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Volumn 16, Issue 3, 2010, Pages 351-359

Engineering tumors: A tissue engineering perspective in cancer biology

Author keywords

[No Author keywords available]

Indexed keywords

3D CULTURE; ANTICANCER DRUG; BIOMEDICAL SCIENCE; CANCER BIOLOGY; CELLULAR AGGREGATES; DRUG RESISTANCE; EX-VIVO; IN-VIVO; MONOLAYER CULTURE; REGENERATIVE MEDICINE; RESEARCH GROUPS; THREE-DIMENSIONAL (3D); TUMOR BIOLOGY; TUMOR MODELS;

EID: 77952932509     PISSN: 19373368     EISSN: None     Source Type: Journal    
DOI: 10.1089/ten.teb.2009.0676     Document Type: Review
Times cited : (158)

References (103)
  • 1
    • 0027595948 scopus 로고
    • Tissue engineering
    • Langer, R., and Vacanti, J.P. Tissue engineering. Science 260, 920, 1993.
    • (1993) Science , vol.260 , pp. 920
    • Langer, R.1    Vacanti, J.P.2
  • 2
    • 57049163042 scopus 로고    scopus 로고
    • From material to tissue: Biomaterial development, scaffold fabrication, and tissue engineering
    • Kretlow, J.D., and Mikos, A.G. From material to tissue: biomaterial development, scaffold fabrication, and tissue engineering. Aiche J 54, 3048, 2008.
    • (2008) Aiche J , vol.54 , pp. 3048
    • Kretlow, J.D.1    Mikos, A.G.2
  • 3
    • 66249146049 scopus 로고    scopus 로고
    • Complexity in biomaterials for tissue engineering
    • Place, E.S., Evans, N.D., and Stevens, M.M. Complexity in biomaterials for tissue engineering. Nat Mater 8, 457, 2009.
    • (2009) Nat Mater , vol.8 , pp. 457
    • Place, E.S.1    Evans, N.D.2    Stevens, M.M.3
  • 4
    • 33644529130 scopus 로고    scopus 로고
    • Capturing complex 3d tissue physiology in vitro
    • Griffith, L.G., and Swartz, M.A. Capturing complex 3d tissue physiology in vitro. Nat Rev Mol Cell Biol 7, 211, 2006.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 211
    • Griffith, L.G.1    Swartz, M.A.2
  • 6
    • 0037184909 scopus 로고    scopus 로고
    • Taking the study of cancer cell survival to a new dimension
    • Jacks, T., and Weinberg, R.A. Taking the study of cancer cell survival to a new dimension. Cell 111, 923, 2002.
    • (2002) Cell , vol.111 , pp. 923
    • Jacks, T.1    Weinberg, R.A.2
  • 7
    • 8144228952 scopus 로고    scopus 로고
    • Friends or foes\bipolar effects of the tumour stroma in cancer
    • Mueller, M.M., and Fusenig, N.E. Friends or foes\bipolar effects of the tumour stroma in cancer. Nat Rev Cancer 4, 839, 2004.
    • (2004) Nat Rev Cancer , vol.4 , pp. 839
    • Mueller, M.M.1    Fusenig, N.E.2
  • 8
    • 33845208108 scopus 로고    scopus 로고
    • Life isn't flat: Taking cancer biology to the next dimension
    • Smalley, K.S., Lioni, M., and Herlyn, M. Life isn't flat: taking cancer biology to the next dimension. In Vitro Cell Dev Biol Anim 42, 242, 2006.
    • (2006) Vitro Cell Dev Biol Anim , vol.42 , pp. 242
    • Smalley, K.S.1    Lioni, M.2    Herlyn, M.3
  • 9
    • 4344645978 scopus 로고    scopus 로고
    • Can the pharmaceutical industry reduce attrition rates?
    • Kola, I., and Landis, J. Can the pharmaceutical industry reduce attrition rates? Nat Rev Drug Discov 3, 711, 2004.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 711
    • Kola, I.1    Landis, J.2
  • 10
    • 9244222261 scopus 로고    scopus 로고
    • Targeted cancer therapy
    • Sawyers, C. Targeted cancer therapy. Nature 432, 294, 2004.
    • (2004) Nature , vol.432 , pp. 294
    • Sawyers, C.1
  • 11
    • 32044463568 scopus 로고    scopus 로고
    • Adopting orphan drugs\two dozen years of treating rare diseases
    • Haffner, M.E. Adopting orphan drugs\two dozen years of treating rare diseases. N Engl J Med 354, 445, 2006.
    • (2006) N Engl J Med , vol.354 , pp. 445
    • Haffner, M.E.1
  • 12
    • 33745172773 scopus 로고    scopus 로고
    • A journey of hope: Lessons learned from studies on rare diseases and orphan drugs
    • Wastfelt, M., Fadeel, B., and Henter, J.I. A journey of hope: lessons learned from studies on rare diseases and orphan drugs. J Intern Med 260, 1, 2006.
