메뉴 건너뛰기




Volumn 5, Issue 3, 2011, Pages 239-248

3D tumour models: Novel in vitro approaches to cancer studies

Author keywords

3D cancer models; Biomimetic; In vitro tumour models; Tumour stroma

Indexed keywords

3' FLUOROTHYMIDINE F 18; CAMPTOTHECIN; DOCETAXEL; DOXORUBICIN; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; FLUORODEOXYGLUCOSE F 18; HYALURONIC ACID; INTERLEUKIN 8; MACROGOL; RAPAMYCIN; SCAFFOLD PROTEIN; UVOMORULIN;

EID: 80054972160     PISSN: 18739601     EISSN: 1873961X     Source Type: Journal    
DOI: 10.1007/s12079-011-0132-4     Document Type: Review
Times cited : (338)

References (60)
  • 1
    • 33750044830 scopus 로고    scopus 로고
    • Use of multiple unconfined compression for control of collagen gel scaffold density and mechanical properties
    • DOI 10.1039/b609784g
    • Abou Neel EA, Cheema U, Knowles JC, Brown RA, Nazhat SN (2006) Use of multiple unconfined compression for control of collagen gel scaffold density and mechanical properties. Soft Matter 2:986-992 (Pubitemid 44583916)
    • (2006) Soft Matter , vol.2 , Issue.11 , pp. 986-992
    • Abou Neel, E.A.1    Cheema, U.2    Knowles, J.C.3    Brown, R.A.4    Nazhat, S.N.5
  • 2
    • 0035089551 scopus 로고    scopus 로고
    • Biodegradable polymeric scaffolds for musculoskeletal tissue engineering
    • DOI 10.1002/1097-4636(200105)55:2<141::AID-JBM1000>3.0.CO;2-J
    • Agrawal CM, Ray RB (2001) Biodegradable polymeric scaffolds for musculoskeletal tissue engineering. J Biomed Mater Res 55:141-150 (Pubitemid 32198496)
    • (2001) Journal of Biomedical Materials Research , vol.55 , Issue.2 , pp. 141-150
    • Agrawal, C.M.1    Ray, R.B.2
  • 3
    • 77951640687 scopus 로고    scopus 로고
    • MYC in oncogenesis and as a target for cancer therapies
    • Albihn A, Johnsen JI, Henriksson MA (2010) MYC in oncogenesis and as a target for cancer therapies. Adv Cancer Res 107:163-224
    • (2010) Adv Cancer Res , vol.107 , pp. 163-224
    • Albihn, A.1    Johnsen, J.I.2    Henriksson, M.A.3
  • 4
    • 24644466511 scopus 로고    scopus 로고
    • Stroma-derived three-dimensional matrices are necessary and sufficient to promote desmoplastic differentiation of normal fibroblasts
    • Amatangelo MD, Bassi DE, Klein-Szanto AJ, Cukierman E (2005) Stroma-derived three-dimensional matrices are necessary and sufficient to promote desmoplastic differentiation of normal fibroblasts. Am J Pathol 167:475-488 (Pubitemid 43026103)
    • (2005) American Journal of Pathology , vol.167 , Issue.2 , pp. 475-488
    • Amatangelo, M.D.1    Bassi, D.E.2    Klein-Szanto, A.J.P.3    Cukierman, E.4
  • 5
    • 0031469819 scopus 로고    scopus 로고
    • Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
    • DOI 10.1038/37126
    • Boehm T, Folkman J, Browder T, O'Reilly MS (1997) Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature 390:404-407 (Pubitemid 28027321)
    • (1997) Nature , vol.390 , Issue.6658 , pp. 404-407
    • Boehm, T.1    Folkman, J.2    Browder, T.3    O'Reilly, M.S.4
  • 6
    • 27744481178 scopus 로고    scopus 로고
    • Ultrarapid engineering of biomimetic materials and tissues: Fabrication of nano- and microstructures by plastic compression
    • DOI 10.1002/adfm.200500042
    • Brown RA, Wiseman M, Chuo C-B, Cheema U, Nazhat SN (2005) Ultrarapid engineering of biomimetic biomaterials and tissues: fabrication of nano-and microstructures by plastic compression. Adv Funct Mater 15:1762-1770 (Pubitemid 41609635)
