Leptin as an immunomodulator

Molecular Aspects of Medicine

Volumn 33, Issue 1, 2012, Pages 35-45

  Procaccini, Claudio ^a   Jirillo, Emilio ^b   Matarese, Giuseppe ^a,b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF BARI   (Italy)

Author keywords

Autoimmunity; Infection diseases; Inflammation; Leptin; Metabolism

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN G; INTERLEUKIN 1; INTERLEUKIN 4; LEPTIN; MAMMALIAN TARGET OF RAPAMYCIN; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA;

ADAPTIVE IMMUNITY; ALLERGIC ENCEPHALOMYELITIS; AUTOIMMUNE DISEASE; AUTOIMMUNITY; B LYMPHOCYTE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL FUNCTION; COLITIS; CONFERENCE PAPER; CYTOKINE PRODUCTION; DENDRITIC CELL; GLOMERULONEPHRITIS; HUMAN; HYPERLEPTINEMIA; IMMUNOREGULATION; INFECTION SENSITIVITY; INFLAMMATION; INNATE IMMUNITY; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MACROPHAGE; MALNUTRITION; MULTIPLE SCLEROSIS; NATURAL KILLER CELL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OBESITY; PNEUMONIA; PRE B LYMPHOCYTE; PROTEIN BLOOD LEVEL; PROTEIN CALORIE MALNUTRITION; REGULATORY T LYMPHOCYTE; SEPSIS; SERUM LEPTIN; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL;

ADAPTIVE IMMUNITY; ANIMALS; AUTOIMMUNITY; COMMUNICABLE DISEASES; DISEASE SUSCEPTIBILITY; HUMANS; IMMUNITY, INNATE; IMMUNOLOGIC FACTORS; LEPTIN; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 84655176433     PISSN: 00982997     EISSN: 18729452     Source Type: Journal    
DOI: 10.1016/j.mam.2011.10.012     Document Type: Conference Paper

References (96)

1. S. Agrawal, S. Gollapudi, H. Su, and S. Gupta Leptin activates human B cells to secrete TNF-α, IL-6, and IL-10 via JAK2/STAT3 and p38MAPK/ERK1/2 signaling pathway J. Clin. Immunol. 31 2011 472 478
2. K. Araki, A.P. Turner, V.O. Shaffer, S. Gangappa, S.A. Keller, M.F. Bachmann, C.P. Larsen, and R. Ahmed MTOR regulates memory CD8 T-cell differentiation Nature 460 2009 108 112
3. A.P. Batocchi, M. Rotondi, M. Caggiula, G. Frisullo, F. Odoardi, V. Nociti, C. Carella, P.A. Tonali, and M. Mirabella Leptin as marker of multiple sclerosis activity in patients treated with interferon-β J. Neuroimmunol. 139 2003 150 154 (Pubitemid 36700419)
4. B.D. Bennett, G.P. Solar, J.Q. Yuan, J. Mathias, G.R. Thomas, and W. Matthews A role for leptin and its cognate receptor in hematopoiesis Curr. Biol. 6 1996 1170 1180 (Pubitemid 26368751)
5. A. Berton, V. Rigot, E. Huet, M. Decarme, Y. Eeckhout, L. Patthy, G. Godeau, W. Hornebeck, G. Bellon, and H. Emonard Involvement of fibronectin type-II repeats in the efficient inhibition of gelatinases A and B by long-chain unsaturated fatty acids J. Biol. Chem. 276 2001 20458 20465
6. P. Black Why is the prevalence of allergy and autoimmunity increasing? Trends Immunol. 22 2001 354 355 (Pubitemid 32673638)
7. G.L. Blackburn Pasteur's quadrant and malnutrition Nature 409 2001 397 401 (Pubitemid 32151253)
8. G.J. Bruining Association between infant growth before onset of juvenile type-1 diabetes and autoantibodies to IA-2. Netherlands Kolibrie study group of childhood diabetes Lancet 356 2000 655 656 (Pubitemid 30627597)
