메뉴 건너뛰기




Volumn 22, Issue 6, 2016, Pages 470-484

Polymeric biomaterials for in vitro cancer tissue engineering and drug testing applications

Author keywords

3D cell culture; biomechanics; biomimetic materials; degradable hydrogels; extracellular matrix; tumor microenvironment

Indexed keywords

BIOMATERIALS; BIOMECHANICS; BIOMIMETIC MATERIALS; BIOMIMETICS; CELL CULTURE; CELLS; CYTOLOGY; DISEASES; ENZYME ACTIVITY; ENZYME INHIBITION; FUNCTIONAL POLYMERS; HYDROGELS; PHYSIOLOGICAL MODELS; POLYMERS; TISSUE; TISSUE ENGINEERING; TISSUE REGENERATION;

EID: 85011643519     PISSN: 19373368     EISSN: 19373376     Source Type: Journal    
DOI: 10.1089/ten.teb.2015.0567     Document Type: Review
Times cited : (62)

References (165)
  • 1
    • 84992041954 scopus 로고    scopus 로고
    • National Cancer Institute
    • Risk Factors for Cancer. National Cancer Institute; 2015.
    • (2015) Risk Factors for Cancer
  • 2
    • 0036219647 scopus 로고    scopus 로고
    • Translating basic cancer research into new cancer therapeutics
    • Workman, P., and Kaye, S.B. Translating basic cancer research into new cancer therapeutics. Trends Mol Med 8, S1, 2002.
    • (2002) Trends Mol Med , vol.8 , pp. S1
    • Workman, P.1    Kaye, S.B.2
  • 3
    • 77957364747 scopus 로고    scopus 로고
    • Translating cancer research into targeted therapeutics
    • de Bono, J.S., and Ashworth, A. Translating cancer research into targeted therapeutics. Nature 467, 543, 2010.
    • (2010) Nature , vol.467 , pp. 543
    • De Bono, J.S.1    Ashworth, A.2
  • 4
    • 33846531356 scopus 로고    scopus 로고
    • The tumour microenvironment as a target for chemoprevention
    • Albini, A., and Sporn, M.B. The tumour microenvironment as a target for chemoprevention. Nat Rev Cancer 7, 139, 2007.
    • (2007) Nat Rev Cancer , vol.7 , pp. 139
    • Albini, A.1    Sporn, M.B.2
  • 5
    • 80054972160 scopus 로고    scopus 로고
    • 3D tumour models: Novel in vitro approaches to cancer studies
    • Nyga, A., Cheema, U., and Loizidou, M. 3D tumour models: novel in vitro approaches to cancer studies. J Cell Commun Signal 5, 239, 2011.
    • (2011) J Cell Commun Signal , vol.5 , pp. 239
    • Nyga, A.1    Cheema, U.2    Loizidou, M.3
  • 6
    • 84991521860 scopus 로고    scopus 로고
    • Toward the broad adoption of 3D tumor models in the cancer drug pipeline
    • Cox, M.C., Reese, L.M., Bickford, L.R., and Verbridge, S.S. Toward the broad adoption of 3D tumor models in the cancer drug pipeline. ACS Biomater Sci Eng 1, 877, 2015.
    • (2015) ACS Biomater Sci Eng , vol.1 , pp. 877
    • Cox, M.C.1    Reese, L.M.2    Bickford, L.R.3    Verbridge, S.S.4
  • 7
    • 77952932509 scopus 로고    scopus 로고
    • Engineering tumors: A tissue engineering perspective in cancer biology
    • Burdett, E., Kasper, F.K., Mikos, A.G., and Ludwig, J.A. Engineering tumors: a tissue engineering perspective in cancer biology. Tissue Eng Part B 16, 351, 2010.
    • (2010) Tissue Eng Part B , vol.16 , pp. 351
    • Burdett, E.1    Kasper, F.K.2    Mikos, A.G.3    Ludwig, J.A.4
  • 9
    • 34548295521 scopus 로고    scopus 로고
    • Three-dimensional polymeric systems for cancer cell studies
    • Xu, F., and Burg, K.J. Three-dimensional polymeric systems for cancer cell studies. Cytotechnology 54, 135, 2007.
    • (2007) Cytotechnology , vol.54 , pp. 135
    • Xu, F.1    Burg, K.J.2
  • 10
    • 84919691161 scopus 로고    scopus 로고
    • Bioengineering 3D environments for cancer models
    • Alemany-Ribes, M., and Semino, C.E. Bioengineering 3D environments for cancer models. Adv Drug Deliv Rev 79, 40, 2014.
    • (2014) Adv Drug Deliv Rev , vol.79 , pp. 40
    • Alemany-Ribes, M.1    Semino, C.E.2
  • 11
    • 84868142730 scopus 로고    scopus 로고
    • Occupy tissue: The movement in cancer metastasis
    • Bradbury, P., Fabry, B., and O Neill, G.M. Occupy tissue: the movement in cancer metastasis. Cell Adh Migr 6, 424, 2012.
    • (2012) Cell Adh Migr , vol.6 , pp. 424
    • Bradbury, P.1    Fabry, B.2    O'Neill, G.M.3
  • 12
    • 84953227804 scopus 로고    scopus 로고
    • 3D scaffolds in breast cancer research
    • Rijal, G., and Li, W. 3D scaffolds in breast cancer research. Biomaterials 81, 135, 2016.
    • (2016) Biomaterials , vol.81 , pp. 135
    • Rijal, G.1    Li, W.2
  • 13
    • 33644529130 scopus 로고    scopus 로고
    • Capturing complex 3D tissue physiology in vitro
    • Griffith, L.G., and Swartz, M.A. Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol 7, 211, 2006.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 211
    • Griffith, L.G.1    Swartz, M.A.2
  • 14
    • 84899966772 scopus 로고    scopus 로고
    • The need for complex 3D culture models to unravel novel pathways and identify accurate biomarkers in breast cancer
    • Weigelt, B., Ghajar, C.M., and Bissell, M.J. The need for complex 3D culture models to unravel novel pathways and identify accurate biomarkers in breast cancer. Adv Drug Deliv Rev 69, 42, 2014.
    • (2014) Adv Drug Deliv Rev , vol.69 , pp. 42
    • Weigelt, B.1    Ghajar, C.M.2    Bissell, M.J.3
  • 15
    • 84964282524 scopus 로고    scopus 로고
    • Cancer stem cells: The promise and the potential
    • Ajani, J.A., Song, S., Hochster, H.S., and Steinberg, I.B. Cancer stem cells: the promise and the potential. Semin Oncol 42 Suppl 1, S3, 2015.
    • (2015) Semin Oncol , vol.42 , Issue.SUPPL1 , pp. S3
    • Ajani, J.A.1    Song, S.2    Hochster, H.S.3    Steinberg, I.B.4
  • 17
    • 84901608764 scopus 로고    scopus 로고
    • Modeling the tumor extracellular matrix: Tissue engineering tools repurposed towards new frontiers in cancer biology
    • Gill, B.J., and West, J.L. Modeling the tumor extracellular matrix: tissue engineering tools repurposed towards new frontiers in cancer biology. J Biomech 47, 1969, 2014.
    • (2014) J Biomech , vol.47 , pp. 1969
    • Gill, B.J.1    West, J.L.2
  • 18
    • 84899914538 scopus 로고    scopus 로고
    • In vitro models of tumor vessels and matrix: Engineering approaches to investigate transport limitations and drug delivery in cancer
    • Seo, B.R., DelNero, P., and Fischbach, C. In vitro models of tumor vessels and matrix: engineering approaches to investigate transport limitations and drug delivery in cancer. Adv Drug Deliv Rev 69, 205, 2014.
    • (2014) Adv Drug Deliv Rev , vol.69 , pp. 205
    • Seo, B.R.1    DelNero, P.2    Fischbach, C.3
  • 19
    • 84919679464 scopus 로고    scopus 로고
    • Tissueengineered 3D tumor angiogenesis models: Potential technologies for anti-cancer drug discovery
    • Chwalek, K., Bray, L.J., and Werner, C. Tissueengineered 3D tumor angiogenesis models: potential technologies for anti-cancer drug discovery. Adv Drug Deliv Rev 79, 30, 2014.
    • (2014) Adv Drug Deliv Rev , vol.79 , pp. 30
    • Chwalek, K.1    Bray, L.J.2    Werner, C.3
  • 20
    • 34547931078 scopus 로고    scopus 로고
    • Modeling tissue morphogenesis and cancer in 3D
    • Yamada, K.M., and Cukierman, E. Modeling tissue morphogenesis and cancer in 3D. Cell 130, 601, 2007.