    • (2006) J Intern Med , vol.260 , pp. 1
    • Wastfelt, M.1    Fadeel, B.2    Henter, J.I.3
  • 14
    • 47249160783 scopus 로고    scopus 로고
    • Ewing sarcoma: Historical perspectives, current state-of-the-art, and opportunities for targeted therapy in the future
    • Ludwig, J.A. Ewing sarcoma: historical perspectives, current state-of-the-art, and opportunities for targeted therapy in the future. Curr Opin Oncol 20, 412, 2008.
    • (2008) Curr Opin Oncol , vol.20 , pp. 412
    • Ludwig, J.A.1
  • 15
    • 33749011163 scopus 로고    scopus 로고
    • The nci60 human tumour cell line anti-cancer drug screen
    • Shoemaker, R.H. The nci60 human tumour cell line anti-cancer drug screen. Nat Rev Cancer 6, 813, 2006.
    • (2006) Nat Rev Cancer , vol.6 , pp. 813
    • Shoemaker, R.H.1
  • 16
    • 1942422761 scopus 로고    scopus 로고
    • Update on nci in vitro drug screen utilities
    • Holbeck, S.L. Update on nci in vitro drug screen utilities. Eur J Cancer 40, 785, 2004.
    • (2004) Eur J Cancer , vol.40 , pp. 785
    • Holbeck, S.L.1
  • 17
    • 0036233675 scopus 로고    scopus 로고
    • Developmental therapeutics program at the nci: Molecular target and drug discovery process
    • Monga, M., and Sausville, E.A. Developmental therapeutics program at the nci: molecular target and drug discovery process. Leukemia 16, 520, 2002.
    • (2002) Leukemia , vol.16 , pp. 520
    • Monga, M.1    Sausville, E.A.2
  • 18
    • 33750996156 scopus 로고    scopus 로고
    • Pathway-specific differences between tumor cell lines and normal and tumor tissue cells
    • Ertel, A., Verghese, A., Byers, S.W., Ochs, M., and Tozeren, A. Pathway-specific differences between tumor cell lines and normal and tumor tissue cells. Mol Cancer 5, 55, 2006.
    • (2006) Mol Cancer , vol.5 , pp. 55
    • Ertel, A.1    Verghese, A.2    Byers, S.W.3    Ochs, M.4    Tozeren, A.5
  • 20
    • 0141566685 scopus 로고    scopus 로고
    • Clinical predictive value of the in vitro cell line, human xeno-graft, and mouse allograft preclinical cancer models
    • Voskoglou-Nomikos, T., Pater, J.L., and Seymour, L. Clinical predictive value of the in vitro cell line, human xeno-graft, and mouse allograft preclinical cancer models. Clin Cancer Res 9, 4227, 2003.
    • (2003) Clin Cancer Res , vol.9 , pp. 4227
    • Voskoglou-Nomikos, T.1    Pater, J.L.2    Seymour, L.3
  • 22
    • 0030843071 scopus 로고    scopus 로고
    • The multiple roles of tumour stroma
    • Wernert, N. The multiple roles of tumour stroma. Virchows Arch 430, 433, 1997.
    • (1997) Virchows Arch , vol.430 , pp. 433
    • Wernert, N.1
  • 23
    • 0035902141 scopus 로고    scopus 로고
    • The microenvironment of the tumour-host interface
    • Liotta, L.A., and Kohn, E.C. The microenvironment of the tumour-host interface. Nature 411, 375, 2001.
    • (2001) Nature , vol.411 , pp. 375
    • Liotta, L.A.1    Kohn, E.C.2
  • 24
    • 0842346275 scopus 로고    scopus 로고
    • Death in the third dimension: Apoptosis regulation and tissue architecture
    • Zahir, N., and Weaver, V.M. Death in the third dimension: apoptosis regulation and tissue architecture. Curr Opin Genet Dev 14, 71, 2004.
    • (2004) Curr Opin Genet Dev , vol.14 , pp. 71
    • Zahir, N.1    Weaver, V.M.2
  • 25
    • 0037599515 scopus 로고    scopus 로고
    • Endocrine=paracrine=autocrine survival factor activity of bone microenvironment participates in the development of androgen ablation and chemotherapy refractoriness of prostate cancer metastasis in skeleton
    • Bogdanos, J., Karamanolakis, D., Tenta, R., Tsintavis, A., Milathianakis, C., Mitsiades, C., and Koutsilieris, M. Endocrine=paracrine=autocrine survival factor activity of bone microenvironment participates in the development of androgen ablation and chemotherapy refractoriness of prostate cancer metastasis in skeleton. Endocr Relat Cancer 10, 279, 2003.
    • (2003) Endocr Relat Cancer , vol.10 , pp. 279
    • Bogdanos, J.1    Karamanolakis, D.2    Tenta, R.3    Tsintavis, A.4    Milathianakis, C.5    Mitsiades, C.6    Koutsilieris, M.7
  • 26
    • 0141520276 scopus 로고    scopus 로고
    • Drug resistance and the microenvironment: Nature and nurture
    • Morin, P.J. Drug resistance and the microenvironment: nature and nurture. Drug Resist Updat 6, 169, 2003.
