A cell-instructive hydrogel to regulate malignancy of 3D tumor spheroids with matrix rigidity

Biomaterials

Volumn 32, Issue 35, 2011, Pages 9308-9315

  Liang, Youyun ^a,c   Jeong, Jaehyun ^a   DeVolder, Ross J ^a   Cha, Chaenyung ^a   Wang, Fei ^b   Tong, Yen Wah ^c   Kong, Hyunjoon ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Cancer model; Cancer spheroid; Collagen gel; Matrix stiffness; Three dimensional hydrogel

Indexed keywords

CANCER CELLS; CANCER MODELS; CANCER SPHEROID; COLLAGEN FIBER; COLLAGEN GEL; COLLAGEN GELS; CURRENT MODELS; EMERGENT BEHAVIORS; GEL SURFACE; HEPATOCELLULAR CARCINOMA CELL; LIVER TUMORS; MALIGNANT CANCERS; MATRIX; MATRIX PERMEABILITY; MATRIX RIGIDITY; MECHANICAL RIGIDITY; MOLECULAR DIFFUSIVITY; SUCCINIC ACIDS; THREE-DIMENSIONAL (3D); TUMOR SPHEROID;

CELLS; COLLAGEN; DISEASES; ELASTIC MODULI; ETHYLENE; GELS; GLYCOLS; HYDROGELS; POLYETHYLENE GLYCOLS; RIGIDITY; STIFFNESS; STIFFNESS MATRIX; TUMORS;

THREE DIMENSIONAL;

COLLAGEN FIBER; COLLAGEN GEL; POLY(ETHYLENE GLYCOL) DI(SUCCINIC ACID N HYDROXYSUCCINIMIDYL ESTER); POLYMER; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; CELL ENCAPSULATION; CHORIOALLANTOIS; HUMAN; HUMAN CELL; HYDROGEL; LIVER CELL CARCINOMA; LIVER TUMOR; MALIGNANT NEOPLASTIC DISEASE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RIGIDITY; TUMOR SPHEROID;

CELL PROLIFERATION; COLLAGEN; EXTRACELLULAR MATRIX; HEP G2 CELLS; HUMANS; HYDROGEL; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; PERMEABILITY; PHENOTYPE; POLYETHYLENE GLYCOLS; SPHEROIDS, CELLULAR;

EID: 80053603679     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.08.045     Document Type: Article

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