    • (2005) Advanced Functional Materials , vol.15 , Issue.11 , pp. 1762-1770
    • Brown, R.A.1    Wiseman, M.2    Chuo, C.-B.3    Cheema, U.4    Nazhat, S.N.5
  • 7
    • 0029609685 scopus 로고
    • Invasive tumors induce c-ets1 transcription factor expression in adjacent stroma
    • DOI 10.1016/0248-4900(96)81318-9
    • Calmels TP, Mattot V, Wernert N, Vandenbunder B, Stehelin D (1995) Invasive tumors induce c-ets1 transcription factor expression in adjacent stroma. Biol Cell 84:53-61 (Pubitemid 26004111)
    • (1995) Biology of the Cell , vol.84 , Issue.1-2 , pp. 53-61
    • Calmels, T.P.G.1    Mattot, V.2    Wernert, N.3    Vandenbunder, B.4    Stehelin, D.5
  • 8
    • 65349130129 scopus 로고    scopus 로고
    • Staged stromal extracellular 3D matrices differentially regulate breast cancer cell responses through PI3K and beta1-integrins
    • Castello-Cros R, Khan DR, Simons J, Valianou M, Cukierman E (2009) Staged stromal extracellular 3D matrices differentially regulate breast cancer cell responses through PI3K and beta1-integrins. BMC Cancer 9:94
    • (2009) BMC Cancer , vol.9 , pp. 94
    • Castello-Cros, R.1    Khan, D.R.2    Simons, J.3    Valianou, M.4    Cukierman, E.5
  • 10
    • 38549148950 scopus 로고    scopus 로고
    • Spatially defined oxygen gradients and vascular endothelial growth factor expression in an engineered 3D cell model
    • Cheema U, Brown RA, Alp B, Macrobert AJ (2008) Spatially defined oxygen gradients and vascular endothelial growth factor expression in an engineered 3D cell model. Cell Mol Life Sci 65:177-186
    • (2008) Cell Mol Life Sci , vol.65 , pp. 177-186
    • Cheema, U.1    Brown, R.A.2    Alp, B.3    Macrobert, A.J.4
  • 11
    • 79952116859 scopus 로고    scopus 로고
    • Switching off angiogenic signalling: Creating channelled constructs for adequate oxygen delivery in tissue engineered constructs
    • Cheema U, Alekseeva T, Abou-Neel EA, Brown RA (2010) Switching off angiogenic signalling: creating channelled constructs for adequate oxygen delivery in tissue engineered constructs. Eur Cell Mater 20:274-280
    • (2010) Eur Cell Mater , vol.20 , pp. 274-280
    • Cheema, U.1    Alekseeva, T.2    Abou-Neel, E.A.3    Brown, R.A.4
  • 13
    • 59649088061 scopus 로고    scopus 로고
    • The role of hydrophobic amino acid grafts in the enhancement of membranedisruptive activity of pH-responsive pseudo-peptides
    • Chen R, Khormaee S, Eccleston ME, Slater NK (2009) The role of hydrophobic amino acid grafts in the enhancement of membranedisruptive activity of pH-responsive pseudo-peptides. Biomaterials 30:1954-1961
    • (2009) Biomaterials , vol.30 , pp. 1954-1961
    • Chen, R.1    Khormaee, S.2    Eccleston, M.E.3    Slater, N.K.4
  • 14
    • 0035941075 scopus 로고    scopus 로고
    • Taking cell-matrix adhesions to the third dimension
    • DOI 10.1126/science.1064829
    • Cukierman E, Pankov R, Stevens DR, Yamada KM (2001) Taking cell-matrix adhesions to the third dimension. Science 294:1708-1712 (Pubitemid 33104840)
    • (2001) Science , vol.294 , Issue.5547 , pp. 1708-1712
    • Cukierman, E.1    Pankov, R.2    Stevens, D.R.3    Yamada, K.M.4
  • 15
    • 0347985280 scopus 로고    scopus 로고
    • Synthetic and biological polymers-merging the interface
    • Cunliffe D, Pennadam S, Alexander C (2004) Synthetic and biological polymers-merging the interface. Eur Polym J 40:5-25
    • (2004) Eur Polym J , vol.40 , pp. 5-25
    • Cunliffe, D.1    Pennadam, S.2    Alexander, C.3
  • 16
