Cell motility and drug gradients in the emergence of resistance to chemotherapy

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 40, 2013, Pages 16103-16108

  Wu, Amy ^a   Loutherback, Keèin ^b   Lambert, Guillaume ^c   Estéèez Salmerón, Luis ^d   Tlsty, Thea D ^d   Austin, Robert H ^e   Sturm, James C ^a  

^a Princeton University   (United States)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER RESISTANCE; CELL MOTILITY; CELL PROLIFERATION; CELL TRACKING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; MICROFLUIDICS; POPULATION DYNAMICS; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; EVOLUTION, MOLECULAR; HUMANS; MICROFLUIDIC ANALYTICAL TECHNIQUES; NEOPLASMS; SELECTION, GENETIC; TIME FACTORS;

EID: 84885079075     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1314385110     Document Type: Article

References (33)

1. Bozic I, et al. (2010) Accumulation of driver and passenger mutations during tumor progression. Proc Natl Acad Sci USA 107(43):18545-18550.
2. Leder K, et al. (2011) Fitness conferred by BCR-ABL kinase domain mutations determines the risk of pre-existing resistance in chronic myeloid leukemia. PLoS ONE 6(11):e27682.
3. Greaves M, Maley CC (2012) Clonal evolution in cancer. Nature 481(7381):306-313.
4. Gillies RJ, Gatenby RA (2007) Adaptive landscapes and emergent phenotypes: Why do cancers have high glycolysis? J Bioenerg Biomembr 39(3):251-257.
5. Lambert G, et al. (2011) An analogy between the evolution of drug resistance in bacterial communities and malignant tissues. Nat Rev Cancer 11(5):375-382.
6. Trédan O, Galmarini CM, Patel K, Tannock IF (2007) Drug resistance and the solid tumor microenvironment. J Natl Cancer Inst 99(19):1441-1454.
7. Zhang Q, et al. (2011) Acceleration of emergence of bacterial antibiotic resistance in connected microenvironments. Science 333(6050):1764-1767.
8. Keenan TM, Folch A (2008) Biomolecular gradients in cell culture systems. Lab Chip 8(1):34-57.
9. Walsh CL, et al. (2009) A multipurpose microfluidic device designed to mimic microenvironment gradients and develop targeted cancer therapeutics. Lab Chip 9(4): 545-554.
10. Chung BG, Choo J (2010) Microfluidic gradient platforms for controlling cellular behavior. Electrophoresis 31(18):3014-3027.
11. Abhyankar VV, et al. (2008) A platform for assessing chemotactic migration within a spatiotemporally defined 3D microenvironment. Lab Chip 8(9):1507-1515.
12. Kim D, Lokuta MA, Huttenlocher A, Beebe DJ (2009) Selective and tunable gradient device for cell culture and chemotaxis study. Lab Chip 9(12):1797-1800.
13. Jeon NL, et al. (2000) Generation of solution and surface gradients using microfluidic systems. Langmuir 16(22):8311-8316.
14. Li Jeon N, et al. (2002) Neutrophil chemotaxis in linear and complex gradients of interleukin-8 formed in a microfabricated device. Nat Biotechnol 20(8):826-830.
15. Paliwal S, et al. (2007) MAPK-mediated bimodal gene expression and adaptive gradient sensing in yeast. Nature 446(7131):46-51.
16. Cimetta E, et al. (2010) Microfluidic device generating stable concentration gradients for long term cell culture: Application to Wnt3a regulation of β-catenin signaling. Lab Chip 10(23):3277-3283.
17. Kim L, Toh YC, Voldman J, Yu H (2007) A practical guide to microfluidic perfusion culture of adherent mammalian cells. Lab Chip 7(6):681-694.
18. Regehr KJ, et al. (2009) Biological implications of polydimethylsiloxane- based microfluidic cell culture. Lab Chip 9(15):2132-2139.
19. Wang SJ, Saadi W, Lin F, Minh-Canh Nguyen C, Li Jeon N (2004) Differential effects of EGF gradient profiles on MDA-MB-231 breast cancer cell chemotaxis. Exp Cell Res 300(1):180-189.
20. Pratap J, et al. (2006) Regulatory roles of Runx2 in metastatic tumor and cancer cell interactions with bone. Cancer Metastasis Rev 25(4):589-600.
21. Gatenby RA, Gillies RJ (2004) Why do cancers have high aerobic glycolysis? Nat Rev Cancer 4(11):891-899
22. Liu L, et al. (2013) Minimization of thermodynamic costs in cancer cell invasion. Proc Natl Acad Sci USA 110(5):1686-1691.
23. Bertout JA, Patel SA, Simon MC (2008) The impact of O2 availability on human cancer. Nat Rev Cancer 8(12):967-975.
24. Zhou M, et al. (2010) Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes taxol-resistant cancer cells to taxol. Mol Cancer 9(1):33.
25. Mosadegh B, et al. (2007) Generation of stable complex gradients across twodimensional surfaces and three-dimensional gels. Langmuir 23(22):10910-10912.
26. Shieh AC, Rozansky HA, Hinz B, Swartz MA (2011) Tumor cell invasion is promoted by interstitial flow-induced matrix priming by stromal fibroblasts. Cancer Res 71(3): 790-800.
27. Smith L, et al. (2006) The analysis of doxorubicin resistance in human breast cancer cells using antibody microarrays. Mol Cancer Ther 5(8):2115-2120.
28. Gouaz-Andersson V, et al. (2007) Ceramide and glucosylceramide upregulate expression of the multidrug resistance gene MDR1 in cancer cells. Biochim Biophys Acta 1771(12):1407-1417.
29. Aroui S, et al. (2009) Maurocalcine as a non toxic drug carrier overcomes doxorubicin resistance in the cancer cell line MDA-MB 231. Pharm Res 26(4):836-845.
30. Jaqaman K, et al. (2008) Robust single-particle tracking in live-cell time-lapse sequences. Nat Methods 5(8):695-702.
31. Davies PF, et al. (1997) Spatial relationships in early signaling events of flow-mediated endothelial mechanotransduction. Annu Rev Physiol 59(1):527-549.
32. Xia Y, Whitesides GM (1998) Soft lithography. Annu Rev Mater Sci 28:153-184.
33. Krouglova T, Vercammen J, Engelborghs Y (2004) Correct diffusion coefficients of proteins in fluorescence correlation spectroscopy. Application to tubulin oligomers induced by Mg2+ and Paclitaxel. Biophys J 87(4):2635-2646.