9. N. Busso, A. So, V. Chobaz-Peclat, C. Morard, E. Martinez-Soria, D. Talabot-Ayer, and C. Gabay Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis J. Immunol. 168 2002 875 882 (Pubitemid 34049591)
10. M. Buyse, F. Berlioz, S. Guilmeau, A. Tsocas, T. Voisin, G. Péranzi, D. Merlin, M. Laburthe, M.J. Lewin, C. Rozé, and A. Bado PepT1-mediated epithelial transport of dipeptides and cephalexin is enhanced by luminal leptin in the small intestine J. Clin. Invest. 108 2001 1483 1494 (Pubitemid 33091986)
11. M. Buyse, S.V. Sitaraman, X. Liu, A. Bado, and D. Merlin Luminal leptin enhances CD147/MCT-1-mediated uptake of butyrate in the human intestinal cell line Caco2-BBE J. Biol. Chem. 277 2002 28182 28190 (Pubitemid 34966772)
12. F. Caldefie-Chezet, A. Poulin, A. Tridon, B. Sion, and M.P. Vasson Leptin: a potential regulator of polymorphonuclear neutrophil bactericidal action? J. Leukoc. Biol. 69 2001 414 418 (Pubitemid 32221445)
13. F. Caldefie-Chezet, A. Poulin, and M.P. Vasson Leptin regulates functional capacities of polymorphonuclear neutrophils Free Radic. Res. 37 2003 809 814 (Pubitemid 36939597)
14. J. Chan, Y. Tian, K.E. Tanaka, M.S. Tsang, K. Yu, P. Salgame, D. Carroll, Y. Kress, R. Teitelbaum, and B.R. Bloom Effects of protein-calorie malnutrition on tuberculosis in mice Proc. Natl. Acad. Sci. USA 93 1996 14857 14861 (Pubitemid 26419059)
15. T. Cederholm, P. Arner, and J. Palmblad Low circulating leptin levels in protein-energy malnourished chronically ill elderly patients J. Intern. Med. 242 1997 377 382 (Pubitemid 27513102)
16. F. Chehab, M. Lim, and R. Lu Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin Nat. Genet. 12 1996 318 320 (Pubitemid 26080094)
17. K. Claycombe, L.E. King, and P.J. Fraker A role for leptin in sustaining lymphopoiesis and myelopoiesis Proc. Natl. Acad. Sci. USA 105 2008 2017 2021 (Pubitemid 351439457)
18. X. Dai, K. Sayama, K. Yamasaki, M. Tohyama, Y. Shirakata, Y. Hanakawa, S. Tokumaru, Y. Yahata, L. Yang, A. Yoshimura, and K. Hashimoto SOCS1-negative feedback of STAT1 activation is a key pathway in the dsRNA-induced innate immune response of human keratinocytes J. Invest. Dermatol. 126 2006 1574 1581
19. V. De Rosa, C. Procaccini, A. La Cava, P. Chieffi, G.F. Nicoletti, S. Fontana, S. Zappacosta, and G. Matarese Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis J. Clin. Invest. 116 2006 447 455 (Pubitemid 43228362)
20. V. De Rosa, C. Procaccini, G. Cal, G. Pirozzi, S. Fontana, S. Zappacosta, A. La Cava, and G. Matarese A key role of leptin in the control of regulatory T cell proliferation Immunity 26 2007 241 255 (Pubitemid 46329441)
21. N.V. Dhurandhar, P.R. Kulkarni, S.M. Ajinkya, A.A. Sherikar, and R.L. Atkinson Association of adenovirus infection with human obesity Obes. Res. 5 1997 464 500
22. P. Ducy, M. Amling, S. Takeda, M. Priemel, A.F. Schilling, F.T. Beil, J. Shen, C. Vinson, J.M. Rueger, and G. Karsenty Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass Cell 100 2000 197 207 (Pubitemid 30064908)
