NLRP3 inflammasome mediates chronic mild stress-induced depression in mice via neuroinflammation

International Journal of Neuropsychopharmacology

Volumn 18, Issue 8, 2015, Pages 1-8

  Zhang, Yi ^a   Liu, Lei ^a   Liu, Yun Zi ^a   Shen, Xiao Liang ^a   Wu, Teng Yun ^a   Zhang, Ting ^a   Wang, Wei ^a   Wang, Yun Xia ^a   Jiang, Chun Lei ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Depression; Inflammation; interleukin 1b; NLRP3 inflammasome; Stress

Indexed keywords

BELNACASAN; CORTICOSTERONE; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; 1-(2-((1-(4-AMINO-3-CHLOROPHENYL)METHANOYL)AMINO)-3,3-DIMETHYLBUTANOYL)PYRROLIDINE-2-CARBOXYLIC ACID; 4 AMINOBENZOIC ACID DERIVATIVE; ANTIDEPRESSANT AGENT; CARRIER PROTEIN; DIPEPTIDE; IL1B PROTEIN, MOUSE; NLRP3 PROTEIN, MOUSE; NONSTEROID ANTIINFLAMMATORY AGENT; SUGAR INTAKE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC MILD STRESS; CHRONIC STRESS; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DEPRESSION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HIPPOCAMPUS; IMMOBILITY; MALE; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; SUCROSE PREFERENCE TEST; TAIL SUSPENSION TEST; WESTERN BLOTTING; ANIMAL; BAGG ALBINO MOUSE; BLOOD; CHRONIC DISEASE; COMPLICATION; DEPRESSIVE DISORDER; DISEASE MODEL; DRUG EFFECTS; FOOD PREFERENCE; IMMUNOMODULATION; INFLAMMATION; MENTAL STRESS; METABOLISM; MOTOR ACTIVITY; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZATION; SUGAR INTAKE; UNCERTAINTY;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIDEPRESSIVE AGENTS; CARRIER PROTEINS; CASPASE 1; CHRONIC DISEASE; CORTICOSTERONE; DEPRESSIVE DISORDER; DIETARY SUCROSE; DIPEPTIDES; DISEASE MODELS, ANIMAL; FOOD PREFERENCES; HIPPOCAMPUS; INFLAMMATION; INTERLEUKIN-1BETA; MALE; MICE, INBRED BALB C; MOTOR ACTIVITY; NEUROIMMUNOMODULATION; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; PARA-AMINOBENZOATES; RANDOM ALLOCATION; STRESS, PSYCHOLOGICAL; UNCERTAINTY;

EID: 84931266463     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1093/ijnp/pyv006     Document Type: Article

References (41)

