메뉴 건너뛰기




Volumn 48, Issue 11, 2003, Pages 3118-3129

Evidence for a Key Role of Leptin in Osteoarthritis

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; LEPTIN RECEPTOR; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA;

EID: 0242552925     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.11303     Document Type: Article
Times cited : (464)

References (64)
  • 1
    • 0029090011 scopus 로고
    • Human obese gene expression: Adipocyte-specific expression and regional differences in the adipose tissue
    • Masuzaki H, Ogawa Y, Isse N, Satoh N, Okazaki T, Shigemoto M, et al. Human obese gene expression: adipocyte-specific expression and regional differences in the adipose tissue. Diabetes 1995;44:855-8.
    • (1995) Diabetes , vol.44 , pp. 855-858
    • Masuzaki, H.1    Ogawa, Y.2    Isse, N.3    Satoh, N.4    Okazaki, T.5    Shigemoto, M.6
  • 4
    • 0029048408 scopus 로고
    • Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central networks
    • Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central networks. Science 1995;269:546-9.
    • (1995) Science , vol.269 , pp. 546-549
    • Campfield, L.A.1    Smith, F.J.2    Guisez, Y.3    Devos, R.4    Burn, P.5
  • 7
  • 8
  • 10
    • 0029776030 scopus 로고    scopus 로고
    • The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors
    • Baumann H, Morella KK, White DW, Dembski M, Bailon PS, Kim H, et al. The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci U S A 1996;93:8374-8.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 8374-8378
    • Baumann, H.1    Morella, K.K.2    White, D.W.3    Dembski, M.4    Bailon, P.S.5    Kim, H.6
  • 11
    • 0035195887 scopus 로고    scopus 로고
    • Leptin regulation of the immune response and the immunodeficiency of malnutrition
    • Faggioni R, Feingold KR, Grunfeld C. Leptin regulation of the immune response and the immunodeficiency of malnutrition. FASEB J 2001;15:2565-71.
    • (2001) FASEB J , vol.15 , pp. 2565-2571
    • Faggioni, R.1    Feingold, K.R.2    Grunfeld, C.3
  • 12
    • 0031575804 scopus 로고    scopus 로고
    • Localization of leptin receptor mRNA splice variants in murine peripheral tissues by RT-PCR and in situ hybridization
    • Hoggard N, Mercer JG, Rayner DV, Moar K, Trayhurn P, Williams LM. Localization of leptin receptor mRNA splice variants in murine peripheral tissues by RT-PCR and in situ hybridization. Biochem Biophys Res Commun 1997;232:383-7.
    • (1997) Biochem Biophys Res Commun , vol.232 , pp. 383-387
    • Hoggard, N.1    Mercer, J.G.2    Rayner, D.V.3    Moar, K.4    Trayhurn, P.5    Williams, L.M.6
  • 13
    • 0034988897 scopus 로고    scopus 로고
    • Leptin and its role in lipid metabolism
    • Hynes GR, Jones PJH. Leptin and its role in lipid metabolism. Curr Opin Lipidol 2001;12:321-7.
    • (2001) Curr Opin Lipidol , vol.12 , pp. 321-327
    • Hynes, G.R.1    Jones, P.J.H.2
  • 14
    • 0031014413 scopus 로고    scopus 로고
    • Early onset of reproductive function in normal female mice treated with leptin
    • Chehab FF, Mounzik K, Lu R, Lim ME. Early onset of reproductive function in normal female mice treated with leptin. Science 1997;275:88-90.
    • (1997) Science , vol.275 , pp. 88-90
    • Chehab, F.F.1    Mounzik, K.2    Lu, R.3    Lim, M.E.4
  • 17
    • 0033782028 scopus 로고    scopus 로고
    • Leptin in the regulation of immunity, inflammation, and hematopoiesis
    • Fantuzzi G, Faggioni R. Leptin in the regulation of immunity, inflammation, and hematopoiesis. J Leukoc Biol 2000;68:437-46.
    • (2000) J Leukoc Biol , vol.68 , pp. 437-446
    • Fantuzzi, G.1    Faggioni, R.2
  • 19
    • 0033521601 scopus 로고    scopus 로고
    • Leptin is an endogenous protective protein against the toxicity exerted by tumor necrosis factor
    • Takahashi N, Waelput W, Guisez Y. Leptin is an endogenous protective protein against the toxicity exerted by tumor necrosis factor. J Exp Med 1999;189:207-12.