    • (2007) Cell , vol.130 , pp. 601
    • Yamada, K.M.1    Cukierman, E.2
  • 21
    • 0036345151 scopus 로고    scopus 로고
    • Photopolymerizable hydrogels for tissue engineering applications
    • Nguyen, K.T., and West, J.L. Photopolymerizable hydrogels for tissue engineering applications. Biomaterials 23, 4307, 2002.
    • (2002) Biomaterials , vol.23 , pp. 4307
    • Nguyen, K.T.1    West, J.L.2
  • 22
    • 84870253512 scopus 로고    scopus 로고
    • Hydrogels for biomedical applications
    • Hoffman, A.S. Hydrogels for biomedical applications. Adv Drug Deliv Rev 64, 18, 2012.
    • (2012) Adv Drug Deliv Rev , vol.64 , pp. 18
    • Hoffman, A.S.1
  • 23
    • 75749158184 scopus 로고    scopus 로고
    • Biomaterials offer cancer research the third dimension
    • Hutmacher, D.W. Biomaterials offer cancer research the third dimension. Nat Mater 9, 90, 2010.
    • (2010) Nat Mater , vol.9 , pp. 90
    • Hutmacher, D.W.1
  • 24
    • 80051804176 scopus 로고    scopus 로고
    • 3D in vitro bioengineered tumors based on collagen i hydrogels
    • Szot, C.S., Buchanan, C.F., Freeman, J.W., and Rylander, M.N. 3D in vitro bioengineered tumors based on collagen I hydrogels. Biomaterials 32, 7905, 2011.
    • (2011) Biomaterials , vol.32 , pp. 7905
    • Szot, C.S.1    Buchanan, C.F.2    Freeman, J.W.3    Rylander, M.N.4
  • 25
    • 83355163224 scopus 로고    scopus 로고
    • The enhancement of cancer stem cell properties of MCF-7 cells in 3D collagen scaffolds for modeling of cancer and anti-cancer drugs
    • Chen, L., Xiao, Z., Meng, Y., Zhao, Y., Han, J., Su, G., Chen, B., and Dai, J. The enhancement of cancer stem cell properties of MCF-7 cells in 3D collagen scaffolds for modeling of cancer and anti-cancer drugs. Biomaterials 33, 1437, 2012.
    • (2012) Biomaterials , vol.33 , pp. 1437
    • Chen, L.1    Xiao, Z.2    Meng, Y.3    Zhao, Y.4    Han, J.5    Su, G.6    Chen, B.7    Dai, J.8
  • 26
    • 0028119642 scopus 로고
    • Three-dimensional type i collagen gel system for the study of osteoblastic metastases produced by metastatic prostate cancer
    • Koutsilieris, M., Sourla, A., Pelletier, G., and Doillon, C.J. Three-dimensional type I collagen gel system for the study of osteoblastic metastases produced by metastatic prostate cancer. J Bone Miner Res 9, 1823, 1994.
    • (1994) J Bone Miner Res , vol.9 , pp. 1823
    • Koutsilieris, M.1    Sourla, A.2    Pelletier, G.3    Doillon, C.J.4
  • 27
    • 84940225690 scopus 로고    scopus 로고
    • Tumor bioengineering using a transglutaminase crosslinked hydrogel
    • Fang, J.Y., Tan, S.J., Yang, Z., Tayag, C., and Han, B. Tumor bioengineering using a transglutaminase crosslinked hydrogel. PLoS One 9, e105616, 2014.
    • (2014) PLoS One , vol.9 , pp. e105616
    • Fang, J.Y.1    Tan, S.J.2    Yang, Z.3    Tayag, C.4    Han, B.5
  • 30
    • 84918787071 scopus 로고    scopus 로고
    • A 3D tension bioreactor platform to study the interplay between ECM stiffness and tumor phenotype
    • Cassereau, L., Miroshnikova, Y.A., Ou, G., Lakins, J., and Weaver, V.M. A 3D tension bioreactor platform to study the interplay between ECM stiffness and tumor phenotype. J Biotechnol 193, 66, 2015.
    • (2015) J Biotechnol , vol.193 , pp. 66
    • Cassereau, L.1    Miroshnikova, Y.A.2    Ou, G.3    Lakins, J.4    Weaver, V.M.5
  • 31
    • 84902083072 scopus 로고    scopus 로고
    • The effect of fibrillar matrix architecture on tumor cell invasion of physically challenging environments
    • Guzman, A., Ziperstein, M.J., and Kaufman, L.J. The effect of fibrillar matrix architecture on tumor cell invasion of physically challenging environments. Biomaterials 35, 6954, 2014.
    • (2014) Biomaterials , vol.35 , pp. 6954
    • Guzman, A.1    Ziperstein, M.J.2    Kaufman, L.J.3
  • 32
    • 84891413831 scopus 로고    scopus 로고
    • Topographical guidance of 3D tumor cell migration at an interface of collagen densities
    • Bordeleau, F., Tang, L.N., and Reinhart-King, C.A. Topographical guidance of 3D tumor cell migration at an interface of collagen densities. Phys Biol 10, 065004, 2013.
    • (2013) Phys Biol , vol.10 , pp. 065004
    • Bordeleau, F.1    Tang, L.N.2    Reinhart-King, C.A.3
  • 33
    • 84932631326 scopus 로고    scopus 로고
    • The phenotype of cancer cell invasion controlled by fibril diameter and pore size of 3D collagen networks
    • Sapudom, J., Rubner, S., Martin, S., Kurth, T., Riedel, S., Mierke, C.T., and Pompe, T. The phenotype of cancer cell invasion controlled by fibril diameter and pore size of 3D collagen networks. Biomaterials 52, 367, 2015.
    • (2015) Biomaterials , vol.52 , pp. 367
    • Sapudom, J.1    Rubner, S.2    Martin, S.3    Kurth, T.4    Riedel, S.5    Mierke, C.T.6    Pompe, T.7
  • 37
    • 84937458537 scopus 로고    scopus 로고
    • Three-dimensional constructs using hyaluronan cell carrier as a tool for the study of cancer stem cells
    • Martinez-Ramos, C., and Lebourg, M. Three-dimensional constructs using hyaluronan cell carrier as a tool for the study of cancer stem cells. J Biomed Mater Res Part B 103, 1249, 2015.
    • (2015) J Biomed Mater Res Part B , vol.103 , pp. 1249
    • Martinez-Ramos, C.1    Lebourg, M.2
  • 38
    • 84866004492 scopus 로고    scopus 로고
    • Characterization of leukemic cell behaviors in a soft marrow mimetic alginate hydrogel
    • Thao, T.T.V., Lim, C., and Lim, M. Characterization of leukemic cell behaviors in a soft marrow mimetic alginate hydrogel. J Biomed Mater Res B 100b, 1980, 2012.
    • (2012) J Biomed Mater Res B , vol.100 B , pp. 1980
    • Thao, T.T.V.1    Lim, C.2    Lim, M.3
  • 39
    • 23744449992 scopus 로고    scopus 로고
    • Matrigel: Basement membrane matrix with biological activity
    • Kleinman, H.K., and Martin, G.R. Matrigel: basement membrane matrix with biological activity. Semin Cancer Biol 15, 378, 2005.
    • (2005) Semin Cancer Biol , vol.15 , pp. 378
    • Kleinman, H.K.1    Martin, G.R.2
  • 41
    • 84898014389 scopus 로고    scopus 로고
    • Dualphase, surface tension-based fabrication method for generation of tumor millibeads
    • Pradhan, S., Chaudhury, C.S., and Lipke, E.A. Dualphase, surface tension-based fabrication method for generation of tumor millibeads. Langmuir 30, 3817, 2014.
    • (2014) Langmuir , vol.30 , pp. 3817
    • Pradhan, S.1    Chaudhury, C.S.2    Lipke, E.A.3
  • 42
    • 84903990671 scopus 로고    scopus 로고
    • Bioengineered 3D brain tumor model to elucidate the effects of matrix stiffness on glioblastoma cell behavior using PEG-based hydrogels
    • Wang, C., Tong, X., and Yang, F. Bioengineered 3D brain tumor model to elucidate the effects of matrix stiffness on glioblastoma cell behavior using PEG-based hydrogels. Mol Pharm 11, 2115, 2014.
    • (2014) Mol Pharm , vol.11 , pp. 2115
    • Wang, C.1    Tong, X.2    Yang, F.3
  • 46
    • 34547451080 scopus 로고    scopus 로고
    • Human bonemarrowstromal cells enhance breast cancer cell growth rates in a cell line-dependentmanner when evaluated in 3D tumor environments
    • Sasser, A.K., Mundy, B.L., Smith, K.M., Studebaker, A.W., Axel, A.E., Haidet, A.M., Fernandez, S.A., and Hall, B.M. Human bonemarrowstromal cells enhance breast cancer cell growth rates in a cell line-dependentmanner when evaluated in 3D tumor environments. Cancer Lett 254, 255, 2007.