    • 3843084007 scopus 로고    scopus 로고
    • Reticulated hyaluronan hydrogels: A model for examining cancer cell invasion in 3D
    • DOI 10.1016/j.matbio.2004.05.005, PII S0945053X04000502
    • David L, Dulong V, Le CD, Chauzy C, Norris V, Delpech B, Lamacz M, Vannier JP (2004) Reticulated hyaluronan hydrogels: a model for examining cancer cell invasion in 3D. Matrix Biol 23:183-193 (Pubitemid 39037253)
    • (2004) Matrix Biology , vol.23 , Issue.3 , pp. 183-193
    • David, L.1    Dulong, V.2    Le Cerf, D.3    Chauzy, C.4    Norris, V.5    Delpech, B.6    Lamacz, M.7    Vannier, J.-P.8
  • 17
    • 0030272735 scopus 로고    scopus 로고
    • Integrin cytoplasmic interactions and bidirectional transmembrane signalling
    • DOI 10.1016/S0955-0674(96)80107-4
    • Dedhar S, Hannigan GE (1996) Integrin cytoplasmic interactions and bidirectional transmembrane signalling. Curr Opin Cell Biol 8:657-669 (Pubitemid 26381723)
    • (1996) Current Opinion in Cell Biology , vol.8 , Issue.5 , pp. 657-669
    • Dedhar, S.1    Hannigan, G.E.2
  • 19
    • 0036931997 scopus 로고    scopus 로고
    • A human ovarian carcinoma murine xenograft model useful for preclinical trials
    • DOI 10.1006/gyno.2002.6819
    • Elkas JC, Baldwin RL, Pegram M, Tseng Y, Slamon D, Karlan BY (2002) A human ovarian carcinoma murine xenograft model useful for preclinical trials. Gynecol Oncol 87:200-206 (Pubitemid 36044087)
    • (2002) Gynecologic Oncology , vol.87 , Issue.2 , pp. 200-206
    • Elkas, J.C.1    Baldwin, R.L.2    Pegram, M.3    Tseng, Y.4    Slamon, D.5    Karlan, B.Y.6
  • 22
    • 0018949129 scopus 로고
    • Selective dissociation and characterization of cells from different regions of multicell tumor spheroids
    • Freyer JP, Sutherland RM (1980) Selective dissociation and characterization of cells from different regions of multicell tumor spheroids. Cancer Res 40:3956-3965 (Pubitemid 10030412)
    • (1980) Cancer Research , vol.40 , Issue.11 , pp. 3956-3965
    • Freyer, J.P.1    Sutherland, R.M.2
  • 23
    • 69249230753 scopus 로고    scopus 로고
    • Hyaluronic acid-based hydrogels as 3D matrices for in vitro evaluation of chemotherapeutic drugs using poorly adherent prostate cancer cells
    • Gurski LA, Jha AK, Zhang C, Jia X, Farach-Carson MC (2009) Hyaluronic acid-based hydrogels as 3D matrices for in vitro evaluation of chemotherapeutic drugs using poorly adherent prostate cancer cells. Biomaterials 30:6076-6085
    • (2009) Biomaterials , vol.30 , pp. 6076-6085
    • Gurski, L.A.1    Jha, A.K.2    Zhang, C.3    Jia, X.4    Farach-Carson, M.C.5
  • 24
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - A key regulatory factor in tumour growth
    • Harris AL (2002) Hypoxia-a key regulatory factor in tumour growth. Nat Rev Cancer 2:38-47 (Pubitemid 37328806)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.1 , pp. 38-47
    • Harris, A.L.1
  • 26
    • 79951576537 scopus 로고    scopus 로고
    • PH-responsive endosomolytic pseudo-peptides for drug delivery to multicellular spheroids tumour models
    • Ho VH, Slater NK, Chen R (2011) pH-responsive endosomolytic pseudo-peptides for drug delivery to multicellular spheroids tumour models. Biomaterials 32:2953-2958
    • (2011) Biomaterials , vol.32 , pp. 2953-2958
    • Ho, V.H.1    Slater, N.K.2    Chen, R.3
  • 27
    • 67549107230 scopus 로고    scopus 로고
    • Novel multicellular organotypic models of normal and malignant breast: Tools for dissecting the role of the microenvironment in breast cancer progression