23. P. Duggal, X. Guo, R. Haque, K.M. Peterson, S. Ricklefs, D. Mondal, F. Alam, Z. Noor, H.P. Verkerke, C. Marie, C.A. Leduc, S.C. Chua Jr., M.G. Myers Jr., R.L. Leibel, E. Houpt, C.A. Gilchrist, A. Sher, S.F. Porcella, and W.A. Petri Jr. A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children J. Clin. Invest. 121 2011 1191 1198
24. R. Faggioni, J. Jones-Carson, D.A. Reed, C.A. Dinarello, K.R. Feingold, C. Grunfeld, and G. Fantuzzi Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: role of tumor necrosis factor α and IL-18 Proc. Natl. Acad. Sci. USA 97 2000 2367 2372 (Pubitemid 30134075)
25. I.S. Farooqi, G. Matarese, G.M. Lord, J.M. Keogh, E. Lawrence, C. Agwu, V. Sanna, S.A. Jebb, F. Perna, S. Fontana, R.I. Lechler, A.M. DePaoli, and S. O'Rahilly Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency J. Clin. Invest. 110 2002 1093 1103 (Pubitemid 35215890)
26. G. Fernandes Dietary lipids and risk of autoimmune disease Clin. Immunol. Immunopathol. 72 1994 193 197 (Pubitemid 24259434)
27. C.J. Field, I.R. Johnson, and P.D. Schley Nutrients and their role in host resistance to infection J. Leukoc. Biol. 71 2002 16 32 (Pubitemid 34062769)
28. L. Fontana, J.C. Eagon, M.E. Trujillo, P.E. Scherer, and S. Klein Visceral fat adipokine secretion is associated with systemic inflammation in obese humans Diabetes 56 2007 1010 1013 (Pubitemid 46525079)
29. D.A. Fraser, J. Thoen, J.E. Reseland, O. Forre, and J. Kjeldsen-Kragh Decreased CD4+ lymphocyte activation and increased interleukin-4 production in peripheral blood of rheumatoid arthritis patients after acute starvation Clin. Rheumatol. 18 1999 394 401 (Pubitemid 29479768)
30. J.M. Friedman, and J.L. Halaas Leptin and the regulation of body weight in mammals Nature 395 1998 763 770 (Pubitemid 28485436)
31. G. Fruhbeck, and J. Gómez-Ambrosi Modulation of the leptin-induced white adipose tissue lipolysis by nitric oxide Cell. Signal. 13 2001 827 833 (Pubitemid 32913691)
32. T. Gainsford, T.A. Willson, D. Metcalf, E. Handman, C. McFarlane, A. Ng, N.A. Nicola, W.S. Alexander, and D.J. Hilton Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells Proc. Natl. Acad. Sci. USA 93 1996 14564 14568 (Pubitemid 26419007)
33. M. Galgani, C. Procaccini, V. De Rosa, F. Carbone, P. Chieffi, A. La Cava, and G. Matarese Leptin modulates the survival of autoreactive CD4+ T cells through the nutrient/energy-sensing mammalian target of rapamycin signaling pathway J. Immunol. 185 2010 7474 7479
34. A. Garcia-Gonzalez, L. Gonzalez-Lopez, I.C. Valera-Gonzalez, E.G. Cardona-Muñoz, M. Salazar-Paramo, M. González-Ortiz, E. Martínez-Abundis, and J.I. Gamez-Nava Serum leptin levels in women with systemic lupus erythematosus Rheumatol. Int. 22 2002 138 141 (Pubitemid 35002203)
35. M.L. Gruen, M. Hao, D.W. Piston, and A.H. Hasty Leptin requires canonical migratory signaling pathways for induction of monocyte and macrophage chemotaxis Am. J. Physiol. Cell. Physiol. 293 2007 C1481 C1488
36. L.S. Harbige Nutrition and autoimmunity with emphasis on infection and autoimmune disease Nutr. Health 10 1996 285 312 (Pubitemid 126460081)
37. L.S. Harbige, L. Layward, M.M. Morris-Downes, D.C. Dumonde, and S. Amor The protective effects of omega-6 fatty acids in experimental autoimmune encephalomyelitis (EAE) in relation to transforming growth factor β1 (TGF-β1) up-regulation and increased prostaglandin E2 (PGE2) production Clin. Exp. Immunol. 122 2000 445 452 (Pubitemid 32002205)