    • (2007) Cancer Lett , vol.254 , pp. 255
    • Sasser, A.K.1    Mundy, B.L.2    Smith, K.M.3    Studebaker, A.W.4    Axel, A.E.5    Haidet, A.M.6    Fernandez, S.A.7    Hall, B.M.8
  • 47
    • 0027240861 scopus 로고
    • Effect of reconstituted basement membrane components on the growth of a panel of human tumour cell lines in nude mice
    • Topley, P., Jenkins, D.C., Jessup, E.A., and Stables, J.N. Effect of reconstituted basement membrane components on the growth of a panel of human tumour cell lines in nude mice. Br J Cancer 67, 953, 1993.
    • (1993) Br J Cancer , vol.67 , pp. 953
    • Topley, P.1    Jenkins, D.C.2    Jessup, E.A.3    Stables, J.N.4
  • 48
    • 77955692939 scopus 로고    scopus 로고
    • Human mammary fibroblasts stimulate invasion of breast cancer cells in a three-dimensional culture and increase stroma development in mouse xenografts
    • Olsen, C.J., Moreira, J., Lukanidin, E.M., and Ambartsumian, N.S. Human mammary fibroblasts stimulate invasion of breast cancer cells in a three-dimensional culture and increase stroma development in mouse xenografts. BMC Cancer 10, 444, 2010.
    • (2010) BMC Cancer , vol.10 , pp. 444
    • Olsen, C.J.1    Moreira, J.2    Lukanidin, E.M.3    Ambartsumian, N.S.4
  • 49
    • 84907961807 scopus 로고    scopus 로고
    • Malignant stroma increases luminal breast cancer cell proliferation and angiogenesis through platelet-derived growth factor signaling
    • Pinto, M.P., Dye, W.W., Jacobsen, B.M., and Horwitz, K.B. Malignant stroma increases luminal breast cancer cell proliferation and angiogenesis through platelet-derived growth factor signaling. BMC Cancer 14, 735, 2014.
    • (2014) BMC Cancer , vol.14 , pp. 735
    • Pinto, M.P.1    Dye, W.W.2    Jacobsen, B.M.3    Horwitz, K.B.4
  • 50
    • 84949323515 scopus 로고    scopus 로고
    • Establishment of a heterotypic 3D culture system to evaluate the interaction of TREG lymphocytes and NK cells with breast cancer
    • Augustine, T.N., Dix-Peek, T., Duarte, R., and Candy, G.P. Establishment of a heterotypic 3D culture system to evaluate the interaction of TREG lymphocytes and NK cells with breast cancer. J Immunol Methods 426, 1, 2015.
    • (2015) J Immunol Methods , vol.426 , pp. 1
    • Augustine, T.N.1    Dix-Peek, T.2    Duarte, R.3    Candy, G.P.4
  • 51
    • 84856700597 scopus 로고    scopus 로고
    • Cells assemble invadopodialike structures and invade into matrigel in a matrix metalloprotease dependent manner in the circular invasion assay
    • Yu, X., and Machesky, L.M. Cells assemble invadopodialike structures and invade into matrigel in a matrix metalloprotease dependent manner in the circular invasion assay. PLoS One 7, e30605, 2012.
    • (2012) PLoS One , vol.7 , pp. e30605
    • Yu, X.1    Machesky, L.M.2
  • 52
    • 84923321140 scopus 로고    scopus 로고
    • Enhanced invasion of metastatic cancer cells via extracellular matrix interface
    • Alliance U.S.-C.P.S.-O.
    • Zhu, J., Liang, L., Jiao, Y., Liu, L., and Alliance, U.S.-C.P. S.-O. Enhanced invasion of metastatic cancer cells via extracellular matrix interface. PLoS One 10, e0118058, 2015.
    • (2015) PLoS One , vol.10 , pp. e0118058
    • Zhu, J.1    Liang, L.2    Jiao, Y.3    Liu, L.4
  • 53
    • 0022619989 scopus 로고
    • Invasion of reconstituted basement membrane matrix by metastatic human tumor cells
    • Kramer, R.H., Bensch, K.G., and Wong, J. Invasion of reconstituted basement membrane matrix by metastatic human tumor cells. Cancer Res 46, 1980, 1986.
    • (1986) Cancer Res , vol.46 , pp. 1980
    • Kramer, R.H.1    Bensch, K.G.2    Wong, J.3
  • 54
    • 0027058972 scopus 로고
    • Molecular and cellular analysis of basement membrane invasion by human breast cancer cells in Matrigel-based in vitro assays
    • Bae, S.N., Arand, G., Azzam, H., Pavasant, P., Torri, J., Frandsen, T.L., and Thompson, E.W. Molecular and cellular analysis of basement membrane invasion by human breast cancer cells in Matrigel-based in vitro assays. Breast Cancer Res Treat 24, 241, 1993.
    • (1993) Breast Cancer Res Treat , vol.24 , pp. 241
    • Bae, S.N.1    Arand, G.2    Azzam, H.3    Pavasant, P.4    Torri, J.5    Frandsen, T.L.6    Thompson, E.W.7
  • 55
    • 84900033724 scopus 로고    scopus 로고
    • Controlled generation of microspheres incorporating extracellular matrix fibrils for three-dimensional cell culture
    • Workman, V.L., Tezera, L.B., Elkington, P.T., and Jayasinghe, S.N. Controlled generation of microspheres incorporating extracellular matrix fibrils for three-dimensional cell culture. Adv Funct Mater 24, 2648, 2014.
    • (2014) Adv Funct Mater , vol.24 , pp. 2648
    • Workman, V.L.1    Tezera, L.B.2    Elkington, P.T.3    Jayasinghe, S.N.4
  • 56
    • 84889041707 scopus 로고    scopus 로고
    • Single-step laser-based fabrication and patterning of cellencapsulated alginate microbeads
    • Kingsley, D.M., Dias, A.D., Chrisey, D.B., and Corr, D.T. Single-step laser-based fabrication and patterning of cellencapsulated alginate microbeads. Biofabrication 5, 045006, 2013.
    • (2013) Biofabrication , vol.5 , pp. 045006
    • Kingsley, D.M.1    Dias, A.D.2    Chrisey, D.B.3    Corr, D.T.4
  • 58
    • 84872549177 scopus 로고    scopus 로고
    • AlgiMatrix (TM) based 3D cell culture system as an in-vitro tumor model for anticancer studies
    • Godugu, C., Patel, A.R., Desai, U., Andey, T., Sams, A., and Singh, M. AlgiMatrix (TM) based 3D cell culture system as an in-vitro tumor model for anticancer studies. PLoS One 8, e53708, 2013.
    • (2013) PLoS One , vol.8 , pp. e53708
    • Godugu, C.1    Patel, A.R.2    Desai, U.3    Andey, T.4    Sams, A.5    Singh, M.6
  • 59
    • 79953271040 scopus 로고    scopus 로고
    • Bioengineering embryonic stem cell microenvironments for exploring inhibitory effects on metastatic breast cancer cells
    • Raof, N.A., Raja, W.K., Castracane, J., and Xie, Y. Bioengineering embryonic stem cell microenvironments for exploring inhibitory effects on metastatic breast cancer cells. Biomaterials 32, 4130, 2011.
    • (2011) Biomaterials , vol.32 , pp. 4130
    • Raof, N.A.1    Raja, W.K.2    Castracane, J.3    Xie, Y.4
  • 60
    • 84896080064 scopus 로고    scopus 로고
    • Enrichment of cancer stemcell-like cells by culture in alginate gel beads
    • Xu, X.X., Liu, C., Liu, Y., Yang, L., Li, N., Guo, X., Sun, G.W., and Ma, X.J. Enrichment of cancer stemcell-like cells by culture in alginate gel beads. J Biotechnol 177, 1, 2014.
    • (2014) J Biotechnol , vol.177 , pp. 1
    • Xu, X.X.1    Liu, C.2    Liu, Y.3    Yang, L.4    Li, N.5    Guo, X.6    Sun, G.W.7    Ma, X.J.8
  • 61
    • 84916934752 scopus 로고    scopus 로고
    • Potential effect of matrix stiffness on the enrichment of tumor initiating cells under three-dimensional culture conditions
    • Liu, C., Liu, Y., Xu, X.X., Wu, H., Xie, H.G., Chen, L., Lu, T., Yang, L., Guo, X., Sun, G.W., Wang, W., Ma, X.J., and He, X. Potential effect of matrix stiffness on the enrichment of tumor initiating cells under three-dimensional culture conditions. Exp Cell Res 330, 123, 2015.
