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Volumn 13, Issue 2, 2017, Pages 100-109

Leptin in the interplay of inflammation, metabolism and immune system disorders

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; LEPTIN RECEPTOR;

EID: 85008312137     PISSN: 17594790     EISSN: 17594804     Source Type: Journal    
DOI: 10.1038/nrrheum.2016.209     Document Type: Review
Times cited : (381)

References (133)
  • 1
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang Y, et al. Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425-432 (1994).
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1
  • 2
    • 18144408371 scopus 로고    scopus 로고
    • Adipose tissue, adipokines, and inflammation
    • Fantuzzi G. Adipose tissue, adipokines, and inflammation. J. Allergy Clin. Immunol. 115, 911-919 (2005).
    • (2005) J. Allergy Clin. Immunol , vol.115 , pp. 911-919
    • Fantuzzi, G.1
  • 3
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-Alpha: Direct role in obesity-linked insulin resistance
    • Hotamisligil G. S, Shargill N. S, & Spiegelman B. M. Adipose expression of tumor necrosis factor-Alpha: direct role in obesity-linked insulin resistance. Science 259, 87-91 (1993).
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 4
    • 0033782028 scopus 로고    scopus 로고
    • Leptin in the regulation of immunity, inflammation, and hematopoiesis
    • Fantuzzi G, & Faggioni R. Leptin in the regulation of immunity, inflammation, and hematopoiesis. J. Leukoc. Biol. 68, 437-446 (2000).
    • (2000) J. Leukoc. Biol , vol.68 , pp. 437-446
    • Fantuzzi, G.1    Faggioni, R.2
  • 6
    • 30344486078 scopus 로고    scopus 로고
    • Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: Synergistic effect of leptin with interleukin 1
    • Otero M, Lago R, Lago F, Reino J. J. G, & Gualillo O. Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin 1. Arthritis Res. Ther. 7, 581-591 (2005).
    • (2005) Arthritis Res. Ther , vol.7 , pp. 581-591
    • Otero, M.1    Lago, R.2    Lago, F.3    Reino, J.J.G.4    Gualillo, O.5
  • 7
    • 33748992313 scopus 로고    scopus 로고
    • Adipocytokines: Mediators linking adipose tissue, inflammation and immunity
    • Tilg H, & Moschen A. R. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat. Rev. Immunol. 6, 772-783 (2006).
    • (2006) Nat. Rev. Immunol , vol.6 , pp. 772-783
    • Tilg, H.1    Moschen, A.R.2
  • 9
    • 34249983235 scopus 로고    scopus 로고
    • The emerging role of adipokines as mediators of inflammation and immune responses
    • Lago F, Dieguez C, Gómez-Reino J, & Gualillo O. The emerging role of adipokines as mediators of inflammation and immune responses. Cytokine Growth Factor Rev. 18, 313-325 (2007).
    • (2007) Cytokine Growth Factor Rev , vol.18 , pp. 313-325
    • Lago, F.1    Dieguez, C.2    Gómez-Reino, J.3    Gualillo, O.4
  • 10
    • 30044434035 scopus 로고    scopus 로고
    • Intracellular signalling pathways activated by leptin
    • Frühbeck G. Intracellular signalling pathways activated by leptin. Biochem. J. 393, 7-20 (2006).
    • (2006) Biochem. J , vol.393 , pp. 7-20
    • Frühbeck, G.1
  • 12
    • 84866764462 scopus 로고    scopus 로고
    • Leptin a neuroendocrine mediator of immune responses, inflammation, and sickness behaviors
    • Carlton E. D, Demas G. E, & French S. S. Leptin, a neuroendocrine mediator of immune responses, inflammation, and sickness behaviors. Horm. Behav. 62, 272-279 (2012).
    • (2012) Horm. Behav , vol.62 , pp. 272-279
    • Carlton, E.D.1    Demas, G.E.2    French, S.S.3
  • 13
    • 2442618838 scopus 로고    scopus 로고
    • The weight of leptin in immunity
    • La Cava A, & Matarese G. The weight of leptin in immunity. Nat. Rev. Immunol. 4, 371-379 (2004).
    • (2004) Nat. Rev. Immunol , vol.4 , pp. 371-379
    • La Cava, A.1    Matarese, G.2
  • 14
    • 84907882182 scopus 로고    scopus 로고
    • 20 years of leptin: Role of leptin in energy homeostasis in humans
    • Rosenbaum M, & Leibel R. L. 20 years of leptin: role of leptin in energy homeostasis in humans. J. Endocrinol. 223, T83-T96 (2014).
    • (2014) J. Endocrinol , vol.223 , pp. T83-T96
    • Rosenbaum, M.1    Leibel, R.L.2
  • 15
    • 0036969502 scopus 로고    scopus 로고
    • Effects of sex steroid hormones and menopause on serum leptin concentrations
    • Di Carlo C, Tommaselli G. A, & Nappi C. Effects of sex steroid hormones and menopause on serum leptin concentrations. Gynecol. Endocrinol. 16, 479-491 (2002).
    • (2002) Gynecol. Endocrinol , vol.16 , pp. 479-491
    • Di Carlo, C.1    Tommaselli, G.A.2    Nappi, C.3
  • 16
    • 0034613023 scopus 로고    scopus 로고
    • Elevated serum leptin concentrations induced by experimental acute inflammation
    • Gualillo O, Eiras S, Lago F, Diéguez C, & Casanueva F. F. Elevated serum leptin concentrations induced by experimental acute inflammation. Life Sci. 67, 2433-2441 (2000).
    • (2000) Life Sci , vol.67 , pp. 2433-2441
    • Gualillo, O.1    Eiras, S.2    Lago, F.3    Diéguez, C.4    Casanueva, F.F.5
  • 17
    • 84866171025 scopus 로고    scopus 로고
    • Alterations of leptin in the course of inflammation and severe sepsis
    • Behnes M, et al. Alterations of leptin in the course of inflammation and severe sepsis. BMC Infect. Dis. 12, 217 (2012).
    • (2012) BMC Infect. Dis , vol.12 , pp. 217
    • Behnes, M.1
  • 18
    • 84944441862 scopus 로고    scopus 로고
    • 20 years of leptin: Role of leptin in cardiomyocyte physiology and physiopathology
    • Feijóo-Bandín S, et al. 20 years of leptin: role of leptin in cardiomyocyte physiology and physiopathology. Life Sci. 140, 10-18 (2015).
    • (2015) Life Sci , vol.140 , pp. 10-18
    • Feijóo-Bandín, S.1
  • 19
    • 84907870320 scopus 로고    scopus 로고
    • 20 years of leptin: Role of leptin in human reproductive disorders
    • Chou S. H, & Mantzoros C. 20 years of leptin: role of leptin in human reproductive disorders. J. Endocrinol. 223, T49-62 (2014).
    • (2014) J. Endocrinol , vol.223 , pp. T49-T62
    • Chou, S.H.1    Mantzoros, C.2
  • 20
    • 84906044365 scopus 로고    scopus 로고
    • An update on leptin as immunomodulator
    • Conde J, et al. An update on leptin as immunomodulator. Expert Rev. Clin. Immunol. 10, 1165-1170 (2014).
