A three-dimensional engineered tumour for spatial snapshot analysis of cell metabolism and phenotype in hypoxic gradients

Nature Materials

Volumn 15, Issue 2, 2016, Pages 227-234

  Rodenhizer, Darren ^a   Gaude, Edoardo ^b   Cojocari, Dan ^c   Mahadevan, Radhakrishnan ^a,d   Frezza, Christian ^b   Wouters, Bradly G ^c   McGuigan, Alison P ^a,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c PRINCESS MARGARET HOSPITAL   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CELLS; CYTOLOGY; DISEASES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; PHYSIOLOGY; SPATIAL VARIABLES MEASUREMENT; TUMORS;

CELL METABOLISM; CELL-TO-CELL INTERACTIONS; CELLULAR METABOLISM; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; METABOLIC RESPONSE; OXYGEN GRADIENTS; SIGNALLING PATHWAYS; SNAPSHOT ANALYSIS;

CELL SIGNALING;

ANTINEOPLASTIC ANTIBIOTIC; DOXORUBICIN; HYPOXIA INDUCIBLE FACTOR 1; OXYGEN;

CELL PROLIFERATION; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; NEOPLASM; RADIATION RESPONSE; SIGNAL TRANSDUCTION; TISSUE ENGINEERING; TISSUE SCAFFOLD; TUMOR CELL LINE;

ANTIBIOTICS, ANTINEOPLASTIC; CELL LINE, TUMOR; CELL PROLIFERATION; DOXORUBICIN; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; NEOPLASMS; OXYGEN; SIGNAL TRANSDUCTION; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 84955478956     PISSN: 14761122     EISSN: 14764660     Source Type: Journal    
DOI: 10.1038/nmat4482     Document Type: Article

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