    • (2015) Exp Cell Res , vol.330 , pp. 123
    • Liu, C.1    Liu, Y.2    Xu, X.X.3    Wu, H.4    Xie, H.G.5    Chen, L.6    Lu, T.7    Yang, L.8    Guo, X.9    Sun, G.W.10    Wang, W.11    Ma, X.J.12    He, X.13
  • 62
    • 84939572283 scopus 로고    scopus 로고
    • Role of threedimensional matrix stiffness in regulating the chemoresistance of hepatocellular carcinoma cells
    • Liu, C., Liu, Y., Xie, H.G., Zhao, S., Xu, X.X., Fan, L.X., Guo, X., Lu, T., Sun, G.W., and Ma, X.J. Role of threedimensional matrix stiffness in regulating the chemoresistance of hepatocellular carcinoma cells. Biotechnol Appl Biochem 62, 556, 2015.
    • (2015) Biotechnol Appl Biochem , vol.62 , pp. 556
    • Liu, C.1    Liu, Y.2    Xie, H.G.3    Zhao, S.4    Xu, X.X.5    Fan, L.X.6    Guo, X.7    Lu, T.8    Sun, G.W.9    Ma, X.J.10
  • 66
    • 84943149860 scopus 로고    scopus 로고
    • MCF-7 human breast cancer cells form differentiated microtissues in scaffold-free hydrogels
    • Vantangoli, M.M., Madnick, S.J., Huse, S.M., Weston, P., and Boekelheide, K. MCF-7 human breast cancer cells form differentiated microtissues in scaffold-free hydrogels. PLoS One 10, e0135426, 2015.
    • (2015) PLoS One , vol.10 , pp. e0135426
    • Vantangoli, M.M.1    Madnick, S.J.2    Huse, S.M.3    Weston, P.4    Boekelheide, K.5
  • 70
    • 84931407643 scopus 로고    scopus 로고
    • A novel role of low molecular weight hyaluronan in breast cancermetastasis
    • Wu, M., Cao, M., He, Y., Liu, Y., Yang, C., Du, Y., Wang, W., and Gao, F. A novel role of low molecular weight hyaluronan in breast cancermetastasis.FASEBJ 29, 1290, 2015.
    • (2015) FASEBJ , vol.29 , pp. 1290
    • Wu, M.1    Cao, M.2    He, Y.3    Liu, Y.4    Yang, C.5    Du, Y.6    Wang, W.7    Gao, F.8
  • 71
    • 84969262552 scopus 로고    scopus 로고
    • High and low, molecular weight hyaluronic acid differentially influence macrophage activation
    • Rayahin, J.E., Buhrman, J.S., Zhang, Y., Koh, T.J., and Gemeinhart, R.A. High and low, molecular weight hyaluronic acid differentially influence macrophage activation. ACS Biomater Sci Eng 1, 481, 2015.
    • (2015) ACS Biomater Sci Eng , vol.1 , pp. 481
    • Rayahin, J.E.1    Buhrman, J.S.2    Zhang, Y.3    Koh, T.J.4    Gemeinhart, R.A.5
  • 72
    • 84869208688 scopus 로고    scopus 로고
    • Hyaluronan (HA) interacting proteins RHAMM and hyaluronidase impact prostate cancer cell behavior and invadopodia formation in 3D HA-based hydrogels
    • Gurski, L.A., Xu, X., Labrada, L.N., Nguyen, N.T., Xiao, L., van Golen, K.L., Jia, X., and Farach-Carson, M.C. Hyaluronan (HA) interacting proteins RHAMM and hyaluronidase impact prostate cancer cell behavior and invadopodia formation in 3D HA-based hydrogels. PLoS One 7, e50075, 2012.
    • (2012) PLoS One , vol.7 , pp. e50075
    • Gurski, L.A.1    Xu, X.2    Labrada, L.N.3    Nguyen, N.T.4    Xiao, L.5    Van Golen, K.L.6    Jia, X.7    Farach-Carson, M.C.8
  • 73
    • 84867142208 scopus 로고    scopus 로고
    • Recreating the tumor microenvironment in a bilayer, hyaluronic acid hydrogel construct for the growth of prostate cancer spheroids
    • Xu, X., Gurski, L.A., Zhang, C., Harrington, D.A., Farach-Carson, M.C., and Jia, X. Recreating the tumor microenvironment in a bilayer, hyaluronic acid hydrogel construct for the growth of prostate cancer spheroids. Biomaterials 33, 9049, 2012.
    • (2012) Biomaterials , vol.33 , pp. 9049
    • Xu, X.1    Gurski, L.A.2    Zhang, C.3    Harrington, D.A.4    Farach-Carson, M.C.5    Jia, X.6
  • 76
    • 79959884148 scopus 로고    scopus 로고
    • Three-dimensional porous silk tumor constructs in the approximation of in vivo osteosarcoma physiology
    • Tan, P.H., Aung, K.Z., Toh, S.L., Goh, J.C., and Nathan, S.S. Three-dimensional porous silk tumor constructs in the approximation of in vivo osteosarcoma physiology. Biomaterials 32, 6131, 2011.
    • (2011) Biomaterials , vol.32 , pp. 6131
    • Tan, P.H.1    Aung, K.Z.2    Toh, S.L.3    Goh, J.C.4    Nathan, S.S.5
  • 77
    • 84884813681 scopus 로고    scopus 로고
    • A silk fibroin based hepatocarcinoma model and the assessment of the drug response in hyaluronan-binding protein 1 overexpressed HepG2 cells
    • Kundu, B., Saha, P., Datta, K., and Kundu, S.C. A silk fibroin based hepatocarcinoma model and the assessment of the drug response in hyaluronan-binding protein 1 overexpressed HepG2 cells. Biomaterials 34, 9462, 2013.
    • (2013) Biomaterials , vol.34 , pp. 9462
    • Kundu, B.1    Saha, P.2    Datta, K.3    Kundu, S.C.4
  • 80
    • 84885361354 scopus 로고    scopus 로고
    • Enhanced chemoresistance of squamous carcinoma cells grown in 3D cryogenic electrospun scaffolds
    • Bulysheva, A.A., Bowlin, G.L., Petrova, S.P., and Yeudall, W.A. Enhanced chemoresistance of squamous carcinoma cells grown in 3D cryogenic electrospun scaffolds. Biomed Mater 8, 055009, 2013.
    • (2013) Biomed Mater , vol.8 , pp. 055009
    • Bulysheva, A.A.1    Bowlin, G.L.2    Petrova, S.P.3    Yeudall, W.A.4
  • 82
    • 84957433332 scopus 로고    scopus 로고
    • Silk protein-based hydrogels: Promising advanced materials for biomedical applications
    • Kapoor, S., and Kundu, S.C. Silk protein-based hydrogels: promising advanced materials for biomedical applications. Acta Biomater 31, 17, 2016.
    • (2016) Acta Biomater , vol.31 , pp. 17
    • Kapoor, S.1    Kundu, S.C.2
  • 83
    • 1942518844 scopus 로고    scopus 로고
    • Characterization and evaluation of chitosan matrix for in vitro growth of MCF-7 breast cancer cell lines
    • Dhiman, H.K., Ray, A.R., and Panda, A.K. Characterization and evaluation of chitosan matrix for in vitro growth of MCF-7 breast cancer cell lines. Biomaterials 25, 5147, 2004.
    • (2004) Biomaterials , vol.25 , pp. 5147
    • Dhiman, H.K.1    Ray, A.R.2    Panda, A.K.3
  • 86
    • 0027948981 scopus 로고
    • In vivo modulation of human tumor cell growth by normal human extracellular matrix
    • Goodly, L.J., Singh, R.K., Wang, M.H., and Siegal, G.P. In vivo modulation of human tumor cell growth by normal human extracellular matrix. Tumour Biol 15, 326, 1994.
    • (1994) Tumour Biol , vol.15 , pp. 326
    • Goodly, L.J.1    Singh, R.K.2    Wang, M.H.3    Siegal, G.P.4
  • 88
    • 77952124277 scopus 로고    scopus 로고
    • Hydrolytically degradable poly(ethylene glycol) hydrogel scaffolds with tunable degradation and mechanical properties
    • Zustiak, S.P., and Leach, J.B. Hydrolytically degradable poly(ethylene glycol) hydrogel scaffolds with tunable degradation and mechanical properties. Biomacromolecules 11, 1348, 2010.
    • (2010) Biomacromolecules , vol.11 , pp. 1348
    • Zustiak, S.P.1    Leach, J.B.2
  • 89
    • 78649968754 scopus 로고    scopus 로고
    • Synthesis of photodegradable hydrogels as dynamically tunable cell culture platforms
    • Kloxin, A.M., Tibbitt, M.W., and Anseth, K.S. Synthesis of photodegradable hydrogels as dynamically tunable cell culture platforms. Nat Protoc 5, 1867, 2010.