    • Holliday DL, Brouilette KT, Markert A, Gordon LA, Jones JL (2009) Novel multicellular organotypic models of normal and malignant breast: tools for dissecting the role of the microenvironment in breast cancer progression. Breast Cancer Res 11:R3
    • (2009) Breast Cancer Res , vol.11
    • Holliday, D.L.1    Brouilette, K.T.2    Markert, A.3    Gordon, L.A.4    Jones, J.L.5
  • 28
    • 0034672872 scopus 로고    scopus 로고
    • Scaffolds in tissue engineering bone and cartilage
    • Hutmacher DW (2000) Scaffolds in tissue engineering bone and cartilage. Biomaterials 21:2529-2543
    • (2000) Biomaterials , vol.21 , pp. 2529-2543
    • Hutmacher, D.W.1
  • 30
    • 77955276217 scopus 로고    scopus 로고
    • The delivery of doxorubicin to 3-D multicellular spheroids and tumors in a murine xenograft model using tumor-penetrating triblock polymeric micelles
    • Kim TH, Mount CW, Gombotz WR, Pun SH (2010) The delivery of doxorubicin to 3-D multicellular spheroids and tumors in a murine xenograft model using tumor-penetrating triblock polymeric micelles. Biomaterials 31:7386-7397
    • (2010) Biomaterials , vol.31 , pp. 7386-7397
    • Kim, T.H.1    Mount, C.W.2    Gombotz, W.R.3    Pun, S.H.4
  • 31
    • 23744449992 scopus 로고    scopus 로고
    • Matrigel: Basement membrane matrix with biological activity
    • DOI 10.1016/j.semcancer.2005.05.004, PII S1044579X05000313
    • Kleinman HK, Martin GR (2005) Matrigel: basement membrane matrix with biological activity. Semin Cancer Biol 15:378-386 (Pubitemid 41140305)
    • (2005) Seminars in Cancer Biology , vol.15 , Issue.5 SPEC. ISS. , pp. 378-386
    • Kleinman, H.K.1    Martin, G.R.2
  • 32
    • 0022619989 scopus 로고
    • Invasion of reconstituted basement membrane matrix by metastatic human tumor cells
    • Kramer RH, Bensch KG, Wong J (1986) Invasion of reconstituted basement membrane matrix by metastatic human tumor cells. Cancer Res 46:1980-1989 (Pubitemid 16117895)
    • (1986) Cancer Research , vol.46 , Issue.4 , pp. 1980-1989
    • Kramer, R.H.1    Bensch, K.G.2    Wong, J.3
  • 33
    • 0031883574 scopus 로고    scopus 로고
    • Multicellular spheroids: A three-dimensional in vitro culture system to study tumour biology
    • DOI 10.1046/j.1365-2613.1998.00051.x
    • Kunz-Schughart LA, Kreutz M, Knuechel R (1998) Multicellular spheroids: a three-dimensional in vitro culture system to study tumour biology. Int J Exp Pathol 79:1-23 (Pubitemid 28137705)
    • (1998) International Journal of Experimental Pathology , vol.79 , Issue.1 , pp. 1-23
    • Kunz-Schughart, L.A.1    Kreutz, M.2    Knuechel, R.3
  • 34
    • 34247864012 scopus 로고    scopus 로고
    • Three-dimensional culture models of normal and malignant breast epithelial cells
    • DOI 10.1038/nmeth1015, PII NMETH1015
    • Lee GY, Kenny PA, Lee EH, Bissell MJ (2007) Three-dimensional culture models of normal and malignant breast epithelial cells. Nat Meth 4:359-365 (Pubitemid 46766981)
    • (2007) Nature Methods , vol.4 , Issue.4 , pp. 359-365
    • Lee, G.Y.1    Kenny, P.A.2    Lee, E.H.3    Bissell, M.J.4
  • 35
    • 77956187576 scopus 로고    scopus 로고
    • Bioengineered 3D platform to explore cell-ECM interactions and drug resistance of epithelial ovarian cancer cells
    • Loessner D, Stok KS, Lutolf MP, Hutmacher DW, Clements JA, Rizzi SC (2010) Bioengineered 3D platform to explore cell-ECM interactions and drug resistance of epithelial ovarian cancer cells. Biomaterials 31:8494-8506