1. Alcocer-Gomez E, de Miguel M, Casas-Barquero N, Nunez-Vasco J, Sanchez-Alcazar JA, Fernandez-Rodriguez A, Cordero MD (2014) NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder. Brain Behav Immun 36:111-117
2. Bauernfeind FG, Horvath G, Stutz A, Alnemri ES, MacDonald K, Speert D, Fernandes-Alnemri T, Wu J, Monks BG, Fitzgerald KA, Hornung V, Latz E (2009) Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol 183:787-791
3. Bernton EW, Beach JE, Holaday JW, Smallridge RC, Fein HG (1987) Release of multiple hormones by a direct action of interleukin- 1 on pituitary cells. Science 238:519-521
4. Cook GP, Savic S, Wittmann M, McDermott MF (2010) The NLRP3 inflammasome, a target for therapy in diverse disease states. Eur J Immunol 40:631-634
5. Denes A, Miyan JA (2014) Brain-immune interactions in health and disease. Front Neurosci 8:382
6. Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, Lanctot KL (2010) A meta-Analysis of cytokines in major depression. Biol Psychiatry 67:446-457
7. Goshen I, Kreisel T, Ben-Menachem-Zidon O, Licht T, Weidenfeld J, Ben-Hur T, Yirmiya R (2008) Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression. Mol Psychiatry 13:717-728
8. Goshen I, Yirmiya R (2009) Interleukin-1 (IL-1): a central regulator of stress responses. Front Neuroendocrinol 30:30-45
9. Gu L, Xie J, Long J, Chen Q, Chen Q, Pan R, Yan Y, Wu G, Liang B, Tan J, Xie X, Wei B, Su L (2013) Epidemiology of major depressive disorder in mainland china: a systematic review. PLoS One 8:e65356
10. Hannestad J, DellaGioia N, Bloch M (2011) The effect of antidepressant medication treatment on serum levels of inflammatory cytokines: a meta-Analysis. Neuropsychopharmacology 36:2452-2459
11. Hosoi T, Okuma Y, Nomura Y (2002) The mechanisms of immuneto- brain communication in inflammation as a drug target. Curr Drug Targets Inflamm Allergy 1:257-262
12. Iwata M, Ota KT, Duman RS (2013) The inflammasome: pathways linking psychological stress, depression, and systemic illnesses. Brain Behav Immun 31:105-114
13. Jafarinaveh HR, Allahtavakoli M, Rezazadeh H, Kazemi Arababadi M, Taghavi MM, Shamsizadeh A, Rahmani MR (2014) Pro-inflammatory cytokines in the embolic model of cerebral ischemia in rat. Iran J Allergy Asthma Immunol 13:125-130
14. Jin C, Flavell RA (2010) Molecular mechanism of NLRP3 inflammasome activation. J Clin Immunol 30:628-631
15. Juliana C, Fernandes-Alnemri T, Wu J, Datta P, Solorzano L, Yu JW, Meng R, Quong AA, Latz E, Scott CP, Alnemri ES (2010) Antiinflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome. J Biol Chem 285:9792-9802
16. Juul SE, McPherson RJ, Bammler TK, Wilkerson J, Beyer RP, Farin FM (2008) Recombinant erythropoietin is neuroprotective in a novel mouse oxidative injury model. Dev Neurosci 30:231-242
17. Kheirbek MA, Klemenhagen KC, Sahay A, Hen R (2012) Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders. Nat Neurosci 15:1613-1620
18. Koo JW, Duman RS (2008) IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress. Proc Natl Acad Sci U S A 105:751-756
19. Kupfer DJ, Frank E, Phillips ML (2012) Major depressive disorder: new clinical, neurobiological, and treatment perspectives. Lancet 379:1045-1055
20. Lamkanfi M, Kanneganti TD (2010) Nlrp3: an immune sensor of cellular stress and infection. Int J Biochem Cell Biol 42:792-795
21. Lamkanfi M, Walle LV, Kanneganti TD (2011) Deregulated inflammasome signaling in disease. Immunol Rev 243:163-173
22. Lopez-Castejon G, Pelegrin P (2012) Current status of inflammasome blockers as anti-inflammatory drugs. Expert Opin Investig Drugs 21:995-1007
23. Lu M, Yang JZ, Geng F, Ding JH, Hu G (2014) Iptakalim confers an antidepressant effect in a chronic mild stress model of depression through regulating neuro-inflammation and neurogenesis. Int J Neuropsychopharmacol:1-10
24. Maes M (1995) Evidence for an immune response in major depression: a review and hypothesis. Prog Neuropsychopharmacol Biol Psychiatry 19:11-38
25. Maes M, Bosmans E, Meltzer HY, Scharpe S, Suy E (1993) Interleukin- 1 beta: a putative mediator of HPA axis hyperactivity in major depression? Am J Psychiatry 150:1189-1193
26. Maroso M, Balosso S, Ravizza T, Iori V, Wright CI, French J, Vezzani A (2011) Interleukin-1beta biosynthesis inhibition reduces acute seizures and drug resistant chronic epileptic activity in mice. Neurotherapeutics 8:304-315
27. Matsunaga M, Bai Y, Yamakawa K, Toyama A, Kashiwagi M, Fukuda K, Oshida A, Sanada K, Fukuyama S, Shinoda J, Yamada J, Sadato N, Ohira H (2013) Brain-immune interaction accompanying odor-evoked autobiographic memory. PLoS One 8:e72523
28. Menu P, Vince JE (2011) The NLRP3 inflammasome in health and disease: the good, the bad and the ugly. Clin Exp Immunol 166:1-15
29. Mukherjee S, Katki K, Arisi GM, Foresti ML, Shapiro LA (2011) Early TBI-induced cytokine alterations are similarly detected by two distinct methods of multiplex assay. Front Mol Neurosci 4:21
30. Murray CJ et al. (2012) Disability-Adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380:2197-2223
31. Pan Y, Chen XY, Zhang QY, Kong LD (2014) Microglial NLRP3 inflammasome activation mediates IL-1beta-related inflammation in prefrontal cortex of depressive rats. Brain Behav Immun 41:90-100
32. Peng YL, Liu YN, Liu L, Wang X, Jiang CL, Wang YX (2012) Inducible nitric oxide synthase is involved in the modulation of depressive behaviors induced by unpredictable chronic mild stress. J Neuroinflammation 9:75
33. Petrilli V, Dostert C, Muruve DA, Tschopp J (2007) The inflammasome: a danger sensing complex triggering innate immunity. Curr Opin Immunol 19:615-622
34. Ravizza T, Lucas SM, Balosso S, Bernardino L, Ku G, Noe F, Malva J, Randle JC, Allan S, Vezzani A (2006) Inactivation of caspase-1 in rodent brain: a novel anticonvulsive strategy. Epilepsia 47:1160-1168
35. Sapolsky R, Rivier C, Yamamoto G, Plotsky P, Vale W (1987) Interleukin- 1 stimulates the secretion of hypothalamic corticotropin- releasing factor. Science 238:522-524
36. Schroder K, Tschopp J (2010) The inflammasomes. Cell 140:821-832
37. Schroder K, Zhou R, Tschopp J (2010) The NLRP3 inflammasome: a sensor for metabolic danger? Science 327:296-300
38. Wannamaker W, Davies R, Namchuk M, Pollard J, Ford P, Ku G, Decker C, Charifson P, Weber P, Germann UA, Kuida K, Randle JC (2007) (S)-1-((S)-2-{[1-(4-Amino-3-chloro-phenyl)-methanoyl]- amino}-3, 3-dimethyl-butanoy l)-pyrrolidine-2-carboxylic acid ((2R, 3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-Amide (VX-765), an orally available selective interleukin (IL)-converting enzyme/caspase-1 inhibitor, exhibits potent antiinflammatory activities by inhibiting the release of IL-1beta and IL-18. J Pharmacol Exp Ther 321:509-516
39. World Health Organization (2008) The global burden of disease: 2004 update. Geneva: World Health Organization
40. World Health Organization (2012) Depression: a global crisis. World Mental Health Day. http://www.who.int/mental- health/management/depression/en/
41. Zhang Y, Liu L, Peng YL, Liu YZ, Wu TY, Shen XL, Zhou JR, Sun DY, Huang AJ, Wang X, Wang YX, Jiang CL (2014) Involvement of inflammasome activation in lipopolysaccharide-induced mice depressive-like behaviors. CNS Neurosci Ther 20:119-124