    • (2010) Nat Protoc , vol.5 , pp. 1867
    • Kloxin, A.M.1    Tibbitt, M.W.2    Anseth, K.S.3
  • 90
    • 64249113913 scopus 로고    scopus 로고
    • Photodegradable hydrogels for dynamic tuning of physical and chemical properties
    • Kloxin, A.M., Kasko, A.M., Salinas, C.N., and Anseth, K.S. Photodegradable hydrogels for dynamic tuning of physical and chemical properties. Science 324, 59, 2009.
    • (2009) Science , vol.324 , pp. 59
    • Kloxin, A.M.1    Kasko, A.M.2    Salinas, C.N.3    Anseth, K.S.4
  • 91
    • 77951089569 scopus 로고    scopus 로고
    • Bioactive modification of poly(ethylene glycol) hydrogels for tissue engineering
    • Zhu, J. Bioactive modification of poly(ethylene glycol) hydrogels for tissue engineering. Biomaterials 31, 4639, 2010.
    • (2010) Biomaterials , vol.31 , pp. 4639
    • Zhu, J.1
  • 92
    • 84928718735 scopus 로고    scopus 로고
    • Multifunctional bioscaffolds for 3D culture of melanoma cells reveal increased MMP activity and migration with BRAF kinase inhibition
    • Leight, J.L., Tokuda, E.Y., Jones, C.E., Lin, A.J., and Anseth, K.S. Multifunctional bioscaffolds for 3D culture of melanoma cells reveal increased MMP activity and migration with BRAF kinase inhibition. Proc Natl Acad Sci U S A 112, 5366, 2015.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. 5366
    • Leight, J.L.1    Tokuda, E.Y.2    Jones, C.E.3    Lin, A.J.4    Anseth, K.S.5
  • 93
    • 23244447869 scopus 로고    scopus 로고
    • Molecularly engineered PEG hydrogels: A novel model system for proteolytically mediated cell migration
    • Raeber, G.P., Lutolf, M.P., and Hubbell, J.A. Molecularly engineered PEG hydrogels: a novel model system for proteolytically mediated cell migration. Biophys J 89, 1374, 2005.
    • (2005) Biophys J , vol.89 , pp. 1374
    • Raeber, G.P.1    Lutolf, M.P.2    Hubbell, J.A.3
  • 94
    • 84869219078 scopus 로고    scopus 로고
    • A synthetic matrix with independently tunable biochemistry and mechanical properties to study epithelial morphogenesis and EMT in a lung adenocarcinoma model
    • Gill, B.J., Gibbons, D.L., Roudsari, L.C., Saik, J.E., Rizvi, Z.H., Roybal, J.D., Kurie, J.M., and West, J.L. A synthetic matrix with independently tunable biochemistry and mechanical properties to study epithelial morphogenesis and EMT in a lung adenocarcinoma model. Cancer Res 72, 6013, 2012.
    • (2012) Cancer Res , vol.72 , pp. 6013
    • Gill, B.J.1    Gibbons, D.L.2    Roudsari, L.C.3    Saik, J.E.4    Rizvi, Z.H.5    Roybal, J.D.6    Kurie, J.M.7    West, J.L.8
  • 95
    • 84901982024 scopus 로고    scopus 로고
    • A peptide functionalized poly(ethylene glycol) (PEG) hydrogel for investigating the influence of biochemical and biophysical matrix properties on tumor cell migration
    • Singh, S.P., Schwartz, M.P., Lee, J.Y., Fairbanks, B.D., and Anseth, K.S. A peptide functionalized poly(ethylene glycol) (PEG) hydrogel for investigating the influence of biochemical and biophysical matrix properties on tumor cell migration. Biomater Sci 2, 1024, 2014.
    • (2014) Biomater Sci , vol.2 , pp. 1024
    • Singh, S.P.1    Schwartz, M.P.2    Lee, J.Y.3    Fairbanks, B.D.4    Anseth, K.S.5
  • 96
    • 84873356030 scopus 로고    scopus 로고
    • Three-dimensional-engineered matrix to study cancer stem cells and tumorsphere formation: Effect of matrix modulus
    • Yang, X., Sarvestani, S.K., Moeinzadeh, S., He, X., and Jabbari, E. Three-dimensional-engineered matrix to study cancer stem cells and tumorsphere formation: effect of matrix modulus. Tissue Eng Part A 19, 669, 2013.
    • (2013) Tissue Eng Part A , vol.19 , pp. 669
    • Yang, X.1    Sarvestani, S.K.2    Moeinzadeh, S.3    He, X.4    Jabbari, E.5
  • 97
    • 84940777013 scopus 로고    scopus 로고
    • Optimum 3D matrix stiffness for maintenance of cancer stem cells is dependent on tissue origin of cancer cells
    • Jabbari, E., Sarvestani, S.K., Daneshian, L., and Moeinzadeh, S. Optimum 3D matrix stiffness for maintenance of cancer stem cells is dependent on tissue origin of cancer cells. PLoS One 10, e0132377, 2015.
    • (2015) PLoS One , vol.10 , pp. e0132377
    • Jabbari, E.1    Sarvestani, S.K.2    Daneshian, L.3    Moeinzadeh, S.4
  • 98
    • 84875079104 scopus 로고    scopus 로고
    • Effect of CD44 binding peptide conjugated to an engineered inert matrix on maintenance of breast cancer stem cells and tumorsphere formation
    • Yang, X., Sarvestani, S.K., Moeinzadeh, S., He, X., and Jabbari, E. Effect of CD44 binding peptide conjugated to an engineered inert matrix on maintenance of breast cancer stem cells and tumorsphere formation. PLoS One 8, e59147, 2013.
    • (2013) PLoS One , vol.8 , pp. e59147
    • Yang, X.1    Sarvestani, S.K.2    Moeinzadeh, S.3    He, X.4    Jabbari, E.5
  • 99
    • 84857441248 scopus 로고    scopus 로고
    • The impact of adhesion peptides within hydrogels on the phenotype and signaling of normal and cancerous mammary epithelial cells
    • Weiss, M.S., Bernabé, B.P., Shikanov, A., Bluver, D.A., Mui, M.D., Shin, S., Broadbelt, L.J., and Shea, L.D. The impact of adhesion peptides within hydrogels on the phenotype and signaling of normal and cancerous mammary epithelial cells. Biomaterials 33, 3548, 2012.
    • (2012) Biomaterials , vol.33 , pp. 3548
    • Weiss, M.S.1    Bernabé, B.P.2    Shikanov, A.3    Bluver, D.A.4    Mui, M.D.5    Shin, S.6    Broadbelt, L.J.7    Shea, L.D.8
  • 100
    • 16344392522 scopus 로고    scopus 로고
    • Characterization of porous PLGA/PLA microparticles as a scaffold for three dimensional growth of breast cancer cells
    • Sahoo, S.K., Panda, A.K., and Labhasetwar, V. Characterization of porous PLGA/PLA microparticles as a scaffold for three dimensional growth of breast cancer cells. Biomacromolecules 6, 1132, 2005.
    • (2005) Biomacromolecules , vol.6 , pp. 1132
    • Sahoo, S.K.1    Panda, A.K.2    Labhasetwar, V.3
  • 101
    • 67649878833 scopus 로고    scopus 로고
    • Cryopreservable and tumorigenic three-dimensional tumor culture in porous poly(lactic-coglycolic acid) microsphere
    • Kang, S.W., andBae, Y.H.Cryopreservable and tumorigenic three-dimensional tumor culture in porous poly(lactic-coglycolic acid) microsphere. Biomaterials 30, 4227, 2009.
    • (2009) Biomaterials , vol.30 , pp. 4227
    • Kang, S.W.1    Bae, Y.H.2
  • 102
    • 48449106284 scopus 로고    scopus 로고
    • Characterization of porous poly(D, L-lacticco-glycolic acid) sponges fabricated by supercritical CO2 gas-foaming method as a scaffold for three-dimensional growth of Hep3B cells
    • Zhu, X.H., Lee, L.Y., Jackson, J.S.H., Tong, Y.W., and Wang, C.-H. Characterization of porous poly(D, L-lacticco-glycolic acid) sponges fabricated by supercritical CO2 gas-foaming method as a scaffold for three-dimensional growth of Hep3B cells. Biotechnol Bioeng 100, 998, 2008.