38. J.K. Howard, G.M. Lord, G. Matarese, S. Vendetti, M.A. Ghatei, M.A. Ritter, R.I. Lechler, and S.R. Bloom Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice J. Clin. Invest. 104 1999 1051 1059 (Pubitemid 29536315)
39. A. Hsu, D.M. Aronoff, J. Phipps, D. Goel, and P. Mancuso Leptin improves pulmonary bacterial clearance and survival in ob/ob mice during pneumococcal pneumonia Clin. Exp. Immunol. 150 2007 332 339 (Pubitemid 47609568)
40. W. Karges, D. Hammond-McKibben, R.K. Cheung, M. Visconti, N. Shibuya, D. Kemp, and H.M. Dosch Immunological aspects of nutritional diabetes prevention in NOD mice: a pilot study for the cow's-milk-based IDDM prevention trial Diabetes 46 1997 557 564 (Pubitemid 27143370)
41. E.A. Karlsson, P.A. Sheridan, and M.A. Beck Diet-induced obesity impairs the T cell memory response to influenza virus infection J. Immunol. 184 2010 3127 3133
42. A. La Cava, and G. Matarese The weight of leptin in immunity Nat. Rev. Immunol. 4 2004 371 379 (Pubitemid 38649279)
43. M. Laplante, and D.M. Sabatini mTOR signaling at a glance J. Cell Sci. 122 2010 3589 3594
44. C.H. Lee, Y.G. Chen, J. Chen, P.C. Reifsnyder, D.V. Serreze, M. Clare-Salzler, M. Rodriguez, C. Wasserfall, M.A. Atkinson, and E.H. Leiter Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: II. Immunologic analysis Diabetes 55 2006 171 178 (Pubitemid 43343312)
45. S. Lin, T.C. Thomas, L.H. Storlien, and X.F. Huang Development of high fat diet-induced obesity and leptin resistance in C57Bl/6J mice Int. J. Obes. Relat. Metab. Disord. 24 2000 639 646 (Pubitemid 30323498)
46. C. Lock, G. Hermans, R. Pedotti, A. Brendolan, E. Schadt, H. Garren, A. Langer-Gould, S. Strober, B. Cannella, J. Allard, P. Klonowski, A. Austin, N. Lad, N. Kaminski, S.J. Galli, J.R. Oksenberg, C.S. Raine, R. Heller, and L. Steinman Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis Nat. Med. 8 2002 500 508 (Pubitemid 34546753)
47. S. Loffreda, S.Q. Yang, H.Z. Lin, C.L. Karp, M.L. Brengman, D.J. Wang, A.S. Klein, G.B. Bulkley, C. Bao, P.W. Noble, M.D. Lane, and A.M. Diehl Leptin regulates proinflammatory immune responses FASEB J. 12 1998 57 65 (Pubitemid 28060271)
48. G.M. Lord, G. Matarese, J.K. Howard, R.J. Baker, S.R. Bloom, and R.I. Lechler Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression Nature 394 1998 897 901 (Pubitemid 28410912)
49. L. Macia, M. Delacre, G. Abboud, T.S. Ouk, A. Delanoye, C. Verwaerde, P. Saule, and I. Wolowczuk Impairment of dendritic cell functionality and steady-state number in obese mice J. Immunol. 177 2006 5997 6006 (Pubitemid 44628813)
50. P. Mancuso, A. Gottschalk, S.M. Phare, M. Peters-Golden, N.W. Lukacs, and G.B. Huffnagle Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia J. Immunol. 168 2002 4018 4024 (Pubitemid 34298407)
51. P. Mancuso, C. Canetti, A. Gottschalk, P.K. Tithof, and M. Peters-Golden Leptin augments alveolar macrophage leukotriene synthesis by increasing phospholipase activity and enhancing group IVC iPLA2 (cPLA2γ) protein expression Am. J. Physiol. 287 2004 L497 502
