High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat

Nature

Volumn 499, Issue 7458, 2013, Pages 346-349

  Tian, Xiao ^a   Azpurua, Jorge ^a   Hine, Christopher ^a   Vaidya, Amita ^a   Myakishev Rempel, Max ^a   Ablaeva, Julia ^a   Mao, Zhiyong ^a,b   Nevo, Eviatar ^c   Gorbunova, Vera ^a   Seluanov, Andrei ^a  

^a UNIVERSITY OF ROCHESTER   (United States)

^b TONGJI UNIVERSITY   (China)

^c UNIVERSITY OF HAIFA   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

HERMES ANTIGEN; HYALURONIC ACID;

CANCER; DISEASE RESISTANCE; ELASTICITY; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC VARIATION; RODENT; SIGNALING; SKIN;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOACCUMULATION; BODY MASS; CANCER RESISTANCE; CONTROLLED STUDY; ELASTICITY; FIBROBLAST; FLOW CYTOMETRY; LIFESPAN; MALIGNANT TRANSFORMATION; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; RAT; SIGNAL TRANSDUCTION; SKIN SECRETION;

AMINO ACID SEQUENCE; ANIMALS; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; CONTACT INHIBITION; DISEASE RESISTANCE; FIBROBLASTS; GLUCURONOSYLTRANSFERASE; GUINEA PIGS; HUMANS; HYALURONIC ACID; MICE; MOLE RATS; MOLECULAR SEQUENCE DATA;

HETEROCEPHALUS GLABER; MUS; MUS MUSCULUS; RODENTIA;

EID: 84880508209     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12234     Document Type: Article

References (21)

1. Buffenstein, R.&Jarvis, J. U. The nakedmole rat-a newrecord for the oldest living rodent. Sci. Aging Knowl. Environ. 2002, pe7 (2002).
2. Buffenstein, R. Negligible senescence in the longest living rodent, the nakedmolerat: insights from a successfully aging species. J. Comp. Physiol. B 178, 439-445 (2008).
3. Kim, E. B. et al. Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature 479, 223-227 (2011).
4. Turturro, A. et al. Growth curves and survival characteristics of the animals used in the Biomarkers of Aging Program. J. Gerontol. A 54, B492-B501 (1999).
5. de Magalhaes, J. P., Costa, J. & Toussaint, O. HAGR: the Human Ageing Genomic Resources. Nucleic Acids Res. 33, D537-D543 (2005).
6. Delaney, M. A., Nagy, L., Kinsel, M. J. & Treuting, P. M. Spontaneous histologic lesions of the adult naked mole rat (Heterocephalus glaber): A retrospective survey of lesions in a zoo population. Vet. Pathol. http://dx.doi.org/10.1177/0300985812471543 (2013).
7. Seluanov, A. et al. Hypersensitivity to contact inhibition provides a clue to cancer resistance of nakedmole-rat. Proc. Natl Acad. Sci. USA 106, 19352-19357 (2009).
8. Abercrombie, M. Contact inhibitionandmalignancy. Nature 281, 259-262 (1979).
9. Toole, B. P. Hyaluronan: from extracellular glue to pericellular cue. Nature Rev. Cancer 4, 528-539 (2004).
10. Kothapalli, D. et al. Hyaluronan and CD44 antagonize mitogen-dependent cyclin D1 expression in mesenchymal cells. J. Cell Biol. 176, 535-544 (2007).
11. Puré, E. & Assoian, R. K. Rheostatic signaling by CD44 and hyaluronan. Cell. Signal. 21, 651-655 (2009).
12. Holmes, M. W., Bayliss, M. T. & Muir, H. Hyaluronic acid in human articular cartilage. Age-related changes in content and size. Biochem. J. 250, 435-441 (1988).
13. Jiang, D., Liang, J. & Noble, P. W. Hyaluronan in tissue injury and repair. Annu. Rev. Cell Dev. Biol. 23, 435-461 (2007).
14. Watanabe, K. & Yamaguchi, Y. Molecular identification of a putative human hyaluronan synthase. J. Biol. Chem. 271, 22945-22948 (1996).
15. Stern, R. & Jedrzejas, M. J. Hyaluronidases: their genomics, structures, and mechanisms of action. Chem. Rev. 106, 818-839 (2006).
16. Ponta, H., Sherman, L. & Herrlich, P. A. CD44: from adhesion molecules to signalling regulators. Nature Rev. Mol. Cell Biol. 4, 33-45 (2003).
17. Morrison, H. et al. The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44. Genes Dev. 15, 968-980 (2001).
18. Hahn, W. C. et al. Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Mol. Cell. Biol. 22, 2111-2123 (2002).
19. Rangarajan, A., Hong, S. J., Gifford, A. & Weinberg, R. A. Species- and cell type-specific requirements for cellular transformation. Cancer Cell 6, 171-183 (2004).
20. Liang, S.,Mele, J.,Wu, Y., Buffenstein, R.&Hornsby, P. J. Resistance to experimental tumorigenesis in cells of a long-lived mammal, the naked mole-rat (Heterocephalus glaber). Aging Cell 9, 626-635 (2010).
21. Lee, H. G. & Cowman, M. K. An agarose gel electrophoretic method for analysis of hyaluronanmolecular weight distribution. Anal. Biochem. 219, 278-287 (1994).