    • (2014) Expert Rev. Clin. Immunol , vol.10 , pp. 1165-1170
    • Conde, J.1
  • 21
    • 84896402811 scopus 로고    scopus 로고
    • Adipokines as drug targets in joint and bone disease
    • Scotece M, et al. Adipokines as drug targets in joint and bone disease. Drug Discov. Today http://dx.doi. org/10.1016/j.drudis.2013.07.012 (2013).
    • (2013) Drug Discov. Today
    • Scotece, M.1
  • 22
    • 80052409973 scopus 로고    scopus 로고
    • What?s new in our understanding of the role of adipokines in rheumatic diseases?
    • Gez R, et al. What?s new in our understanding of the role of adipokines in rheumatic diseases?. Nat. Rev. Rheumatol. 7, 528-536 (2011).
    • (2011) Nat. Rev. Rheumatol , vol.7 , pp. 528-536
    • Gez, R.1
  • 23
    • 84878985298 scopus 로고    scopus 로고
    • The effects of bariatric surgery weight loss on knee pain in patients with osteoarthritis of the knee
    • Edwards C, et al. The effects of bariatric surgery weight loss on knee pain in patients with osteoarthritis of the knee. Arthritis 2012, 504189 (2012).
    • (2012) Arthritis , vol.2012 , pp. 504189
    • Edwards, C.1
  • 25
    • 77950302564 scopus 로고    scopus 로고
    • Association between weight or body mass index and hand osteoarthritis: A systematic review
    • Yusuf E, et al. Association between weight or body mass index and hand osteoarthritis: a systematic review. Ann. Rheum. Dis. 69, 761-765 (2010).
    • (2010) Ann. Rheum. Dis , vol.69 , pp. 761-765
    • Yusuf, E.1
  • 26
    • 54949121316 scopus 로고    scopus 로고
    • Obesity and osteoarthritis in knee, hip and/or hand: An epidemiological study in the general population with 10 years follow up
    • Grotle M, Hagen K. B, Natvig B, Dahl F. A, & Kvien T. K. Obesity and osteoarthritis in knee, hip and/or hand: an epidemiological study in the general population with 10 years follow up. BMC Musculoskelet. Disord. 9, 132 (2008).
    • (2008) BMC Musculoskelet. Disord , vol.9 , pp. 132
    • Grotle, M.1    Hagen, K.B.2    Natvig, B.3    Dahl, F.A.4    Kvien, T.K.5
  • 27
    • 0031857341 scopus 로고    scopus 로고
    • T cells and T cell cytokine transcripts in the synovial membrane in patients with osteoarthritis
    • Sakkas L. I, et al. T cells and T cell cytokine transcripts in the synovial membrane in patients with osteoarthritis. Clin. Diagn. Lab. Immunol. 5, 430-437 (1998).
    • (1998) Clin. Diagn. Lab. Immunol , vol.5 , pp. 430-437
    • Sakkas, L.I.1
  • 29
    • 0036255913 scopus 로고    scopus 로고
    • Characterization of infiltrating T cells and Th1/Th2 type cytokines in the synovium of patients with osteoarthritis
    • Ishii H, et al. Characterization of infiltrating T cells and Th1/Th2 type cytokines in the synovium of patients with osteoarthritis. Osteoarthritis Cartilage 10, 277-281 (2002).
    • (2002) Osteoarthritis Cartilage , vol.10 , pp. 277-281
    • Ishii, H.1
  • 30
    • 0036431034 scopus 로고    scopus 로고
    • Impaired natural killer (NK) cell activity in leptin receptor deficient mice: Leptin as a critical regulator in NK cell development and activation
    • Tian Z, Sun R, Wei H, & Gao B. Impaired natural killer (NK) cell activity in leptin receptor deficient mice: leptin as a critical regulator in NK cell development and activation. Biochem. Biophys. Res. Commun. 298, 297-302 (2002).
    • (2002) Biochem. Biophys. Res. Commun , vol.298 , pp. 297-302
    • Tian, Z.1    Sun, R.2    Wei, H.3    Gao, B.4
  • 31
    • 0037427522 scopus 로고    scopus 로고
    • Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines
    • Zhao Y, Sun R, You L, Gao C, & Tian Z. Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines. Biochem. Biophys. Res. Commun. 300, 247-252 (2003).
    • (2003) Biochem. Biophys. Res. Commun , vol.300 , pp. 247-252
    • Zhao, Y.1    Sun, R.2    You, L.3    Gao, C.4    Tian, Z.5
  • 32
    • 46349104319 scopus 로고    scopus 로고
    • Resistance of Janus kinase 2 dependent leptin signaling in natural killer (NK) cells: A novel mechanism of NK cell dysfunction in diet-induced obesity
    • Nave H, et al. Resistance of Janus kinase 2 dependent leptin signaling in natural killer (NK) cells: a novel mechanism of NK cell dysfunction in diet-induced obesity. Endocrinology 149, 3370-3378 (2008).
    • (2008) Endocrinology , vol.149 , pp. 3370-3378
    • Nave, H.1
  • 33
    • 70350776515 scopus 로고    scopus 로고
    • Leptin signaling protects NK cells from apoptosis during development in mouse bone marrow
    • Lo C. K. C, et al. Leptin signaling protects NK cells from apoptosis during development in mouse bone marrow. Cell. Mol. Immunol. 6, 353-360 (2009).
    • (2009) Cell. Mol. Immunol , vol.6 , pp. 353-360
    • Lo, C.K.C.1
  • 34
    • 84974578446 scopus 로고    scopus 로고
    • Altered NK cell function in obese healthy humans
    • Laue T, et al. Altered NK cell function in obese healthy humans. BMC Obes. 2, 1 (2015).
    • (2015) BMC Obes , vol.2 , pp. 1
    • Laue, T.1
  • 35
    • 83455198332 scopus 로고    scopus 로고
    • Short-Term and long-Term leptin exposure differentially affect human natural killer cell immune functions
    • Wrann C. D, et al. Short-Term and long-Term leptin exposure differentially affect human natural killer cell immune functions. Am. J. Physiol. Endocrinol. Metab. 302, E108-E116 (2012).
    • (2012) Am. J. Physiol. Endocrinol. Metab , vol.302 , pp. E108-E116
    • Wrann, C.D.1
  • 36
    • 84874220772 scopus 로고    scopus 로고
    • Leptin modulates dose-dependently the metabolic and cytolytic activities of NK 92 cells
    • Lamas B, et al. Leptin modulates dose-dependently the metabolic and cytolytic activities of NK 92 cells. J. Cell. Physiol. 228, 1202-1209 (2013).
    • (2013) J. Cell. Physiol , vol.228 , pp. 1202-1209
    • Lamas, B.1
  • 37
    • 84946492239 scopus 로고    scopus 로고
    • Decreased NK cell functions in obesity can be reactivated by fat mass reduction
    • Jahn J, et al. Decreased NK cell functions in obesity can be reactivated by fat mass reduction. Obes. (Silver Spring). 23, 2233-2241 (2015).
    • (2015) Obes. (Silver Spring , vol.23 , pp. 2233-2241
    • Jahn, J.1
  • 38
    • 0035109175 scopus 로고    scopus 로고
    • Leptin: A potential regulator of polymorphonuclear neutrophil bactericidal action?