    • (2008) Biotechnol Bioeng , vol.100 , pp. 998
    • Zhu, X.H.1    Lee, L.Y.2    Jackson, J.S.H.3    Tong, Y.W.4    Wang, C.-H.5
  • 103
    • 78449290991 scopus 로고    scopus 로고
    • Incorporation of multicellular spheroids into 3-D polymeric scaffolds provides an improved tumor model for screening anticancer drugs
    • Ho, W.J., Pham, E.a., Kim, J.W., Ng, C.W., Kim, J.H., Kamei, D.T., and Wu, B.M. Incorporation of multicellular spheroids into 3-D polymeric scaffolds provides an improved tumor model for screening anticancer drugs. Cancer Sci 101, 2637, 2010.
    • (2010) Cancer Sci , vol.101 , pp. 2637
    • Ho, W.J.1    Pham, E.A.2    Kim, J.W.3    Ng, C.W.4    Kim, J.H.5    Kamei, D.T.6    Wu, B.M.7
  • 104
    • 84898687960 scopus 로고    scopus 로고
    • The controllable preparation of porous PLGA microspheres by the oil/water emulsion method and its application in 3D culture of ovarian cancer cells
    • Zhang, T., Zhang, Q., Chen, J., Fang, K., Dou, J., and Gu, N. The controllable preparation of porous PLGA microspheres by the oil/water emulsion method and its application in 3D culture of ovarian cancer cells. Colloids Surf A 452, 115, 2014.
    • (2014) Colloids Surf A , vol.452 , pp. 115
    • Zhang, T.1    Zhang, Q.2    Chen, J.3    Fang, K.4    Dou, J.5    Gu, N.6
  • 109
    • 84915784640 scopus 로고    scopus 로고
    • Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium
    • Chaudhuri, O., Koshy, S.T., Branco da Cunha, C., Shin, J.W., Verbeke, C.S., Allison, K.H., and Mooney, D.J. Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium. Nat Mater 13, 970, 2014.
    • (2014) Nat Mater , vol.13 , pp. 970
    • Chaudhuri, O.1    Koshy, S.T.2    Branco da Cunha, C.3    Shin, J.W.4    Verbeke, C.S.5    Allison, K.H.6    Mooney, D.J.7
  • 110
    • 80053603679 scopus 로고    scopus 로고
    • A cell-instructive hydrogel to regulate malignancy of 3D tumor spheroids with matrix rigidity
    • Liang, Y., Jeong, J., DeVolder, R.J., Cha, C., Wang, F., Tong, Y.W., and Kong, H. A cell-instructive hydrogel to regulate malignancy of 3D tumor spheroids with matrix rigidity. Biomaterials 32, 9308, 2011.
    • (2011) Biomaterials , vol.32 , pp. 9308
    • Liang, Y.1    Jeong, J.2    DeVolder, R.J.3    Cha, C.4    Wang, F.5    Tong, Y.W.6    Kong, H.7
  • 111
    • 84884815469 scopus 로고    scopus 로고
    • The independent roles of mechanical, structural and adhesion characteristics of 3D hydrogels on the regulation of cancer invasion and dissemination
    • Beck, J.N., Singh, A., Rothenberg, A.R., Elisseeff, J.H., and Ewald, A.J. The independent roles of mechanical, structural and adhesion characteristics of 3D hydrogels on the regulation of cancer invasion and dissemination. Biomaterials 34, 9486, 2013.
    • (2013) Biomaterials , vol.34 , pp. 9486
    • Beck, J.N.1    Singh, A.2    Rothenberg, A.R.3    Elisseeff, J.H.4    Ewald, A.J.5
  • 112
    • 84903688702 scopus 로고    scopus 로고
    • Prostate cancer xenografts engineered from 3D precision-porous poly(2-hydroxyethyl methacrylate) hydrogels as models for tumorigenesis and dormancy escape
    • Long, T.J., Sprenger, C.C., Plymate, S.R., and Ratner, B.D. Prostate cancer xenografts engineered from 3D precision-porous poly(2-hydroxyethyl methacrylate) hydrogels as models for tumorigenesis and dormancy escape. Biomaterials 35, 8164, 2014.
    • (2014) Biomaterials , vol.35 , pp. 8164
    • Long, T.J.1    Sprenger, C.C.2    Plymate, S.R.3    Ratner, B.D.4
  • 113
    • 10044290786 scopus 로고    scopus 로고
    • Biosynthetic hydrogel scaffolds made from fibrinogen and polyethylene glycol for 3D cell cultures
    • Almany, L., and Seliktar, D. Biosynthetic hydrogel scaffolds made from fibrinogen and polyethylene glycol for 3D cell cultures. Biomaterials 26, 2467, 2005.
    • (2005) Biomaterials , vol.26 , pp. 2467
    • Almany, L.1    Seliktar, D.2
  • 114
    • 80054996604 scopus 로고    scopus 로고
    • Effects of PEG size on structure, function and stability of PEGylated BSA
    • Plesner, B., Fee, C.J., Westh, P., and Nielsen, A.D. Effects of PEG size on structure, function and stability of PEGylated BSA. Eur J Pharm Biopharm 79, 399, 2011.
    • (2011) Eur J Pharm Biopharm , vol.79 , pp. 399
    • Plesner, B.1    Fee, C.J.2    Westh, P.3    Nielsen, A.D.4
  • 116
    • 33751345331 scopus 로고    scopus 로고
    • Matrix stiffness affects spontaneous contraction of cardiomyocytes cultured within a PEGylated fibrinogen biomaterial
    • Shapira-Schweitzer, K., and Seliktar, D. Matrix stiffness affects spontaneous contraction of cardiomyocytes cultured within a PEGylated fibrinogen biomaterial. Acta Biomater 3, 33, 2007.
    • (2007) Acta Biomater , vol.3 , pp. 33
    • Shapira-Schweitzer, K.1    Seliktar, D.2
  • 118
    • 82855178721 scopus 로고    scopus 로고
    • 3D cell entrapment in crosslinked thiolated gelatin-poly(ethylene glycol) diacrylate hydrogels
    • Fu, Y., Xu, K., Zheng, X., Giacomin, A.J., Mix, A.W., and Kao, W.J. 3D cell entrapment in crosslinked thiolated gelatin-poly(ethylene glycol) diacrylate hydrogels. Biomaterials 33, 48, 2012.
    • (2012) Biomaterials , vol.33 , pp. 48
    • Fu, Y.1    Xu, K.2    Zheng, X.3    Giacomin, A.J.4    Mix, A.W.5    Kao, W.J.6
  • 120
    • 84930819565 scopus 로고    scopus 로고
    • Threedimensional (3D) culture of bone-derived human 786-O renal cell carcinoma retains relevant clinical characteristics of bone metastases
    • Pan, T., Fong, E.L., Martinez, M., Harrington, D.A., Lin, S.H., Farach-Carson, M.C., and Satcher, R.L. Threedimensional (3D) culture of bone-derived human 786-O renal cell carcinoma retains relevant clinical characteristics of bone metastases. Cancer Lett 365, 89, 2015.
    • (2015) Cancer Lett , vol.365 , pp. 89
    • Pan, T.1    Fong, E.L.2    Martinez, M.3    Harrington, D.A.4    Lin, S.H.5    Farach-Carson, M.C.6    Satcher, R.L.7
  • 121
    • 84880509585 scopus 로고    scopus 로고
    • Regulation of glioma cell phenotype in 3D matrices by hyaluronic acid
    • Pedron, S., Becka, E., and Harley, B.A. Regulation of glioma cell phenotype in 3D matrices by hyaluronic acid. Biomaterials 34, 7408, 2013.
    • (2013) Biomaterials , vol.34 , pp. 7408
    • Pedron, S.1    Becka, E.2    Harley, B.A.3
  • 122
    • 84875204499 scopus 로고    scopus 로고
    • Peptide hydrogelation and cell encapsulation for 3D culture of MCF-7 breast cancer cells
    • Huang, H., Ding, Y., Sun, X.S., and Nguyen, T.A. Peptide hydrogelation and cell encapsulation for 3D culture of MCF-7 breast cancer cells. PLoS One 8, e59482, 2013.
    • (2013) PLoS One , vol.8 , pp. e59482
    • Huang, H.1    Ding, Y.2    Sun, X.S.3    Nguyen, T.A.4
  • 123
    • 84876750358 scopus 로고    scopus 로고
    • 3D porous chitosan-Alginate scaffolds: A new matrix for studying prostate cancer cell-lymphocyte interactions in vitro
    • Florczyk, S.J., Liu, G., Kievit, F.M., Lewis, A.M., Wu, J.D., and Zhang, M. 3D porous chitosan-Alginate scaffolds: a new matrix for studying prostate cancer cell-lymphocyte interactions in vitro. Adv Healthc Mater 1, 590, 2012.