    • (1999) J Exp Med , vol.189 , pp. 207-212
    • Takahashi, N.1    Waelput, W.2    Guisez, Y.3
  • 20
    • 0141737573 scopus 로고    scopus 로고
    • Leptin inhibits bone formation through a hypothalamic relay: A central control of bone mass
    • Ducy P, Amling M, Takeda S, Priemel M, Schilling AF, Beil FT, et al. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 2000;100:197-207.
    • (2000) Cell , vol.100 , pp. 197-207
    • Ducy, P.1    Amling, M.2    Takeda, S.3    Priemel, M.4    Schilling, A.F.5    Beil, F.T.6
  • 21
    • 0036847619 scopus 로고    scopus 로고
    • Leptin regulates bone formation via the sympathetic nervous system
    • Takeda S, Elefteriou F, Levasseur R, Liu X, Zhao L, Parker KL, et al. Leptin regulates bone formation via the sympathetic nervous system. Cell 2002;111:305-17.
    • (2002) Cell , vol.111 , pp. 305-317
    • Takeda, S.1    Elefteriou, F.2    Levasseur, R.3    Liu, X.4    Zhao, L.5    Parker, K.L.6
  • 22
    • 0036234187 scopus 로고    scopus 로고
    • Leptin stimulates human osteoblastic cell proliferation, de novo collagen synthesis, and mineralization: Impact on differentiation markers, apoptosis, and osteoclastic signaling
    • Gordeladze JO, Drevon CA, Syversen U, Reseland JE. Leptin stimulates human osteoblastic cell proliferation, de novo collagen synthesis, and mineralization: impact on differentiation markers, apoptosis, and osteoclastic signaling. J Cell Biochem 2002;85:825-36.
    • (2002) J Cell Biochem , vol.85 , pp. 825-836
    • Gordeladze, J.O.1    Drevon, C.A.2    Syversen, U.3    Reseland, J.E.4
  • 26
    • 0026725714 scopus 로고
    • The interleukin-1 receptor in normal and osteoarthritic human articular chondrocytes: Identification as the type 1 receptor and analysis of binding kinetics and biologic function
    • Martel-Pelletier J, McCollum R, DiBattista J, Faure MP, Chin JA, Fournier S, et al. The interleukin-1 receptor in normal and osteoarthritic human articular chondrocytes: identification as the type 1 receptor and analysis of binding kinetics and biologic function. Arthritis Rheum 1992;35:530-40.
    • (1992) Arthritis Rheum , vol.35 , pp. 530-540
    • Martel-Pelletier, J.1    McCollum, R.2    DiBattista, J.3    Faure, M.P.4    Chin, J.A.5    Fournier, S.6
  • 27
    • 0029981825 scopus 로고    scopus 로고
    • Cytokines in osteoarthritis: Mediators or markers of joint destruction?
    • Westacott CI, Sharif M. Cytokines in osteoarthritis: mediators or markers of joint destruction? Semin Arthritis Rheum 1996;25:254-72.
    • (1996) Semin Arthritis Rheum , vol.25 , pp. 254-272
    • Westacott, C.I.1    Sharif, M.2
  • 28
    • 0030815332 scopus 로고    scopus 로고
    • Chondrocyte tumor necrosis factor receptors and focal loss of cartilage in osteoarthritis
    • Webb GR, Westacott CI, Elson CJ. Chondrocyte tumor necrosis factor receptors and focal loss of cartilage in osteoarthritis. Osteoarthritis Cartilage 1997;5:427-37.
    • (1997) Osteoarthritis Cartilage , vol.5 , pp. 427-437
    • Webb, G.R.1    Westacott, C.I.2    Elson, C.J.3
  • 29
    • 0032990777 scopus 로고    scopus 로고
    • The role of cytokines as inflammatory mediators in osteoarthritis: Lessons from animal models
    • Goldring MB. The role of cytokines as inflammatory mediators in osteoarthritis: lessons from animal models. Connect Tissue Res 1999;40:1-11.
    • (1999) Connect Tissue Res , vol.40 , pp. 1-11
    • Goldring, M.B.1
  • 30
    • 0014770490 scopus 로고
    • Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips
    • Mankin HJ, Lippiello L. Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. J Bone Joint Surg Am 1970;52:424-34.