    • (2003) Drug Resist Updat , vol.6 , pp. 169
    • Morin, P.J.1
  • 27
    • 0036726312 scopus 로고    scopus 로고
    • Beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium
    • Weaver, V.M., Lelievre, S., Lakins, J.N., Chrenek, M.A., Jones, J.C., Giancotti, F., Werb, Z., and Bissell, M.J. Beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell 2, 205, 2002.
    • (2002) Cancer Cell , vol.2 , pp. 205
    • Weaver, V.M.1    Lelievre, S.2    Lakins, J.N.3    Chrenek, M.A.4    Jones, J.C.5    Giancotti, F.6    Werb, Z.7    Bissell, M.J.8
  • 29
    • 0036204974 scopus 로고    scopus 로고
    • Extracellular matrix regulation of drug resistance in small-cell lung cancer
    • Rintoul, R.C., and Sethi, T. Extracellular matrix regulation of drug resistance in small-cell lung cancer. Clin Sci (Lond) 102, 417, 2002.
    • (2002) Clin Sci (Lond) , vol.102 , pp. 417
    • Rintoul, R.C.1    Sethi, T.2
  • 30
    • 0033105537 scopus 로고    scopus 로고
    • Cell adhesion mediated drug resistance (cam-dr): Role of integrins and resistance to apoptosis in human myeloma cell lines
    • Damiano, J.S., Cress, A.E., Hazlehurst, L.A., Shtil, A.A., and Dalton, W.S. Cell adhesion mediated drug resistance (cam-dr): role of integrins and resistance to apoptosis in human myeloma cell lines. Blood 93, 1658, 1999.
    • (1999) Blood , vol.93 , pp. 1658
    • Damiano, J.S.1    Cress, A.E.2    Hazlehurst, L.A.3    Shtil, A.A.4    Dalton, W.S.5
  • 31
    • 33845206491 scopus 로고    scopus 로고
    • Practices and pitfalls of mouse cancer models in drug discovery
    • Kung, A.L. Practices and pitfalls of mouse cancer models in drug discovery. Adv Cancer Res 96, 191, 2007.
    • (2007) Adv Cancer Res , vol.96 , pp. 191
    • Kung, A.L.1
  • 32
    • 33750435151 scopus 로고    scopus 로고
    • Tumor models for efficacy determination
    • Teicher, B.A. Tumor models for efficacy determination. Mol Cancer Ther 5, 2435, 2006.
    • (2006) Mol Cancer Ther , vol.5 , pp. 2435
    • Teicher, B.A.1
  • 33
    • 1942422743 scopus 로고    scopus 로고
    • Of mice and men: Values and liabilities of the athymic nude mouse model in anticancer drug development
    • Kelland, L.R. Of mice and men: values and liabilities of the athymic nude mouse model in anticancer drug development. Eur J Cancer 40, 827, 2004.
    • (2004) Eur J Cancer , vol.40 , pp. 827
    • Kelland, L.R.1
  • 35
    • 0032410157 scopus 로고    scopus 로고
    • Orthotopic models are necessary to predict therapy of transplantable tumors in mice
    • Killion, J.J., Radinsky, R., and Fidler, I.J. Orthotopic models are necessary to predict therapy of transplantable tumors in mice. Cancer Metastasis Rev 17, 279, 1998.
    • (1998) Cancer Metastasis Rev , vol.17 , pp. 279
    • Killion, J.J.1    Radinsky, R.2    Fidler, I.J.3
  • 36
    • 33748331308 scopus 로고    scopus 로고
    • The mighty mouse: Genetically engineered mouse models in cancer drug development
    • Sharpless, N.E., and Depinho, R.A. The mighty mouse: genetically engineered mouse models in cancer drug development. Nat Rev Drug Discov 5, 741, 2006.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 741
    • Sharpless, N.E.1    Depinho, R.A.2
  • 37
    • 0022549481 scopus 로고
    • Therapy of autochthonous skin cancers in mice with intravenously injected liposomes containing muramyltripeptide
    • Talmadge, J.E., Lenz, B.F., Klabansky, R., Simon, R., Riggs, C., Guo, S., Oldham, R.K., and Fidler, I.J. Therapy of autochthonous skin cancers in mice with intravenously injected liposomes containing muramyltripeptide. Cancer Res 46, 1160, 1986.
    • (1986) Cancer Res , vol.46 , pp. 1160
    • Talmadge, J.E.1    Lenz, B.F.2    Klabansky, R.3    Simon, R.4    Riggs, C.5    Guo, S.6    Oldham, R.K.7    Fidler, I.J.8
  • 38
    • 34247876272 scopus 로고    scopus 로고
    • Murine models to evaluate novel and conventional therapeutic strategies for cancer
    • Talmadge, J.E., Singh, R.K., Fidler, I.J., and Raz, A. Murine models to evaluate novel and conventional therapeutic strategies for cancer. Am J Pathol 170, 793, 2007.