    • (2010) Biomaterials , vol.31 , pp. 8494-8506
    • Loessner, D.1    Stok, K.S.2    Lutolf, M.P.3    Hutmacher, D.W.4    Clements, J.A.5    Rizzi, S.C.6
  • 36
    • 80054968242 scopus 로고    scopus 로고
    • Current status and future perspectives of in vivo small animal imaging using radiolabeled nanoparticles
    • Loudos G, Kagadis GC, Psimadas D (2010) Current status and future perspectives of in vivo small animal imaging using radiolabeled nanoparticles. Eur J Radiol
    • (2010) Eur J Radiol
    • Loudos, G.1    Kagadis, G.C.2    Psimadas, D.3
  • 37
    • 41049111197 scopus 로고    scopus 로고
    • A novel method for dissolution and stabilization of non-mulberry silk gland protein fibroin using anionic surfactant sodium dodecyl sulfate
    • DOI 10.1002/bit.21699
    • Mandal BB, Kundu SC (2007) A novel method for dissolution and stabilization of non-mulberry silk gland protein fibroin using anionic surfactant sodium dodecyl sulfate. Biotechnol Bioeng 99:1482-1489 (Pubitemid 351548688)
    • (2008) Biotechnology and Bioengineering , vol.99 , Issue.6 , pp. 1482-1489
    • Mandal, B.B.1    Kundu, S.C.2
  • 39
    • 62549150761 scopus 로고    scopus 로고
    • Evaluation of the Hsp90 inhibitor NVP-AUY922 in multicellular tumour spheroids with respect to effects on growth and PET tracer uptake
    • Monazzam A, Razifar P, Ide S, Rugaard JM, Josephsson R, Blomqvist C, Langstrom B, Bergstrom M (2009) Evaluation of the Hsp90 inhibitor NVP-AUY922 in multicellular tumour spheroids with respect to effects on growth and PET tracer uptake. Nucl Med Biol 36:335-342
    • (2009) Nucl Med Biol , vol.36 , pp. 335-342
    • Monazzam, A.1    Razifar, P.2    Ide, S.3    Rugaard, J.M.4    Josephsson, R.5    Blomqvist, C.6    Langstrom, B.7    Bergstrom, M.8
  • 40
    • 0030697292 scopus 로고    scopus 로고
    • Three-dimensional cell cultures: From molecular mechanisms to clinical applications
    • Mueller-Klieser W (1997) Three-dimensional cell cultures: from molecular mechanisms to clinical applications. Am J Physiol 273:C1109-C1123 (Pubitemid 127797683)
    • (1997) American Journal of Physiology , vol.273 , Issue.4 PART 1
    • Mueller-Klieser, W.1
  • 41
    • 0036161276 scopus 로고    scopus 로고
    • An in vivo mouse reporter gene (human secreted alkaline phosphatase) model to monitor ovarian tumor growth and response to therapeutics
    • DOI 10.1007/s00280-001-0396-0
    • Nilsson EE, Westfall SD, McDonald C, Lison T, Sadler-Riggleman I, Skinner MK (2002) An in vivo mouse reporter gene (human secreted alkaline phosphatase) model to monitor ovarian tumor growth and response to therapeutics. Cancer Chemother Pharmacol 49:93-100 (Pubitemid 34119006)
    • (2002) Cancer Chemotherapy and Pharmacology , vol.49 , Issue.2 , pp. 93-100
    • Nilsson, E.E.1    Westfall, S.D.2    McDonald, C.3    Lison, T.4    Sadler-Riggleman, I.5    Skinner, M.K.6
  • 42
    • 69249215169 scopus 로고    scopus 로고
    • Ovarian cancer cells stimulate uPA gene expression in fibroblastic stromal cells via multiple paracrine and autocrine mechanisms
    • Noskova V, Ahmadi S, Asander E, Casslen B (2009) Ovarian cancer cells stimulate uPA gene expression in fibroblastic stromal cells via multiple paracrine and autocrine mechanisms. Gynecol Oncol 115:121-126
    • (2009) Gynecol Oncol , vol.115 , pp. 121-126
    • Noskova, V.1    Ahmadi, S.2    Asander, E.3    Casslen, B.4
  • 45
    • 69049098045 scopus 로고    scopus 로고