52. M.A. Mandel, and A.A. Mahmoud Impairment of cell-mediated immunity in mutation diabetic mice (db/db) J. Immunol. 120 1978 1375 1377 (Pubitemid 8334546)
53. C. Martin-Romero, J. Santos-Alvarez, R. Goberna, and V. Sanchez-Margalet Human leptin enhances activation and proliferation of human circulating T lymphocytes Cell. Immunol. 199 2000 15 24 (Pubitemid 30118591)
54. G. Matarese Leptin and the immune system: how nutritional status influences the immune response Eur. Cytokine Netw. 11 2000 7 14
55. G. Matarese, A. Di Giacomo, V. Sanna, G.M. Lord, J.K. Howard, A. Di Tuoro, S.R. Bloom, R.I. Lechler, S. Zappacosta, and S. Fontana Requirement for leptin in the induction and progression of autoimmune encephalomyelitis J. Immunol. 166 2001 5909 5916 (Pubitemid 32440714)
56. G. Matarese, V. Sanna, A. Di Giacomo, G.M. Lord, J.K. Howard, S.R. Bloom, R.I. Lechler, S. Fontana, and S. Zappacosta Leptin potentiates experimental autoimmune encephalomyelitis in SJL female mice and confers susceptibility to males Eur. J. Immunol. 31 2001 1324 1332 (Pubitemid 32454681)
57. G. Matarese, A. La Cava, V. Sanna, G.M. Lord, R.I. Lechler, S. Fontana, and S. Zappacosta Balancing susceptibility to infection and autoimmunity: a role for leptin? Trends Immunol. 23 2002 182 187 (Pubitemid 34260933)
58. G. Matarese, V. Sanna, R.I. Lechler, N. Sarvetnick, S. Fontana, S. Zappacosta, and A. La Cava Leptin accelerates autoimmune diabetes in female NOD mice Diabetes 51 2002 1356 1361 (Pubitemid 34826599)
59. G. Matarese, P.B. Carrieri, A. La Cava, F. Perna, V. Sanna, V. De Rosa, D. Aufiero, S. Fontana, and S. Zappacosta Leptin increase in multiple sclerosis associates with reduced number of CD4(+)CD25+ regulatory T cells Proc. Natl. Acad. Sci. USA 102 2005 5150 5155
60. B. Mattioli, L. Giordani, M.G. Quaranta, and M. Viora Leptin exerts an anti-apoptotic effect on human dendritic cells via the PI3K-Akt signaling pathway FEBS Lett. 583 2009 1102 1106
61. B. Mattioli, E. Straface, M.G. Quaranta, L. Giordani, and M. Viora Leptin promotes differentiation and survival of human dendritic cells and licenses them for Th1 priming J. Immunol. 174 2005 6820 6828 (Pubitemid 40705645)
62. B. Mattioli, E. Straface, P. Matarrese, M.G. Quaranta, L. Giordani, W. Malorni, and M. Viora Leptin as an immunological adjuvant: enhanced migratory and CD8+ T cell stimulatory capacity of human dendritic cells exposed to leptin FASEB J. 22 2008 2012 2022 (Pubitemid 351811477)
63. A.R. Muthukumar, C.A. Jolly, K. Zaman, and G. Fernandes Calorie restriction decreases proinflammatory cytokines and polymeric Ig receptor expression in the submandibular glands of autoimmune-prone (NZB × NZW)F1 mice J. Clin. Immunol. 20 2000 354 361
64. M. Ozata, I.C. Ozdemir, and J. Licinio Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects J. Clin. Endocrinol. Metab. 84 1999 3686 3695 (Pubitemid 30645226)
65. H.Y. Park, H.M. Kwon, H.J. Lim, B.K. Hong, J.Y. Lee, B.E. Park, Y. Jang, S.Y. Cho, and H.S. Kim Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro Exp. Mol. Med. 33 2001 95 102 (Pubitemid 32655888)