    • (2007) Am J Pathol , vol.170 , pp. 793
    • Talmadge, J.E.1    Singh, R.K.2    Fidler, I.J.3    Raz, A.4
  • 39
    • 0037050258 scopus 로고    scopus 로고
    • Anchorage-independent multi-cellular spheroids as an in vitro model of growth signaling in ewing tumors
    • Lawlor, E.R., Scheel, C., Irving, J., and Sorensen, P.H. Anchorage-independent multi-cellular spheroids as an in vitro model of growth signaling in ewing tumors. On-cogene 21, 307, 2002.
    • (2002) On-cogene , vol.21 , pp. 307
    • Lawlor, E.R.1    Scheel, C.2    Irving, J.3    Sorensen, P.H.4
  • 40
    • 17144369867 scopus 로고    scopus 로고
    • P38mapk-dependent sensitivity of Ewing's sarcoma family of tumors to fenretinide-induced cell death
    • Myatt, S.S., Redfern, C.P., and Burchill, S.A. P38mapk-dependent sensitivity of Ewing's sarcoma family of tumors to fenretinide-induced cell death. Clin Cancer Res 11, 3136, 2005.
    • (2005) Clin Cancer Res , vol.11 , pp. 3136
    • Myatt, S.S.1    Redfern, C.P.2    Burchill, S.A.3
  • 41
    • 58749093939 scopus 로고    scopus 로고
    • Recent advances in three-dimensional multicellular spheroid culture for biomedical research
    • Lin, R.Z., and Chang, H.Y. Recent advances in three-dimensional multicellular spheroid culture for biomedical research. Biotechnol J 3, 1172, 2008.
    • (2008) Biotechnol J , vol.3 , pp. 1172
    • Lin, R.Z.1    Chang, H.Y.2
  • 42
    • 36849009670 scopus 로고    scopus 로고
    • Experimental anti-tumor therapy in 3-d: Spheroids\old hat or new challenge?
    • Friedrich, J., Ebner, R., and Kunz-Schughart, L.A. Experimental anti-tumor therapy in 3-d: spheroids\old hat or new challenge? Int J Radiat Biol 83, 849, 2007.
    • (2007) Int J Radiat Biol , vol.83 , pp. 849
    • Friedrich, J.1    Ebner, R.2    Kunz-Schughart, L.A.3
  • 43
    • 0033101647 scopus 로고    scopus 로고
    • Multicellular tumor spheroids: Intermediates between monolayer culture and in vivo tumor
    • Kunz-Schughart, L.A. Multicellular tumor spheroids: intermediates between monolayer culture and in vivo tumor. Cell Biol Int 23, 157, 1999.
    • (1999) Cell Biol Int , vol.23 , pp. 157
    • Kunz-Schughart, L.A.1
  • 45
    • 0023093713 scopus 로고
    • Multicellular spheroids. A review on cellular aggregates in cancer research
    • Mueller-Klieser, W. Multicellular spheroids. A review on cellular aggregates in cancer research. J Cancer Res Clin Oncol 113, 101, 1987.
    • (1987) J Cancer Res Clin Oncol , vol.113 , pp. 101
    • Mueller-Klieser, W.1
  • 46
    • 0030697292 scopus 로고    scopus 로고
    • Three-dimensional cell cultures: From molecular mechanisms to clinical applications
    • Mueller-Klieser, W. Three-dimensional cell cultures: from molecular mechanisms to clinical applications. Am J Phy-siol 273, C1109, 1997.
    • (1997) Am J Phy-siol , vol.273
    • Mueller-Klieser, W.1
  • 48
    • 0015312069 scopus 로고
    • Effects of intercellular contact on repair of radiation damage
    • Durand, R.E., and Sutherland, R.M. Effects of intercellular contact on repair of radiation damage. Exp Cell Res 71, 75, 1972.
    • (1972) Exp Cell Res , vol.71 , pp. 75
    • Durand, R.E.1    Sutherland, R.M.2
  • 49
    • 0017726744 scopus 로고
    • A simplified method for production and growth of multicel-lular tumor spheroids
    • Yuhas, J.M., Li, A.P., Martinez, A.O., and Ladman, A.J. A simplified method for production and growth of multicel-lular tumor spheroids. Cancer Res 37, 3639, 1977.
    • (1977) Cancer Res , vol.37 , pp. 3639
    • Yuhas, J.M.1    Li, A.P.2    Martinez, A.O.3    Ladman, A.J.4
  • 50
    • 60549103259 scopus 로고    scopus 로고
    • Spheroid-based drug screen: Considerations and practical approach
    • Friedrich, J., Seidel, C., Ebner, R., and Kunz-Schughart, L.A. Spheroid-based drug screen: considerations and practical approach. Nat Protoc 4, 309, 2009.
    • (2009) Nat Protoc , vol.4 , pp. 309
    • Friedrich, J.1    Seidel, C.2    Ebner, R.3    Kunz-Schughart, L.A.4
  • 51
    • 38449089459 scopus 로고    scopus 로고
    • Generation of multicel-lular tumor spheroids by the hanging-drop method
    • Timmins, N.E., and Nielsen, L.K. Generation of multicel-lular tumor spheroids by the hanging-drop method. Methods Mol Med 140, 141, 2007.