    • (2012) Adv Healthc Mater , vol.1 , pp. 590
    • Florczyk, S.J.1    Liu, G.2    Kievit, F.M.3    Lewis, A.M.4    Wu, J.D.5    Zhang, M.6
  • 125
    • 52949114165 scopus 로고    scopus 로고
    • Silk fibroin/chitosan scaffold: Preparation, characterization, and culture with HepG2 cell
    • She, Z., Jin, C., Huang, Z., Zhang, B., Feng, Q., and Xu, Y. Silk fibroin/chitosan scaffold: preparation, characterization, and culture with HepG2 cell. J Mater Sci 19, 3545, 2008.
    • (2008) J Mater Sci , vol.19 , pp. 3545
    • She, Z.1    Jin, C.2    Huang, Z.3    Zhang, B.4    Feng, Q.5    Xu, Y.6
  • 126
    • 84868581287 scopus 로고    scopus 로고
    • Recapitulating tumour microenvironment in chitosan-gelatin three-dimensional scaffolds: An improved in vitro tumour model
    • Arya, N., Sardana, V., Saxena, M., Rangarajan, A., and Katti, D.S. Recapitulating tumour microenvironment in chitosan-gelatin three-dimensional scaffolds: an improved in vitro tumour model. J R Soc Interface 9, 3288, 2012.
    • (2012) J R Soc Interface , vol.9 , pp. 3288
    • Arya, N.1    Sardana, V.2    Saxena, M.3    Rangarajan, A.4    Katti, D.S.5
  • 127
    • 73249141139 scopus 로고    scopus 로고
    • Probing cellular mechanobiology in threedimensional culture with collagen-Agarose matrices
    • Ulrich, T.A., Jain, A., Tanner, K., MacKay, J.L., and Kumar, S. Probing cellular mechanobiology in threedimensional culture with collagen-Agarose matrices. Biomaterials 31, 1875, 2010.
    • (2010) Biomaterials , vol.31 , pp. 1875
    • Ulrich, T.A.1    Jain, A.2    Tanner, K.3    MacKay, J.L.4    Kumar, S.5
  • 129
    • 84934764749 scopus 로고    scopus 로고
    • Peptide hydrogels-versatile matrices for 3D cell culture in cancer medicine
    • Worthington, P., Pochan, D.J., and Langhans, S.A. Peptide hydrogels-versatile matrices for 3D cell culture in cancer medicine. Front Oncol 5, 92, 2015.
    • (2015) Front Oncol , vol.5 , pp. 92
    • Worthington, P.1    Pochan, D.J.2    Langhans, S.A.3
  • 130
    • 84938930401 scopus 로고    scopus 로고
    • Molecular structure of monomorphic peptide fibrils within a kinetically trapped hydrogel network
    • Nagy-Smith, K., Moore, E., Schneider, J., and Tycko, R. Molecular structure of monomorphic peptide fibrils within a kinetically trapped hydrogel network. Proc Natl Acad Sci U S A 112, 9816, 2015.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. 9816
    • Nagy-Smith, K.1    Moore, E.2    Schneider, J.3    Tycko, R.4
  • 131
    • 79959529448 scopus 로고    scopus 로고
    • A 3D model of ovarian cancer cell lines on peptide nanofiber scaffold to explore the cellscaffold interaction and chemotherapeutic resistance of anticancer drugs
    • Yang, Z., and Zhao, X. A 3D model of ovarian cancer cell lines on peptide nanofiber scaffold to explore the cellscaffold interaction and chemotherapeutic resistance of anticancer drugs. Int J Nanomed 6, 303, 2011.
    • (2011) Int J Nanomed , vol.6 , pp. 303
    • Yang, Z.1    Zhao, X.2
  • 135
    • 84907970042 scopus 로고    scopus 로고
    • Creation of macropores in three-dimensional bacterial cellulose scaffold for potential cancer cell culture
    • Xiong, G.Y., Luo, H.L., Zhu, Y., Raman, S., and Wan, Y.Z. Creation of macropores in three-dimensional bacterial cellulose scaffold for potential cancer cell culture. Carbohydr Polym 114, 553, 2014.
    • (2014) Carbohydr Polym , vol.114 , pp. 553
    • Xiong, G.Y.1    Luo, H.L.2    Zhu, Y.3    Raman, S.4    Wan, Y.Z.5
  • 137
    • 84955478956 scopus 로고    scopus 로고
    • A threedimensional engineered tumour for spatial snapshot analysis of cell metabolism and phenotype in hypoxic gradients
    • Rodenhizer, D., Gaude, E., Cojocari, D., Mahadevan, R., Frezza, C., Wouters, B.G., and McGuigan, A.P. A threedimensional engineered tumour for spatial snapshot analysis of cell metabolism and phenotype in hypoxic gradients. Nat Mater 15, 227, 2016.
    • (2016) Nat Mater , vol.15 , pp. 227
    • Rodenhizer, D.1    Gaude, E.2    Cojocari, D.3    Mahadevan, R.4    Frezza, C.5    Wouters, B.G.6    McGuigan, A.P.7
  • 141
    • 84950144809 scopus 로고    scopus 로고
    • Threedimensional microfluidic tri-culture model of the bone marrow microenvironment for study of acute lymphoblastic leukemia
    • Bruce, A., Evans, R., Mezan, R., Shi, L., Moses, B.S., Martin, K.H., Gibson, L.F., and Yang, Y. Threedimensional microfluidic tri-culture model of the bone marrow microenvironment for study of acute lymphoblastic leukemia. PLoS One 10, e0140506, 2015.
    • (2015) PLoS One , vol.10 , pp. e0140506
    • Bruce, A.1    Evans, R.2    Mezan, R.3    Shi, L.4    Moses, B.S.5    Martin, K.H.6    Gibson, L.F.7    Yang, Y.8
  • 143
    • 78751560396 scopus 로고    scopus 로고
    • High-Throughput 3D spheroid culture and drug testing using a 384 hanging drop array
    • Tung, Y.C., Hsiao, A.Y., Allen, S.G., Torisawa, Y.S., Ho, M., and Takayama, S. High-Throughput 3D spheroid culture and drug testing using a 384 hanging drop array. Analyst 136, 473, 2011.
    • (2011) Analyst , vol.136 , pp. 473
    • Tung, Y.C.1    Hsiao, A.Y.2    Allen, S.G.3    Torisawa, Y.S.4    Ho, M.5    Takayama, S.6
  • 145
    • 84860372850 scopus 로고    scopus 로고
    • Importance of intracellular pH in determining the uptake and efficacy of the weakly basic chemotherapeutic drug, doxorubicin
    • Swietach, P., Hulikova, A., Patiar, S., Vaughan-Jones, R.D., and Harris, A.L. Importance of intracellular pH in determining the uptake and efficacy of the weakly basic chemotherapeutic drug, doxorubicin. PLoS One 7, e35949, 2012.
    • (2012) PLoS One , vol.7 , pp. e35949
    • Swietach, P.1    Hulikova, A.2    Patiar, S.3    Vaughan-Jones, R.D.4    Harris, A.L.5
  • 146
    • 80052325855 scopus 로고    scopus 로고
    • Alginate based 3D hydrogels as an in vitro co-culture model platform for the toxicity screening of new chemical entities
    • Lan, S.F., and Starly, B. Alginate based 3D hydrogels as an in vitro co-culture model platform for the toxicity screening of new chemical entities. Toxicol Appl Pharmacol 256, 62, 2011.
    • (2011) Toxicol Appl Pharmacol , vol.256 , pp. 62
    • Lan, S.F.1    Starly, B.2
  • 147
    • 23244447397 scopus 로고    scopus 로고
    • Development of an in vitro multicellular tumor spheroid model using microencapsulation and its application in anticancer drug screening and testing
    • Zhang, X.X., Wang, W., Yu, W., Xie, Y., Zhang, Y., and Ma, X. Development of an in vitro multicellular tumor spheroid model using microencapsulation and its application in anticancer drug screening and testing. Biotechnol Prog 21, 1289, 2005.
    • (2005) Biotechnol Prog , vol.21 , pp. 1289
    • Zhang, X.X.1    Wang, W.2    Yu, W.3    Xie, Y.4    Zhang, Y.5    Ma, X.6
  • 149
    • 4544382532 scopus 로고    scopus 로고
    • Threedimensional chitosan scaffold-based MCF-7 cell culture for the determination of the cytotoxicity of tamoxifen
    • Dhiman, H.K., Ray, A.R., and Panda, A.K. Threedimensional chitosan scaffold-based MCF-7 cell culture for the determination of the cytotoxicity of tamoxifen. Biomaterials 26, 979, 2005.
