Bioengineered 3D brain tumor model to elucidate the effects of matrix stiffness on glioblastoma cell behavior using peg-based hydrogels

Molecular Pharmaceutics

Volumn 11, Issue 7, 2014, Pages 2115-2125

  Wang, Christine ^a   Tong, Xinming ^b   Yang, Fan ^a,b  

^a Stanford University   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

glioblastoma; hydrogels; three dimensional; tumor microenvironment; tumor model

Indexed keywords

GELATINASE A; GELATINASE B; HYALURONIC ACID; INTERSTITIAL COLLAGENASE; MACROGOL; RAS PROTEIN; GLUCURONOSYLTRANSFERASE; HAS1 PROTEIN, HUMAN; HRAS PROTEIN, HUMAN; HYDROGEL; MACROGOL DERIVATIVE; PROTEIN P21; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA PROTEIN, HUMAN; ROCK1 PROTEIN, HUMAN;

ARTICLE; BRAIN TUMOR; CANCER CELL; CELL AGGREGATION; CELL ENCAPSULATION; CELL FUNCTION; CELL GROWTH; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DNA CONTENT; EXTRACELLULAR MATRIX; GENE EXPRESSION; GLIOBLASTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROGEL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE ENGINEERING; TUMOR MODEL; UPREGULATION; BIOMIMETICS; BRAIN; CELL COMMUNICATION; CELL MOTION; DOWN REGULATION; DRUG EFFECTS; GENETICS; METABOLISM; MULTICELLULAR SPHEROID; PATHOLOGY; PHARMACOLOGY; PROCEDURES; TUMOR CELL LINE;

BIOMIMETICS; BRAIN; BRAIN NEOPLASMS; CELL COMMUNICATION; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DOWN-REGULATION; EXTRACELLULAR MATRIX; GENE EXPRESSION; GLIOBLASTOMA; GLUCURONOSYLTRANSFERASE; HUMANS; HYALURONIC ACID; HYDROGELS; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 9; POLYETHYLENE GLYCOLS; PROTO-ONCOGENE PROTEINS P21(RAS); RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; SPHEROIDS, CELLULAR; UP-REGULATION;

EID: 84903990671     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp5000828     Document Type: Article

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