    • (1970) J Bone Joint Surg Am , vol.52 , pp. 424-434
    • Mankin, H.J.1    Lippiello, L.2
  • 31
    • 0021238506 scopus 로고
    • In vivo and in vitro stimulation of chondrocyte biosynthetic activity in early experimental osteoarthritis
    • Sandy JD, Adams ME, Billingham ME, Plaas A, Muir H. In vivo and in vitro stimulation of chondrocyte biosynthetic activity in early experimental osteoarthritis. Arthritis Rheum 1984;27:388-97.
    • (1984) Arthritis Rheum , vol.27 , pp. 388-397
    • Sandy, J.D.1    Adams, M.E.2    Billingham, M.E.3    Plaas, A.4    Muir, H.5
  • 32
    • 0024209843 scopus 로고
    • Insulin-like growth factor maintains steady-state metabolism of proteoglycan in bovine articular cartilage explants
    • Luyten FP, Hascall VC, Nissley SP, Morales TI, Reddi AH. Insulin-like growth factor maintains steady-state metabolism of proteoglycan in bovine articular cartilage explants. Arch Biochem Biophys 1988;267:416-25.
    • (1988) Arch Biochem Biophys , vol.267 , pp. 416-425
    • Luyten, F.P.1    Hascall, V.C.2    Nissley, S.P.3    Morales, T.I.4    Reddi, A.H.5
  • 33
    • 0030773419 scopus 로고    scopus 로고
    • Chondrocyte cytokine and growth factor expression in murine osteoarthritis
    • Chambers MG, Bayliss MT, Mason RM. Chondrocyte cytokine and growth factor expression in murine osteoarthritis. Osteoarthritis Cartilage 1997;5:301-8.
    • (1997) Osteoarthritis Cartilage , vol.5 , pp. 301-308
    • Chambers, M.G.1    Bayliss, M.T.2    Mason, R.M.3
  • 34
    • 0028169834 scopus 로고
    • Transforming growth factor-beta 1 stimulates articular chondrocyte proteoglycan synthesis and induces osteophyte formation in the murine knee joint
    • Van Beuningen HM, van der Kraan PM, Arntz OJ, van den Berg WB. Transforming growth factor-beta 1 stimulates articular chondrocyte proteoglycan synthesis and induces osteophyte formation in the murine knee joint. Lab Invest 1994;7:279-90.
    • (1994) Lab Invest , vol.7 , pp. 279-290
    • Van Beuningen, H.M.1    Van der Kraan, P.M.2    Arntz, O.J.3    Van den Berg, W.B.4
  • 35
    • 0028128443 scopus 로고
    • In vivo protection against interleukin-l-induced articular cartilage damage by transforming growth factor-beta 1: Age-related differences
    • Van Beuningen HM, van der Kraan PM, Arntz OJ, van den Berg WB. In vivo protection against interleukin-l-induced articular cartilage damage by transforming growth factor-beta 1: age-related differences. Ann Rheum Dis 1994;53:593-600.
    • (1994) Ann Rheum Dis , vol.53 , pp. 593-600
    • Van Beuningen, H.M.1    Van der Kraan, P.M.2    Arntz, O.J.3    Van den Berg, W.B.4
  • 36
    • 0036194798 scopus 로고    scopus 로고
    • Body mass indices in patients with disabling hip osteoarthritis
    • Marks R, Allegrante JP. Body mass indices in patients with disabling hip osteoarthritis. Arthritis Res 2002;4:112-6.
    • (2002) Arthritis Res , vol.4 , pp. 112-116
    • Marks, R.1    Allegrante, J.P.2
  • 37
    • 0029682257 scopus 로고    scopus 로고
    • The association of obesity with osteoarthritis of the hand and knee in women: A twin study
    • Cicuttini FM, Baker JR, Spector TD. The association of obesity with osteoarthritis of the hand and knee in women: a twin study. J Rheumatol 1996;23:1221-6.
    • (1996) J Rheumatol , vol.23 , pp. 1221-1226
    • Cicuttini, F.M.1    Baker, J.R.2    Spector, T.D.3
  • 38
    • 0032964421 scopus 로고    scopus 로고
    • Body weight, body mass index, and incident symptomatic osteoarthritis of the hand, hip, and knee
    • Oliveria SA, Felson DT, Cirillo PA, Reed JI, Walker AM. Body weight, body mass index, and incident symptomatic osteoarthritis of the hand, hip, and knee. Epidemiology 1999;10:161-6.
