PlGFMMP9-engineered iPS cells supported on a PEGfibrinogen hydrogel scaffold possess an enhanced capacity to repair damaged myocardium

Cell Death and Disease

Volumn 5, Issue 2, 2014, Pages

  Bearzi, C ^a,b   Gargioli, C ^a   Baci, D ^a   Fortunato, O ^a   Shapira Schweitzer, K ^c   Kossover, O ^c   Latronico, M V G ^d   Seliktar, D ^c   Condorelli, G ^d   Rizzi, R ^a,b  

^a IRCCS MULTIMEDICA   (Italy)

^b CNR   (Italy)

^c TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^d HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

Author keywords

angiogenesis; cardiac tissue engineering; hydrogel; induced pluripotent stem cells; matrix metalloproteinase

Indexed keywords

FIBRINOGEN; GELATINASE B; MACROGOL; MOLECULAR SCAFFOLD; PLACENTAL GROWTH FACTOR; MACROGOL DERIVATIVE; PLACENTA PROTEIN; TISSUE SCAFFOLD;

ACUTE HEART INFARCTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOCOMPATIBILITY; CELL DIFFERENTIATION; CELL ENGINEERING; CELL MIGRATION; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; FEMALE; HEART HEMODYNAMICS; HEART MUSCLE; HEART MUSCLE REVASCULARIZATION; HYDROGEL; MALE; MOUSE; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; RIGIDITY; STEM CELL TRANSPLANTATION; UMBILICAL VEIN ENDOTHELIAL CELL; ANGIOGENESIS; ANIMAL; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; CONVALESCENCE; DISEASE MODEL; ENZYMOLOGY; GENETIC ENGINEERING; GENETIC TRANSDUCTION; GENETIC TRANSFECTION; GENETICS; HEART CONTRACTION; HEART INFARCTION; HEART MUSCLE CELL; HEMODYNAMICS; HUMAN; METABOLISM; METHODOLOGY; NONOBESE DIABETIC MOUSE; PATHOLOGY; PATHOPHYSIOLOGY; REGENERATION; SCID MOUSE; TIME; TISSUE ENGINEERING; TRANSPLANTATION;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; DISEASE MODELS, ANIMAL; FEMALE; FIBRINOGEN; GENETIC ENGINEERING; HEMODYNAMICS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MALE; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED NOD; MICE, SCID; MYOCARDIAL CONTRACTION; MYOCARDIAL INFARCTION; MYOCARDIUM; MYOCYTES, CARDIAC; NEOVASCULARIZATION, PHYSIOLOGIC; POLYETHYLENE GLYCOLS; PREGNANCY PROTEINS; RECOVERY OF FUNCTION; REGENERATION; TIME FACTORS; TISSUE ENGINEERING; TISSUE SCAFFOLDS; TRANSDUCTION, GENETIC; TRANSFECTION;

EID: 84896761439     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.12     Document Type: Article

References (30)

