메뉴 건너뛰기




Volumn 20, Issue , 2016, Pages 5-11

Altered blood–brain barrier transport in neuro-inflammatory disorders

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; BLOOD BRAIN BARRIER; CELL INFILTRATION; CELL TRANSPORT; DRUG DELIVERY SYSTEM; DRUG TARGETING; ENDOCYTOSIS; GLIA CELL; HOMEOSTASIS; HUMAN; IMMUNOCOMPETENT CELL; MULTIPLE SCLEROSIS; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONHUMAN; REVIEW; CENTRAL NERVOUS SYSTEM DISEASES; INFLAMMATION; METABOLISM; TRANSPORT AT THE CELLULAR LEVEL;

EID: 85003837094     PISSN: None     EISSN: 17406749     Source Type: Journal    
DOI: 10.1016/j.ddtec.2016.07.002     Document Type: Review
Times cited : (34)

References (89)
  • 1
    • 0036319335 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions and blood-brain barrier permeability
    • [1] Abbott, N.J., Astrocyte-endothelial interactions and blood-brain barrier permeability. J Anat 200 (2002), 629–638.
    • (2002) J Anat , vol.200 , pp. 629-638
    • Abbott, N.J.1
  • 2
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions at the blood-brain barrier
    • [2] Abbott, N.J., Ronnback, L., Hansson, E., Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci 7 (2006), 41–53.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 41-53
    • Abbott, N.J.1    Ronnback, L.2    Hansson, E.3
  • 3
    • 33746829163 scopus 로고    scopus 로고
    • Brain's firewall: blood-brain barrier actively regulates neuroimmune information flow
    • [3] Quan, N., Brain's firewall: blood-brain barrier actively regulates neuroimmune information flow. Brain Behav Immun 20 (2006), 447–448.
    • (2006) Brain Behav Immun , vol.20 , pp. 447-448
    • Quan, N.1
  • 4
    • 22944483792 scopus 로고    scopus 로고
    • The blood-brain barrier/neurovascular unit in health and disease
    • [4] Hawkins, B.T., Davis, T.P., The blood-brain barrier/neurovascular unit in health and disease. Pharmacol Rev 57 (2005), 173–185.
    • (2005) Pharmacol Rev , vol.57 , pp. 173-185
    • Hawkins, B.T.1    Davis, T.P.2
  • 5
    • 0030099527 scopus 로고    scopus 로고
    • Transporting therapeutics across the blood-brain barrier
    • [5] Abbott, N.J., Romero, I.A., Transporting therapeutics across the blood-brain barrier. Mol Med Today 2 (1996), 106–113.
    • (1996) Mol Med Today , vol.2 , pp. 106-113
    • Abbott, N.J.1    Romero, I.A.2
  • 6
    • 40849113545 scopus 로고    scopus 로고
    • Early disruptions of the blood-brain barrier may contribute to exacerbated neuronal damage and prolonged functional recovery following stroke in aged rats
    • [6] DiNapoli, V.A., Huber, J.D., Houser, K., Li, X., Rosen, C.L., Early disruptions of the blood-brain barrier may contribute to exacerbated neuronal damage and prolonged functional recovery following stroke in aged rats. Neurobiol Aging 29 (2008), 753–764.
    • (2008) Neurobiol Aging , vol.29 , pp. 753-764
    • DiNapoli, V.A.1    Huber, J.D.2    Houser, K.3    Li, X.4    Rosen, C.L.5
  • 7
    • 66149130750 scopus 로고    scopus 로고
    • Differential receptor-mediated drug targeting to the diseased brain
    • [7] Rip, J., Schenk, G.J., de Boer, A.G., Differential receptor-mediated drug targeting to the diseased brain. Expert Opin Drug Deliv 6 (2009), 227–237.
    • (2009) Expert Opin Drug Deliv , vol.6 , pp. 227-237
    • Rip, J.1    Schenk, G.J.2    de Boer, A.G.3
  • 8
    • 84865735385 scopus 로고    scopus 로고
    • The Trojan Horse Liposome Technology for Nonviral Gene Transfer across the Blood-Brain Barrier
    • [8] Boado, R.J., Pardridge, W.M., The Trojan Horse Liposome Technology for Nonviral Gene Transfer across the Blood-Brain Barrier. J Drug Deliv, 2011, 2011, p296151.
    • (2011) J Drug Deliv , vol.2011 , pp. p296151
    • Boado, R.J.1    Pardridge, W.M.2
  • 9
    • 79955681508 scopus 로고    scopus 로고
    • Molecular cascades that mediate the influence of inflammation on epilepsy
    • [9] Friedman, A., Dingledine, R., Molecular cascades that mediate the influence of inflammation on epilepsy. Epilepsia 52:Suppl. 3 (2011), 33–39.
    • (2011) Epilepsia , vol.52 , pp. 33-39
    • Friedman, A.1    Dingledine, R.2
  • 10
    • 84870408539 scopus 로고    scopus 로고
    • The blood-brain barrier in health and disease
    • [10] Daneman, R., The blood-brain barrier in health and disease. Ann Neurol 72 (2012), 648–672.
    • (2012) Ann Neurol , vol.72 , pp. 648-672
    • Daneman, R.1
  • 11
    • 84856034604 scopus 로고    scopus 로고
    • Neuroinflammation: a common pathway in CNS diseases as mediated at the blood-brain barrier
    • [11] Erickson, M.A., Dohi, K., Banks, W.A., Neuroinflammation: a common pathway in CNS diseases as mediated at the blood-brain barrier. Neuroimmunomodulation 19 (2012), 121–130.