    • Caldefie-Chezet F, Poulin A, Tridon A, Sion B, & Vasson M. P. Leptin: a potential regulator of polymorphonuclear neutrophil bactericidal action?. J. Leukoc. Biol. 69, 414-418 (2001).
    • (2001) J. Leukoc. Biol , vol.69 , pp. 414-418
    • Caldefie-Chezet, F.1    Poulin, A.2    Tridon, A.3    Sion, B.4    Vasson, M.P.5
  • 39
    • 1642525689 scopus 로고    scopus 로고
    • Leptin indirectly activates human neutrophils via induction of TNF-α
    • Zarkesh-Esfahani H, et al. Leptin indirectly activates human neutrophils via induction of TNF-α. J. Immunol. 172, 1809-1814 (2004).
    • (2004) J. Immunol , vol.172 , pp. 1809-1814
    • Zarkesh-Esfahani, H.1
  • 40
    • 0031436148 scopus 로고    scopus 로고
    • Divergent signaling capacities of the long and short isoforms of the leptin receptor
    • Bjorbaek C, Uotani S, da Silva B, & Flier J. S. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J. Biol. Chem. 272, 32686-32695 (1997).
    • (1997) J. Biol. Chem , vol.272 , pp. 32686-32695
    • Bjorbaek, C.1    Uotani, S.2    Da Silva, B.3    Flier, J.S.4
  • 41
    • 0043198155 scopus 로고    scopus 로고
    • Leptin regulates functional capacities of polymorphonuclear neutrophils
    • Caldefie-Chezet F, Poulin A, & Vasson M. P. Leptin regulates functional capacities of polymorphonuclear neutrophils. Free Radic. Res. 37, 809-814 (2003).
    • (2003) Free Radic. Res , vol.37 , pp. 809-814
    • Caldefie-Chezet, F.1    Poulin, A.2    Vasson, M.P.3
  • 42
    • 33745624549 scopus 로고    scopus 로고
    • Induction of neutrophil chemotaxis by leptin: Crucial role for p38 and Src kinases
    • Montecucco F, et al. Induction of neutrophil chemotaxis by leptin: crucial role for p38 and Src kinases. Ann. NY Acad. Sci. 1069, 463-471 (2006).
    • (2006) Ann. NY Acad. Sci , vol.1069 , pp. 463-471
    • Montecucco, F.1
  • 43
    • 20444403798 scopus 로고    scopus 로고
    • Apoptotic pathways are inhibited by leptin receptor activation in neutrophils
    • Bruno A, Conus S, Schmid I, & Simon H. U. Apoptotic pathways are inhibited by leptin receptor activation in neutrophils. J. Immunol. 174, 8090-8096 (2005).
    • (2005) J. Immunol , vol.174 , pp. 8090-8096
    • Bruno, A.1    Conus, S.2    Schmid, I.3    Simon, H.U.4
  • 44
    • 84873186320 scopus 로고    scopus 로고
    • Leptin inhibits neutrophil apoptosis in children via ERK/.NF ?B dependent pathways
    • Sun Z, Dragon S, Becker A, & Gounni A. S. Leptin inhibits neutrophil apoptosis in children via ERK/.NF ?B dependent pathways. PLoS ONE 8, e55249 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e55249
    • Sun, Z.1    Dragon, S.2    Becker, A.3    Gounni, A.S.4
  • 45
    • 84884180175 scopus 로고    scopus 로고
    • Physiological concentrations of leptin do not affect human neutrophils
    • Kamp V. M, et al. Physiological concentrations of leptin do not affect human neutrophils. PLoS ONE 8, e73170 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e73170
    • Kamp, V.M.1
  • 46
    • 84880449036 scopus 로고    scopus 로고
    • A high-fat diet increases interleukin 3 and granulocyte colony-stimulating factor production by bone marrow cells and triggers bone marrow hyperplasia and neutrophilia in Wistar rats
    • do Carmo L. S, et al. A high-fat diet increases interleukin 3 and granulocyte colony-stimulating factor production by bone marrow cells and triggers bone marrow hyperplasia and neutrophilia in Wistar rats. Exp. Biol. Med. (Maywood). 238, 375-384 (2013).
    • (2013) Exp. Biol. Med. (Maywood , vol.238 , pp. 375-384
    • Do Carmo, L.S.1
  • 47
    • 84930413869 scopus 로고    scopus 로고
    • Neutrophil functions in morbidly obese subjects
    • Brotfain E, et al. Neutrophil functions in morbidly obese subjects. Clin. Exp. Immunol. 181, 156-163 (2015).
    • (2015) Clin. Exp. Immunol , vol.181 , pp. 156-163
    • Brotfain, E.1
  • 49
    • 79951852559 scopus 로고    scopus 로고
    • Leptin has a priming effect on eotaxin-induced human eosinophil chemotaxis
    • Kato H, et al. Leptin has a priming effect on eotaxin-induced human eosinophil chemotaxis. Int. Arch. Allergy Immunol. 155, 335-344 (2011).
    • (2011) Int. Arch. Allergy Immunol , vol.155 , pp. 335-344
    • Kato, H.1
  • 50
    • 34547860034 scopus 로고    scopus 로고
    • Leptin-mediated cytokine release and migration of eosinophils: Implications for immunopathophysiology of allergic inflammation
    • Wong C. K, Cheung P. F. Y, & Lam C. W. K. Leptin-mediated cytokine release and migration of eosinophils: implications for immunopathophysiology of allergic inflammation. Eur. J. Immunol. 37, 2337-2348 (2007).
    • (2007) Eur. J. Immunol , vol.37 , pp. 2337-2348
    • Wong, C.K.1    Cheung, P.F.Y.2    Lam, C.W.K.3
  • 51
    • 79955526579 scopus 로고    scopus 로고
    • Leptin enhances survival and induces migration, degranulation, and cytokine synthesis of human basophils
    • Suzukawa M, et al. Leptin enhances survival and induces migration, degranulation, and cytokine synthesis of human basophils. J. Immunol. 186, 5254-5260 (2011).
    • (2011) J. Immunol , vol.186 , pp. 5254-5260
    • Suzukawa, M.1
  • 52
    • 0034534905 scopus 로고    scopus 로고
    • Expression of the long and short leptin receptor isoforms in peripheral blood mononuclear cells: Implications for leptin?s actions
    • Tsiotra P. C, Pappa V, Raptis S. A, & Tsigos C. Expression of the long and short leptin receptor isoforms in peripheral blood mononuclear cells: implications for leptin?s actions. Metabolism. 49, 1537-1541 (2000).
    • (2000) Metabolism , vol.49 , pp. 1537-1541
    • Tsiotra, P.C.1    Pappa, V.2    Raptis, S.A.3    Tsigos, C.4
  • 53
    • 0035039275 scopus 로고    scopus 로고
    • Insulin and leptin acutely regulate cholesterol ester metabolism in macrophages by novel signaling pathways
    • O?Rourke L, Yeaman S. J, & Shepherd P. R. Insulin and leptin acutely regulate cholesterol ester metabolism in macrophages by novel signaling pathways. Diabetes 50, 955-961 (2001).