    • (2007) Methods Mol Med , vol.140 , pp. 141
    • Timmins, N.E.1    Nielsen, L.K.2
  • 52
    • 40349103280 scopus 로고    scopus 로고
    • Microfluidic self-assembly of tumor spheroids for anticancer drug discovery
    • Wu, L.Y., Di Carlo, D., and Lee, L.P. Microfluidic self-assembly of tumor spheroids for anticancer drug discovery. Biomed Microdevices 10, 197, 2008.
    • (2008) Biomed Microdevices , vol.10 , pp. 197
    • Wu, L.Y.1    Di Carlo, D.2    Lee, L.P.3
  • 53
    • 37749053847 scopus 로고    scopus 로고
    • Screening for compounds that induce apoptosis of cancer cells grown as multicellular spheroids
    • Herrmann, R., Fayad, W., Schwarz, S., Berndtsson, M., and Linder, S. Screening for compounds that induce apoptosis of cancer cells grown as multicellular spheroids. J Biomol Screen 13, 1, 2008.
    • (2008) J Biomol Screen , vol.13 , pp. 1
    • Herrmann, R.1    Fayad, W.2    Schwarz, S.3    Berndtsson, M.4    Linder, S.5
  • 55
    • 0032508679 scopus 로고    scopus 로고
    • Multicellular spheroids as an in vitro tumor model
    • Hamilton, G. Multicellular spheroids as an in vitro tumor model. Cancer Lett 131, 29, 1998.
    • (1998) Cancer Lett , vol.131 , pp. 29
    • Hamilton, G.1
  • 56
    • 0037444270 scopus 로고    scopus 로고
    • Theoretical analysis of antibody targeting of tumor spheroids: Importance of dosage for penetration, and affinity for retention
    • Graff, C.P., and Wittrup, K.D. Theoretical analysis of antibody targeting of tumor spheroids: importance of dosage for penetration, and affinity for retention. Cancer Res 63, 1288, 2003.
    • (2003) Cancer Res , vol.63 , pp. 1288
    • Graff, C.P.1    Wittrup, K.D.2
  • 57
    • 51049105989 scopus 로고    scopus 로고
    • Effect of antigen turnover rate and expression level on antibody penetration into tumor spheroids
    • Ackerman, M.E., Pawlowski, D., and Wittrup, K.D. Effect of antigen turnover rate and expression level on antibody penetration into tumor spheroids. Mol Cancer Ther 7, 2233, 2008.
    • (2008) Mol Cancer Ther , vol.7 , pp. 2233
    • Ackerman, M.E.1    Pawlowski, D.2    Wittrup, K.D.3
  • 58
    • 44849135212 scopus 로고    scopus 로고
    • Quantitative spatio-temporal analysis of antibody fragment diffusion and en-docytic consumption in tumor spheroids
    • Thurber, G.M., and Wittrup, K.D. Quantitative spatio-temporal analysis of antibody fragment diffusion and en-docytic consumption in tumor spheroids. Cancer Res 68, 3334, 2008.
    • (2008) Cancer Res , vol.68 , pp. 3334
    • Thurber, G.M.1    Wittrup, K.D.2
  • 59
    • 17144429653 scopus 로고    scopus 로고
    • The challenge to measure cell proliferation in two and three dimensions
    • Ng, K.W., Leong, D.T., and Hutmacher, D.W. The challenge to measure cell proliferation in two and three dimensions. Tissue Eng 11, 182, 2005.
    • (2005) Tissue Eng , vol.11 , pp. 182
    • Ng, K.W.1    Leong, D.T.2    Hutmacher, D.W.3
  • 60
    • 0035014916 scopus 로고    scopus 로고
    • A multicellular spheroid-based sensor for anti-cancer therapeutics
    • Thielecke, H., Mack, A., and Robitzki, A. A multicellular spheroid-based sensor for anti-cancer therapeutics. Biosens Bioelectron 16, 261, 2001.
    • (2001) Biosens Bioelectron , vol.16 , pp. 261
    • Thielecke, H.1    MacK, A.2    Robitzki, A.3
  • 62
    • 0029007273 scopus 로고
    • Biomaterials in tissue engineering
    • Hubbell, J.A. Biomaterials in tissue engineering. Biotechnology (N Y) 13, 565, 1995.
    • (1995) Biotechnology (N Y) , vol.13 , pp. 565
    • Hubbell, J.A.1
  • 63
    • 0022549554 scopus 로고
    • In vivo-like growth of human tumors in vitro.
    • Freeman, A.E., and Hoffman, R.M. In vivo-like growth of human tumors in vitro. Proc Natl Acad Sci USA 83, 2694, 1986.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 2694
    • Freeman, A.E.1    Hoffman, R.M.2
  • 64
    • 0023693626 scopus 로고
    • Collagen gel culture of rat mammary tumor cells as an assay system for determination of therapeutic efficacy of chemotherapeutic agents
    • Sinha, D.K., and White, C.J. Collagen gel culture of rat mammary tumor cells as an assay system for determination of therapeutic efficacy of chemotherapeutic agents. In Vitro Cell Dev Biol 24, 525, 1988.
