Influence of soluble PEG-OH incorporation in a 3D cell-laden PEG-fibrinogen (PF) hydrogel on smooth muscle cell morphology and growth

Journal of Biomaterials Science, Polymer Edition

Volumn 25, Issue 4, 2014, Pages 394-409

  Lee, Bae Hoon ^a   Tin, Stella Poh Hui ^a   Chaw, Su Yin ^a   Cao, Ye ^a   Xia, Yun ^a   Steele, Terry W J ^a   Seliktar, Dror ^b   Bianco Peled, Havazelet ^b   Venkatraman, Subbu S ^a  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Encapsulation; Fibrinogen; Hydrogel; Poly(ethylene glycol); Tissue engineering

Indexed keywords

CELL MORPHOLOGY; CELL SPREADING; COMPLEX SHEAR MODULUS; FIBRINOGEN; HYDROGEL NETWORKS; LEACHANTS; MORPHOMETRICS; SMOOTH MUSCLE CELLS;

CELLS; COMPLEX NETWORKS; COMPLIANCE CONTROL; CYTOLOGY; ELASTIC MODULI; ENCAPSULATION; GELATION; MORPHOLOGY; PHASE SEPARATION; POLYETHYLENE GLYCOLS; THREE DIMENSIONAL; TISSUE ENGINEERING;

HYDROGELS;

FIBRINOGEN; MACROGOL;

ACTIN FILAMENT; ARTICLE; CELL CULTURE; CELL ELONGATION; CELL ENCAPSULATION; CELL GROWTH; CELL PROLIFERATION; CELL SHAPE; CELL SPREADING; CELL STRUCTURE; CELL VIABILITY; COMPLIANCE (PHYSICAL); CONFOCAL MICROSCOPY; CROSS LINKING; CULTURE MEDIUM; EXPERIMENTAL THERAPY; FLOW KINETICS; FLOW MEASUREMENT; GELATION; GROWTH RATE; HYDROGEL; HYPOTHESIS; IMMUNOFLUORESCENCE; MACROMOLECULE; MICROENVIRONMENT; MOLECULAR WEIGHT; MORPHOGENESIS; PHASE SEPARATION; POROSITY; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPE; SMOOTH MUSCLE FIBER; STORAGE; TISSUE ENGINEERING; TURBIDITY;

BIOCOMPATIBLE MATERIALS; CELL SHAPE; FIBRINOGEN; FLUORESCENT ANTIBODY TECHNIQUE; GELATIN; HUMANS; HYDROGELS; MATERIALS TESTING; MICROSCOPY, CONFOCAL; MYOCYTES, SMOOTH MUSCLE; POLYETHYLENE GLYCOLS; RHEOLOGY; TISSUE ENGINEERING;

EID: 84892368547     PISSN: 09205063     EISSN: 15685624     Source Type: Journal    
DOI: 10.1080/09205063.2013.862401     Document Type: Article

References (28)