    • Tissue resident stem cells produce CCL5 under the influence of cancer cells and thereby promote breast cancer cell invasion
    • Pinilla S, Alt E, Abdul Khalek FJ, Jotzu C, Muehlberg F, Beckmann C, Song YH (2009) Tissue resident stem cells produce CCL5 under the influence of cancer cells and thereby promote breast cancer cell invasion. Cancer Lett 284:80-85
    • (2009) Cancer Lett , vol.284 , pp. 80-85
    • Pinilla, S.1    Alt, E.2    Abdul Khalek, F.J.3    Jotzu, C.4    Muehlberg, F.5    Beckmann, C.6    Song, Y.H.7
  • 46
    • 0347123433 scopus 로고    scopus 로고
    • Tumour-educated macrophages promote tumour progression and metastasis
    • Pollard JW (2004) Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer 4:71-78 (Pubitemid 38082155)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.1 , pp. 71-78
    • Pollard, J.W.1
  • 47
    • 27544456436 scopus 로고    scopus 로고
    • Cancer therapeutics: Targeting the dark side of Myc
    • DOI 10.1016/j.ejca.2005.08.017, PII S0959804905007161, Transcription Factors in Cancer
    • Ponzielli R, Katz S, Barsyte-Lovejoy D, Penn LZ (2005) Cancer therapeutics: targeting the dark side of Myc. Eur J Cancer 41:2485-2501 (Pubitemid 41540625)
    • (2005) European Journal of Cancer , vol.41 , Issue.16 , pp. 2485-2501
    • Ponzielli, R.1    Katz, S.2    Barsyte-Lovejoy, D.3    Penn, L.Z.4
  • 48
    • 23244447869 scopus 로고    scopus 로고
    • Molecularly engineered PEG hydrogels: A novel model system for proteolytically mediated cell migration
    • DOI 10.1529/biophysj.104.050682
    • Raeber GP, Lutolf MP, Hubbell JA (2005) Molecularly engineered PEG hydrogels: a novel model system for proteolytically mediated cell migration. Biophys J 89:1374-1388 (Pubitemid 41099019)
    • (2005) Biophysical Journal , vol.89 , Issue.2 , pp. 1374-1388
    • Raeber, G.P.1    Lutolf, M.P.2    Hubbell, J.A.3
  • 49
    • 64249106832 scopus 로고    scopus 로고
    • Mouse xenograft models vs GEM models for human cancer therapeutics
    • Richmond A, Su Y (2008) Mouse xenograft models vs GEM models for human cancer therapeutics. Dis Model Mech 1:78-82
    • (2008) Dis Model Mech , vol.1 , pp. 78-82
    • Richmond, A.1    Su, Y.2
  • 50
    • 77957287327 scopus 로고    scopus 로고
    • Interaction and selforganization of human mesenchymal stem cells and neuroblastoma SH-SY5Y cells under co-culture conditions: A novel system for modeling cancer cell micro-environment
    • Rizvanov AA, Yalvac ME, Shafigullina AK, Salafutdinov II, Blatt NL, Sahin F, Kiyasov AP, Palotas A (2010) Interaction and selforganization of human mesenchymal stem cells and neuroblastoma SH-SY5Y cells under co-culture conditions: a novel system for modeling cancer cell micro-environment. Eur J Pharm Biopharm 76:253-259
    • (2010) Eur J Pharm Biopharm , vol.76 , pp. 253-259
    • Rizvanov, A.A.1    Yalvac, M.E.2    Shafigullina, A.K.3    Salafutdinov, I.I.4    Blatt, N.L.5    Sahin, F.6    Kiyasov, A.P.7    Palotas, A.8
  • 51
    • 16344392522 scopus 로고    scopus 로고
    • Characterization of porous PLGA/PLA microparticles as a scaffold for three dimensional growth of breast cancer cells
    • DOI 10.1021/bm0492632
    • Sahoo SK, Panda AK, Labhasetwar V (2005) Characterization of porous PLGA/PLA microparticles as a scaffold for three dimensional growth of breast cancer cells. Biomacromolecules 6:1132-1139 (Pubitemid 40467862)
    • (2005) Biomacromolecules , vol.6 , Issue.2 , pp. 1132-1139
    • Sahoo, S.K.1    Panda, A.K.2    Labhasetwar, V.3