    • (1988) Vitro Cell Dev Biol , vol.24 , pp. 525
    • Sinha, D.K.1    White, C.J.2
  • 65
    • 0026077646 scopus 로고
    • Correlation of histology and drug response of human tumors grown in native-state three-dimensional histo-culture and in nude mice
    • Vescio, R.A., Connors, K.M., Kubota, T., and Hoffman, R.M. Correlation of histology and drug response of human tumors grown in native-state three-dimensional histo-culture and in nude mice. Proc Natl Acad Sci USA 88, 5163, 1991.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 5163
    • Vescio, R.A.1    Connors, K.M.2    Kubota, T.3    Hoffman, R.M.4
  • 67
    • 0037139372 scopus 로고    scopus 로고
    • Prediction of chemotherapeutic response by collagen gel droplet embedded culture-drug sensitivity test in human breast cancers
    • Takamura, Y., Kobayashi, H., Taguchi, T., Motomura, K., Inaji, H., and Noguchi, S. Prediction of chemotherapeutic response by collagen gel droplet embedded culture-drug sensitivity test in human breast cancers. Int J Cancer 98, 450, 2002.
    • (2002) Int J Cancer , vol.98 , pp. 450
    • Takamura, Y.1    Kobayashi, H.2    Taguchi, T.3    Motomura, K.4    Inaji, H.5    Noguchi, S.6
  • 68
    • 33846294015 scopus 로고    scopus 로고
    • Clinical evaluation of chemosensitivity testing for patients with un-resectable non-small cell lung cancer (nsclc) using collagen gel droplet embedded culture drug sensitivity test (cd-dst)
    • Kawamura, M., Gika, M., Abiko, T., Inoue, Y., Oyama, T., Izumi, Y., Kobayashi, H., and Kobayashi, K. Clinical evaluation of chemosensitivity testing for patients with un-resectable non-small cell lung cancer (nsclc) using collagen gel droplet embedded culture drug sensitivity test (cd-dst). Cancer Chemother Pharmacol 59, 507, 2007.
    • (2007) Cancer Chemother Pharmacol , vol.59 , pp. 507
    • Kawamura, M.1    Gika, M.2    Abiko, T.3    Inoue, Y.4    Oyama, T.5    Izumi, Y.6    Kobayashi, H.7    Kobayashi, K.8
  • 70
    • 0022374626 scopus 로고
    • Factors affecting growth and drug sensitivity of mouse mammary tumor lines in collagen gel cultures
    • Miller, B.E., Miller, F.R., and Heppner, G.H. Factors affecting growth and drug sensitivity of mouse mammary tumor lines in collagen gel cultures. Cancer Res 45, 4200, 1985.
    • (1985) Cancer Res , vol.45 , pp. 4200
    • Miller, B.E.1    Miller, F.R.2    Heppner, G.H.3
  • 71
    • 9644255820 scopus 로고    scopus 로고
    • Multi-channel 3-d cell culture device integrated on a silicon chip for anticancer drug sensitivity test
    • Torisawa, Y.S., Shiku, H., Yasukawa, T., Nishizawa, M., and Matsue, T. Multi-channel 3-d cell culture device integrated on a silicon chip for anticancer drug sensitivity test. Biomaterials 26, 2165, 2005.
    • (2005) Biomaterials , vol.26 , pp. 2165
    • Torisawa, Y.S.1    Shiku, H.2    Yasukawa, T.3    Nishizawa, M.4    Matsue, T.5
  • 72
    • 34548295521 scopus 로고    scopus 로고
    • Three-dimensional polymeric systems for cancer cell studies
    • Xu, F., and Burg, K.J. Three-dimensional polymeric systems for cancer cell studies. Cytotechnology 54, 135, 2007.
    • (2007) Cytotechnology , vol.54 , pp. 135
    • Xu, F.1    Burg, K.J.2
  • 74
    • 0020629613 scopus 로고
    • A new method for the three-dimensional in vitro growth of human cancer cells
    • Kupchik, H.Z., Langer, R.S., Haberern, C., El Deriny, S., and O'Brien, M. A new method for the three-dimensional in vitro growth of human cancer cells. Exp Cell Res 147, 454, 1983.
    • (1983) Exp Cell Res , vol.147 , pp. 454
    • Kupchik, H.Z.1    Langer, R.S.2    Haberern, C.3    El Deriny, S.4    O'Brien, M.5
  • 75
    • 0028672771 scopus 로고
    • A new method for the 3-d in vitro growth of human rt112 bladder carcinoma cells using the alginate culture technique
    • Boxberger, H.J., and Meyer, T.F. A new method for the 3-d in vitro growth of human rt112 bladder carcinoma cells using the alginate culture technique. Biol Cell 82, 109, 1994.
    • (1994) Biol Cell , vol.82 , pp. 109
    • Boxberger, H.J.1    Meyer, T.F.2
  • 77
    • 23244447397 scopus 로고    scopus 로고
    • Development of an in vitro multicellular tumor spheroid model using microencapsulation and its application in an-ticancer drug screening and testing
    • Zhang, X., Wang, W., Yu, W., Xie, Y., Zhang, Y., and Ma, X. Development of an in vitro multicellular tumor spheroid model using microencapsulation and its application in an-ticancer drug screening and testing. Biotechnol Prog 21, 1289, 2005.