    • (2012) Neuroimmunomodulation , vol.19 , pp. 121-130
    • Erickson, M.A.1    Dohi, K.2    Banks, W.A.3
  • 12
    • 84957840947 scopus 로고    scopus 로고
    • Immune cell trafficking across the barriers of the central nervous system in multiple sclerosis and stroke
    • [12] Lopes Pinheiro, M.A., Kooij, G., Mizee, M.R., Kamermans, A., Enzmann, G., Lyck, R., et al. Immune cell trafficking across the barriers of the central nervous system in multiple sclerosis and stroke. Biochim Biophys Acta 1862 (2016), 461–471.
    • (2016) Biochim Biophys Acta , vol.1862 , pp. 461-471
    • Lopes Pinheiro, M.A.1    Kooij, G.2    Mizee, M.R.3    Kamermans, A.4    Enzmann, G.5    Lyck, R.6
  • 13
    • 67349142021 scopus 로고    scopus 로고
    • Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease
    • [13] Bell, R.D., Zlokovic, B.V., Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease. Acta Neuropathol 118 (2009), 103–113.
    • (2009) Acta Neuropathol , vol.118 , pp. 103-113
    • Bell, R.D.1    Zlokovic, B.V.2
  • 14
    • 43849102672 scopus 로고    scopus 로고
    • Deficits of the cholinergic system in early AD
    • [14] Herholz, K., Weisenbach, S., Kalbe, E., Deficits of the cholinergic system in early AD. Neuropsychologia 46 (2008), 1642–1647.
    • (2008) Neuropsychologia , vol.46 , pp. 1642-1647
    • Herholz, K.1    Weisenbach, S.2    Kalbe, E.3
  • 16
    • 38549130325 scopus 로고    scopus 로고
    • Acetylcholinesterase inhibitors, neuropsychiatric symptoms, and Alzheimer's disease subtypes: an alternate hypothesis to global cognitive enhancement
    • [16] Brousseau, G., Rourke, B.P., Burke, B., Acetylcholinesterase inhibitors, neuropsychiatric symptoms, and Alzheimer's disease subtypes: an alternate hypothesis to global cognitive enhancement. Exp Clin Psychopharmacol 15 (2007), 546–554.
    • (2007) Exp Clin Psychopharmacol , vol.15 , pp. 546-554
    • Brousseau, G.1    Rourke, B.P.2    Burke, B.3
  • 17
    • 76649134799 scopus 로고    scopus 로고
    • Evidence of carrier-mediated transport in the penetration of donepezil into the rat brain
    • [17] Kim, M.H., Maeng, H.J., Yu, K.H., Lee, K.R., Tsuruo, T., Kim, D.D., et al. Evidence of carrier-mediated transport in the penetration of donepezil into the rat brain. J Pharm Sci 99 (2010), 1548–1566.
    • (2010) J Pharm Sci , vol.99 , pp. 1548-1566
    • Kim, M.H.1    Maeng, H.J.2    Yu, K.H.3    Lee, K.R.4    Tsuruo, T.5    Kim, D.D.6
  • 18
    • 33847275232 scopus 로고    scopus 로고
    • In vivo evaluation of P-glycoprotein modulation of 8 PET radioligands used clinically
    • [18] Ishiwata, K., Kawamura, K., Yanai, K., Hendrikse, N.H., In vivo evaluation of P-glycoprotein modulation of 8 PET radioligands used clinically. J Nucl Med 48 (2007), 81–87.
    • (2007) J Nucl Med , vol.48 , pp. 81-87
    • Ishiwata, K.1    Kawamura, K.2    Yanai, K.3    Hendrikse, N.H.4
  • 19
    • 84882294308 scopus 로고    scopus 로고
    • OCTN cation transporters in health and disease: role as drug targets and assay development
    • [19] Pochini, L., Scalise, M., Galluccio, M., Indiveri, C., OCTN cation transporters in health and disease: role as drug targets and assay development. J Biomol Screen 18 (2013), 851–867.
    • (2013) J Biomol Screen , vol.18 , pp. 851-867
    • Pochini, L.1    Scalise, M.2    Galluccio, M.3    Indiveri, C.4
  • 24
    • 50349092250 scopus 로고    scopus 로고
    • LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies
    • [24] Lillis, A.P., Van Duyn, L.B., Murphy-Ullrich, J.E., Strickland, D.K., LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies. Physiol Rev 88:3 (2008), 887–918.
    • (2008) Physiol Rev , vol.88 , Issue.3 , pp. 887-918
    • Lillis, A.P.1    Van Duyn, L.B.2    Murphy-Ullrich, J.E.3    Strickland, D.K.4
  • 25
    • 4043061467 scopus 로고    scopus 로고
    • LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms
    • [25] Deane, R., Wu, Z., Sagare, A., Davis, J., Du Yan, S., Hamm, K., et al. LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron 43:3 (2004), 333–344.