    • (1999) Epidemiology , vol.10 , pp. 161-166
    • Oliveria, S.A.1    Felson, D.T.2    Cirillo, P.A.3    Reed, J.I.4    Walker, A.M.5
  • 39
    • 0022465236 scopus 로고
    • Development of criteria for the classification and reporting of osteoarthritis: Classification of osteoarthritis of the knee
    • Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, et al. Development of criteria for the classification and reporting of osteoarthritis: classification of osteoarthritis of the knee. Arthritis Rheum 1986;29:1039-49.
    • (1986) Arthritis Rheum , vol.29 , pp. 1039-1049
    • Altman, R.1    Asch, E.2    Bloch, D.3    Bole, G.4    Borenstein, D.5    Brandt, K.6
  • 40
    • 0015046195 scopus 로고
    • Biochemical and metabolic abnormalities in articular cartilage from osteoarthritic human hips. II. Correlation of morphology with biochemical and metabolic data
    • Mankin HJ, Dorfman H, Lippiello L, Zarins A. Biochemical and metabolic abnormalities in articular cartilage from osteoarthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am 1971;53:523-37.
    • (1971) J Bone Joint Surg Am , vol.53 , pp. 523-537
    • Mankin, H.J.1    Dorfman, H.2    Lippiello, L.3    Zarins, A.4
  • 42
    • 0030936759 scopus 로고    scopus 로고
    • Suppression of cartilage matrix gene expression in upper zone chondrocytes of osteoarthritic cartilage
    • Aigner T, Vornehm SI, Zeiler G, Dudhia J, von der Mark K, Bayliss MT. Suppression of cartilage matrix gene expression in upper zone chondrocytes of osteoarthritic cartilage. Arthritis Rheum 1997;40:562-9.
    • (1997) Arthritis Rheum , vol.40 , pp. 562-569
    • Aigner, T.1    Vornehm, S.I.2    Zeiler, G.3    Dudhia, J.4    Von der Mark, K.5    Bayliss, M.T.6
  • 43
    • 0033986279 scopus 로고    scopus 로고
    • Osteoarthritis-like changes in the murine knee joint resulting from intra-articular transforming growth factor-β injections
    • Van Beuningen HM, Glansbeek HL, van der Kraan PM, van den Berg WB. Osteoarthritis-like changes in the murine knee joint resulting from intra-articular transforming growth factor-β injections. Osteoarthritis Cartilage 2000;8:25-33.
    • (2000) Osteoarthritis Cartilage , vol.8 , pp. 25-33
    • Van Beuningen, H.M.1    Glansbeek, H.L.2    Van der Kraan, P.M.3    Van den Berg, W.B.4
  • 45
    • 0035999436 scopus 로고    scopus 로고
    • Leptin acts as growth factor on the chondrocytes of skeletal growth centers
    • Maor G, Rochwerger M, Segev Y, Phillip M. Leptin acts as growth factor on the chondrocytes of skeletal growth centers. J Bone Miner Res 2002;17:1034-43.
    • (2002) J Bone Miner Res , vol.17 , pp. 1034-1043
    • Maor, G.1    Rochwerger, M.2    Segev, Y.3    Phillip, M.4
  • 46
    • 0029907076 scopus 로고    scopus 로고
    • IGF and IGF-binding protein system in the synovial fluid of osteoarthritic and rheumatoid arthritic patients
    • Tavera C, Abribat T, Reboul P, Dore S, Brazeau P, Pelletier JP, et al. IGF and IGF-binding protein system in the synovial fluid of osteoarthritic and rheumatoid arthritic patients. Osteoarthritis Cartilage 1996;4:263-74.
    • (1996) Osteoarthritis Cartilage , vol.4 , pp. 263-274
    • Tavera, C.1    Abribat, T.2    Reboul, P.3    Dore, S.4    Brazeau, P.5    Pelletier, J.P.6
  • 47
    • 0029895089 scopus 로고    scopus 로고
    • Different cytokine profiles in the synovial fluid of patients with osteoarthritis, rheumatoid arthritis and seronegative spondylarthropathies
    • Schlaak JF, Pfers I, Meyer Zum Buschenfelde KH, Marker-Hermann E. Different cytokine profiles in the synovial fluid of patients with osteoarthritis, rheumatoid arthritis and seronegative spondylarthropathies. Clin Exp Rheumatol 1996;14:155-62.