1. Seliktar D. Designing cell-compatible hydrogels for biomedical applications. Science. 2012;336:1124-1128.
2. Ye Z, Zhou Y, Cai H, Tan W. Myocardial regeneration: roles of stem cells and hydrogels. Adv. Drug Delivery Rev. 2011;63:688-697.
3. Kim B-S, Park I-K, Hoshiba T, Jiang H-L, Choi Y-J, Akaike T, Cho C-S. Design of artificial extracellular matrices for tissue engineering. Prog. Polym. Sci. 2011;36:238-268.
4. Valarmathi MT, Fuseler JW, Goodwin RL, Davis JM, Potts JD. The mechanical coupling of adult marrow stromal stem cells during cardiac regeneration assessed in a 2-D co-culture model. Biomaterials. 2011;32:2834-2850.
5. Kim IA, Park SA, Kim YJ, Kim SH, Shin HJ, Lee YJ, Kang SG, Shin JW. Effects of mechanical stimuli and microfiber-based substrate on neurite outgrowth and guidance. J. Biosci. Bioeng. 2006;101:120-126.
6. Liu TY, Zhou GD, Miao CL, Wei X, Chen FG, Cui L, Liu W, Cao YL. Influence of mechanical stress on chondrogenesis of in vitro cultured porcine bone marrow stem cells: a preliminary study. Zhonghua Yi Xue Za Zhi. 2004;84:1997-2001.
7. Engler AJ, Sen S, Sweeney HL, Discher DE. Matrix elasticity directs stem cell lineage specification. Cell. 2006;126:677-689.
8. Huebsch N, Arany PR, Mao AS, Shvartsman D, Ali OA, Bencherif SA, Rivera-Feliciano J, Mooney DJ. Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate. Nat. Mater. 2010;9:518-526.
9. Hwang CM, Sant S, Masaeli M, Kachouie NN, Zamanian B, Lee SH, Khademhosseini A. Fabrication of three-dimensional porous cell-laden hydrogel for tissue engineering. Biofabrication. 2010;2:1-12.
10. Frisman I, Seliktar D, Bianco-Peled H. Nanostructuring biosynthetic hydrogels for tissue engineering: a cellular and structural analysis. Acta Biomater. 2012;8:51-60.
11. Ou L, Li W, Zhang Y, Wang W, Liu J, Sorg H, Furlani D, Gabel R, Mark P, Klopsch C, Wang L, Lutzow K, Lendlein A, Wagner K, Klee D, Liebold A, Li RK, Kong D, Steinhoff G, Ma N. Intracardiac injection of matrigel induces stem cell recruitment and improves cardiac functions in a rat myocardial infarction model. J. Cell. Mol. Med. 2011;15:13101-1318.
12. Yanagawa F, Kaji H, Jang YH, Bae H, Du YA, Fukuda J, Qi H, Khademhosseini A. Directed assembly of cell-laden microgels for building porous three-dimensional tissue constructs. J. Biomed. Mat. Res. Part A. 2011;97A:93-102.
13. Griffith LG, Naughton G. Tissue engineering - current challenges and expanding opportunities. Science. 2002;295:1009-1014.
14. Wan ACA, Ying JY. Nanomaterials for in situ cell delivery and tissue regeneration. Adv. Drug Delivery Rev. 2010;62:731-740.
15. Liu B, Liu Y, Lewis AK, Shen W. Modularly assembled porous cell-laden hydrogels. Biomaterials. 2010;31:4918-4925.
16. Badiger MV, McNeill ME, Graham NB. Porogens in the preparation of microporous hydrogels based on poly(ethylene oxides). Biomaterials. 1993;14:1059-1063.
17. Dikovsky D, Bianco-Peled H, Seliktar D. The effect of structural alterations of PEG-fibrinogen hydrogel scaffolds on 3-D cellular morphology and cellular migration. Biomaterials. 2006;27:1496-1506.
18. Peyton SR, Kim PD, Ghajar CM, Seliktar D, Putnam AJ. The effects of matrix stiffness and RhoA on the phenotypic plasticity of smooth muscle cells in a 3-D biosynthetic hydrogel system. Biomaterials. 2008;29:2597-2607.
19. Kim PD, Peyton SR, VanStrien AJ, Putnam AJ. The influence of ascorbic acid, TGF-?1, and cell-mediated remodeling on the bulk mechanical properties of 3-D PEG-fibrinogen constructs. Biomaterials. 2009;30:3854-3864.
20. Frisman I, Seliktar D, Bianco-Peled H. Nanostructuring PEG-fibrinogen hydrogels to control cellular morphogenesis. Biomaterials. 2011;32:7839-7846.
21. Lee AG, Arena CP, Beebe DJ, Palecek SP. Development of macroporous poly(ethylene glycol) hydrogel arrays within microfluidic channels. Biomacromolecules. 2010;11:3316-3324.
22. Almany L, Seliktar D. Biosynthetic hydrogel scaffolds made from fibrinogen and polyethylene. Biomaterials. 2005;26:2467-2477.
23. Mironi-Harpaz I, Wang DY, Venkatraman S, Seliktar D. Photopolymerization of cell-encapsulating hydrogels: crosslinking efficiency versus cytotoxicity. Acta Biomater. 2012;8:1838-1848.
24. Stites J, Wessels D, Uhl, Egelhoff T, Shutt D, Soll DR. Phosphorylation of the dictyostelium myosin II heavy chain is necessary for maintaining cellular polarity and suppressing turning during chemotaxis. Cell Motil. Cytoskeleton. 1998;39:31-51.
25. Shapira-Schweitzer K, Seliktar D. Matrix stiffness affects spontaneous contraction of cardiomyocytes cultured within a PEGylated fibrinogen biomaterial. Acta Biomater. 2007;3:33-41.
26. Dikovsky D, Bianco-Peled H, Seliktar D. Defining the role of matrix compliance and proteolysis in three-dimensional cell spreading and remodeling. Biophys. J. 2008;94:2914-2925.
27. Elbert DL. Liquid-liquid two-phase systems for the production of porous hydrogels and hydrogel microspheres for biomedical applications: a tutorial review. Acta Biomater. 2011;7:31-56.
28. Nicodemus GD, Bryant SJ. Cell encapsulation in biodegradable hydrogels for tissue engineering applications. Tissue Eng. Part B: Rev. 2008;14:149-165.