    • (2004) Neuron , vol.43 , Issue.3 , pp. 333-344
    • Deane, R.1    Wu, Z.2    Sagare, A.3    Davis, J.4    Du Yan, S.5    Hamm, K.6
  • 26
    • 34948888151 scopus 로고    scopus 로고
    • Clearance of amyloid-beta by circulating lipoprotein receptors
    • [26] Sagare, A., Deane, R., Bell, R.D., Johnson, B., Hamm, K., Pendu, R., et al. Clearance of amyloid-beta by circulating lipoprotein receptors. Nat Med 13:9 (2007), 1029–1031.
    • (2007) Nat Med , vol.13 , Issue.9 , pp. 1029-1031
    • Sagare, A.1    Deane, R.2    Bell, R.D.3    Johnson, B.4    Hamm, K.5    Pendu, R.6
  • 27
    • 84956617728 scopus 로고    scopus 로고
    • Endothelial LRP1 transports amyloid-beta1-42 across the blood-brain barrier
    • [27] Storck, S.E., Meister, S., Nahrath, J., Meissner, J.N., Schubert, N., Di Spiezio, A., et al. Endothelial LRP1 transports amyloid-beta1-42 across the blood-brain barrier. J Clin Invest 126:1 (2016), 123–136.
    • (2016) J Clin Invest , vol.126 , Issue.1 , pp. 123-136
    • Storck, S.E.1    Meister, S.2    Nahrath, J.3    Meissner, J.N.4    Schubert, N.5    Di Spiezio, A.6
  • 28
    • 47849132772 scopus 로고    scopus 로고
    • Peripheral chemokine receptors, their ligands, cytokines and Alzheimer's disease
    • [28] Reale, M., Iarlori, C., Feliciani, C., Gambi, D., Peripheral chemokine receptors, their ligands, cytokines and Alzheimer's disease. J Alzheimers Dis 14:2 (2008), 147–159.
    • (2008) J Alzheimers Dis , vol.14 , Issue.2 , pp. 147-159
    • Reale, M.1    Iarlori, C.2    Feliciani, C.3    Gambi, D.4
  • 29
    • 67849099661 scopus 로고    scopus 로고
    • Testing the neurovascular hypothesis of Alzheimer's disease: LRP-1 antisense reduces blood-brain barrier clearance, increases brain levels of amyloid-beta protein, and impairs cognition
    • [29] Jaeger, L.B., Dohgu, S., Hwang, M.C., Farr, S.A., Murphy, M.P., Fleegal-DeMotta, M.A., et al. Testing the neurovascular hypothesis of Alzheimer's disease: LRP-1 antisense reduces blood-brain barrier clearance, increases brain levels of amyloid-beta protein, and impairs cognition. J Alzheimers Dis 17:3 (2009), 553–570.
    • (2009) J Alzheimers Dis , vol.17 , Issue.3 , pp. 553-570
    • Jaeger, L.B.1    Dohgu, S.2    Hwang, M.C.3    Farr, S.A.4    Murphy, M.P.5    Fleegal-DeMotta, M.A.6
  • 30
    • 63249094657 scopus 로고    scopus 로고
    • Lipopolysaccharide alters the blood-brain barrier transport of amyloid beta protein: a mechanism for inflammation in the progression of Alzheimer's disease
    • [30] Jaeger, L.B., Dohgu, S., Sultana, R., Lynch, J.L., Owen, J.B., Erickson, M.A., et al. Lipopolysaccharide alters the blood-brain barrier transport of amyloid beta protein: a mechanism for inflammation in the progression of Alzheimer's disease. Brain Behav Immun 23:4 (2009), 507–517.
    • (2009) Brain Behav Immun , vol.23 , Issue.4 , pp. 507-517
    • Jaeger, L.B.1    Dohgu, S.2    Sultana, R.3    Lynch, J.L.4    Owen, J.B.5    Erickson, M.A.6
  • 31
    • 84889593832 scopus 로고    scopus 로고
    • ATP-binding cassette transporters P-glycoprotein and breast cancer related protein are reduced in capillary cerebral amyloid angiopathy
    • [31] Carrano, A., Snkhchyan, H., Kooij, G., van der Pol, S., van Horssen, J., Veerhuis, R., et al. ATP-binding cassette transporters P-glycoprotein and breast cancer related protein are reduced in capillary cerebral amyloid angiopathy. Neurobiol Aging 35:3 (2014), 565–575.
    • (2014) Neurobiol Aging , vol.35 , Issue.3 , pp. 565-575
    • Carrano, A.1    Snkhchyan, H.2    Kooij, G.3    van der Pol, S.4    van Horssen, J.5    Veerhuis, R.6
  • 32
    • 84908884134 scopus 로고    scopus 로고
    • Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates
    • [32] Yu, Y.J., Atwal, J.K., Zhang, Y., Tong, R.K., Wildsmith, K.R., Tan, C., et al. Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates. Sci Transl Med, 6(261), 2014, 261ra154.
    • (2014) Sci Transl Med , vol.6 , Issue.261 , pp. 261ra154
    • Yu, Y.J.1    Atwal, J.K.2    Zhang, Y.3    Tong, R.K.4    Wildsmith, K.R.5    Tan, C.6
  • 33
    • 78149477007 scopus 로고    scopus 로고
    • Regulation of ABC transporters at the blood-brain barrier: new targets for CNS therapy
    • [33] Hartz, A.M., Bauer, B., Regulation of ABC transporters at the blood-brain barrier: new targets for CNS therapy. Mol Interv 10:5 (2010), 293–304.
