Impaired natural killer (NK) cell activity in leptin receptor deficient mice: Leptin as a critical regulator in NK cell development and activation

Biochemical and Biophysical Research Communications

Volumn 298, Issue 3, 2002, Pages 297-302

  Tian, Zhigang ^a,b,c   Sun, Rui ^a,b,c   Wei, Haiming ^a,b   Gao, Bin ^c  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^b SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY   (China)

^c NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

Cell differentiation; db db Mice; Hormone; IL 15; Immunoregulation; Leptin; Natural cytotoxicity; NK cells; Poly I:C

Indexed keywords

INTERLEUKIN 15; LEPTIN; LEPTIN RECEPTOR; LYMPHOCYTE SURFACE MARKER; POLYINOSINIC POLYCYTIDYLIC ACID;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL ACTIVITY; CELL COUNT; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; CYTOLYSIS; DRUG POTENTIATION; IMMUNOREGULATION; LIVER; LUNG; MOUSE; NATURAL KILLER CELL; NONHUMAN; PERIPHERAL CIRCULATION; PRIORITY JOURNAL; REGULATORY MECHANISM; SPLEEN; SPLEEN CELL;

ANIMALS; FLOW CYTOMETRY; KILLER CELLS, NATURAL; LEPTIN; LIVER; LUNG; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; POLY I-C; RECEPTORS, CELL SURFACE; RECOMBINANT PROTEINS; SPLEEN;

EID: 0036431034     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)02462-2     Document Type: Article

References (31)