    • (2005) Biomaterials , vol.26 , pp. 979
    • Dhiman, H.K.1    Ray, A.R.2    Panda, A.K.3
  • 150
    • 77955466694 scopus 로고    scopus 로고
    • Chitosan-Alginate scaffold culture system for hepatocellular carcinoma increases malignancy and drug resistance
    • Leung, M., Kievit, F.M., Florczyk, S.J., Veiseh, O., Wu, J., Park, J.O., and Zhang, M. Chitosan-Alginate scaffold culture system for hepatocellular carcinoma increases malignancy and drug resistance. Pharm Res 27, 1939, 2010.
    • (2010) Pharm Res , vol.27 , pp. 1939
    • Leung, M.1    Kievit, F.M.2    Florczyk, S.J.3    Veiseh, O.4    Wu, J.5    Park, J.O.6    Zhang, M.7
  • 151
    • 38949188565 scopus 로고    scopus 로고
    • Hyaluronan hydrogel: An appropriate three-dimensional model for evaluation of anticancer drug sensitivity
    • David, L., Dulong, V., Le Cerf, D., Cazin, L., Lamacz, M., and Vannier, J.P. Hyaluronan hydrogel: an appropriate three-dimensional model for evaluation of anticancer drug sensitivity. Acta Biomater 4, 256, 2008.
    • (2008) Acta Biomater , vol.4 , pp. 256
    • David, L.1    Dulong, V.2    Le Cerf, D.3    Cazin, L.4    Lamacz, M.5    Vannier, J.P.6
  • 152
    • 69249230753 scopus 로고    scopus 로고
    • Hyaluronic acid-based hydrogels as 3D matrices for in vitro evaluation of chemotherapeutic drugs using poorly adherent prostate cancer cells
    • Gurski, L.A., Jha, A.K., Zhang, C., Jia, X., and Farach-Carson, M.C. Hyaluronic acid-based hydrogels as 3D matrices for in vitro evaluation of chemotherapeutic drugs using poorly adherent prostate cancer cells. Biomaterials 30, 6076, 2009.
    • (2009) Biomaterials , vol.30 , pp. 6076
    • Gurski, L.A.1    Jha, A.K.2    Zhang, C.3    Jia, X.4    Farach-Carson, M.C.5
  • 155
    • 84883749372 scopus 로고    scopus 로고
    • Effect of 3D matrix compositions on the efficacy of EGFR inhibition in pancreatic ductal adenocarcinoma cells
    • Ki, C.S., Shih, H., and Lin, C.C. Effect of 3D matrix compositions on the efficacy of EGFR inhibition in pancreatic ductal adenocarcinoma cells. Biomacromolecules 14, 3017, 2013.
    • (2013) Biomacromolecules , vol.14 , pp. 3017
    • Ki, C.S.1    Shih, H.2    Lin, C.C.3
  • 156
    • 84884336670 scopus 로고    scopus 로고
    • BMP4 inhibits the proliferation of breast cancer cells and induces an MMP-dependent migratory phenotype in MDA-MB-231 cells in 3D environment
    • Ampuja, M., Jokimaki, R., Juuti-Uusitalo, K., Rodriguez-Martinez, A., Alarmo, E.L., and Kallioniemi, A. BMP4 inhibits the proliferation of breast cancer cells and induces an MMP-dependent migratory phenotype in MDA-MB-231 cells in 3D environment. BMC Cancer 13, 429, 2013.
    • (2013) BMC Cancer , vol.13 , pp. 429
    • Ampuja, M.1    Jokimaki, R.2    Juuti-Uusitalo, K.3    Rodriguez-Martinez, A.4    Alarmo, E.L.5    Kallioniemi, A.6
  • 157
    • 84922424405 scopus 로고    scopus 로고
    • Target specific delivery of anticancer drug in silk fibroin based 3D distribution model of bone-breast cancer cells
    • Subia, B., Dey, T., Sharma, S., and Kundu, S.C. Target specific delivery of anticancer drug in silk fibroin based 3D distribution model of bone-breast cancer cells. ACS Appl Mater Interfaces 7, 2269, 2015.
    • (2015) ACS Appl Mater Interfaces , vol.7 , pp. 2269
    • Subia, B.1    Dey, T.2    Sharma, S.3    Kundu, S.C.4
  • 158
    • 84944112089 scopus 로고    scopus 로고
    • 3D porous chitosan-Alginate scaffolds as an in vitro model for evaluating nanoparticle-mediated tumor targeting and gene delivery to prostate cancer
    • Wang, K., Kievit, F.M., Florczyk, S.J., Stephen, Z.R., and Zhang, M. 3D porous chitosan-Alginate scaffolds as an in vitro model for evaluating nanoparticle-mediated tumor targeting and gene delivery to prostate cancer. Biomacromolecules 16, 3362, 2015.
    • (2015) Biomacromolecules , vol.16 , pp. 3362
    • Wang, K.1    Kievit, F.M.2    Florczyk, S.J.3    Stephen, Z.R.4    Zhang, M.5
  • 159
    • 84938149992 scopus 로고    scopus 로고
    • The use of collagen-based scaffolds to simulate prostate cancer bone metastases with potential for evaluating delivery of nanoparticulate gene therapeutics
    • Fitzgerald, K.A., Guo, J.F., Tierney, E.G., Curtin, C.M., Malhotra, M., Darcy, R., O Brien, F.J., and O Driscoll, C.M. The use of collagen-based scaffolds to simulate prostate cancer bone metastases with potential for evaluating delivery of nanoparticulate gene therapeutics. Biomaterials 66, 53, 2015.
    • (2015) Biomaterials , vol.66 , pp. 53
    • Fitzgerald, K.A.1    Guo, J.F.2    Tierney, E.G.3    Curtin, C.M.4    Malhotra, M.5    Darcy, R.6    O'Brien, F.J.7    O'Driscoll, C.M.8
  • 160
    • 84867139870 scopus 로고    scopus 로고
    • Effect of homotypic and heterotypic interaction in 3D on the E-selectin mediated adhesive properties of breast cancer cell lines
    • Chandrasekaran, S., Geng, Y., DeLouise, L.A., and King, M.R. Effect of homotypic and heterotypic interaction in 3D on the E-selectin mediated adhesive properties of breast cancer cell lines. Biomaterials 33, 9037, 2012.
    • (2012) Biomaterials , vol.33 , pp. 9037
    • Chandrasekaran, S.1    Geng, Y.2    DeLouise, L.A.3    King, M.R.4
  • 161
    • 79961226547 scopus 로고    scopus 로고
    • A novel 3-dimensional culture system uncovers growth stimulatory actions by TGFb in pancreatic cancer cells
    • Sempere, L.F., Gunn, J.R., and Korc, M. A novel 3-dimensional culture system uncovers growth stimulatory actions by TGFb in pancreatic cancer cells. Cancer Biol Ther 12, 198, 2011.
    • (2011) Cancer Biol Ther , vol.12 , pp. 198
    • Sempere, L.F.1    Gunn, J.R.2    Korc, M.3
  • 163
    • 84874964737 scopus 로고    scopus 로고
    • Application of a microfluidic chip-based 3D co-culture to test drug sensitivity for individualized treatment of lung cancer
    • Xu, Z., Gao, Y., Hao, Y., Li, E., Wang, Y., Zhang, J., Wang, W., Gao, Z., and Wang, Q. Application of a microfluidic chip-based 3D co-culture to test drug sensitivity for individualized treatment of lung cancer. Biomaterials 34, 4109, 2013.
    • (2013) Biomaterials , vol.34 , pp. 4109
    • Xu, Z.1    Gao, Y.2    Hao, Y.3    Li, E.4    Wang, Y.5    Zhang, J.6    Wang, W.7    Gao, Z.8    Wang, Q.9
  • 164
    • 73149098114 scopus 로고    scopus 로고
    • A microfluidic chip with poly(ethylene glycol) hydrogel microarray on nanoporous alumina membrane for cell patterning and drug testing
    • Liu, Z.-B., Zhang, Y., Yu, J.-J., Mak, A.F.-T., Li, Y., and Yang, M. A microfluidic chip with poly(ethylene glycol) hydrogel microarray on nanoporous alumina membrane for cell patterning and drug testing. Sens Actuators B 143, 776, 2010.
    • (2010) Sens Actuators B , vol.143 , pp. 776
    • Liu, Z.-B.1    Zhang, Y.2    Yu, J.-J.3    Mak, A.F.-T.4    Li, Y.5    Yang, M.6
  • 165
    • 65649133932 scopus 로고    scopus 로고
    • A micro cell culture analog (microCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anticancer drugs
    • Sung, J.H., and Shuler, M.L. A micro cell culture analog (microCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anticancer drugs. Lab Chip 9, 1385, 2009.
    • (2009) Lab Chip , vol.9 , pp. 1385
    • Sung, J.H.1    Shuler, M.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.