    • (2001) Diabetes , vol.50 , pp. 955-961
    • O'Rourke, L.1    Yeaman, S.J.2    Shepherd, P.R.3
  • 54
    • 0033602850 scopus 로고    scopus 로고
    • Human leptin stimulates proliferation and activation of human circulating monocytes
    • Santos-Alvarez J, Goberna R, & Schez-Margalet V. Human leptin stimulates proliferation and activation of human circulating monocytes. Cell. Immunol. 194, 6-11 (1999).
    • (1999) Cell. Immunol , vol.194 , pp. 6-11
    • Santos-Alvarez, J.1    Goberna, R.2    Schez-Margalet, V.3
  • 55
    • 77956544806 scopus 로고    scopus 로고
    • At the crossroad between immunity and metabolism: Focus on leptin
    • Conde J, et al. At the crossroad between immunity and metabolism: focus on leptin. Expert Rev. Clin. Immunol. 6, 801-808 (2010).
    • (2010) Expert Rev. Clin. Immunol , vol.6 , pp. 801-808
    • Conde, J.1
  • 56
    • 84857827167 scopus 로고    scopus 로고
    • Haematopoietic leptin receptor deficiency does not affect macrophage accumulation in adipose tissue or systemic insulin sensitivity
    • Gutierrez D. A, & Hasty A. H. Haematopoietic leptin receptor deficiency does not affect macrophage accumulation in adipose tissue or systemic insulin sensitivity. J. Endocrinol. 212, 343-351 (2012).
    • (2012) J. Endocrinol , vol.212 , pp. 343-351
    • Gutierrez, D.A.1    Hasty, A.H.2
  • 57
    • 84874585039 scopus 로고    scopus 로고
    • High insulin and leptin increase resistin and inflammatory cytokine production from human mononuclear cells
    • Tsiotra P. C, Boutati E, Dimitriadis G, & Raptis S. A. High insulin and leptin increase resistin and inflammatory cytokine production from human mononuclear cells. Biomed. Res. Int. 2013, 487081 (2013).
    • (2013) Biomed. Res. Int , vol.2013 , pp. 487081
    • Tsiotra, P.C.1    Boutati, E.2    Dimitriadis, G.3    Raptis, S.A.4
  • 58
    • 84892486282 scopus 로고    scopus 로고
    • Leptin enhances the secretion of interleukin (IL)-18, but not IL 1β, from human monocytes via activation of caspase 1
    • Jitprasertwong P, Jaedicke K. M, Nile C. J, Preshaw P. M, & Taylor J. J. Leptin enhances the secretion of interleukin (IL)-18, but not IL 1β, from human monocytes via activation of caspase 1. Cytokine 65, 222-230 (2014).
    • (2014) Cytokine , vol.65 , pp. 222-230
    • Jitprasertwong, P.1    Jaedicke, K.M.2    Nile, C.J.3    Preshaw, P.M.4    Taylor, J.J.5
  • 60
    • 84875670302 scopus 로고    scopus 로고
    • Leptin up regulates TLR2 in human monocytes
    • Jaedicke K. M, et al. Leptin up regulates TLR2 in human monocytes. J. Leukoc. Biol. 93, 561-571 (2013).
    • (2013) J. Leukoc. Biol , vol.93 , pp. 561-571
    • Jaedicke, K.M.1
  • 61
    • 84879189907 scopus 로고    scopus 로고
    • Participation of leptin in the determination of the macrophage phenotype: An additional role in adipocyte and macrophage crosstalk
    • Acedo S. C, Gambero S, Cunha F. G. P, Lorand-Metze I, & Gambero A. Participation of leptin in the determination of the macrophage phenotype: an additional role in adipocyte and macrophage crosstalk. In Vitro Cell. Dev. Biol. Anim. 49, 473-478 (2013).
    • (2013) Vitro Cell. Dev. Biol. Anim , vol.49 , pp. 473-478
    • Acedo, S.C.1    Gambero, S.2    Cunha, F.G.P.3    Lorand-Metze, I.4    Gambero, A.5
  • 62
    • 84902295194 scopus 로고    scopus 로고
    • Leptin-mediated increases in catecholamine signaling reduce adipose tissue inflammation via activation of macrophage HDAC4
    • Luan B, et al. Leptin-mediated increases in catecholamine signaling reduce adipose tissue inflammation via activation of macrophage HDAC4. Cell Metab. 19, 1058-1065 (2014).
    • (2014) Cell Metab , vol.19 , pp. 1058-1065
    • Luan, B.1
  • 63
    • 84951823798 scopus 로고    scopus 로고
    • Leptin deficiency shifts mast cells toward anti-inflammatory actions and protects mice from obesity and diabetes by polarizing M2 macrophages
    • Zhou Y, et al. Leptin deficiency shifts mast cells toward anti-inflammatory actions and protects mice from obesity and diabetes by polarizing M2 macrophages. Cell Metab. 22, 1045-1058 (2015).
    • (2015) Cell Metab , vol.22 , pp. 1045-1058
    • Zhou, Y.1
  • 64
    • 44849120407 scopus 로고    scopus 로고
    • Apoptosis in the pathogenesis of systemic lupus erythematosus
    • Munoz L. E, et al. Apoptosis in the pathogenesis of systemic lupus erythematosus. Lupus 17, 371-375 (2008).
    • (2008) Lupus , vol.17 , pp. 371-375
    • Munoz, L.E.1
  • 65
    • 84912036032 scopus 로고    scopus 로고
    • Leptin enhances availability of apoptotic cell-derived self-Antigen in systemic lupus erythematosus
    • Amarilyo G, Iikuni N, Liu A, Matarese G, & La Cava A. Leptin enhances availability of apoptotic cell-derived self-Antigen in systemic lupus erythematosus. PLoS ONE 9, e112826 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e112826
    • Amarilyo, G.1    Iikuni, N.2    Liu, A.3    Matarese, G.4    La Cava, A.5
  • 66
    • 84947618707 scopus 로고    scopus 로고
    • Hyperleptinemia suppresses aggravation of arthritis of collagen-Antibody-induced arthritis in mice
    • Okano T, et al. Hyperleptinemia suppresses aggravation of arthritis of collagen-Antibody-induced arthritis in mice. J. Orthop. Sci. 20, 1106-1113 (2015).
    • (2015) J. Orthop. Sci , vol.20 , pp. 1106-1113
    • Okano, T.1
  • 67
    • 84931840791 scopus 로고    scopus 로고
    • Effect of inhibition of interleukin 12/23 by ustekinumab on the expression of leptin and leptin receptor in human THP 1 macrophages
    • Voloshyna I, Mounessa J, Carsons S. E, & Reiss A. B. Effect of inhibition of interleukin 12/23 by ustekinumab on the expression of leptin and leptin receptor in human THP 1 macrophages. Clin. Exp. Dermatol. 41, 308-311 (2016).
    • (2016) Clin. Exp. Dermatol , vol.41 , pp. 308-311
    • Voloshyna, I.1    Mounessa, J.2    Carsons, S.E.3    Reiss, A.B.4
  • 68
    • 84921458812 scopus 로고    scopus 로고
    • Establishment And characterization of DB 1: A leptin receptor-deficient murine macrophage cell line
    • Dib L. H, Ortega M. T, Melgarejo T, & Chapes S. K. Establishment and characterization of DB 1: a leptin receptor-deficient murine macrophage cell line. Cytotechnology http://dx.doi.org/10.1007/.s10616 015 9843 3 (2015).
