NLRP3 inflammasome: A new target in major depressive disorder

CNS Neuroscience and Therapeutics

Volumn 20, Issue 3, 2014, Pages 294-295

  Alcocer Gómez, Elísabet ^a   Cordero, Mario D ^b  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

^b UNIVERSITY OF SEVILLE   (Spain)

Author keywords

Antidepressants; Depression; Inflammasome

Indexed keywords

ANTIDEPRESSANTS; DEPRESSION; INFLAMMASOME;

ANTIDEPRESSIVE AGENTS; CARRIER PROTEINS; DEPRESSIVE DISORDER, MAJOR; GENE EXPRESSION REGULATION; HUMANS;

EID: 84894258609     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12230     Document Type: Letter

References (13)

1. Menu P, Vince JE. The NLRP3 inflammasome in health and disease: the good, the bad and the ugly. Clin Exp Immunol 2011;166:1-15.
2. Leemans JC, Cassel SL, Sutterwala FS. Sensing damage by the NLRP3 inflammasome. Immunol Rev 2011;243:152-162.
3. Iwata M, Ota KT, Duman RS. The inflammasome: pathways linking psychological stress, depression, and systemic illnesses. Brain Behav Immun 2013;31:105-114.
4. Zhang Y, Liu L, Peng YL, et al. Involvement of inflammasome activation in lipopolysaccharide-induced mice depressive-like behaviors. CNS Neurosci Ther 2013; 20:119-124.
5. Alcocer-Gómez E, de Miguel M, Casas-Barquero N, et al. NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder. Brain Behav Immun 2013;36:111-117.
6. Limone P, Biglino A, Bottino F, et al. Evidence for a positive correlation between serum cortisol levels and IL-1beta production by peripheral mononuclear cells in anorexia nervosa. J Endocrinol Invest 2000;23:422-427.
7. Tang SW, Helmeste D, Leonard B. Is neurogenesis relevant in depression and in the mechanism of antidepressant drug action? A critical review. World J Biol Psychiatry 2012;13:402-412.
8. Zhang K, Xu H, Cao L, Li K, Huang Q. Interleukin-1β inhibits the differentiation of hippocampal neural precursor cells into serotonergic neurons. Brain Res 2013;1490:193-201.
9. Hannestad J, DellaGioia N, Bloch M. The effect of antidepressant medication treatment on serum levels of inflammatory cytokines: a metaanalysis. Neuropsychopharmacology 2011;36:2452-2459.
10. Pineda EA, Hensler JG, Sankar R, Shin D, Burke TF, Mazarati AM. Interleukin-1β causes fluoxetine resistance in an animal model of epilepsy-associated depression. Neurotherapeutics 2012;9:477-485.
11. Borkowska P, Kucia K, Rzezniczek S, et al. Interleukin-1beta promoter (-31T/C and -511C/T) polymorphisms in major recurrent depression. J Mol Neurosci 2011;44:12-16.
12. Haastrup E, Bukh JD, Bock C, et al. Promoter variants in IL18 are associated with onset of depression in patients previously exposed to stressful-life events. J Affect Disord 2012;136:134-138.
13. Hwang JP, Tsai SJ, Hong CJ, Yang CH, Hsu CD, Liou YJ. Interleukin-1 beta -511C/T genetic polymorphism is associated with age of onset of geriatric depression. Neuromolecular Med 2009;11:322-327.