    • (1996) Clin Exp Rheumatol , vol.14 , pp. 155-162
    • Schlaak, J.F.1    Pfers, I.2    Meyer Zum Buschenfelde, K.H.3    Marker-Hermann, E.4
  • 48
    • 0030064177 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF) receptor, IGF-I, interleukin-1 beta (IL-1 beta), and IL-6 mRNA expression in osteoarthritic and normal human cartilage
    • Middleton J, Manthey A, Tyler J. Insulin-like growth factor (IGF) receptor, IGF-I, interleukin-1 beta (IL-1 beta), and IL-6 mRNA expression in osteoarthritic and normal human cartilage. J Histochem Cytochem 1996;44:133-41.
    • (1996) J Histochem Cytochem , vol.44 , pp. 133-141
    • Middleton, J.1    Manthey, A.2    Tyler, J.3
  • 49
    • 0032963536 scopus 로고    scopus 로고
    • Immunohistochemical analysis of cytokine expression in human osteoarthritic and healthy cartilage
    • Moos V, Fickert S, Müller B, Weber U, Sieper J. Immunohistochemical analysis of cytokine expression in human osteoarthritic and healthy cartilage. J Rheumatol 1999;26:870-9.
    • (1999) J Rheumatol , vol.26 , pp. 870-879
    • Moos, V.1    Fickert, S.2    Müller, B.3    Weber, U.4    Sieper, J.5
  • 50
    • 0033711672 scopus 로고    scopus 로고
    • Modulation of collagenase 3 in human osteoarthritic cartilage by activation of extracellular transforming growth factor β: Role of furin convertase
    • Moldovan F, Pelletier JP, Mineau F, Dupuis M, Cloutier JM, Martel-Pelletier J. Modulation of collagenase 3 in human osteoarthritic cartilage by activation of extracellular transforming growth factor β: role of furin convertase. Arthritis Rheum 2000; 43:2100-9.
    • (2000) Arthritis Rheum , vol.43 , pp. 2100-2109
    • Moldovan, F.1    Pelletier, J.P.2    Mineau, F.3    Dupuis, M.4    Cloutier, J.M.5    Martel-Pelletier, J.6
  • 52
    • 0031941319 scopus 로고    scopus 로고
    • Stimulation of articular cartilage repair in established arthritis by local administration of transforming growth factor-beta into murine knee joints
    • Glansbeek GL, van Beuningen HM, Vitters EL, van der Kraan PM, van den Berg WB. Stimulation of articular cartilage repair in established arthritis by local administration of transforming growth factor-beta into murine knee joints. Lab Invest 1998;78:133-42.
    • (1998) Lab Invest , vol.78 , pp. 133-142
    • Glansbeek, G.L.1    Van Beuningen, H.M.2    Vitters, E.L.3    Van der Kraan, P.M.4    Van den Berg, W.B.5
  • 53
    • 0035992496 scopus 로고    scopus 로고
    • Recent advances in TGF-β effects on chondrocyte metabolism: Potential therapeutic roles of TGF-β in cartilage disorders
    • Grimaud E, Heymann D, Rédini F. Recent advances in TGF-β effects on chondrocyte metabolism: potential therapeutic roles of TGF-β in cartilage disorders. Cytokine Growth Factor Rev 2002; 13:241-57.
    • (2002) Cytokine Growth Factor Rev , vol.13 , pp. 241-257
    • Grimaud, E.1    Heymann, D.2    Rédini, F.3
  • 54
    • 0030199364 scopus 로고    scopus 로고
    • Effect of transforming growth factor-beta and platelet-derived growth factor-BB on articular cartilage in rats
    • Hulth A, Johnell O, Miyazono K, Lindberg L, Heinegard D, Heldin CH. Effect of transforming growth factor-beta and platelet-derived growth factor-BB on articular cartilage in rats. J Orthop Res 1996;14:547-53.