    • (2015) Cytotechnology
    • Dib, L.H.1    Ortega, M.T.2    Melgarejo, T.3    Chapes, S.K.4
  • 69
    • 18944364947 scopus 로고    scopus 로고
    • Leptin promotes differentiation and survival of human dendritic cells and licenses them for Th1 priming
    • Mattioli B, Straface E, Quaranta M. G, Giordani L, & Viora M. Leptin promotes differentiation and survival of human dendritic cells and licenses them for Th1 priming. J. Immunol. 174, 6820-6828 (2005).
    • (2005) J. Immunol , vol.174 , pp. 6820-6828
    • Mattioli, B.1    Straface, E.2    Quaranta, M.G.3    Giordani, L.4    Viora, M.5
  • 70
    • 33845566273 scopus 로고    scopus 로고
    • Involvement of leptin signaling in the survival and maturation of bone marrow-derived dendritic cells
    • Lam Q. L. K, Liu S, Cao X, & Lu L. Involvement of leptin signaling in the survival and maturation of bone marrow-derived dendritic cells. Eur. J. Immunol. 36, 3118-3130 (2006).
    • (2006) Eur. J. Immunol , vol.36 , pp. 3118-3130
    • Lam, Q.L.K.1    Liu, S.2    Cao, X.3    Lu, L.4
  • 71
    • 62849114121 scopus 로고    scopus 로고
    • Leptin exerts an anti-Apoptotic effect on human dendritic cells via the PI3K Akt signaling pathway
    • Mattioli B, Giordani L, Quaranta M. G, & Viora M. Leptin exerts an anti-Apoptotic effect on human dendritic cells via the PI3K Akt signaling pathway. FEBS Lett. 583, 1102-1106 (2009).
    • (2009) FEBS Lett , vol.583 , pp. 1102-1106
    • Mattioli, B.1    Giordani, L.2    Quaranta, M.G.3    Viora, M.4
  • 72
    • 84879350349 scopus 로고    scopus 로고
    • A mechanistic role for leptin in human dendritic cell migration: Differences between ileum and colon in health and Crohn?s disease
    • Al Hassi H. O, et al. A mechanistic role for leptin in human dendritic cell migration: differences between ileum and colon in health and Crohn?s disease. Mucosal Immunol. 6, 751-761 (2013).
    • (2013) Mucosal Immunol , vol.6 , pp. 751-761
    • Al Hassi, H.O.1
  • 73
    • 44949172568 scopus 로고    scopus 로고
    • Leptin as an immunological adjuvant: Enhanced migratory and CD8+ T cell stimulatory capacity of human dendritic cells exposed to leptin
    • Mattioli B, et al. Leptin as an immunological adjuvant: enhanced migratory and CD8+ T cell stimulatory capacity of human dendritic cells exposed to leptin. FASEB J. 22, 2012-2022 (2008).
    • (2008) FASEB J , vol.22 , pp. 2012-2022
    • Mattioli, B.1
  • 74
    • 84896053507 scopus 로고    scopus 로고
    • Leptin deficiency impairs maturation of dendritic cells and enhances induction of regulatory T and Th17 cells
    • Moraes-Vieira P. M. M, et al. Leptin deficiency impairs maturation of dendritic cells and enhances induction of regulatory T and Th17 cells. Eur. J. Immunol. 44, 794-806 (2014).
    • (2014) Eur. J. Immunol , vol.44 , pp. 794-806
    • Moraes-Vieira, P.M.M.1
  • 75
    • 84911372986 scopus 로고    scopus 로고
    • Leptin deficiency in vivo enhances the ability of splenic dendritic cells to activate T cells
    • Ramirez O, & Garza K. M. Leptin deficiency in vivo enhances the ability of splenic dendritic cells to activate T cells. Int. Immunol. 26, 627-636 (2014).
    • (2014) Int. Immunol , vol.26 , pp. 627-636
    • Ramirez, O.1    Garza, K.M.2
  • 76
    • 18744435491 scopus 로고    scopus 로고
    • T lymphopenia in obese diabetic (db/db) mice is non-selective and thymus independent
    • Kimura M, et al. T lymphopenia in obese diabetic (db/db) mice is non-selective and thymus independent. Life Sci. 62, 1243-1250 (1998).
    • (1998) Life Sci , vol.62 , pp. 1243-1250
    • Kimura, M.1
  • 77
    • 0032572722 scopus 로고    scopus 로고
    • Leptin modulates the T cell immune response and reverses starvation-induced immunosuppression
    • Lord G. M, et al. Leptin modulates the T cell immune response and reverses starvation-induced immunosuppression. Nature 394, 897-901 (1998).
    • (1998) Nature , vol.394 , pp. 897-901
    • Lord, G.M.1
  • 78
    • 0035838266 scopus 로고    scopus 로고
    • Human leptin signaling in human peripheral blood mononuclear cells: Activation of the JAK-STAT pathway
    • Sanchez-Margalet V, & Martin-Romero C. Human leptin signaling in human peripheral blood mononuclear cells: activation of the JAK-STAT pathway. Cell. Immunol. 211, 30-36 (2001).
    • (2001) Cell. Immunol , vol.211 , pp. 30-36
    • Sanchez-Margalet, V.1    Martin-Romero, C.2
  • 79
    • 33847312289 scopus 로고    scopus 로고
    • A key role of leptin in the control of regulatory T cell proliferation
    • De Rosa V, et al. A key role of leptin in the control of regulatory T cell proliferation. Immunity 26, 241-255 (2007).
    • (2007) Immunity , vol.26 , pp. 241-255
    • De Rosa, V.1
  • 80
    • 0036800760 scopus 로고    scopus 로고
    • Beneficial effects of leptin on obesity T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
    • Farooqi I. S, et al. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J. Clin. Invest. 110, 1093-1103 (2002).
    • (2002) J. Clin. Invest , vol.110 , pp. 1093-1103
    • Farooqi, I.S.1
  • 81
    • 73649112416 scopus 로고    scopus 로고
    • Leptin: A critical regulator of CD4+ T cell polarization in vitro and in vivo
    • Batra A, et al. Leptin: a critical regulator of CD4+ T cell polarization in vitro and in vivo. Endocrinology 151, 56-62 (2010).
    • (2010) Endocrinology , vol.151 , pp. 56-62
    • Batra, A.1
  • 82
    • 77950517397 scopus 로고    scopus 로고
    • Preferential effects of leptin on CD4 T cells in central and peripheral immune system are critically linked to the expression of leptin receptor
    • Kim S. Y, et al. Preferential effects of leptin on CD4 T cells in central and peripheral immune system are critically linked to the expression of leptin receptor. Biochem. Biophys. Res. Commun. 394, 562-568 (2010).
    • (2010) Biochem. Biophys. Res. Commun , vol.394 , pp. 562-568
    • Kim, S.Y.1
  • 84
    • 84908259384 scopus 로고    scopus 로고
    • Leptin modulates autophagy in human CD4+CD25-conventional T cells
    • Cassano S, et al. Leptin modulates autophagy in human CD4+CD25-conventional T cells. Metabolism. 63, 1272-1279 (2014).