    • (2005) Biotechnol Prog , vol.21 , pp. 1289
    • Zhang, X.1    Wang, W.2    Yu, W.3    Xie, Y.4    Zhang, Y.5    Ma, X.6
  • 78
    • 23744449992 scopus 로고    scopus 로고
    • Basement membrane matrix with biological activity
    • Kleinman, H.K., and Martin, G.R. Matrigel: basement membrane matrix with biological activity. Semin Cancer Biol 15, 378, 2005.
    • (2005) Semin Cancer Biol , vol.15 , pp. 378
    • Kleinman, H.K.1    Matrigel, R.M.G.2
  • 79
    • 0026738947 scopus 로고
    • Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells
    • Petersen, O.W., Ronnov-Jessen, L., Howlett, A.R., and Bis-sell, M.J. Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells. Proc Natl Acad Sci USA 89, 9064, 1992.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 9064
    • Petersen, O.W.1    Ronnov-Jessen, L.2    Howlett, A.R.3    Bis-Sell, M.J.4
  • 80
    • 0031408202 scopus 로고    scopus 로고
    • Acinar differentiation by non-malignant immortalized human prostatic epithelial cells and its loss by malignant cells
    • Webber, M.M., Bello, D., Kleinman, H.K., and Hoffman, M.P. Acinar differentiation by non-malignant immortalized human prostatic epithelial cells and its loss by malignant cells. Carcinogenesis 18, 1225, 1997.
    • (1997) Carcinogenesis , vol.18 , pp. 1225
    • Webber, M.M.1    Bello, D.2    Kleinman, H.K.3    Hoffman, M.P.4
  • 81
    • 34247864012 scopus 로고    scopus 로고
    • Three-dimensional culture models of normal and malignant breast epithelial cells
    • Lee, G.Y., Kenny, P.A., Lee, E.H., and Bissell, M.J. Three-dimensional culture models of normal and malignant breast epithelial cells. Nat Methods 4, 359, 2007.
    • (2007) Nat Methods , vol.4 , pp. 359
    • Lee, G.Y.1    Kenny, P.A.2    Lee, E.H.3    Bissell, M.J.4
  • 82
    • 0030936450 scopus 로고    scopus 로고
    • Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies
    • Weaver, V.M., Petersen, O.W., Wang, F., Larabell, C.A., Briand, P., Damsky, C., and Bissell, M.J. Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies. J Cell Biol 137, 231, 1997.
    • (1997) J Cell Biol , vol.137 , pp. 231
    • Weaver, V.M.1    Petersen, O.W.2    Wang, F.3    Larabell, C.A.4    Briand, P.5    Damsky, C.6    Bissell, M.J.7
  • 83
    • 0032217084 scopus 로고    scopus 로고
    • Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: A different perspective in epithelial biology
    • Wang, F., Weaver, V.M., Petersen, O.W., Larabell, C.A., Dedhar, S., Briand, P., Lupu, R., and Bissell, M.J. Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology. Proc Natl Acad Sci USA 95, 14821, 1998.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 14821
    • Wang, F.1    Weaver, V.M.2    Petersen, O.W.3    Larabell, C.A.4    Dedhar, S.5    Briand, P.6    Lupu, R.7    Bissell, M.J.8
  • 86
    • 0036708471 scopus 로고    scopus 로고
    • Diffusion and convection in collagen gels: Implications for transport in the tumor interstitium
    • Ramanujan, S., Pluen, A., McKee, T.D., Brown, E.B., Boucher, Y., and Jain, R.K. Diffusion and convection in collagen gels: implications for transport in the tumor interstitium. Biophys J 83, 1650, 2002.
    • (2002) Biophys J , vol.83 , pp. 1650
    • Ramanujan, S.1    Pluen, A.2    McKee, T.D.3    Brown, E.B.4    Boucher, Y.5    Jain, R.K.6
  • 87
    • 1942518844 scopus 로고    scopus 로고
    • Characterization and evaluation of chitosan matrix for in vitro growth of mcf-7 breast cancer cell lines
    • Dhiman, H.K., Ray, A.R., and Panda, A.K. Characterization and evaluation of chitosan matrix for in vitro growth of mcf-7 breast cancer cell lines. Biomaterials 25, 5147, 2004.
    • (2004) Biomaterials , vol.25 , pp. 5147
    • Dhiman, H.K.1    Ray, A.R.2    Panda, A.K.3
  • 88
    • 4544382532 scopus 로고    scopus 로고
    • Three-dimensional chitosan scaffold-based mcf-7 cell culture for the determination of the cytotoxicity of tamoxifen
    • Dhiman, H.K., Ray, A.R., and Panda, A.K. Three-dimensional chitosan scaffold-based mcf-7 cell culture for the determination of the cytotoxicity of tamoxifen. Bioma-terials 26, 979, 2005.