    • (1996) J Orthop Res , vol.14 , pp. 547-553
    • Hulth, A.1    Johnell, O.2    Miyazono, K.3    Lindberg, L.4    Heinegard, D.5    Heldin, C.H.6
  • 55
    • 0028181448 scopus 로고
    • Effects of interleukin-1 beta on insulin-like growth factor-I autocrine/paracrine axis in cultured rat articular chondrocytes
    • Matsumoto T, Tsukazaki T, Enomoto H, Iwasaki K, Yamashita S. Effects of interleukin-1 beta on insulin-like growth factor-I autocrine/paracrine axis in cultured rat articular chondrocytes. Ann Rheum Dis 1994;53:128-33.
    • (1994) Ann Rheum Dis , vol.53 , pp. 128-133
    • Matsumoto, T.1    Tsukazaki, T.2    Enomoto, H.3    Iwasaki, K.4    Yamashita, S.5
  • 56
    • 0030583393 scopus 로고    scopus 로고
    • Prostaglandin E2 stimulates incorporation of proline into collagenase digestible proteins in human articular chondrocytes: Identification of an effector autocrine loop involving insulin-like growth factor I
    • DiBattista JA, Dore S, Martel-Pelletier J, Pelletier JP. Prostaglandin E2 stimulates incorporation of proline into collagenase digestible proteins in human articular chondrocytes: identification of an effector autocrine loop involving insulin-like growth factor I. Mol Cell Endocrinol 1996;123:27-35.
    • (1996) Mol Cell Endocrinol , vol.123 , pp. 27-35
    • DiBattista, J.A.1    Dore, S.2    Martel-Pelletier, J.3    Pelletier, J.P.4
  • 57
    • 0029121280 scopus 로고
    • Osteoblasts and osteoclasts in adult human osteophyte tissue express the mRNAs for insulin-like growth factors I and II and the type I IGF receptor
    • Middleton J, Arnott N, Walsh S, Beresford J. Osteoblasts and osteoclasts in adult human osteophyte tissue express the mRNAs for insulin-like growth factors I and II and the type I IGF receptor. Bone 1995;16:287-95.
    • (1995) Bone , vol.16 , pp. 287-295
    • Middleton, J.1    Arnott, N.2    Walsh, S.3    Beresford, J.4
  • 58
    • 0033304859 scopus 로고    scopus 로고
    • Expression of insulin-like growth factor I messenger ribonucleic acid in developing osteophytes in murine experimental osteoarthritis and in rats inoculated with growth hormone-secreting tumor
    • Okazaki K, Jingushi S, Ikenoue T, Urabe K, Sakai H, Ohtsuru A, et al. Expression of insulin-like growth factor I messenger ribonucleic acid in developing osteophytes in murine experimental osteoarthritis and in rats inoculated with growth hormone-secreting tumor. Endocrinology 1999;140:4821-30.
    • (1999) Endocrinology , vol.140 , pp. 4821-4830
    • Okazaki, K.1    Jingushi, S.2    Ikenoue, T.3    Urabe, K.4    Sakai, H.5    Ohtsuru, A.6
  • 59
    • 0033867517 scopus 로고    scopus 로고
    • Growth factor expression in the osteophytes of the human femoral head in osteoarthritis
    • Uchino M, Izumi T, Tominaga T, Wakita R, Minehara H, Sekiguchi M, et al. Growth factor expression in the osteophytes of the human femoral head in osteoarthritis. Clin Orthop 2000;377:119-25.
    • (2000) Clin Orthop , vol.377 , pp. 119-125
    • Uchino, M.1    Izumi, T.2    Tominaga, T.3    Wakita, R.4    Minehara, H.5    Sekiguchi, M.6
  • 61
    • 0029156745 scopus 로고
    • Differential expression of collagen types I, II, III, and X in human osteophytes
    • Aigner T, Dietz U, Stöss H, von der Mark K. Differential expression of collagen types I, II, III, and X in human osteophytes. Lab Invest 1995;73:236-43.
    • (1995) Lab Invest , vol.73 , pp. 236-243
    • Aigner, T.1    Dietz, U.2    Stöss, H.3    Von der Mark, K.4
  • 64
    • 0035820271 scopus 로고    scopus 로고
    • Osteoarthritis as a systemic disorder including stromal cell differentiation and lipid metabolism
    • Aspden RM, Scheven BAA, Hutchison JD. Osteoarthritis as a systemic disorder including stromal cell differentiation and lipid metabolism. Lancet 2001;357:1118-20.
    • (2001) Lancet , vol.357 , pp. 1118-1120
    • Aspden, R.M.1    Scheven, B.A.A.2    Hutchison, J.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.