    • (2014) Metabolism , vol.63 , pp. 1272-1279
    • Cassano, S.1
  • 85
    • 84866168094 scopus 로고    scopus 로고
    • Leptin-induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4+ effector T cell responses
    • Procaccini C, et al. Leptin-induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4+ effector T cell responses. J. Immunol. 189, 2941-2953 (2012).
    • (2012) J. Immunol , vol.189 , pp. 2941-2953
    • Procaccini, C.1
  • 86
    • 84961238742 scopus 로고    scopus 로고
    • Elevated serum leptin levels in patients with systemic lupus erythematosus
    • Ma L, et al. Elevated serum leptin levels in patients with systemic lupus erythematosus. Pharmazie 70, 720-723 (2015).
    • (2015) Pharmazie , vol.70 , pp. 720-723
    • Ma, L.1
  • 87
    • 84863135746 scopus 로고    scopus 로고
    • Cutting edge: Fasting-induced hypoleptinemia expands functional regulatory T cells in systemic lupus erythematosus
    • Liu Y, Yu Y, Matarese G, & La Cava A. Cutting edge: Fasting-induced hypoleptinemia expands functional regulatory T cells in systemic lupus erythematosus. J. Immunol. 188, 2070-2073 (2012).
    • (2012) J. Immunol , vol.188 , pp. 2070-2073
    • Liu, Y.1    Yu, Y.2    Matarese, G.3    La Cava, A.4
  • 88
    • 84893362864 scopus 로고    scopus 로고
    • Deficient leptin signaling ameliorates systemic lupus erythematosus lesions in MRL/Mp Fas lpr mice
    • Fujita Y, et al. Deficient leptin signaling ameliorates systemic lupus erythematosus lesions in MRL/Mp Fas lpr mice. J. Immunol. 192, 979-984 (2014).
    • (2014) J. Immunol , vol.192 , pp. 979-984
    • Fujita, Y.1
  • 89
    • 85017192383 scopus 로고    scopus 로고
    • Relationship between leptin and regulatory T cells in systemic lupus erythematosus: Preliminary results
    • Margiotta D, et al. Relationship between leptin and regulatory T cells in systemic lupus erythematosus: preliminary results. Eur. Rev. Med. Pharmacol. Sci. 20, 636-641 (2016).
    • (2016) Eur. Rev. Med. Pharmacol. Sci , vol.20 , pp. 636-641
    • Margiotta, D.1
  • 90
    • 84875464349 scopus 로고    scopus 로고
    • Cutting edge: Leptin-induced RORγt expression in CD4+ T cells promotes Th17 responses in systemic lupus erythematosus
    • Yu Y, et al. Cutting edge: Leptin-induced RORγt expression in CD4+ T cells promotes Th17 responses in systemic lupus erythematosus. J. Immunol. 190, 3054-3058 (2013).
    • (2013) J. Immunol , vol.190 , pp. 3054-3058
    • Yu, Y.1
  • 91
    • 84868129089 scopus 로고    scopus 로고
    • Leptin exacerbates collagen-induced arthritis via enhancement of Th17 cell response
    • Deng J, et al. Leptin exacerbates collagen-induced arthritis via enhancement of Th17 cell response. Arthritis Rheum. 64, 3564-3573 (2012).
    • (2012) Arthritis Rheum , vol.64 , pp. 3564-3573
    • Deng, J.1
  • 92
    • 84929649679 scopus 로고    scopus 로고
    • Leptin receptor signaling in T cells is required for Th17 differentiation
    • Reis B. S, et al. Leptin receptor signaling in T cells is required for Th17 differentiation. J. Immunol. 194, 5253-5260 (2015).
    • (2015) J. Immunol , vol.194 , pp. 5253-5260
    • Reis, B.S.1
  • 93
    • 0037080196 scopus 로고    scopus 로고
    • Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis
    • Busso N, et al. Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis. J. Immunol. 168, 875-882 (2002).
    • (2002) J. Immunol , vol.168 , pp. 875-882
    • Busso, N.1
  • 94
    • 0030250892 scopus 로고    scopus 로고
    • A role for leptin and its cognate receptor in hematopoiesis
    • Bennett B. D, et al. A role for leptin and its cognate receptor in hematopoiesis. Curr. Biol. 6, 1170-1180 (1996).
    • (1996) Curr. Biol , vol.6 , pp. 1170-1180
    • Bennett, B.D.1
  • 95
    • 41149162617 scopus 로고    scopus 로고
    • A role for leptin in sustaining lymphopoiesis and myelopoiesis
    • Claycombe K, King L. E, & Fraker P. J. A role for leptin in sustaining lymphopoiesis and myelopoiesis. Proc. Natl Acad. Sci. USA 105, 2017-2021 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 2017-2021
    • Claycombe, K.1    King, L.E.2    Fraker, P.J.3
  • 96
    • 77956373481 scopus 로고    scopus 로고
    • Leptin signaling maintains B cell homeostasis via induction of Bcl 2 and Cyclin D1
    • Lam Q. L. K, Wang S, Ko O. K. H, Kincade P. W, & Lu L. Leptin signaling maintains B cell homeostasis via induction of Bcl 2 and Cyclin D1. Proc. Natl Acad. Sci. USA 107, 13812-13817 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 13812-13817
    • Lam, Q.L.K.1    Wang, S.2    Ko, O.K.H.3    Kincade, P.W.4    Lu, L.5
  • 97
    • 79961167339 scopus 로고    scopus 로고
    • Leptin activates human B cells to secrete TNF α IL 6, and IL 10 via JAK2/STAT3 and p38MAPK/ERK1/2 signaling pathway
    • Agrawal S, Gollapudi S, Su H, & Gupta S. Leptin activates human B cells to secrete TNF α, IL 6, and IL 10 via JAK2/STAT3 and p38MAPK/ERK1/2 signaling pathway. J. Clin. Immunol. 31, 472-478 (2011).
    • (2011) J. Clin. Immunol , vol.31 , pp. 472-478
    • Agrawal, S.1    Gollapudi, S.2    Su, H.3    Gupta, S.4
  • 98
    • 84872534007 scopus 로고    scopus 로고
    • Increased activation and cytokine secretion in B cells stimulated with leptin in aged humans
    • Gupta S, Agrawal S, & Gollapudi S. Increased activation and cytokine secretion in B cells stimulated with leptin in aged humans. Immun. Ageing 10, 3 (2013).
    • (2013) Immun. Ageing , vol.10 , pp. 3
    • Gupta, S.1    Agrawal, S.2    Gollapudi, S.3
  • 99
    • 79958292985 scopus 로고    scopus 로고
    • Role of central leptin signaling in the starvation-induced alteration of B cell development
    • Tanaka M, et al. Role of central leptin signaling in the starvation-induced alteration of B cell development. J. Neurosci. 31, 8373-8380 (2011).
    • (2011) J. Neurosci , vol.31 , pp. 8373-8380
    • Tanaka, M.1
  • 100
    • 84856023086 scopus 로고    scopus 로고
    • Prevention of fasting-mediated bone marrow atrophy by leptin administration
    • Fujita Y, et al. Prevention of fasting-mediated bone marrow atrophy by leptin administration. Cell. Immunol. 273, 52-58 (2012).