  • 52
    • 48149105146 scopus 로고    scopus 로고
    • Fibroblast-derived 3D matrix differentially regulates the growth and drug-responsiveness of human cancer cells
    • Serebriiskii I, Castello-Cros R, Lamb A, Golemis EA, Cukierman E (2008) Fibroblast-derived 3D matrix differentially regulates the growth and drug-responsiveness of human cancer cells. Matrix Biol 27:573-585
    • (2008) Matrix Biol , vol.27 , pp. 573-585
    • Serebriiskii, I.1    Castello-Cros, R.2    Lamb, A.3    Golemis, E.A.4    Cukierman, E.5
  • 53
    • 0035866363 scopus 로고    scopus 로고
    • Breast stroma plays a dominant regulatory role in breast epithelial growth and differentiation: Implications for tumor development and progression
    • Shekhar MP, Werdell J, Santner SJ, Pauley RJ, Tait L (2001) Breast stroma plays a dominant regulatory role in breast epithelial growth and differentiation: implications for tumor development and progression. Cancer Res 61:1320-1326 (Pubitemid 34292550)
    • (2001) Cancer Research , vol.61 , Issue.4 , pp. 1320-1326
    • Shekhar, M.P.V.1    Werdell, J.2    Santner, S.J.3    Pauley, R.J.4    Tait, L.5
  • 54
    • 0024281372 scopus 로고
    • Cell and environment interactions in tumor microregions: The multicell spheroid model
    • Sutherland RM (1988) Cell and environment interactions in tumor microregions: the multicell spheroid model. Science 240:177-184
    • (1988) Science , vol.240 , pp. 177-184
    • Sutherland, R.M.1
  • 56
    • 13244274899 scopus 로고    scopus 로고
    • Basement membrane proteins play an active role in the invasive process of human hepatocellular carcinoma cells with high metastasis potential
    • DOI 10.1007/s00432-004-0614-3
    • Tian B, Li Y, Ji XN, Chen J, Xue Q, Ye SL, Liu YK, Tang ZY (2005) Basement membrane proteins play an active role in the invasive process of human hepatocellular carcinoma cells with high metastasis potential. J Cancer Res Clin Oncol 131:80-86 (Pubitemid 40192932)
    • (2005) Journal of Cancer Research and Clinical Oncology , vol.131 , Issue.2 , pp. 80-86
    • Tian, B.1    Li, Y.2    Ji, X.-N.3    Chen, J.4    Xue, Q.5    Ye, S.-L.6    Liu, Y.-K.7    Tang, Z.-Y.8
  • 58
    • 70349120335 scopus 로고    scopus 로고
    • Cell-matrix interactions and dynamic mechanical loading influence chondrocyte gene expression and bioactivity in PEG-RGD hydrogels
    • Villanueva I, Weigel CA, Bryant SJ (2009) Cell-matrix interactions and dynamic mechanical loading influence chondrocyte gene expression and bioactivity in PEG-RGD hydrogels. Acta Biomater 5:2832-2846
    • (2009) Acta Biomater , vol.5 , pp. 2832-2846
    • Villanueva, I.1    Weigel, C.A.2    Bryant, S.J.3
  • 59
    • 0031408202 scopus 로고    scopus 로고
    • Acinar differentiation by non-malignant immortalized human prostatic epithelial cells and its loss by malignant cells
    • DOI 10.1093/carcin/18.6.1225
    • Webber MM, Bello D, Kleinman HK, Hoffman MP (1997) Acinar differentiation by non-malignant immortalized human prostatic epithelial cells and its loss by malignant cells. Carcinogenesis 18:1225-1231 (Pubitemid 28132514)
    • (1997) Carcinogenesis , vol.18 , Issue.6 , pp. 1225-1231
    • Webber, M.M.1    Bello, D.2    Kleinman, H.K.3    Hoffman, M.P.4
  • 60
    • 84957940642 scopus 로고    scopus 로고
    • Accessed 08 March 2011
    • World Health Organization. Cancer. http://www.who.int/cancer/en. Accessed 08 March 2011
    • Cancer


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.