Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium

Nature Materials

Volumn 13, Issue 10, 2014, Pages 970-978

  Chaudhuri, Ovijit ^a,b,c   Koshy, Sandeep T ^a,b,d   Branco Da Cunha, Cristiana ^a,b,e   Shin, Jae Won ^a,b   Verbeke, Catia S ^a,b   Allison, Kimberly H ^f   Mooney, David J ^a,b  

^a HARVARD UNIVERSITY   (United States)

^b HARVARD UNIVERSITY   (United States)

^c Stanford University   (United States)

^d HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^e UNIVERSITY OF PORTO   (Portugal)

^f STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUILDINGS; LIGANDS; NETWORK ARCHITECTURE; STIFFNESS;

BASEMENT MEMBRANE; EXTRACELLULAR MATRICES; HEMIDESMOSOMES; IN-VITRO MODELS; INTEGRIN CLUSTERING; INTEGRINS; MAMMARY EPITHELIAL CELLS;

STIFFNESS MATRIX;

ALGINIC ACID; ALPHA6BETA4 INTEGRIN; BIOMATERIAL; GLUCURONIC ACID; HEXURONIC ACID; LIGAND; PHOSPHATIDYLINOSITOL 3 KINASE; RAC1 PROTEIN; RAC1 PROTEIN, HUMAN;

BASEMENT MEMBRANE; BIOLOGICAL MODEL; BIOPHYSICS; CELL LINE; CELL TRANSFORMATION; EPITHELIUM; EXTRACELLULAR MATRIX; FEMALE; HEMIDESMOSOME; HUMAN; MAMMARY GLAND; MECHANOTRANSDUCTION; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHENOTYPE; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ALGINATES; BASEMENT MEMBRANE; BIOCOMPATIBLE MATERIALS; BIOPHYSICAL PHENOMENA; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; EPITHELIUM; EXTRACELLULAR MATRIX; FEMALE; GLUCURONIC ACID; HEMIDESMOSOMES; HEXURONIC ACIDS; HUMANS; INTEGRIN ALPHA6BETA4; LIGANDS; MAMMARY GLANDS, HUMAN; MECHANOTRANSDUCTION, CELLULAR; MODELS, BIOLOGICAL; PHENOTYPE; PHOSPHATIDYLINOSITOL 3-KINASES; RAC1 GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION;

EID: 84915784640     PISSN: 14761122     EISSN: 14764660     Source Type: Journal    
DOI: 10.1038/nmat4009     Document Type: Article

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