    • (2012) Cell. Immunol , vol.273 , pp. 52-58
    • Fujita, Y.1
  • 101
    • 84959456985 scopus 로고    scopus 로고
    • Obesity decreases B cell responses in young and elderly individuals
    • Frasca D, et al. Obesity decreases B cell responses in young and elderly individuals. Obesity 24, 615-625 (2016).
    • (2016) Obesity , vol.24 , pp. 615-625
    • Frasca, D.1
  • 102
    • 84944513747 scopus 로고    scopus 로고
    • Leptin in osteoarthritis: Focus on articular cartilage and chondrocytes
    • Scotece M, & Mobasheri A. Leptin in osteoarthritis: focus on articular cartilage and chondrocytes. Life Sci. 140, 75-78 (2015).
    • (2015) Life Sci , vol.140 , pp. 75-78
    • Scotece, M.1    Mobasheri, A.2
  • 103
    • 84863001000 scopus 로고    scopus 로고
    • Serum adipokines in osteoarthritis; Comparison with controls and relationship with local parameters of synovial inflammation and cartilage damage
    • de Boer T. N, et al. Serum adipokines in osteoarthritis; comparison with controls and relationship with local parameters of synovial inflammation and cartilage damage. Osteoarthritis Cartilage 20, 846-853 (2012).
    • (2012) Osteoarthritis Cartilage , vol.20 , pp. 846-853
    • De Boer, T.N.1
  • 105
    • 0242552925 scopus 로고    scopus 로고
    • Evidence for a key role of leptin in osteoarthritis
    • Dumond H, et al. Evidence for a key role of leptin in osteoarthritis. Arthritis Rheum. 48, 3118-3129 (2003).
    • (2003) Arthritis Rheum , vol.48 , pp. 3118-3129
    • Dumond, H.1
  • 106
    • 0037332229 scopus 로고    scopus 로고
    • Synergistic induction of nitric oxide synthase type II: In vitro effect of leptin and interferon-gamma in human chondrocytes and ATDC5 chondrogenic cells
    • Otero M, Gomez Reino J. J, & Gualillo O. Synergistic induction of nitric oxide synthase type II: in vitro effect of leptin and interferon-gamma in human chondrocytes and ATDC5 chondrogenic cells. Arthritis Rheum. 48, 404-409 (2003).
    • (2003) Arthritis Rheum , vol.48 , pp. 404-409
    • Otero, M.1    Gomez Reino, J.J.2    Gualillo, O.3
  • 107
    • 84860425185 scopus 로고    scopus 로고
    • Adipokines and osteoarthritis: Novel molecules involved in the pathogenesis and progression of disease
    • Conde J, et al. Adipokines and osteoarthritis: novel molecules involved in the pathogenesis and progression of disease. Arthritis 2011, 1-8 (2011).
    • (2011) Arthritis , vol.2011 , pp. 1-8
    • Conde, J.1
  • 108
    • 34247639924 scopus 로고    scopus 로고
    • The contribution of adipose tissue and adipokines to inflammation in joint diseases
    • Toussirot E, Streit G, & Wendling D. The contribution of adipose tissue and adipokines to inflammation in joint diseases. Curr. Med. Chem. 14, 1095-1100 (2007).
    • (2007) Curr. Med. Chem , vol.14 , pp. 1095-1100
    • Toussirot, E.1    Streit, G.2    Wendling, D.3
  • 109
    • 84857239741 scopus 로고    scopus 로고
    • Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases
    • Hui W, et al. Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases. Ann. Rheum. Dis. 71, 455-462 (2012).
    • (2012) Ann. Rheum. Dis , vol.71 , pp. 455-462
    • Hui, W.1
  • 110
    • 77956946117 scopus 로고    scopus 로고
    • Leptin plays a catabolic role on articular cartilage
    • Bao J, et al. Leptin plays a catabolic role on articular cartilage. Mol. Biol. Rep. 37, 3265-3272 (2010).
    • (2010) Mol. Biol. Rep , vol.37 , pp. 3265-3272
    • Bao, J.1
  • 111
    • 80053564876 scopus 로고    scopus 로고
    • Adiponectin and leptin increase IL 8 production in human chondrocytes
    • Gómez R, et al. Adiponectin and leptin increase IL 8 production in human chondrocytes. Ann. Rheum. Dis. 70, 2052-2054 (2011).
    • (2011) Ann. Rheum. Dis , vol.70 , pp. 2052-2054
    • Gómez, R.1
  • 112
    • 84871306140 scopus 로고    scopus 로고
    • Adiponectin and leptin induce VCAM 1 expression in human and murine chondrocytes
    • Conde J, et al. Adiponectin and leptin induce VCAM 1 expression in human and murine chondrocytes. PLoS ONE 7, e52533 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e52533
    • Conde, J.1
  • 113
    • 84945471772 scopus 로고    scopus 로고
    • How leukocytes cross the vascular endothelium
    • Vestweber D. How leukocytes cross the vascular endothelium. Nat. Rev. Immunol. 15, 692-704 (2015).
    • (2015) Nat. Rev. Immunol , vol.15 , pp. 692-704
    • Vestweber, D.1
  • 114
    • 79951511147 scopus 로고    scopus 로고
    • Expanding the adipokine network in cartilage: Identification and regulation of novel factors in human and murine chondrocytes
    • Conde J, et al. Expanding the adipokine network in cartilage: identification and regulation of novel factors in human and murine chondrocytes. Ann. Rheum. Dis. 70, 551-559 (2011).
    • (2011) Ann. Rheum. Dis , vol.70 , pp. 551-559
    • Conde, J.1
  • 115
    • 84925488456 scopus 로고    scopus 로고
    • Basic aspects of adipokines in bone metabolism
    • Conde J, et al. Basic aspects of adipokines in bone metabolism. Clin. Rev. Bone Miner. Metab. 13, 11-19 (2015).
    • (2015) Clin. Rev. Bone Miner. Metab , vol.13 , pp. 11-19
    • Conde, J.1
  • 116
    • 84895919105 scopus 로고    scopus 로고
    • Osteoblast-chondrocyte interactions in osteoarthritis
    • Findlay D. M, & Atkins G. J. Osteoblast-chondrocyte interactions in osteoarthritis. Curr. Osteoporos. Rep. 12, 127-134 (2014).
    • (2014) Curr. Osteoporos. Rep , vol.12 , pp. 127-134
    • Findlay, D.M.1    Atkins, G.J.2
  • 117
    • 77955176027 scopus 로고    scopus 로고
    • Local leptin production in osteoarthritis subchondral osteoblasts may be responsible for their abnormal phenotypic expression
    • Mutabaruka M. S, Aoulad Aissa M, Delalandre A, Lavigne M, & Lajeunesse D. Local leptin production in osteoarthritis subchondral osteoblasts may be responsible for their abnormal phenotypic expression. Arthritis Res. Ther. 12, R20 (2010).
    • (2010) Arthritis Res. Ther , vol.12 , pp. R20
    • Mutabaruka, M.S.1    Aoulad Aissa, M.2    Delalandre, A.3    Lavigne, M.4    Lajeunesse, D.5
  • 118
    • 0141737573 scopus 로고    scopus 로고
    • Leptin inhibits bone formation through a hypothalamic relay: A central control of bone mass
    • Ducy P, et al. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 100, 197-207 (2000).