    • (2010) Mol Interv , vol.10 , Issue.5 , pp. 293-304
    • Hartz, A.M.1    Bauer, B.2
  • 34
    • 78650173611 scopus 로고    scopus 로고
    • Disruption of central nervous system barriers in multiple sclerosis
    • [34] Alvarez, J.I., Cayrol, R., Prat, A., Disruption of central nervous system barriers in multiple sclerosis. Biochim Biophys Acta 1812:2 (2011), 252–264.
    • (2011) Biochim Biophys Acta , vol.1812 , Issue.2 , pp. 252-264
    • Alvarez, J.I.1    Cayrol, R.2    Prat, A.3
  • 35
    • 81755179424 scopus 로고    scopus 로고
    • How do immune cells overcome the blood-brain barrier in multiple sclerosis?
    • [35] Larochelle, C., Alvarez, J.I., Prat, A., How do immune cells overcome the blood-brain barrier in multiple sclerosis?. FEBS Lett 585:23 (2011), 3770–3780.
    • (2011) FEBS Lett , vol.585 , Issue.23 , pp. 3770-3780
    • Larochelle, C.1    Alvarez, J.I.2    Prat, A.3
  • 36
    • 0025854083 scopus 로고
    • Serial gadolinium-enhanced magnetic resonance imaging scans in patients with early, relapsing-remitting multiple sclerosis: implications for clinical trials and natural history
    • [36] Harris, J.O., Frank, J.A., Patronas, N., McFarlin, D.E., McFarland, H.F., Serial gadolinium-enhanced magnetic resonance imaging scans in patients with early, relapsing-remitting multiple sclerosis: implications for clinical trials and natural history. Ann Neurol 29:5 (1991), 548–555.
    • (1991) Ann Neurol , vol.29 , Issue.5 , pp. 548-555
    • Harris, J.O.1    Frank, J.A.2    Patronas, N.3    McFarlin, D.E.4    McFarland, H.F.5
  • 37
    • 78549234073 scopus 로고    scopus 로고
    • Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis
    • [37] Dutta, R., Trapp, B.D., Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis. Prog Neurobiol 93:1 (2011), 1–12.
    • (2011) Prog Neurobiol , vol.93 , Issue.1 , pp. 1-12
    • Dutta, R.1    Trapp, B.D.2
  • 38
    • 0141926694 scopus 로고    scopus 로고
    • Tight junctional abnormality in multiple sclerosis white matter affects all calibres of vessel and is associated with blood-brain barrier leakage and active demyelination
    • [38] Kirk, J., Plumb, J., Mirakhur, M., McQuaid, S., Tight junctional abnormality in multiple sclerosis white matter affects all calibres of vessel and is associated with blood-brain barrier leakage and active demyelination. J Pathol 201:2 (2003), 319–327.
    • (2003) J Pathol , vol.201 , Issue.2 , pp. 319-327
    • Kirk, J.1    Plumb, J.2    Mirakhur, M.3    McQuaid, S.4
  • 39
    • 34948909646 scopus 로고    scopus 로고
    • Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation
    • [39] Kebir, H., Kreymborg, K., Ifergan, I., Dodelet-Devillers, A., Cayrol, R., Bernard, M., et al. Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat Med 13:10 (2007), 1173–1175.
    • (2007) Nat Med , vol.13 , Issue.10 , pp. 1173-1175
    • Kebir, H.1    Kreymborg, K.2    Ifergan, I.3    Dodelet-Devillers, A.4    Cayrol, R.5    Bernard, M.6
  • 40
    • 38349176343 scopus 로고    scopus 로고
    • Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system
    • [40] Cayrol, R., Wosik, K., Berard, J.L., Dodelet-Devillers, A., Ifergan, I., Kebir, H., et al. Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system. Nat Immunol 9:2 (2008), 137–145.
    • (2008) Nat Immunol , vol.9 , Issue.2 , pp. 137-145
    • Cayrol, R.1    Wosik, K.2    Berard, J.L.3    Dodelet-Devillers, A.4    Ifergan, I.5    Kebir, H.6
  • 41
    • 33846134731 scopus 로고    scopus 로고
    • Persistent endothelial abnormalities and blood-brain barrier leak in primary and secondary progressive multiple sclerosis
    • [41] Leech, S., Kirk, J., Plumb, J., McQuaid, S., Persistent endothelial abnormalities and blood-brain barrier leak in primary and secondary progressive multiple sclerosis. Neuropathol Appl Neurobiol 33:1 (2007), 86–98.
    • (2007) Neuropathol Appl Neurobiol , vol.33 , Issue.1 , pp. 86-98
    • Leech, S.1    Kirk, J.2    Plumb, J.3    McQuaid, S.4
  • 42
    • 84899985105 scopus 로고    scopus 로고
    • P-glycoprotein regulates trafficking of CD8(+) T cells to the brain parenchyma
    • [42] Kooij, G., Kroon, J., Paul, D., Reijerkerk, A., Geerts, D., van der Pol, S.M., et al. P-glycoprotein regulates trafficking of CD8(+) T cells to the brain parenchyma. Acta Neuropathol 127:5 (2014), 699–711.