66. E.L. Pearce, M.C. Walsh, P.J. Cejas, G.M. Harms, H. Shen, L.S. Wang, R.G. Jones, and Y. Choi Enhancing CD8 T-cell memory by modulating fatty acid metabolism Nature 460 2009 103 107
67. L. Piccio, J.L. Stark, and A.H. Cross Chronic calorie restriction attenuates experimental autoimmune encephalomyelitis J. Leukoc. Biol. 84 2008 940 948
68. C. Procaccini, V. De Rosa, M. Galgani, L. Abanni, G. Cal, A. Porcellini, F. Carbone, S. Fontana, T.L. Horvath, A. La Cava, and G. Matarese An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness Immunity 33 2010 929 941
69. R.R. Rao, Q. Li, K. Odunsi, and P.A. Shrikant The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin Immunity 32 2010 67 78
70. C. Rummel, W. Inoue, S. Poole, and G.N. Luheshi Leptin regulates leukocyte recruitment into the brain following systemic LPS-induced inflammation Mol. Psychiatr. 15 2010 523 534
71. V. Sanchez-Margalet, C. Martín-Romero, J. Santos-Alvarez, R. Goberna, S. Najib, and C. Gonzalez-Yanes Role of leptin as an immunomodulator of blood mononuclear cells: mechanisms of action Clin. Exp. Immunol. 133 2003 11 19 (Pubitemid 36791936)
72. V. Sanna, A. Di Giacomo, A. La Cava, R.I. Lechler, S. Fontana, S. Zappacosta, and G. Matarese Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses J. Clin. Invest. 111 2003 241 250 (Pubitemid 36105923)
73. W. Savino The thymus gland is a target in malnutrition Eur. J. Clin. Nutr. 56 2002 S46 S49
74. B. Siegmund, K.C. Lear-Kaul, R. Faggioni, and G. Fantuzzi Leptin deficiency, not obesity, protects mice from Con A-induced hepatitis Eur. J. Immunol. 32 2002 552 560 (Pubitemid 34173346)
75. B. Siegmund, H.A. Lehr, and G. Fantuzzi Leptin: a pivotal mediator of intestinal inflammation in mice Gastroenterology 122 2002 2011 2025 (Pubitemid 34651443)
76. M.R. Sierra-Honigmann, A.K. Nath, C. Murakami, G. García- Cardeña, A. Papapetropoulos, W.C. Sessa, L.A. Madge, J.S. Schechner, M.B. Schwabb, P.J. Polverini, and J.R. Flores-Riveros Biological action of leptin as an angiogenic factor Science 281 1998 1683 1686 (Pubitemid 28435586)
77. A.G. Smith, P.A. Sheridan, J.B. Harp, and M.A. Beck Diet-induced obese mice have increased mortality and altered immune responses when infected with influenza virus J. Nutr. 137 2007 1236 1243 (Pubitemid 46701917)
78. A.T. Soliman, M.M. ElZalabany, M. Salama, and B.M. Ansari Serum leptin concentrations during protein-energy malnutrition: correlation with growth parameters and endocrine function Metabolism 49 2000 819 825 (Pubitemid 30483431)
79. M. Tanaka, T. Suganami, S. Sugita, Y. Shimoda, M. Kasahara, S. Aoe, M. Takeya, S. Takeda, Y. Kamei, and Y. Ogawa Role of central leptin signaling in renal macrophage infiltration Endocr. J. 57 2010 61 72
80. M. Tanaka, T. Suganami, M. Kim-Saijo, C. Toda, M. Tsuiji, K. Ochi, Y. Kamei, Y. Minokoshi, and Y. Ogawa Role of central leptin signaling in the starvation-induced alteration of B-cell development J. Neurosci. 31 2011 8373 8380
81. R.M. Tarzi, T.H. Cook, I. Jackson, C.D. Pusey, and G.M. Lord Leptin-deficient mice are protected from accelerated nephrotoxic nephritis Am. J. Pathol. 164 2004 385 390 (Pubitemid 38364654)