    • (2005) Bioma-terials , vol.26 , pp. 979
    • Dhiman, H.K.1    Ray, A.R.2    Panda, A.K.3
  • 89
    • 16344392522 scopus 로고    scopus 로고
    • Characterization of porous plga=pla microparticles as a scaffold for three dimensional growth of breast cancer cells
    • Sahoo, S.K., Panda, A.K., and Labhasetwar, V. Characterization of porous plga=pla microparticles as a scaffold for three dimensional growth of breast cancer cells. Bioma-cromolecules 6, 1132, 2005.
    • (2005) Bioma-cromolecules , vol.6 , pp. 1132
    • Sahoo, S.K.1    Panda, A.K.2    Labhasetwar, V.3
  • 92
    • 0042562089 scopus 로고    scopus 로고
    • Biomimetic materials for tissue engineering
    • Shin, H., Jo, S., and Mikos, A.G. Biomimetic materials for tissue engineering. Biomaterials 24, 4353, 2003.
    • (2003) Biomaterials , vol.24 , pp. 4353
    • Shin, H.1    Jo, S.2    Mikos, A.G.3
  • 93
    • 0036984640 scopus 로고    scopus 로고
    • Role of angiogenesis in tumor growth and metastasis
    • Folkman, J. Role of angiogenesis in tumor growth and metastasis. Semin Oncol 29, 15, 2002.
    • (2002) Semin Oncol , vol.29 , pp. 15
    • Folkman, J.1
  • 94
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet, P., and Jain, R.K. Angiogenesis in cancer and other diseases. Nature 407, 249, 2000.
    • (2000) Nature , vol.407 , pp. 249
    • Carmeliet, P.1    Jain, R.K.2
  • 95
    • 1642563967 scopus 로고    scopus 로고
    • The role of biore-actors in tissue engineering
    • Martin, I., Wendt, D., and Heberer, M. The role of biore-actors in tissue engineering. Trends Biotechnol 22, 80, 2004.
    • (2004) Trends Biotechnol , vol.22 , pp. 80
    • Martin, I.1    Wendt, D.2    Heberer, M.3
  • 96
    • 0037937606 scopus 로고    scopus 로고
    • Design of a flow perfusion bioreactor system for bone tissue-engineering applications
    • Bancroft, G.N., Sikavitsas, V.I., and Mikos, A.G. Design of a flow perfusion bioreactor system for bone tissue-engineering applications. Tissue Eng 9, 549, 2003.
    • (2003) Tissue Eng , vol.9 , pp. 549
    • Bancroft, G.N.1    Sikavitsas, V.I.2    Mikos, A.G.3
  • 97
    • 0036299881 scopus 로고    scopus 로고
    • Bioreactors and bioproces-sing for tissue engineering
    • Ratcliffe, A., and Niklason, L.E. Bioreactors and bioproces-sing for tissue engineering. Ann N Y Acad Sci 961, 210, 2002.
    • (2002) Ann N y Acad Sci , vol.961 , pp. 210
    • Ratcliffe, A.1    Niklason, L.E.2
  • 99
    • 0035835829 scopus 로고    scopus 로고
    • Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation
    • Elenbaas, B., and Weinberg, R.A. Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation. Exp Cell Res 264, 169, 2001.
    • (2001) Exp Cell Res , vol.264 , pp. 169
    • Elenbaas, B.1    Weinberg, R.A.2
  • 100
    • 42649097906 scopus 로고    scopus 로고
    • Coevolution in the tumor microenviron-ment
    • Weinberg, R.A. Coevolution in the tumor microenviron-ment. Nat Genet 40, 494, 2008.
    • (2008) Nat Genet , vol.40 , pp. 494
    • Weinberg, R.A.1
  • 101
    • 0035872250 scopus 로고    scopus 로고
    • A heterologous 3-d coculture model of breast tumor cells and fibroblasts to study tumor-associated fi-broblast differentiation
    • Kunz-Schughart, L.A., Heyder, P., Schroeder, J., and Knuechel, R. A heterologous 3-d coculture model of breast tumor cells and fibroblasts to study tumor-associated fi-broblast differentiation. Exp Cell Res 266, 74, 2001.
    • (2001) Exp Cell Res , vol.266 , pp. 74
    • Kunz-Schughart, L.A.1    Heyder, P.2    Schroeder, J.3    Knuechel, R.4
  • 102
    • 0027765545 scopus 로고
    • Macrophages and multicellular tumor spheroids in co-culture: A three-dimensional model to study tumor-host interactions. Evidence for macrophage-mediated tumor cell proliferation and migration
    • Hauptmann, S., Zwadlo-Klarwasser, G., Jansen, M., Klosterhalfen, B., and Kirkpatrick, C.J. Macrophages and multicellular tumor spheroids in co-culture: a three-dimensional model to study tumor-host interactions. Evidence for macrophage-mediated tumor cell proliferation and migration. Am J Pathol 143, 1406, 1993.
    • (1993) Am J Pathol , vol.143 , pp. 1406
    • Hauptmann, S.1    Zwadlo-Klarwasser, G.2    Jansen, M.3    Klosterhalfen, B.4    Kirkpatrick, C.J.5


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