS:528:DC%2BC38XltVGisQ%3D%3D 10.1016/j.taap.2011.10.005
    • Kim SJ, Lee SM (2012) Effect of baicalin on toll-like receptor 4-mediated ischemia/reperfusion inflammatory responses in alcoholic fatty liver condition. Toxicol Appl Pharmacol 258(1):43-50. doi: 10.1016/j.taap.2011.10.005
    • (2012) Toxicol Appl Pharmacol , vol.258 , Issue.1 , pp. 43-50
    • Kim, S.J.1    Lee, S.M.2
  • 130
    • 84055199416 scopus 로고    scopus 로고
    • Baicalin suppresses expression of TLR2/4 and NF-κB in Chlamydia trachomatis-infected mice
    • 10.3109/08923973.2011.580756 21612566 1:CAS:528:DC%2BC3MXhs1Cju7nJ 10.3109/08923973.2011.580756
    • Hao H, Gufu H, Lei F, Dang L, Zhongliang Y (2012) Baicalin suppresses expression of TLR2/4 and NF-κB in Chlamydia trachomatis-infected mice. Immunopharmacol Immunotoxicol 34(1):89-94. doi: 10.3109/08923973.2011.580756
    • (2012) Immunopharmacol Immunotoxicol , vol.34 , Issue.1 , pp. 89-94
    • Hao, H.1    Gufu, H.2    Lei, F.3    Dang, L.4    Zhongliang, Y.5
  • 131
    • 80655146260 scopus 로고    scopus 로고
    • Baicalin inhibits TLR2/4 signaling pathway in rat brain following permanent cerebral ischemia
    • 10.1007/s10753-010-9254-8 20859668 1:CAS:528:DC%2BC3MXhtFKrsLzM 10.1007/s10753-010-9254-8
    • Tu XK, Yang WZ, Shi SS, Chen Y, Wang CH, Chen CM, Chen Z (2011) Baicalin inhibits TLR2/4 signaling pathway in rat brain following permanent cerebral ischemia. Inflammation 34(5):463-70. doi: 10.1007/s10753-010-9254-8
    • (2011) Inflammation , vol.34 , Issue.5 , pp. 463-470
    • Tu, X.K.1    Yang, W.Z.2    Shi, S.S.3    Chen, Y.4    Wang, C.H.5    Chen, C.M.6    Chen, Z.7
  • 132
    • 84863686606 scopus 로고    scopus 로고
    • Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases
    • 10.1155/2012/353152 22720117 10.1155/2012/353152 1:CAS:528: DC%2BC38XoslKms7c%3D
    • Ohno K, Ito M, Ichihara M, Ito M (2012) Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases. Oxid Med Cell Longev 2012:353152. doi: 10.1155/2012/353152
    • (2012) Oxid Med Cell Longev , vol.2012 , pp. 353152
    • Ohno, K.1    Ito, M.2    Ichihara, M.3    Ito, M.4
  • 133
    • 84863674857 scopus 로고    scopus 로고
    • Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies
    • 10.1186/2045-9912-1-24 22146674 1:CAS:528:DC%2BC3MXhs1Oqur7J 10.1186/2045-9912-1-24
    • Ito M, Ibi T, Sahashi K, Ichihara M, Ito M, Ohno K (2011) Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies. Med Gas Res 1(1):24. doi: 10.1186/2045-9912-1-24
    • (2011) Med Gas Res , vol.1 , Issue.1 , pp. 24
    • Ito, M.1    Ibi, T.2    Sahashi, K.3    Ichihara, M.4    Ito, M.5    Ohno, K.6
  • 134
    • 84868578416 scopus 로고    scopus 로고
    • Protective effects of hydrogen-rich saline in a rat model of permanent focal cerebral ischemia via reducing oxidative stress and inflammatory cytokines
    • 10.1016/j.brainres.2012.09.031 23010312 1:CAS:528:DC%2BC38XhsVKgs7rF 10.1016/j.brainres.2012.09.031
    • Li J, Dong Y, Chen H, Han H, Yu Y, Wang G, Zeng Y, Xie K (2012) Protective effects of hydrogen-rich saline in a rat model of permanent focal cerebral ischemia via reducing oxidative stress and inflammatory cytokines. Brain Res 1486:103-11. doi: 10.1016/j.brainres.2012.09.031
    • (2012) Brain Res , vol.1486 , pp. 103-111
    • Li, J.1    Dong, Y.2    Chen, H.3    Han, H.4    Yu, Y.5    Wang, G.6    Zeng, Y.7    Xie, K.8
  • 135
    • 84859903016 scopus 로고    scopus 로고
    • Molecular hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice through reducing inflammation and apoptosis
    • 10.1097/SHK.0b013e31824ddc81 22508291 1:CAS:528:DC%2BC38XlslWqsLw%3D
    • Xie K, Yu Y, Huang Y, Zheng L, Li J, Chen H, Han H, Hou L, Gong G, Wang G (2012) Molecular hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice through reducing inflammation and apoptosis. Shock 37(5):548-55. doi: 10.1097/SHK.0b013e31824ddc81
    • (2012) Shock , vol.37 , Issue.5 , pp. 548-555
    • Xie, K.1    Yu, Y.2    Huang, Y.3    Zheng, L.4    Li, J.5    Chen, H.6    Han, H.7    Hou, L.8    Gong, G.9    Wang, G.10
  • 136
    • 20144377088 scopus 로고    scopus 로고
    • C-reactive protein-induced in vitro endothelial cell activation is an artefact caused by azide and lipopolysaccharide
    • 15802626 1:CAS:528:DC%2BD2MXksVWqtLw%3D 10.1161/01.ATV.0000164623.41250. 28
    • Taylor KE, Giddings JC, van den Berg CW (2005) C-reactive protein-induced in vitro endothelial cell activation is an artefact caused by azide and lipopolysaccharide. Arterioscler Thromb Vasc Biol 25(6):1225-30
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , Issue.6 , pp. 1225-1230
    • Taylor, K.E.1    Giddings, J.C.2    Van Den Berg, C.W.3
  • 138
    • 79955473132 scopus 로고    scopus 로고
    • Determination of cell surface expression of Toll-like receptor 4 by cellular enzyme-linked immunosorbent assay and radiolabeling
    • 10.1016/j.ab.2011.02.031 21354097 10.1016/j.ab.2011.02.031 1:CAS:528:DC%2BC3MXltFais7c%3D
    • Józefowski S, Czerkies M, Sobota A, Kwiatkowska K (2011) Determination of cell surface expression of Toll-like receptor 4 by cellular enzyme-linked immunosorbent assay and radiolabeling. Anal Biochem 413(2):185-91. doi: 10.1016/j.ab.2011.02.031
    • (2011) Anal Biochem , vol.413 , Issue.2 , pp. 185-191
    • Józefowski, S.1    Czerkies, M.2    Sobota, A.3    Kwiatkowska, K.4


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