    • (2014) Acta Neuropathol , vol.127 , Issue.5 , pp. 699-711
    • Kooij, G.1    Kroon, J.2    Paul, D.3    Reijerkerk, A.4    Geerts, D.5    van der Pol, S.M.6
  • 43
    • 79551692740 scopus 로고    scopus 로고
    • Adenosine triphosphate-binding cassette transporters mediate chemokine (C–C motif) ligand 2 secretion from reactive astrocytes: relevance to multiple sclerosis pathogenesis
    • [43] Kooij, G., Mizee, M.R., van Horssen, J., Reijerkerk, A., Witte, M.E., Drexhage, J.A., et al. Adenosine triphosphate-binding cassette transporters mediate chemokine (C–C motif) ligand 2 secretion from reactive astrocytes: relevance to multiple sclerosis pathogenesis. Brain 134:Pt 2 (2011), 555–570.
    • (2011) Brain , vol.134 , pp. 555-570
    • Kooij, G.1    Mizee, M.R.2    van Horssen, J.3    Reijerkerk, A.4    Witte, M.E.5    Drexhage, J.A.6
  • 44
    • 79960989910 scopus 로고    scopus 로고
    • Multiple sclerosis: pathogenesis and treatment
    • [44] Loma, I., Heyman, R., Multiple sclerosis: pathogenesis and treatment. Curr Neuropharmacol 9:3 (2011), 409–416.
    • (2011) Curr Neuropharmacol , vol.9 , Issue.3 , pp. 409-416
    • Loma, I.1    Heyman, R.2
  • 46
    • 54149084585 scopus 로고    scopus 로고
    • Multiple sclerosis
    • [46] Compston, A., Coles, A., Multiple sclerosis. Lancet 372:9648 (2008), 1502–1517.
    • (2008) Lancet , vol.372 , Issue.9648 , pp. 1502-1517
    • Compston, A.1    Coles, A.2
  • 47
    • 65649106553 scopus 로고    scopus 로고
    • High dose oral steroids commonly used to treat relapses in Canadian MS clinics
    • [47] Morrow, S.A., Metz, L.M., Kremenchutzky, M., High dose oral steroids commonly used to treat relapses in Canadian MS clinics. Can J Neurol Sci 36:2 (2009), 213–215.
    • (2009) Can J Neurol Sci , vol.36 , Issue.2 , pp. 213-215
    • Morrow, S.A.1    Metz, L.M.2    Kremenchutzky, M.3
  • 48
    • 77949518424 scopus 로고    scopus 로고
    • PRISMS: the story of a pivotal clinical trial series in multiple sclerosis
    • [48] Cohen, B.A., Rivera, V.M., PRISMS: the story of a pivotal clinical trial series in multiple sclerosis. Curr Med Res Opin 26:4 (2010), 827–838.
    • (2010) Curr Med Res Opin , vol.26 , Issue.4 , pp. 827-838
    • Cohen, B.A.1    Rivera, V.M.2
  • 50
    • 77951828930 scopus 로고    scopus 로고
    • Evidence Report: The efficacy and safety of mitoxantrone (Novantrone) in the treatment of multiple sclerosis: Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology
    • [50] Marriott, J.J., Miyasaki, J.M., Gronseth, G., O'Connor, P.W., Evidence Report: The efficacy and safety of mitoxantrone (Novantrone) in the treatment of multiple sclerosis: Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 74:18 (2010), 1463–1470.
    • (2010) Neurology , vol.74 , Issue.18 , pp. 1463-1470
    • Marriott, J.J.1    Miyasaki, J.M.2    Gronseth, G.3    O'Connor, P.W.4
  • 51
    • 76449087805 scopus 로고    scopus 로고
    • Natalizumab treatment in multiple sclerosis: marked decline of chemokines and cytokines in cerebrospinal fluid
    • [51] Mellergard, J., Edstrom, M., Vrethem, M., Ernerudh, J., Dahle, C., Natalizumab treatment in multiple sclerosis: marked decline of chemokines and cytokines in cerebrospinal fluid. Mult Scler 16:2 (2010), 208–217.
    • (2010) Mult Scler , vol.16 , Issue.2 , pp. 208-217
    • Mellergard, J.1    Edstrom, M.2    Vrethem, M.3    Ernerudh, J.4    Dahle, C.5
  • 52
    • 84951191914 scopus 로고    scopus 로고
    • The potential role for ocrelizumab in the treatment of multiple sclerosis: current evidence and future prospects
    • [52] Sorensen, P.S., Blinkenberg, M., The potential role for ocrelizumab in the treatment of multiple sclerosis: current evidence and future prospects. Ther Adv Neurol Disord 9:1 (2016), 44–52.
    • (2016) Ther Adv Neurol Disord , vol.9 , Issue.1 , pp. 44-52
    • Sorensen, P.S.1    Blinkenberg, M.2
  • 56
    • 3342933212 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 upregulates the tight junction and P-glycoprotein of brain microvascular endothelial cells
    • [56] Dohgu, S., Yamauchi, A., Takata, F., Naito, M., Tsuruo, T., Higuchi, S., et al. Transforming growth factor-beta1 upregulates the tight junction and P-glycoprotein of brain microvascular endothelial cells. Cell Mol Neurobiol 24:3 (2004), 491–497.