82. L. Tauchmanova, G. Matarese, C. Carella, G. De Rosa, B. Serio, P. Ricci, G. Lombardi, B. Rotoli, A. Colao, and C. Selleri High serum leptin in patients with chronic graft-versus-host disease after hematopoietic stem cell transplantation Transplantation 78 2004 1376 1383 (Pubitemid 39507979)
83. Z. Tian, R. Sun, H. Wei, and B. Gao Impaired natural killer (NK) cell activity in leptin receptor deficient mice: leptin as a critical regulator in NK cell development and activation Biochem. Biophys. Res. Commun. 298 2002 297 302 (Pubitemid 35333704)
84. H. Tilg, and A.R. Moschen Adipocytokines: mediators linking adipose tissue, inflammation and immunity Nat. Rev. Immunol. 6 2006 772 783 (Pubitemid 44453463)
85. K.J. Tracey Physiology and immunology of the cholinergic antiinflammatory pathway J. Clin. Invest. 117 2007 289 296 (Pubitemid 46203953)
86. J. Tschöp, R. Nogueiras, S. Haas-Lockie, K.R. Kasten, T.R. Castañeda, N. Huber, K. Guanciale, D. Perez-Tilve, K. Habegger, N. Ottaway, S.C. Woods, B. Oldfield, I. Clarke, S. Chua Jr., I.S. Farooqi, S. O'Rahilly, C.C. Caldwell, and M.H. Tschöp CNS leptin action modulates immune response and survival in sepsis J. Neurosci. 30 2010 6036 6047
87. K. Ueki, T. Kondo, Y.H. Tseng, and C.R. Kahn Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse Proc. Natl. Acad. Sci. USA 101 2004 10422 10427 (Pubitemid 38924941)
88. R. van Crevel, E. Karyadi, M.G. Netea, H. Verhoef, R.H. Nelwan, C.E. West, and J.W. van der Meer Decreased plasma leptin concentrations in tuberculosis patients are associated with wasting and inflammation J. Clin. Endocrinol. Metab. 87 2002 758 763 (Pubitemid 34158249)
89. G. Vlotides, A.S. Sorensen, F. Kopp, K. Zitzmann, N. Cengic, S. Brand, R. Zachoval, and C.J. Auernhammer SOCS-1 and SOCS-3 inhibit IFN-[alpha]-induced expression of the antiviral proteins 2, 5-OAS and MxA Biochem. Biophys. Res. Commun. 320 2004 1007 1014 (Pubitemid 38887243)
90. C.C. Whitacre Sex differences in autoimmune disease Nat. Immunol. 2 2001 777 780
91. C.W. Wieland, S. Florquin, E.D. Chan, J.C. Leemans, S. Weijer, A. Verbon, G. Fantuzzi, and T. van der Poll Pulmonary mycobacterium tuberculosis infection in leptin-deficient ob/ob mice Int. Immunol. 17 2005 1399 1408 (Pubitemid 41631316)
92. B. Woodward Protein, calories, and immune defenses Nutr. Rev. 56 1998 S84 S92
93. H. Zarkesh-Esfahani, G. Pockley, R.A. Metcalfe, M. Bidlingmaier, Z. Wu, A. Ajami, A.P. Weetman, C.J. Strasburger, and R.J. Ross High-dose leptin activates human leukocytes via receptor expression on monocytes J. Immunol. 167 2001 4593 4599 (Pubitemid 32954339)
94. H. Zarkesh-Esfahani, A.G. Pockley, Z. Wu, P.G. Hellewell, A.P. Weetman, and R.J. Ross Leptin indirectly activates human neutrophils via induction of TNF-α J. Immunol. 172 2004 1809 1814 (Pubitemid 38116829)
95. Y. Zhao, R. Sun, L. You, C. Gao, and Z. Tian Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines Biochem. Biophys. Res. Commun. 300 2003 247 252 (Pubitemid 38375801)
96. Y. Zhang, J.T. Wilsey, C.D. Frase, M.M. Matheny, B.S. Bender, S. Zolotukhin, and P.J. Scarpace Peripheral but not central leptin prevents the immunosuppression associated with hypoleptinemia in rats J. Endocrinol. 174 2002 455 461