1. Pal SN, Kofidis T. New cell therapies in cardiology. Expert Rev Cardiovasc Ther 2012; 10 1037.
2. Laflamme MA, Murry CE. Heart regeneration. Nature 2011; 473: 326-335.
3. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006; 126: 663-676.
4. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007; 131 872.
5. Rizzi R, Di Pasquale E, Portararo P, Papait R, Cattaneo P, Latronico MV et al. Post-natal cardiomyocytes can generate iPS cells with an enhanced capacity toward cardiomyogenic re-differentation. Cell Death Differ 2012; 19: 1162-1174.
6. Diez Villanueva P, Sanz-Ruiz R, Nunez Garcia A, Fernandez Santos ME, Sanchez PL, Fernandez-Aviles F. Functional multipotency of stem cells: What do we need from them in the heart? Stem Cells Int 2012; 2012: 817364.
7. De Falco S, Gigante B, Persico MG. Structure and function of placental growth factor. Trends Cardiovasc Med 2002; 12: 241-246.
8. De Falco S. The discovery of placenta growth factor and its biological activity. Exp Mol Med 2012; 44: 1-9.
9. Van den Steen PE, Dubois B, Nelissen I, Rudd PM, Dwek RA, Opdenakker G. Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9). Crit Rev Biochem Mol Biol 2002; 37: 375-536.
10. Fuoco C, Salvatori ML, Biondo A, Shapira-Schweitzer K, Santoleri S, Antonini S et al. Injectable polyethylene glycol-fibrinogen hydrogel adjuvant improves survival and differentiation of transplanted mesoangioblasts in acute and chronic skeletal-muscle degeneration. Skelet Muscle 2012; 2: 24.
11. Gargioli C, Coletta M, De Grandis F, Cannata SM, Cossu G. PlGF-MMP-9-expressing cells restore microcirculation and efficacy of cell therapy in aged dystrophic muscle. Nat Med 2008; 14: 973-978.
12. Iwasaki H, Kawamoto A, Tjwa M, Horii M, Hayashi S, Oyamada A et al. PlGF repairs myocardial ischemia through mechanisms of angiogenesis, cardioprotection and recruitment of myo-Angiogenic competent marrow progenitors. PLoS One 2011; 6: E24872.
13. Morgan J, Rouche A, Bausero P, Houssaini A, Gross J, Fiszman MY et al. MMP-9 overexpression improves myogenic cell migration and engraftment. Muscle Nerve 2010 584-595.
14. Lam MT, Wu JC. Biomaterial applications in cardiovascular tissue repair and regeneration. Expert Rev Cardiovasc Ther 2012; 10: 1039-1049.
15. Liau B, Zhang D, Bursac N. Functional cardiac tissue engineering. Regen Med 2012; 7 206.
16. Seliktar D. Extracellular stimulation in tissue engineering. Ann NY Acad Sci 2005; 1047 394.
17. Seliktar D. Designing cell-compatible hydrogels for biomedical applications. Science 2012 1124-1128.
18. Shapira-Schweitzer K, Seliktar D. Matrix stiffness affects spontaneous contraction of cardiomyocytes cultured within a PEGylated fibrinogen biomaterial. Acta Biomater 2007; 3 41.
19. Sarig-Nadir O, Livnat N, Zajdman R, Shoham S, Seliktar D. Laser photoablation of guidance microchannels into hydrogels directs cell growth in three dimensions. Biophys J 2009; 96: 4743-4752.
20. Puceat M. Protocols for cardiac differentiation of embryonic stem cells. Methods 2008; 45 171.
21. Jones DA, Choudry F, Mathur A. Cell therapy in cardiovascular disease: The national society journals present selected research that has driven recent advances in clinical cardiology. Heart 2012; 98: 1626-1631.
22. Segers VF, Lee RT. Biomaterials to enhance stem cell function in the heart. Circ Res 2011 910-922.
23. Zwi-Dantsis L, Gepstein L. Induced pluripotent stem cells for cardiac repair. Cell Mol Life Sci 2012; 69: 3285-3299.
24. Udelsman BV, Maxfield MW, Breuer CK. Tissue engineering of blood vessels in cardiovascular disease: Moving towards clinical translation. Heart 2013; 99: 454-460.
25. Kurobe H, Maxfield MW, Breuer CK, Shinoka T. Concise review: Tissue-engineered vascular grafts for cardiac surgery: Past, present, and future. Stem Cells Transl Med 2012 566-571.
26. Discher DE, Mooney DJ, Zandstra PW. Growth factors, matrices, and forces combine and control stem cells. Science 2009; 324: 1673-1677.
27. Nemir S,West JL. Synthetic materials in the study of cell response to substrate rigidity. Ann Biomed Eng 2010; 38: 2-20.
28. Marklein RA, Burdick JA. Controlling stem cell fate with material design. Adv Mater 2010 175-189.
29. Dikovsky D, Bianco-Peled H, Seliktar D. Defining the role of matrix compliance and proteolysis in three-dimensional cell spreading and remodeling. Biophys J 2008; 94 2925.
30. Dikovsky D, Bianco-Peled H, Seliktar D. The effect of structural alterations of PEG-fibrinogen hydrogel scaffolds on 3-D cellular morphology and cellular migration. Biomaterials 2006; 27: 1496-1506.