    • (2004) Cell Mol Neurobiol , vol.24 , Issue.3 , pp. 491-497
    • Dohgu, S.1    Yamauchi, A.2    Takata, F.3    Naito, M.4    Tsuruo, T.5    Higuchi, S.6
  • 57
    • 0029126861 scopus 로고
    • Exposure of tumor necrosis factor-alpha to luminal membrane of bovine brain capillary endothelial cells cocultured with astrocytes induces a delayed increase of permeability and cytoplasmic stress fiber formation of actin
    • [57] Deli, M.A., Descamps, L., Dehouck, M.P., Cecchelli, R., Joo, F., Abraham, C.S., et al. Exposure of tumor necrosis factor-alpha to luminal membrane of bovine brain capillary endothelial cells cocultured with astrocytes induces a delayed increase of permeability and cytoplasmic stress fiber formation of actin. J Neurosci Res 41:6 (1995), 717–726.
    • (1995) J Neurosci Res , vol.41 , Issue.6 , pp. 717-726
    • Deli, M.A.1    Descamps, L.2    Dehouck, M.P.3    Cecchelli, R.4    Joo, F.5    Abraham, C.S.6
  • 58
    • 0032977248 scopus 로고    scopus 로고
    • Interferon-gamma decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin
    • [58] Youakim, A., Ahdieh, M., Interferon-gamma decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin. Am J Physiol 276:5 Pt 1 (1999), G1279–G1288.
    • (1999) Am J Physiol , vol.276 , Issue.5 , pp. G1279-G1288
    • Youakim, A.1    Ahdieh, M.2
  • 59
    • 84983384418 scopus 로고    scopus 로고
    • Exploiting Bacterial Pathways for BBB Crossing with PLGA Nanoparticles Modified with a Mutated Form of Diphtheria Toxin (CRM197): In Vivo Experiments
    • [59] Tosi, G., Vilella, A., Veratti, P., Belletti, D., Pederzoli, F., Ruozi, B., et al. Exploiting Bacterial Pathways for BBB Crossing with PLGA Nanoparticles Modified with a Mutated Form of Diphtheria Toxin (CRM197): In Vivo Experiments. Mol Pharm 12:10 (2015), 3672–3684.
    • (2015) Mol Pharm , vol.12 , Issue.10 , pp. 3672-3684
    • Tosi, G.1    Vilella, A.2    Veratti, P.3    Belletti, D.4    Pederzoli, F.5    Ruozi, B.6
  • 61
    • 79960821108 scopus 로고    scopus 로고
    • Tight junctions and tissue barriers
    • [61] Blasig, I.E., Haseloff, R.F., Tight junctions and tissue barriers. Antioxid Redox Signal 15:5 (2011), 1163–1166.
    • (2011) Antioxid Redox Signal , vol.15 , Issue.5 , pp. 1163-1166
    • Blasig, I.E.1    Haseloff, R.F.2
  • 62
    • 0027410291 scopus 로고
    • Modulation of human endothelial cell permeability by combinations of the cytokines interleukin-1 alpha/beta, tumor necrosis factor-alpha and interferon-gamma
    • [62] Burke-Gaffney, A., Keenan, A.K., Modulation of human endothelial cell permeability by combinations of the cytokines interleukin-1 alpha/beta, tumor necrosis factor-alpha and interferon-gamma. Immunopharmacology 25:1 (1993), 1–9.
    • (1993) Immunopharmacology , vol.25 , Issue.1 , pp. 1-9
    • Burke-Gaffney, A.1    Keenan, A.K.2
  • 64
    • 26244442836 scopus 로고    scopus 로고
    • Mechanism of IFN-gamma-induced endocytosis of tight junction proteins: myosin II-dependent vacuolarization of the apical plasma membrane
    • [64] Utech, M., Ivanov, A.I., Samarin, S.N., Bruewer, M., Turner, J.R., Mrsny, R.J., et al. Mechanism of IFN-gamma-induced endocytosis of tight junction proteins: myosin II-dependent vacuolarization of the apical plasma membrane. Mol Biol Cell 16:10 (2005), 5040–5052.
    • (2005) Mol Biol Cell , vol.16 , Issue.10 , pp. 5040-5052
    • Utech, M.1    Ivanov, A.I.2    Samarin, S.N.3    Bruewer, M.4    Turner, J.R.5    Mrsny, R.J.6
  • 65
    • 0023200855 scopus 로고
    • Absorptive-mediated endocytosis of cationized albumin and a beta-endorphin-cationized albumin chimeric peptide by isolated brain capillaries. Model system of blood-brain barrier transport
    • [65] Kumagai, A.K., Eisenberg, J.B., Pardridge, W.M., Absorptive-mediated endocytosis of cationized albumin and a beta-endorphin-cationized albumin chimeric peptide by isolated brain capillaries. Model system of blood-brain barrier transport. J Biol Chem 262:31 (1987), 15214–15219.
    • (1987) J Biol Chem , vol.262 , Issue.31 , pp. 15214-15219
    • Kumagai, A.K.1    Eisenberg, J.B.2    Pardridge, W.M.3
  • 66
    • 0023186714 scopus 로고
    • Chimeric peptides as a vehicle for peptide pharmaceutical delivery through the blood-brain barrier
    • [66] Pardridge, W.M., Kumagai, A.K., Eisenberg, J.B., Chimeric peptides as a vehicle for peptide pharmaceutical delivery through the blood-brain barrier. Biochem Biophys Res Commun 146:1 (1987), 307–313.
    • (1987) Biochem Biophys Res Commun , vol.146 , Issue.1 , pp. 307-313
    • Pardridge, W.M.1    Kumagai, A.K.2    Eisenberg, J.B.3
  • 67
    • 0042232110 scopus 로고    scopus 로고
    • Studies on the internalization mechanism of cationic cell-penetrating peptides
    • [67] Drin, G., Cottin, S., Blanc, E., Rees, A.R., Temsamani, J., Studies on the internalization mechanism of cationic cell-penetrating peptides. J Biol Chem 278:33 (2003), 31192–31201.
