Interleukin-18 directly protects cortical neurons by activating PI3K/AKT/NF-κB/CREB pathways

Cytokine

Volumn 69, Issue 1, 2014, Pages 29-38

  Zhou, Jia ^a   Ping, Feng feng ^a,b   Lv, Wen ting ^a   Feng, Jun yi ^a   Shang, Jing ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b WUXI PEOPLE S HOSPITAL AFFILIATED TO NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Cortical neurons; CREB; IL 18; NF B; PI3K Akt

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CASPASE 3; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OLIGONUCLEOTIDE; OXYGEN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; RECOMBINANT INTERLEUKIN 18; ANDROSTANE DERIVATIVE; CASP3 PROTEIN, RAT; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; INTERLEUKIN 18; NEUROPROTECTIVE AGENT; PROTEIN KINASE INHIBITOR; PTEN PROTEIN, RAT; WORTMANNIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CELL; CELL LEVEL; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; IN VITRO STUDY; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; BRAIN CORTEX; CYTOLOGY; DRUG EFFECTS; ENZYME ACTIVATION; METABOLISM; NERVE CELL; PHOSPHORYLATION;

ANDROSTADIENES; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CASPASE 3; CEREBRAL CORTEX; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; ENZYME ACTIVATION; GLYCOGEN SYNTHASE KINASE 3; INTERLEUKIN-18; NEURONS; NEUROPROTECTIVE AGENTS; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; PTEN PHOSPHOHYDROLASE; RATS;

EID: 84901799651     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2014.05.003     Document Type: Article

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