    • (2000) Cell , vol.100 , pp. 197-207
    • Ducy, P.1
  • 119
    • 84867404141 scopus 로고    scopus 로고
    • Leptin levels are increased and its negative regulators SOCS 3 and sOb R are decreased in obese patients with osteoarthritis: A link between obesity and osteoarthritis
    • Vuolteenaho K, Koskinen A, Moilanen T, & Moilanen E. Leptin levels are increased and its negative regulators, SOCS 3 and sOb R are decreased in obese patients with osteoarthritis: a link between obesity and osteoarthritis. Ann. Rheum. Dis. 71, 1912-1913 (2012).
    • (2012) Ann. Rheum. Dis , vol.71 , pp. 1912-1913
    • Vuolteenaho, K.1    Koskinen, A.2    Moilanen, T.3    Moilanen, E.4
  • 120
    • 79955654715 scopus 로고    scopus 로고
    • Leptin enhances MMP 1 MMP 3 and MMP 13 production in human osteoarthritic cartilage and correlates with MMP 1 and MMP 3 in synovial fluid from OA patients
    • Koskinen A, Vuolteenaho K, Nieminen R, Moilanen T, & Moilanen E. Leptin enhances MMP 1, MMP 3 and MMP 13 production in human osteoarthritic cartilage and correlates with MMP 1 and MMP 3 in synovial fluid from OA patients. Clin. Exp. Rheumatol. 29, 57-64 (2011).
    • (2011) Clin. Exp. Rheumatol , vol.29 , pp. 57-64
    • Koskinen, A.1    Vuolteenaho, K.2    Nieminen, R.3    Moilanen, T.4    Moilanen, E.5
  • 121
    • 85016642847 scopus 로고    scopus 로고
    • Adipokines induce pro-inflammatory factors in activated CD4+ T cells from osteoarthritis patients
    • Scotece M, et al. Adipokines induce pro-inflammatory factors in activated CD4+ T cells from osteoarthritis patients. J. Orthop. Res. http://dx.doi.org/10.1002/.jor.23377 (2016).
    • (2016) J. Orthop. Res
    • Scotece, M.1
  • 122
    • 70349771971 scopus 로고    scopus 로고
    • Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis
    • Griffin T. M, Huebner J. L, Kraus V. B, & Guilak F. Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis. Arthritis Rheum. 60, 2935-2944 (2009).
    • (2009) Arthritis Rheum , vol.60 , pp. 2935-2944
    • Griffin, T.M.1    Huebner, J.L.2    Kraus, V.B.3    Guilak, F.4
  • 123
    • 84868122256 scopus 로고    scopus 로고
    • Adipokine hormones and hand osteoarthritis: Radiographic severity and pain
    • Massengale M, Lu B, Pan J. J, Katz J. N, & Solomon D. H. Adipokine hormones and hand osteoarthritis: radiographic severity and pain. PLoS ONE 7, e47860 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e47860
    • Massengale, M.1    Lu, B.2    Pan, J.J.3    Katz, J.N.4    Solomon, D.H.5
  • 124
    • 84893718893 scopus 로고    scopus 로고
    • Differential expression of adipokines in infrapatellar fat pad (IPFP) and synovium of osteoarthritis patients and healthy individuals
    • Conde J, et al. Differential expression of adipokines in infrapatellar fat pad (IPFP) and synovium of osteoarthritis patients and healthy individuals. Ann. Rheum. Dis. 73, 631-633 (2014).
    • (2014) Ann. Rheum. Dis , vol.73 , pp. 631-633
    • Conde, J.1
  • 125
    • 85006796634 scopus 로고    scopus 로고
    • Leptin changes differentiation fate and induces senescence in chondrogenic progenitor cells
    • Zhao X, et al. Leptin changes differentiation fate and induces senescence in chondrogenic progenitor cells. Cell Death Dis. 7, e2188 (2016).
    • (2016) Cell Death Dis , vol.7 , pp. e2188
    • Zhao, X.1
  • 126
    • 33947137320 scopus 로고    scopus 로고
    • Measurement of the serum leptin level could assist disease activity monitoring in rheumatoid arthritis
    • Lee S. W, Park M. C, Park Y. B, & Lee S. K. Measurement of the serum leptin level could assist disease activity monitoring in rheumatoid arthritis. Rheumatol. Int. 27, 537-540 (2007).
    • (2007) Rheumatol. Int , vol.27 , pp. 537-540
    • Lee, S.W.1    Park, M.C.2    Park, Y.B.3    Lee, S.K.4
  • 127
    • 41049083323 scopus 로고    scopus 로고
    • Leptin serum levels in rheumatoid arthritis patients: Relation to disease duration and activity
    • Targonska-Stepniak B, Majdan M, & Dryglewska M. Leptin serum levels in rheumatoid arthritis patients: relation to disease duration and activity. Rheumatol. Int. 28, 585-591 (2008).
    • (2008) Rheumatol. Int , vol.28 , pp. 585-591
    • Targonska-Stepniak, B.1    Majdan, M.2    Dryglewska, M.3
  • 128
    • 77951024909 scopus 로고    scopus 로고
    • Adiponectin and leptin serum concentrations in patients with rheumatoid arthritis
    • Targonska-Stepniak B, Dryglewska M, & Majdan M. Adiponectin and leptin serum concentrations in patients with rheumatoid arthritis. Rheumatol. Int. 30, 731-737 (2010).
    • (2010) Rheumatol. Int , vol.30 , pp. 731-737
    • Targonska-Stepniak, B.1    Dryglewska, M.2    Majdan, M.3
  • 129
    • 84863309135 scopus 로고    scopus 로고
    • Synovial/serum leptin ratio in rheumatoid arthritis: The association with activity and erosion
    • Olama S. M, Senna M. K, & Elarman M. Synovial/serum leptin ratio in rheumatoid arthritis: the association with activity and erosion. Rheumatol. Int. 32, 683-690 (2012).
    • (2012) Rheumatol. Int , vol.32 , pp. 683-690
    • Olama, S.M.1    Senna, M.K.2    Elarman, M.3
  • 131
  • 132
    • 84931025156 scopus 로고    scopus 로고
    • Metreleptin and generalized lipodystrophy and evolving therapeutic perspectives
    • Tchang B. G, Shukla A. P, & Aronne L. J. Metreleptin and generalized lipodystrophy and evolving therapeutic perspectives. Expert Opin. Biol. Ther. 15, 1061-1075 (2015).
    • (2015) Expert Opin. Biol. Ther , vol.15 , pp. 1061-1075
    • Tchang, B.G.1    Shukla, A.P.2    Aronne, L.J.3
  • 133
    • 84874480871 scopus 로고    scopus 로고
    • Selective capacity of metreleptin administration to reconstitute CD4+ T cell number in females with acquired hypoleptinemia
    • Matarese G, et al. Selective capacity of metreleptin administration to reconstitute CD4+ T cell number in females with acquired hypoleptinemia. Proc. Natl Acad. Sci. USA 110, E818-E827 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. E818-E827
    • Matarese, G.1


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