    • (2003) J Biol Chem , vol.278 , Issue.33 , pp. 31192-31201
    • Drin, G.1    Cottin, S.2    Blanc, E.3    Rees, A.R.4    Temsamani, J.5
  • 68
    • 1842588603 scopus 로고    scopus 로고
    • Structural pathways for macromolecular and cellular transport across the blood-brain barrier during inflammatory conditions. Review
    • [68] Lossinsky, A.S., Shivers, R.R., Structural pathways for macromolecular and cellular transport across the blood-brain barrier during inflammatory conditions. Review. Histol Histopathol 19:2 (2004), 535–564.
    • (2004) Histol Histopathol , vol.19 , Issue.2 , pp. 535-564
    • Lossinsky, A.S.1    Shivers, R.R.2
  • 69
    • 34447114618 scopus 로고    scopus 로고
    • Transvascular delivery of small interfering RNA to the central nervous system
    • [69] Kumar, P., Wu, H., McBride, J.L., Jung, K.E., Kim, M.H., Davidson, B.L., et al. Transvascular delivery of small interfering RNA to the central nervous system. Nature 448:7149 (2007), 39–43.
    • (2007) Nature , vol.448 , Issue.7149 , pp. 39-43
    • Kumar, P.1    Wu, H.2    McBride, J.L.3    Jung, K.E.4    Kim, M.H.5    Davidson, B.L.6
  • 70
    • 0030253214 scopus 로고    scopus 로고
    • Effects of tumor necrosis factor-alpha and interleukin-6 on fluid-phase permeability and ammonia diffusion in CNS-derived endothelial cells
    • [70] Duchini, A., Govindarajan, S., Santucci, M., Zampi, G., Hofman, F.M., Effects of tumor necrosis factor-alpha and interleukin-6 on fluid-phase permeability and ammonia diffusion in CNS-derived endothelial cells. J Investig Med 44:8 (1996), 474–482.
    • (1996) J Investig Med , vol.44 , Issue.8 , pp. 474-482
    • Duchini, A.1    Govindarajan, S.2    Santucci, M.3    Zampi, G.4    Hofman, F.M.5
  • 71
    • 0033030441 scopus 로고    scopus 로고
    • Adsorptive endocytosis of HIV-1gp120 by blood-brain barrier is enhanced by lipopolysaccharide
    • [71] Banks, W.A., Kastin, A.J., Brennan, J.M., Vallance, K.L., Adsorptive endocytosis of HIV-1gp120 by blood-brain barrier is enhanced by lipopolysaccharide. Exp Neurol 156:1 (1999), 165–171.
    • (1999) Exp Neurol , vol.156 , Issue.1 , pp. 165-171
    • Banks, W.A.1    Kastin, A.J.2    Brennan, J.M.3    Vallance, K.L.4
  • 72
    • 2542501568 scopus 로고    scopus 로고
    • Transcellular transport as a mechanism of blood-brain barrier disruption during stroke
    • [72] Cipolla, M.J., Crete, R., Vitullo, L., Rix, R.D., Transcellular transport as a mechanism of blood-brain barrier disruption during stroke. Front Biosci 9 (2004), 777–785.
    • (2004) Front Biosci , vol.9 , pp. 777-785
    • Cipolla, M.J.1    Crete, R.2    Vitullo, L.3    Rix, R.D.4
  • 73
    • 84859958800 scopus 로고    scopus 로고
    • Nanotechnological advances for the delivery of CNS therapeutics
    • [73] Wong, H.L., Wu, X.Y., Bendayan, R., Nanotechnological advances for the delivery of CNS therapeutics. Adv Drug Deliv Rev, 2012.
    • (2012) Adv Drug Deliv Rev
    • Wong, H.L.1    Wu, X.Y.2    Bendayan, R.3
  • 74
    • 0033961684 scopus 로고    scopus 로고
    • Carrier-mediated delivery of metabotrophic glutamate receptor ligands to the central nervous system: structural tolerance and potential of the L-system amino acid transporter at the blood-brain barrier
    • [74] Reichel, A., Begley, D.J., Abbott, N.J., Carrier-mediated delivery of metabotrophic glutamate receptor ligands to the central nervous system: structural tolerance and potential of the L-system amino acid transporter at the blood-brain barrier. J Cereb Blood Flow Metab 20:1 (2000), 168–174.
    • (2000) J Cereb Blood Flow Metab , vol.20 , Issue.1 , pp. 168-174
    • Reichel, A.1    Begley, D.J.2    Abbott, N.J.3
  • 75
    • 0034888307 scopus 로고    scopus 로고
    • Affinity for the P-glycoprotein efflux pump at the blood-brain barrier may explain the lack of CNS side-effects of modern antihistamines
    • [75] Chishty, M., Reichel, A., Siva, J., Abbott, N.J., Begley, D.J., Affinity for the P-glycoprotein efflux pump at the blood-brain barrier may explain the lack of CNS side-effects of modern antihistamines. J Drug Target 9:3 (2001), 223–228.