1. Y. Zhang, R. Proenca, M. Maffei, M. Barone, L. Leopold, J. Friedman, Positional cloning of the mouse obese gene and its human homologue, Nature 372 (1994) 425-432.
2. M. Maffei, H. Fei, G. Lee, C. Dani, P. Leroy, Y. Zhang, R. Proenca, R. Negrel, G. Ailhaud, J. Friedman, Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus, Proc. Natl. Acad. Sci. USA 92 (1995) 6957-6960.
3. J. Flier, The adipocyte: Storage depot or node on the energy information superhighway? Cell 80 (1995) 15-18.
4. R. Frederich, B. Lollmann, A. Hamann, A. Napolitano-Rosen, B. Kahn, B. Lowell, J. Flier, Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity, J. Clin. Invest. 96 (1995) 1658-1663.
5. G. Fantuzzi, R. Faggioni, Leptin in the regulation of immunity, inflammation, and hematopoiesis, J. Leukoc. Biol. 68 (2000) 437-446.
6. S. Loffreda, S. Yang, H. Lin, C. Karp, M. Brengman, D. Wang, A. Klein, G. Bulkley, C. Bao, P. Noble, M. Lane, A. Diehl, Leptin regulates proinflammatory immune responses, FASEB J. 12 (1998) 57-65.
7. R. Faggioni, K. Feingold, C. Grunfeld, Leptin regulation of the immune response and the immunodeficiency of malnutrition, FASEB J. 15 (2001) 2565-2571.
8. R. Faggioni, G. Fantuzzi, C. Gabay, A. Moser, C. Dinarello, K. Feingold, C. Grunfeld, Leptin deficiency enhances sensitivity to endotoxin-induced lethality, Am. J. Physiol. 276 (1999) R136-142.
9. R. Faggioni, J. Jones-Carson, D. Reed, C. Dinarello, K. Feingold, C. Grunfeld, G. Fantuzzi, Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: Role of tumor necrosis factor a and IL-18, Proc. Natl. Acad. Sci. USA 97 (2000) 2367-2372.
10. F. Lee, Y. Li, E. Yang, S. Yang, H. Lin, M. Trush, A. Dannenberg, A. Diehl, Phenotypic abnormalities in macrophages from leptin-deficient, obese mice, Am. J. Physiol. 276 (1999) C386-C394.
11. S. Yang, H. Lin, M. Lane, M. Clemens, A. Diehl, Obesity increases sensitivity to endotoxin liver injury: Implications for the pathogenesis of steatohepatitis, Proc. Natl. Acad. Sci. USA 94 (1997) 2557-2562.
12. G. Lord, G. Matarese, J. Howard, R. Baker, S. Bloom, R. Lechler, Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression, Nature 394 (1998) 897-901.
13. J. Howard, G. Lord, G. Matarese, S. Vendetti, M. Ghatei, M. Ritter, R. Lechler, S. Bloom, Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice, J. Clin. Invest. 104 (1999) 1051-1059.
14. B. Bennett, G. Solar, J. Yuan, J. Mathias, G. Thomas, W. Matthews, A role for leptin and its cognate receptor in hematopoiesis, Curr. Biol. 6 (1996) 1170-1180.
15. J. Santos-Alvarez, R. Goberna, V. Sanchez-Margalet, Human leptin stimulates proliferation and activation of human circulating monocytes, Cell. Immunol. 194 (1999) 6-11.
16. T. Gainsford, T. Willson, D. Metcalf, E. Handman, C. McFarlane, A. Ng, N. Nicola, W. Alexander, D. Hilton, Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells, Proc. Natl. Acad. Sci. USA 93 (1996) 14564-14568.
17. W. Goodson 3rd, T. Hunt, Wound collagen accumulation in obese hyperglycemic mice, Diabetes 35 (1986) 491-495.
18. R. Tsuboi, D. Rifkin, Recombinant basic fibroblast growth factor stimulates wound healing in healing-impaired db/db mice, J. Exp. Med. 172 (1990) 245-251.
19. M. Guebre-Xabier, S. Yang, H. Lin, R. Schwenk, U. Krzych, A. Diehl, Altered hepatic lymphocyte subpopulations in obesity-related murine fatty livers: Potential mechanism for sensitization to liver damage, Hepatology 31 (2000) 633-640.
20. M. Ozata, I. Ozdemir, J. Licinio, Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects, J. Clin. Endocrinol. Metab. 84 (1999) 3686-3695.
21. L. Tartaglia, M. Dembski, X. Weng, N. Deng, J. Culpepper, R. Devos, G. Richards, L. Campfield, F. Clark, J. Deeds, et al., Identification and expression cloning of a leptin receptor, OB-R, Cell 83 (1995) 1263-1271.
22. C. Vaisse, J. Halaas, C. Horvath, J. Darnell Jr., M. Sto)el, J. Friedman, Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice, Nat. Genet. 14 (1996) 95-97.
23. C. Rosenblum, M. Tota, D. Cully, T. Smith, R. Collum, S. Qureshi, J. Hess, M. Phillips, P. Hey, A. Vongs, et al., Functional STAT 1 and 3 signaling by the leptin receptor (OB-R); reduced expression of the rat fatty leptin receptor in transfected cells, Endocrinology 137 (1996) 5178-5181.
24. F. Hong, B. Jaruga, W. Kim, S. Radaeva, O. El-Assal, Z. Tian, V. Nguyen, B. Gao, Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: Regulation by SOCS, J. Clin. Invest., 2002, in press.
25. O. Asai, D. Longo, Z. Tian, R. Hornung, D. Taub, F. Ruscetti, W. Murphy, Suppression of graft-versus-host disease and amplification of graft- versus-tumor effects by activated natural killer cells after allogeneic bone marrow transplantation, J. Clin. Invest. 101 (1998) 1835-1842.
26. C. Martin-Romero, J. Santos-Alvarez, R. Goberna, V. Sanchez-Margalet, Human leptin enhances activation and proliferation of human circulating T lymphocytes, Cell. Immunol. 199 (2000) 15-24.
27. M. Konopleva, A. Mikhail, Z. Estrov, S. Zhao, D. Harris, G. Sanchez-Williams, S. Kornblau, J. Dong, K. Kliche, S. Jiang, et al., Expression and function of leptin receptor isoforms in myeloid leukemia and myelodysplastic syndromes: Proliferative and anti-apoptotic activities, Blood 93 (1999) 1668-1676.
28. K. Takeda, T. Kaisho, N. Yoshida, J. Takeda, T. Kishimoto, S. Akira, Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: Generation and characterization of T cell-specific Stat3-deficient mice, J. Immunol. 161 (1998) 4652-4660.
29. C. Scanga, T. Verde, A. Paolone, R. Andersen, T. Wadden, Effects of weight loss and exercise training on natural killer cell activity in obese women, Med. Sci. Sports Exerc. 30 (1998) 1666-1671.
30. G. Ravaglia, P. Forti, F. Maioli, L. Bastagli, A. Facchini, E. Mariani, L. Savarino, S. Sassi, D. Cucinotta, G. Lenaz, Effect of micronutrient status on natural killer cell immune function in healthy free-living subjects aged ≥90 y, Am. J. Clin. Nutr. 71 (2000) 590-598.
31. E. Mariani, G. Ravaglia, P. Forti, A. Meneghetti, A. Tarozzi, F. Maioli, F. Boschi, L. Pratelli, A. Pizzoferrato, F. Piras, et al., Vitamin D, thyroid hormones and muscle mass influence natural killer (NK) innate immunity in healthy nonagenarians and centenarians, Clin. Exp. Immunol. 116 (1999) 19-27.