Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression

Nature Communications

Volumn 5, Issue , 2014, Pages

  Tan, Youhua ^a,b   Tajik, Arash ^b   Chen, Junwei ^a   Jia, Qiong ^a   Chowdhury, Farhan ^c   Wang, Lili ^a   Chen, Junjian ^a   Zhang, Shuang ^a   Hong, Ying ^a   Yi, Haiying ^a   Wu, Douglas C ^b   Zhang, Yuejin ^a   Wei, Fuxiang ^a   Poh, Yeh Chuin ^a,b   Seong, Jihye ^b,g   Singh, Rishi ^b   Lin, Li Jung ^b   Doǧanay, Sultan ^b,c   Li, Yong ^d   Jia, Haibo ^a   Ha, Taekjip ^b,c   Wang, Yingxiao ^e   Huang, Bo ^d,f   Wang, Ning ^a,b   more..

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b University of Illinois at Urbana Champaign   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^d HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^e UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^f INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^g Korea Institute of Science and Technology   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRIN; HISTONE H3; HISTONE METHYLTRANSFERASE; LYSINE; PROTEIN CDC42; TRANSCRIPTION FACTOR SOX2; BETA1 INTEGRIN; HISTONE; HISTONE LYSINE METHYLTRANSFERASE; SMALL INTERFERING RNA; SOX2 PROTEIN, MOUSE; TRANSCRIPTION FACTOR SOX;

CANCER; DISEASE INCIDENCE; ENZYME ACTIVITY; GENE EXPRESSION; METHYLATION; PLASTICITY;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CARCINOGENICITY; CELL DIFFERENTIATION; CELL POPULATION; CELL RENEWAL; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION; GROWTH INHIBITION; HISTONE METHYLATION; IN VITRO STUDY; IN VIVO STUDY; MEDIATOR; MELANOMA; MELANOMA CELL; MOUSE; NONHUMAN; PROMOTER REGION; SOFT TISSUE; TUMOR CELL; TUMOR REPOPULATING CELL; TUMOR XENOGRAFT; ANIMAL; C57BL MOUSE; CANCER STEM CELL; CANCER TRANSPLANTATION; CELL PROLIFERATION; CHEMISTRY; DISEASE COURSE; DNA METHYLATION; EXPERIMENTAL MELANOMA; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE SILENCING; GENETIC PROCEDURES; METABOLISM; METASTASIS; METHYLATION; SKIN TUMOR; TIME; TUMOR CELL LINE;

ANIMALS; ANTIGENS, CD29; BIOSENSING TECHNIQUES; CELL LINE, TUMOR; CELL PROLIFERATION; DISEASE PROGRESSION; DNA METHYLATION; FEMALE; FIBRIN; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE SILENCING; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; LYSINE; MELANOMA; MELANOMA, EXPERIMENTAL; METHYLATION; MICE; MICE, INBRED C57BL; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; NEOPLASTIC STEM CELLS; PROMOTER REGIONS, GENETIC; RNA, SMALL INTERFERING; SKIN NEOPLASMS; SOXB1 TRANSCRIPTION FACTORS; TIME FACTORS;

EID: 84907325176     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms5619     Document Type: Article

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