    • (2001) J Drug Target , vol.9 , Issue.3 , pp. 223-228
    • Chishty, M.1    Reichel, A.2    Siva, J.3    Abbott, N.J.4    Begley, D.J.5
  • 77
    • 0023227218 scopus 로고
    • Human blood-brain barrier transferrin receptor
    • [77] Pardridge, W.M., Eisenberg, J., Yang, J., Human blood-brain barrier transferrin receptor. Metabolism 36:9 (1987), 892–895.
    • (1987) Metabolism , vol.36 , Issue.9 , pp. 892-895
    • Pardridge, W.M.1    Eisenberg, J.2    Yang, J.3
  • 79
    • 0002595302 scopus 로고    scopus 로고
    • Targeting rat anti-mouse transferrin receptor monoclonal antibodies through blood–brain barrier in mouse
    • [79] Lee, H.J., Engelhardt, B., Lesley, J., Bickel, U., Pardridge, W.M., Targeting rat anti-mouse transferrin receptor monoclonal antibodies through blood–brain barrier in mouse. J Pharmacol Exp Ther 292:3 (2000), 1048–1052.
    • (2000) J Pharmacol Exp Ther , vol.292 , Issue.3 , pp. 1048-1052
    • Lee, H.J.1    Engelhardt, B.2    Lesley, J.3    Bickel, U.4    Pardridge, W.M.5
  • 80
    • 80052443097 scopus 로고    scopus 로고
    • Enhanced transferrin receptor expression by proinflammatory cytokines in enterocytes as a means for local delivery of drugs to inflamed gut mucosa
    • [80] Harel, E., Rubinstein, A., Nissan, A., Khazanov, E., Nadler Milbauer, M., Barenholz, Y., et al. Enhanced transferrin receptor expression by proinflammatory cytokines in enterocytes as a means for local delivery of drugs to inflamed gut mucosa. PLoS One, 6(9), 2011, e24202.
    • (2011) PLoS One , vol.6 , Issue.9 , pp. e24202
    • Harel, E.1    Rubinstein, A.2    Nissan, A.3    Khazanov, E.4    Nadler Milbauer, M.5    Barenholz, Y.6
  • 81
    • 23644456974 scopus 로고    scopus 로고
    • Targeted delivery across the blood-brain barrier
    • [81] Gaillard, P.J., Visser, C.C., de Boer, A.G., Targeted delivery across the blood-brain barrier. Expert Opin Drug Deliv 2:2 (2005), 299–309.
    • (2005) Expert Opin Drug Deliv , vol.2 , Issue.2 , pp. 299-309
    • Gaillard, P.J.1    Visser, C.C.2    de Boer, A.G.3
  • 82
    • 34548770175 scopus 로고    scopus 로고
    • A novel opportunity for targeted drug delivery to the brain
    • [82] Gaillard, P.J., de Boer, A.G., A novel opportunity for targeted drug delivery to the brain. J Control Release 116:2 (2006), pe60–pe62.
    • (2006) J Control Release , vol.116 , Issue.2 , pp. pe60-pe62
    • Gaillard, P.J.1    de Boer, A.G.2
  • 83
    • 79955734571 scopus 로고    scopus 로고
    • CRM197-induced blood-brain barrier permeability increase is mediated by upregulation of caveolin-1 protein
    • [83] Wang, P., Liu, Y., Shang, X., Xue, Y., CRM197-induced blood-brain barrier permeability increase is mediated by upregulation of caveolin-1 protein. J Mol Neurosci 43:3 (2011), 485–492.
    • (2011) J Mol Neurosci , vol.43 , Issue.3 , pp. 485-492
    • Wang, P.1    Liu, Y.2    Shang, X.3    Xue, Y.4
  • 86
    • 1642454475 scopus 로고    scopus 로고
    • ABC transporters and the blood-brain barrier
    • [86] Begley, D.J., ABC transporters and the blood-brain barrier. Curr Pharm Des 10:12 (2004), 1295–1312.
    • (2004) Curr Pharm Des , vol.10 , Issue.12 , pp. 1295-1312
    • Begley, D.J.1
  • 87
    • 70449529633 scopus 로고    scopus 로고
    • The blood-brain barrier and immune function and dysfunction
    • [87] Banks, W.A., Erickson, M.A., The blood-brain barrier and immune function and dysfunction. Neurobiol Dis 37:1 (2010), 26–32.
    • (2010) Neurobiol Dis , vol.37 , Issue.1 , pp. 26-32
    • Banks, W.A.1    Erickson, M.A.2
  • 88
    • 84855761366 scopus 로고    scopus 로고
    • Attaching the phage display-selected GLA peptide to liposomes: factors influencing target binding
    • [88] van Rooy, I., Hennink, W.E., Storm, G., Schiffelers, R.M., Mastrobattista, E., Attaching the phage display-selected GLA peptide to liposomes: factors influencing target binding. Eur J Pharm Sci 45:3 (2012), 330–335.
    • (2012) Eur J Pharm Sci , vol.45 , Issue.3 , pp. 330-335
    • van Rooy, I.1    Hennink, W.E.2    Storm, G.3    Schiffelers, R.M.4    Mastrobattista, E.5
  • 89
    • 77649215791 scopus 로고    scopus 로고
    • Blood-brain barrier as a regulatory interface
    • [89] Banks, W.A., Blood-brain barrier as a regulatory interface. Forum Nutr 63 (2010), 102–110.
    • (2010) Forum Nutr , vol.63 , pp. 102-110
    • Banks, W.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.